S Rossner

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion
    Ingo Schulz
    Probiodrug AG, Halle S, Germany
    J Neurochem 94:970-9. 2005
  2. doi request reprint NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42
    Virginie Buggia-Prevot
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS UNSA, Equipe labellisée Fondation pour la Recherche Médicale, 06560 Valbonne, France
    J Biol Chem 283:10037-47. 2008
  3. ncbi request reprint Protein kinase Calpha and beta1 isoforms are regulators of alpha-secretory proteolytic processing of amyloid precursor protein in vivo
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 13:1644-8. 2001
  4. ncbi request reprint New players in old amyloid precursor protein-processing pathways
    Steffen Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Janhnallee 59, 04109 Leipzig, Germany
    Int J Dev Neurosci 22:467-74. 2004
  5. ncbi request reprint Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology
    S Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    J Neurosci Res 64:437-46. 2001
  6. ncbi request reprint Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing
    Steffen Rossner
    Paul Flechsig Institut für Hirnforschung, Abteilung Neurochemie, Universitat Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    J Biol Chem 279:27841-4. 2004
  7. ncbi request reprint Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 13:269-78. 2001
  8. ncbi request reprint Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 12:3191-200. 2000
  9. ncbi request reprint Intracerebroventricular infusion of CHO5, a rat monoclonal antibody directed against mouse low-affinity nerve growth factor receptor (p75NTR), specifically labels basal forebrain cholinergic neurons in mouse brain
    S Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Germany
    Metab Brain Dis 15:17-27. 2000
  10. ncbi request reprint Regulated secretion of amyloid precursor protein by TrkA receptor stimulation in rat pheochromocytoma-12 cells is mitogen activated protein kinase sensitive
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Leipzig, Germany
    Neurosci Lett 271:97-100. 1999

Collaborators

Detail Information

Publications40

  1. ncbi request reprint Subcellular localization suggests novel functions for prolyl endopeptidase in protein secretion
    Ingo Schulz
    Probiodrug AG, Halle S, Germany
    J Neurochem 94:970-9. 2005
    ....
  2. doi request reprint NFkappaB-dependent control of BACE1 promoter transactivation by Abeta42
    Virginie Buggia-Prevot
    Institut de Pharmacologie Moleculaire et Cellulaire, UMR 6097 CNRS UNSA, Equipe labellisée Fondation pour la Recherche Médicale, 06560 Valbonne, France
    J Biol Chem 283:10037-47. 2008
    ....
  3. ncbi request reprint Protein kinase Calpha and beta1 isoforms are regulators of alpha-secretory proteolytic processing of amyloid precursor protein in vivo
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 13:1644-8. 2001
    ....
  4. ncbi request reprint New players in old amyloid precursor protein-processing pathways
    Steffen Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Janhnallee 59, 04109 Leipzig, Germany
    Int J Dev Neurosci 22:467-74. 2004
    ..Therefore, agonists specific for the Munc13-1 C1-domain or small molecules mimicking the function of the endogenous Munc13-1 activator RIM1 may prove useful to shift APP processing towards the non-amyloidogenic pathway...
  5. ncbi request reprint Neuronal and glial beta-secretase (BACE) protein expression in transgenic Tg2576 mice with amyloid plaque pathology
    S Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    J Neurosci Res 64:437-46. 2001
    ....
  6. ncbi request reprint Munc13-1-mediated vesicle priming contributes to secretory amyloid precursor protein processing
    Steffen Rossner
    Paul Flechsig Institut für Hirnforschung, Abteilung Neurochemie, Universitat Leipzig, Jahnallee 59, D 04109 Leipzig, Germany
    J Biol Chem 279:27841-4. 2004
    ..We establish that, in addition to PKC, Munc13-1 significantly contributes to the regulation of secretory APP metabolism...
  7. ncbi request reprint Increased neuronal and glial expression of protein kinase C isoforms in neocortex of transgenic Tg2576 mice with amyloid pathology
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 13:269-78. 2001
    ..The induction of the PKC gamma and PKC lambda isoforms in reactive astrocytes surrounding amyloid plaques might be required for astrocyte activation and astrocytic cytokine expression in response to amyloid plaque formation...
