Siegfried Roth

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. ncbi request reprint The role of Dpp and its inhibitors during eggshell patterning in Drosophila
    Bhupendra V Shravage
    Institute of Developmental Biology, University of Cologne, Gyrhofstr 17, D 50931, Germany
    Development 134:2261-71. 2007
  2. doi request reprint Self-regulatory circuits in dorsoventral axis formation of the short-germ beetle Tribolium castaneum
    Rodrigo Nunes da Fonseca
    Institute of Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50931 Cologne, Germany
    Dev Cell 14:605-15. 2008
  3. doi request reprint Evolution of axis formation: mRNA localization, regulatory circuits and posterior specification in non-model arthropods
    Rodrigo Nunes da Fonseca
    Institute of Developmental Biology, University of Cologne, D 50923, Germany
    Curr Opin Genet Dev 19:404-11. 2009
  4. pmc Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila
    Martin Technau
    Institute for Developmental Biology, Biocenter, University of Cologne, Zuelpicher Straße 47b, 50674, Cologne, Germany
    Dev Genes Evol 222:1-17. 2012
  5. doi request reprint Axis formation: microtubules push in the right direction
    Siegfried Roth
    Institute of Developmental Biology, Biocenter, University of Cologne, Zülpicher Strasse 47b, 50674 Cologne, Germany
    Curr Biol 22:R537-9. 2012
  6. pmc The maternal and early embryonic transcriptome of the milkweed bug Oncopeltus fasciatus
    Ben Ewen-Campen
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    BMC Genomics 12:61. 2011
  7. pmc Mathematics and biology: a Kantian view on the history of pattern formation theory
    Siegfried Roth
    Institute of Developmental Biology, University of Cologne, Biowissenschaftliches Zentrum, Zülpicher Strasse 47b, 50674 Cologne, Germany
    Dev Genes Evol 221:255-79. 2011
  8. ncbi request reprint Siegfried Roth
    Siegfried Roth
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstr 17, 50923 Koln, Germany
    Curr Biol 14:R734-5. 2004
  9. pmc The origin of dorsoventral polarity in Drosophila
    Siegfried Roth
    Institut fur Entwicklungsbiologie, Universitat Koln, Gyrhofstrasse 17, 50923 Koln, Germany
    Philos Trans R Soc Lond B Biol Sci 358:1317-29; discussion 1329. 2003
  10. pmc Symmetry breaking during Drosophila oogenesis
    Siegfried Roth
    Institute of Developmental Biology, University of Cologne, Gyrhofstr 17, D 50923 Cologne, Germany
    Cold Spring Harb Perspect Biol 1:a001891. 2009

