C Roth

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome
    C Roth
    J Pediatr Endocrinol Metab 15:945-8. 2002
  2. ncbi request reprint Therapeutic potential of GnRH antagonists in the treatment of precocious puberty
    Christian Roth
    Children s Hospital Medical Center, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    Expert Opin Investig Drugs 11:1253-9. 2002
  3. ncbi request reprint Antagonistic and agonistic GnRH analogue treatment of precocious puberty: tracking gonadotropin concentrations in urine
    C L Roth
    Department of Pediatrics, University of Bonn, Bonn, Germany
    Horm Res 63:257-62. 2005
  4. ncbi request reprint Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss
    Christian L Roth
    Department of Pediatrics, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    J Clin Endocrinol Metab 90:6386-91. 2005
  5. ncbi request reprint Different effects of agonistic vs. antagonistic gnrh-analogues (triptorelin vs. cetrorelix) on bone modeling and remodeling in peripubertal female rats
    C L Roth
    Department of Pediatrics, University of Bonn, Germany
    Exp Clin Endocrinol Diabetes 113:451-6. 2005
  6. ncbi request reprint Modulation of circulating IGF-I and IGFBP-3 levels by hormonal regulators of energy homeostasis in obese children
    J F Woelfle
    Children s Hospital, University of Bonn, Bonn, Germany
    Exp Clin Endocrinol Diabetes 115:17-23. 2007
  7. ncbi request reprint Complete virilization in congenital adrenal hyperplasia: clinical course, medical management and disease-related complications
    J Woelfle
    Children s Hospital, University of Bonn, Germany
    Clin Endocrinol (Oxf) 56:231-8. 2002
  8. pmc 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
  9. ncbi request reprint Rate of hypoglycaemia and insulin dosage in children during the initial therapy of type 1 diabetes mellitus
    Antje Herbst
    Department of Paediatrics, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    Eur J Pediatr 164:633-8. 2005
  10. ncbi request reprint Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity
    Thomas Reinehr
    Department of Endocrinology and Diabetes, Vestische Youth Hospital, University of Witten Herdecke, Datteln, Germany
    Pediatr Diabetes 6:5-12. 2005