  8. ncbi request reprint Constitutive overactivation of protein kinase C in guinea pig brain increases alpha-secretory APP processing without decreasing beta-amyloid generation
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 12:3191-200. 2000
    ....
  9. ncbi request reprint Intracerebroventricular infusion of CHO5, a rat monoclonal antibody directed against mouse low-affinity nerve growth factor receptor (p75NTR), specifically labels basal forebrain cholinergic neurons in mouse brain
    S Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Germany
    Metab Brain Dis 15:17-27. 2000
    ....
  10. ncbi request reprint Regulated secretion of amyloid precursor protein by TrkA receptor stimulation in rat pheochromocytoma-12 cells is mitogen activated protein kinase sensitive
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Leipzig, Germany
    Neurosci Lett 271:97-100. 1999
    ..This suggests that pharmacological manipulations activating the MAP kinase pathway may result in increased secretory APP processing...
  11. ncbi request reprint Alzheimer's disease beta-secretase BACE1 is not a neuron-specific enzyme
    Steffen Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Leipzig, Germany
    J Neurochem 92:226-34. 2005
    ..Also, there are differences in responses to chronic versus acute stress, suggesting that one consequence of chronic stress is an incremental shift to different phenotypic cellular states...
  12. ncbi request reprint Brain prolyl endopeptidase expression in aging, APP transgenic mice and Alzheimer's disease
    Steffen Rossner
    epartment of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, 04109, Leipzig, Germany
    Neurochem Res 30:695-702. 2005
    ....
  13. ncbi request reprint Transcriptional and translational regulation of BACE1 expression--implications for Alzheimer's disease
    Steffen Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Prog Neurobiol 79:95-111. 2006
    ....
  14. ncbi request reprint Astrocytic expression of the Alzheimer's disease beta-secretase (BACE1) is stimulus-dependent
    Maike Hartlage-Rübsamen
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
    Glia 41:169-79. 2003
    ..Additionally, we observed BACE1-immunoreactive astrocytes in proximity to beta-amyloid plaques in the brains of aged Tg2576 mice and Alzheimer's disease patients...
  15. ncbi request reprint Basal forebrain cholinergic immunolesion by 192IgG-saporin: evidence for a presynaptic location of subpopulations of alpha 2- and beta-adrenergic as well as 5-HT2A receptors on cortical cholinergic terminals
    M Heider
    Paul Flechsig Institute for Brain Research, University Leipzig, Germany
    Neurochem Res 22:957-66. 1997
    ..The lesion-induced receptor changes suggest that the alterations in cortical 5-HT2 receptor binding observed in patients with Alzheimer's disease might be secondary to cholinergic deficits...
  16. ncbi request reprint Iodo-QNB cortical binding and brain perfusion: effects of a cholinergic basal forebrain lesion in the rat
    D Sorger
    Department of Nuclear Medicine, University of Leipzig, Germany
    Nucl Med Biol 26:9-16. 1999
    ..Impaired cholinergic transmission was paralleled by a 10-15% increase of [125I]iodo-QNB binding in the regions of cortex and hippocampus. The local cerebral blood flow remained unchanged after cholinergic lesion...
  17. ncbi request reprint The transcription factor Yin Yang 1 is an activator of BACE1 expression
    Katrin Nowak
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Leipzig, Germany
    J Neurochem 96:1696-707. 2006
    ..Our observations suggest that interfering with expression, translocation or binding of YY1 to its BACE1 promoter-specific sequence may have therapeutic potential for treating patients with AD...
  18. ncbi request reprint Developmentally induced microencephalopathy in guinea pigs--embryonic glial cell activation marks selective neuronal death
    S Rossner
    Department of Neurochemistry, Paul Flechsig Institute for Brain Research, Jahnallee 59, 04109, Leipzig, Germany
    Int J Dev Neurosci 19:313-8. 2001
    ....
  19. ncbi request reprint Cellular and ultra structural evidence for cytoskeletal localization of prolyl endopeptidase-like protein in neurons
    M Morawski
    Paul Flechsig Institute for Brain Research, University of Leipzig, 04109 Leipzig, Jahnallee 59, Germany
    Neuroscience 242:128-39. 2013
    ..Our data indicate physiological functions of PREPL associated with the cytoskeleton, which may be affected under conditions of cytoskeletal degeneration...