Collaborators

Detail Information

Publications33

  1. ncbi request reprint The role of Dpp and its inhibitors during eggshell patterning in Drosophila
    Bhupendra V Shravage
    Institute of Developmental Biology, University of Cologne, Gyrhofstr 17, D 50931, Germany
    Development 134:2261-71. 2007
    ....
  2. doi request reprint Self-regulatory circuits in dorsoventral axis formation of the short-germ beetle Tribolium castaneum
    Rodrigo Nunes da Fonseca
    Institute of Developmental Biology, University of Cologne, Gyrhofstrasse 17, 50931 Cologne, Germany
    Dev Cell 14:605-15. 2008
    ..Our results also elucidate how extraembryonic tissues are organized in short-germ embryos, and how patterning information is transmitted from the early embryo to the growth zone...
  3. doi request reprint Evolution of axis formation: mRNA localization, regulatory circuits and posterior specification in non-model arthropods
    Rodrigo Nunes da Fonseca
    Institute of Developmental Biology, University of Cologne, D 50923, Germany
    Curr Opin Genet Dev 19:404-11. 2009
    ..In the end, we try to integrate these new findings with non-model arthropods in a common framework and discuss the major gaps of knowledge that should be addressed by future studies...
  4. pmc Molecular mechanisms of EGF signaling-dependent regulation of pipe, a gene crucial for dorsoventral axis formation in Drosophila
    Martin Technau
    Institute for Developmental Biology, Biocenter, University of Cologne, Zuelpicher Straße 47b, 50674, Cologne, Germany
    Dev Genes Evol 222:1-17. 2012
    ..Thus, EGF signaling does not act by down-regulating an activator of pipe as previously suggested but rather by activating a repressor. Surprisingly, this repressor acts independent of the common co-repressors Groucho or CtBP...
  5. doi request reprint Axis formation: microtubules push in the right direction
    Siegfried Roth
    Institute of Developmental Biology, Biocenter, University of Cologne, Zülpicher Strasse 47b, 50674 Cologne, Germany
    Curr Biol 22:R537-9. 2012
    ..Live imaging reveals that the Drosophila oocyte nucleus is pushed by growing microtubules to break the radial symmetry of the oocyte and establish dorsoventral polarity...
  6. pmc The maternal and early embryonic transcriptome of the milkweed bug Oncopeltus fasciatus
    Ben Ewen-Campen
    Department of Organismic and Evolutionary Biology, Harvard University, 16 Divinity Avenue, Cambridge, MA 02138, USA
    BMC Genomics 12:61. 2011
    ..Within insects, although large volumes of sequence data are available for holometabolous insects, developmental studies of basally branching hemimetabolous insects typically suffer from low rates of gene discovery...
  7. pmc Mathematics and biology: a Kantian view on the history of pattern formation theory
    Siegfried Roth
    Institute of Developmental Biology, University of Cologne, Biowissenschaftliches Zentrum, Zülpicher Strasse 47b, 50674 Cologne, Germany
    Dev Genes Evol 221:255-79. 2011
    ....
  8. ncbi request reprint Siegfried Roth
    Siegfried Roth
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstr 17, 50923 Koln, Germany
    Curr Biol 14:R734-5. 2004
  9. pmc The origin of dorsoventral polarity in Drosophila
    Siegfried Roth
    Institut fur Entwicklungsbiologie, Universitat Koln, Gyrhofstrasse 17, 50923 Koln, Germany
    Philos Trans R Soc Lond B Biol Sci 358:1317-29; discussion 1329. 2003
    ..This leads to a nuclear concentration gradient of Dorsal that specifies the cell types along the DV axis of the embryo...
  10. pmc Symmetry breaking during Drosophila oogenesis
    Siegfried Roth
    Institute of Developmental Biology, University of Cologne, Gyrhofstr 17, D 50923 Cologne, Germany
    Cold Spring Harb Perspect Biol 1:a001891. 2009
    ..The asymmetric positioning of the oocyte nucleus defines a cortical region of the oocyte where gurken mRNA is localized, thus breaking the dorsal-ventral symmetry of the egg and embryo...
  11. doi request reprint Evolution of extracellular Dpp modulators in insects: The roles of tolloid and twisted-gastrulation in dorsoventral patterning of the Tribolium embryo
    Rodrigo Nunes da Fonseca
    Institute of Developmental Biology, University of Cologne, Cologne, Gyrhofstrasse 17, D 50931, Germany
    Dev Biol 345:80-93. 2010
    ..Thus, our results suggest that the role of Tsg proteins for BMP gradient formation has changed during insect evolution...
  12. ncbi request reprint Mechanisms of Gurken-dependent pipe regulation and the robustness of dorsoventral patterning in Drosophila
    Francesca Peri
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstr 17, D 50923 Köln, Germany
    Development 129:2965-75. 2002
    ..This indicates that potent inhibitory processes prevent pipe dependent Toll activation at the dorsal side of the egg...
  13. pmc The phylogenetic origin of oskar coincided with the origin of maternally provisioned germ plasm and pole cells at the base of the Holometabola
    Jeremy A Lynch
    Institute for Developmental Biology, University of Cologne, Cologne, Germany
    PLoS Genet 7:e1002029. 2011
    ..We propose that the ancestral role of osk was to connect an upstream network ancestrally involved in mRNA localization and translational control to a downstream regulatory network ancestrally involved in executing the germ cell program...
  14. ncbi request reprint The Drosophila KASH domain proteins Msp-300 and Klarsicht and the SUN domain protein Klaroid have no essential function during oogenesis
    Martin Technau
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Koln, Germany
    Fly (Austin) 2:82-91. 2008
    ..Germ line nuclear envelope localization of both KASH domain proteins depends on klaroid, the only Drosophila SUN domain homolog expressed in females. Like Msp-300 and klar, klaroid is also dispensable for normal ovarian development...
  15. pmc EGF signaling and the origin of axial polarity among the insects
    Jeremy A Lynch
    Institute of Developmental Biology, University of Cologne, Zülpicher Strasse 47b, 50674 Cologne, Germany
    Curr Biol 20:1042-7. 2010
    ..These results provide insights into the evolutionary origins of the unique strategy employed by insects to establish embryonic axial polarity during oogenesis...
  16. doi request reprint Patterning the dorsal-ventral axis of the wasp Nasonia vitripennis