Detail Information

Publications22

  1. ncbi request reprint Effective aromatase inhibition by anastrozole in a patient with gonadotropin-independent precocious puberty in McCune-Albright syndrome
    C Roth
    J Pediatr Endocrinol Metab 15:945-8. 2002
    ..The potent estrogen suppressive action and simple dosage regimen of anastrozole suggest it may be advantageous compared to other aromatase inhibitors such as testolactone or anti-estrogens...
  2. ncbi request reprint Therapeutic potential of GnRH antagonists in the treatment of precocious puberty
    Christian Roth
    Children s Hospital Medical Center, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    Expert Opin Investig Drugs 11:1253-9. 2002
    ..Our animal tests indicate strong potential for the development and testing of long-acting depot preparations of GnRH antagonists in treating precocious puberty...
  3. ncbi request reprint Antagonistic and agonistic GnRH analogue treatment of precocious puberty: tracking gonadotropin concentrations in urine
    C L Roth
    Department of Pediatrics, University of Bonn, Bonn, Germany
    Horm Res 63:257-62. 2005
    ..The question is if combining a short-acting antagonist with a long-acting agonist can diminish gonadotropin flare-up...
  4. ncbi request reprint Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss
    Christian L Roth
    Department of Pediatrics, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    J Clin Endocrinol Metab 90:6386-91. 2005
    ..The gut hormone peptide YY(3-36) (PYY) reduces food intake via hypothalamic Y2 receptors in the brain. There is not much known about PYY in obese children...
  5. ncbi request reprint Different effects of agonistic vs. antagonistic gnrh-analogues (triptorelin vs. cetrorelix) on bone modeling and remodeling in peripubertal female rats
    C L Roth
    Department of Pediatrics, University of Bonn, Germany
    Exp Clin Endocrinol Diabetes 113:451-6. 2005
    ..When using new GnRH antagonists for treating precocious puberty in humans, parameters for bone strength and mineralization should be monitored...
  6. ncbi request reprint Modulation of circulating IGF-I and IGFBP-3 levels by hormonal regulators of energy homeostasis in obese children
    J F Woelfle
    Children s Hospital, University of Bonn, Bonn, Germany
    Exp Clin Endocrinol Diabetes 115:17-23. 2007
    ..In linear regression analyses, leptin SDS, IGFBP-3 SDS and BMI SDS contributed significantly to the variation of IGF-I SDS values, and explained 53.3% of the variability of IGF-I SDS levels in male subjects...
  7. ncbi request reprint Complete virilization in congenital adrenal hyperplasia: clinical course, medical management and disease-related complications
    J Woelfle
    Children s Hospital, University of Bonn, Germany
    Clin Endocrinol (Oxf) 56:231-8. 2002
    ....
  8. pmc 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
    ..Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism...
  9. ncbi request reprint Rate of hypoglycaemia and insulin dosage in children during the initial therapy of type 1 diabetes mellitus
    Antje Herbst
    Department of Paediatrics, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    Eur J Pediatr 164:633-8. 2005
    ..0147), in patients with high HbA1c (P = 0.0001), high BG (P <0.0001), or low pH (P <0.0001). There was no influence of age on the insulin dosage...
  10. ncbi request reprint Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity
    Thomas Reinehr
    Department of Endocrinology and Diabetes, Vestische Youth Hospital, University of Witten Herdecke, Datteln, Germany
    Pediatr Diabetes 6:5-12. 2005
    ..Insulin resistance is well recognized both in type 1 diabetes mellitus (T1DM) and in obesity. Studies concerning the relation between insulin resistance and overweight in T1DM have not yet been carried out...
  11. ncbi request reprint Fasting glucagon-like peptide-1 and its relation to insulin in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten, Germany
    J Pediatr Gastroenterol Nutr 44:608-12. 2007
    ..To study the relationships between glucagon-like peptide-1 (GLP-1), weight status, insulin, and insulin resistance in the fasting state...
  12. ncbi request reprint Peptide YY and glucagon-like peptide-1 in morbidly obese patients before and after surgically induced weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Obes Surg 17:1571-7. 2007
    ..The aim of this study was to analyze the relationships between fasting PYY, GLP-1, and weight status in morbidly obese patients before and after surgically induced weight loss...
  13. ncbi request reprint Adipocyte fatty acid-binding protein in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, 45711, Datteln, Germany
    Metabolism 56:1735-41. 2007
    ..Further longitudinal studies are necessary to study the relationship between A-FABP concentrations and parameters of the metabolic syndrome...
  14. ncbi request reprint Amylin and its relation to insulin and lipids in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Obesity (Silver Spring) 15:2006-11. 2007
    ..There are limited data concerning the relationships between amylin, weight status, lipids, insulin, and insulin resistance in obese humans. Therefore, the aim was to study these relationships in cross-sectional and longitudinal analyses...
  15. pmc Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Strasse 5, Datteln, Germany
    J Clin Endocrinol Metab 93:2287-93. 2008
    ..There are limited and controversial data concerning the relationships between retinol-binding protein 4 (RBP4), weight status, and insulin resistance in obese humans and especially in children...
  16. ncbi request reprint Type 2 diabetes in children and adolescents in a 2-year follow-up: insufficient adherence to diabetes centers
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Horm Res 69:107-13. 2008
    ..To study the 2-year course of children and adolescents with type 2 diabetes mellitus (T2DM) in general practice to present (1) the treatment modalities, (2) patient adherence, and (3) the occurrence of comorbidities...
  17. pmc Enhanced at puberty 1 (EAP1) is a new transcriptional regulator of the female neuroendocrine reproductive axis
    Sabine Heger
    Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    J Clin Invest 117:2145-54. 2007
    ..These results suggest that EAP1 is a transcriptional regulator that, acting within the neuroendocrine brain, contributes to controlling female reproductive function...
  18. ncbi request reprint Expression of a tumor-related gene network increases in the mammalian hypothalamus at the time of female puberty
    Christian L Roth
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Science University, Beaverton, OR 97006, USA
    Endocrinology 148:5147-61. 2007
    ..TRGs may be expressed in the mammalian hypothalamus as components of a regulatory gene network that facilitates and integrates cellular and cell-cell communication programs required for the acquisition of female reproductive competence...
  19. ncbi request reprint Reduced sympathetic metabolites in urine of obese patients with craniopharyngioma
    Christian L Roth
    Pediatric Endocrinology, Children s Hospital and Regional Medical Center, University of Washington, Seattle, WA 98105, USA
    Pediatr Res 61:496-501. 2007
    ..In further studies investigating treatment options for hypothalamic obesity, disturbed sympathetic tone should be considered...
  20. ncbi request reprint Quantitative proteomics identifies a change in glial glutamate metabolism at the time of female puberty
    Christian L Roth
    Division of Neuroscience, Oregon National Primate Research Center, Oregon Health and Sciences University, 505 NW 185th Avenue, Beaverton, OR 97006, USA
    Mol Cell Endocrinol 254:51-9. 2006
    ..Thus, an increase excitatory drive to the LHRH neuronal network provided by glutamatergic inputs of glial origin, is an event contributing to the pubertal activation of LHRH secretion...
  21. ncbi request reprint Cord blood leptin and IGF-I in relation to birth weight differences and head circumference in monozygotic twins
    Bettina C Gohlke
    Departments of Pediatrics, University of Bonn, Germany
    J Pediatr Endocrinol Metab 19:3-9. 2006
    ..To investigate a potential role of leptin and insulin-like growth factor (IGF)-I on fetal growth and metabolic function we determined plasma leptin and IGF-I concentrations in twins in relation to discordant fetal growth...
  22. ncbi request reprint High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, D 45711 Datteln, Germany
    Metabolism 54:1155-61. 2005
    ..The chronic inflammation markers TNF-alpha and hsCRP were independent of lipids, blood pressure, and insulin resistance index. Weight loss was associated with the significant decrease of hsCRP and triglyceride levels, and blood pressure...