  20. ncbi request reprint Cerebrospinal fluid cholinesterases--markers for loss of cholinergic basal forebrain neurons?
    S Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Germany
    Int J Dev Neurosci 16:669-73. 1998
    ....
  21. ncbi request reprint Cholinergic immunolesions by 192IgG-saporin--useful tool to simulate pathogenic aspects of Alzheimer's disease
    S Rossner
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Germany
    Int J Dev Neurosci 15:835-50. 1997
    ..Application of the model to animal species that can develop beta-amyloid plaques could provide information about the contribution of cholinergic function to amyloidogenic APP processing...
  22. ncbi request reprint Cloning and expression of the rat BACE1 promoter
    Christine Lange-Dohna
    Department of Neurochemistry, University of Leipzig, Leipzig, Germany
    J Neurosci Res 73:73-80. 2003
    ..The BACE1 promoter sequence data and the constructs described here will be useful to identify factors that influence the expression of BACE1 in experimental paradigms in vitro...
  23. ncbi request reprint Formation of perineuronal nets in organotypic mouse brain slice cultures is independent of neuronal glutamatergic activity
    Sabrina Reimers
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Eur J Neurosci 25:2640-8. 2007
    ..These results indicate that neuronal activity is required but that the glutamatergic system is not essential for PN development...
  24. ncbi request reprint Amyloid precursor protein processing in vivo--insights from a chemically-induced constitutive overactivation of protein kinase C in Guinea pig brain
    Volker Bigl
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Curr Med Chem 10:871-82. 2003
    ..Our results indicate that both pathways of APP processing are differentially controlled under these experimental conditions in vivo...
  25. ncbi request reprint Decomposition and long-lasting downregulation of extracellular matrix in perineuronal nets induced by focal cerebral ischemia in rats
    Carsten Hobohm
    Department of Neurology, University of Leipzig, Leipzig, Germany
    J Neurosci Res 80:539-48. 2005
    ..These deficits may contribute to the long-lasting functional impairments after stroke...
  26. ncbi request reprint Oxygen/glucose deprivation increases the integration of recombinant P2X7 receptors into the plasma membrane of HEK293 cells
    Doreen Milius
    Rudolf Boehm Institute for Pharmacology and Toxicology, University of Leipzig, D 04107 Leipzig, Germany
    Toxicology 238:60-9. 2007
    ..In conclusion, P2X(7) receptors may alter their trafficking properties during ischemia and thereby contribute to the ATP-induced damage of various cell-types including neurons...
  27. doi request reprint Developmental expression and subcellular localization of glutaminyl cyclase in mouse brain
    Maike Hartlage-Rübsamen
    Paul Flechsig Institute for Brain Research, University of Leipzig, Leipzig, Germany
    Int J Dev Neurosci 27:825-35. 2009
    ..Our results are in compliance with a role of QC in hypothalamic hormone maturation and suggest additional, yet unidentified QC functions in brain regions relevant for learning and memory which are affected in Alzheimer's disease...
  28. ncbi request reprint BACE1 is a newly discovered protein secreted by the pancreas which cleaves enteropeptidase in vitro
    Albrecht Hoffmeister
    Department of Internal Medicine II, University of Leipzig, Leipzig, Germany
    JOP 10:501-6. 2009
    ..Strong BACE1 expression has also been described in pancreatic tissue...
  29. ncbi request reprint Reduced infarct volume and differential effects on glial cell activation after hyperbaric oxygen treatment in rat permanent focal cerebral ischaemia
    Albrecht Günther
    Department of Neurology, University of Leipzig, Liebigstrasse 22a, 04103 Leipzig, Germany
    Eur J Neurosci 21:3189-94. 2005
    ..Our data indicate that HBO-induced suppression of microgliosis and aggravated response of astrocytes might contribute to the reported beneficial effects of early HBO treatment in cerebral ischaemia...
  30. ncbi request reprint P2X7 receptor expression after ischemia in the cerebral cortex of rats
    Heike Franke
    Rudolf Boehm Institute of Pharmacology and Toxicology, University of Leipzig, Leipzig, Germany
    J Neuropathol Exp Neurol 63:686-99. 2004
    ..In conclusion, the present data demonstrate a postischemic, time-dependent upregulation of the P2X7 receptor-subtype on neurons and glial cells and suggest a role for this receptor in the pathophysiology of cerebral ischemia in vivo...