    Thomas Buchta
    Institute for Developmental Biology, University of Cologne, Zülpichstrasse 47b, 50674 Cologne, Germany
    Dev Biol 381:189-202. 2013
    ..From this we conclude that many network structures are available to evolution to achieve particular developmental ends. ..
  17. pmc Sog/Chordin is required for ventral-to-dorsal Dpp/BMP transport and head formation in a short germ insect
    Maurijn van der Zee
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, 50923 Cologne, Germany
    Proc Natl Acad Sci U S A 103:16307-12. 2006
    ..Thus, in Tribolium, the system of BMP and its antagonists is less complex than in Drosophila or vertebrates and combines features from both, suggesting that it might represent an ancestral state...
  18. pmc The evolution of dorsal-ventral patterning mechanisms in insects
    Jeremy A Lynch
    Institute for Developmental Biology, University of Cologne, 50674 Cologne, Germany
    Genes Dev 25:107-18. 2011
    ..Here, we review recent progress made in this field, compare our emerging molecular understanding to classical embryological experiments, and suggest future directions of inquiry...
  19. doi request reprint TGFbeta signaling in Tribolium: vertebrate-like components in a beetle
    Maurijn van der Zee
    Institute for Genetics, University of Cologne, Zulpicher Strasse 47, 50674 Cologne, Germany
    Dev Genes Evol 218:203-13. 2008
    ..Tribolium is an excellent model to study the function of these ancestral signaling components in insects...
  20. ncbi request reprint Distinct functions of the Tribolium zerknüllt genes in serosa specification and dorsal closure
    Maurijn van der Zee
    Institut fur Entwicklungsbiologie, Universitat zu Koln, Gyrhofstrasse 17, D 50931 Köln, Germany
    Curr Biol 15:624-36. 2005
    ..In Drosophila, amnioserosa formation depends on the dorsoventral patterning gene zerknüllt (zen), a derived Hox3 gene...
  21. doi request reprint Epithelial reorganization events during late extraembryonic development in a hemimetabolous insect
    Kristen A Panfilio
    Institute for Developmental Biology, University of Cologne, Gyrhofstrabetae 17, 50931 Cologne, Germany
    Dev Biol 340:100-15. 2010
    ..These data also address the long-standing question of the final fate of the amnion: it undergoes apoptosis during dorsal closure and thus is likely to be solely extraembryonic...
  22. doi request reprint Development: getting into the groove, or evolving off the rails?
    Kristen A Panfilio
    Institute for Developmental Biology, University of Cologne, Biocenter, Zülpicher Straße 47b, 50674 Koln, Germany Electronic address
    Curr Biol 23:R1101-3. 2013
    ..A new study identifies a genetic circuit dedicated to canalization in Drosophila melanogaster and shows striking variability in its use in different fly species. ..
  23. ncbi request reprint Does the bicoid gradient matter?
    Siegfried Roth
    Institut of Developmental Biology, Biocenter, University of Cologne, Zülpicher Straße 47b, 50674 Koln, Germany
    Cell 149:511-2. 2012
    ..In this issue, Chen et al. report discoveries made in the Drosophila embryo that give new insights into how positional information can be produced by patterning gradients...
  24. ncbi request reprint Developmental biology: sharp peaks from shallow sources
    Hans Meinhardt
    Nature 419:261-2. 2002
  25. ncbi request reprint A serpin regulates dorsal-ventral axis formation in the Drosophila embryo
    Petros Ligoxygakis
    Genetics Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford OX1 3QU, UK
    Curr Biol 13:2097-102. 2003
    ..Since this serpin has been recently shown to restrain an immune reaction in the blood of Drosophila, it demonstrates that proteolysis can be regulated by the same serpin in different biological contexts...
  26. ncbi request reprint Tribolium castaneum twist: gastrulation and mesoderm formation in a short-germ beetle
    Klaus Handel
    Roche Diagnostics GmbH, Nonnenwald 2, 82377 Penzberg, Germany
    Dev Genes Evol 215:13-31. 2005
    ....
  27. ncbi request reprint Dorsoventral axis formation in the Drosophila embryo--shaping and transducing a morphogen gradient
    Bernard Moussian
    Department of Genetics, Max Planck Institute for Developmental Biology, Spemannstr 35, 72076 Tubingen, Germany
    Curr Biol 15:R887-99. 2005
    ....
  28. ncbi request reprint Drosophila Cornichon acts as cargo receptor for ER export of the TGFalpha-like growth factor Gurken
    Christian Bökel
    Max Planck Institut für molekulare Zellbiologie und Genetik, Dresden, Germany
    Development 133:459-70. 2006
    ....
  29. ncbi request reprint Vertebrate Rel proteins exhibit Dorsal-like activities in early Drosophila embryogenesis
    Christian Prothmann
    Adolf Butenandt Institut, Ludwif Maximilians Universität München, Schillerstrasse 44, D 80336 Munich, Germany
    Dev Dyn 235:949-57. 2006
    ..Our results suggest the interaction between Rel proteins and their cytoplasmic inhibitors as an important interface of evolutionary adaptation...
  30. doi request reprint The genome of the model beetle and pest Tribolium castaneum
    Stephen Richards
    Human Genome Sequencing Center, Baylor College of Medicine, One Baylor Plaza, Houston, Texas 77030, USA
    Nature 452:949-55. 2008
    ..Systemic RNA interference in T. castaneum functions differently from that in Caenorhabditis elegans, but nevertheless offers similar power for the elucidation of gene function and identification of targets for selective insect control...
  31. ncbi request reprint Polar transport in the Drosophila oocyte requires Dynein and Kinesin I cooperation
    Jens Januschke
    Laboratory of Developmental Biology, Institut Jacques Monod, 2 place Jussieu, 75251 Paris Cedex 05, France
    Curr Biol 12:1971-81. 2002
    ....
  32. doi request reprint Development of Tribolium castaneum
    Siegfried Roth
    Dev Genes Evol 218:115-8. 2008
  33. pmc Drosophila stathmin: a microtubule-destabilizing factor involved in nervous system formation
    Sylvie Ozon
    Institut National de la Santé et de la Recherche Médicale U440 Université Pierre et Marie Curie, Institut du Fer a Moulin, 75005 Paris, France
    Mol Biol Cell 13:698-710. 2002
    ..We demonstrate for the first time their direct involvement in major biological processes such as development of the reproductive and nervous systems...