  31. ncbi request reprint Role of prolyl endopeptidase in intracellular transport and protein secretion
    M Morawski
    Paul Flechsig Institute for Brain Research, University of Leipzig, Faculty of Medicine, Germany
    CNS Neurol Disord Drug Targets 10:327-32. 2011
    ....
  32. ncbi request reprint In vivo [125I]-iodobenzovesamicol binding reflects cortical cholinergic deficiency induced by specific immunolesion of rat basal forebrain cholinergic system
    D Sorger
    Department of Nuclear Medicine, University of Leipzig, Germany
    Nucl Med Biol 27:23-31. 2000
    ....
  33. pmc Distinct glutaminyl cyclase expression in Edinger-Westphal nucleus, locus coeruleus and nucleus basalis Meynert contributes to pGlu-Abeta pathology in Alzheimer's disease
    Markus Morawski
    University of Leipzig, Leipzig, Germany
    Acta Neuropathol 120:195-207. 2010
    ..Our results may explain the high vulnerability of defined subcortical neuronal populations and their central target areas in AD as a consequence of QC expression and pE-Abeta formation...
  34. ncbi request reprint Guinea pigs as a nontransgenic model for APP processing in vitro and in vivo
    Mike Beck
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig, Jahnallee 59, 04109 Leipzig, Germany
    Neurochem Res 28:637-44. 2003
    ..In this article we highlight the advantages and limitations of using guinea pigs as experimental models to study APP processing...
  35. ncbi request reprint Changes in activity and expression of phosphofructokinase in different rat brain regions after basal forebrain cholinergic lesion
    Ulrike Zeitschel
    Paul Flechsig Institute for Brain Research, Department of Neurochemistry, University of Leipzig Medical Faculty, Leipzig, Germany
    J Neurochem 83:371-80. 2002
    ..It is concluded that common metabolic mechanisms may underlie the degenerative and repair processes in denervated rat brain and in the diseased Alzheimer's brain...
  36. doi request reprint Glutaminyl cyclase inhibition attenuates pyroglutamate Abeta and Alzheimer's disease-like pathology
    Stephan Schilling
    Probiodrug AG, Weinbergweg 22, 06120 Halle S, Germany
    Nat Med 14:1106-11. 2008
    ..The reduction of brain pE-Abeta by inhibition of glutaminyl cyclase offers a new therapeutic option for the treatment of Alzheimer's disease and provides implications for other amyloidoses, such as familial Danish dementia...
  37. ncbi request reprint Differential regulation of BACE1 promoter activity by nuclear factor-kappaB in neurons and glia upon exposure to beta-amyloid peptides
    Krystyn Z Bourne
    Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555 1072, USA
    J Neurosci Res 85:1194-204. 2007
    ....
  38. pmc Nonsteroidal anti-inflammatory drugs repress beta-secretase gene promoter activity by the activation of PPARgamma
    Magdalena Sastre
    Department of Neurology, University of Bonn, Sigmund Freud Strasse 25, 53127 Bonn, Germany
    Proc Natl Acad Sci U S A 103:443-8. 2006
    ....
  39. ncbi request reprint D-ribose improves cardiac contractility and hemodynamics, and reduces expression of c-fos in the hippocampus during sustained slow ventricular tachycardia in rats
    Hans Jürgen Schneider
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Regensburg, Franz Joseph Strauss Allee 11, 93053 Regensburg, Deutschland, Germany
    Int J Cardiol 125:49-56. 2008
    ..We hypothesized that cerebral ischemia during slow VT may lead to the expression of immediate early genes related to neurodegeneration. This expression may be prevented by d-ribose substitution...
  40. ncbi request reprint Changes in cortical acetyl-CoA metabolism after selective basal forebrain cholinergic degeneration by 192IgG-saporin
    Maria Tomaszewicz
    Department of Laboratory Medicine, Medical University of Gdansk, Poland
    J Neurochem 87:318-24. 2003
    ..There are also indications that cholinergic activity affects acetyl-CoA level and its intracellular distribution in glial and other non-cholinergic cortical cells...