Affiliation: University of Essen
Rosskopf D, Manthey I, Siffert W. Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit. Pharmacogenetics. 2002;12:209-20 pubmed
..Furthermore, they will contribute to the understanding of GNB3-related population-specific pharmacogenetic differences in the response to major drugs, as already shown for diuretics and antidepressants. ..
Rosskopf D, Kielbik M, Manthey I, Bilmen G, Eisenhardt A, Siffert W. Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit. Biochim Biophys Acta. 2003;1626:33-42 pubmed
..However, there is no association with an allele of the GNB3 C825T polymorphism, which suggests that Gbeta3v does not contribute to the complex phenotype observed in association with the 825T-allele. ..
Rosskopf D, Nikula C, Manthey I, Joisten M, Frey U, Kohnen S, et al
. The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction. FEBS Lett. 2003;544:27-32 pubmed
Rosskopf D, Busch S, Manthey I, Siffert W. G protein beta 3 gene: structure, promoter, and additional polymorphisms. Hypertension. 2000;36:33-41 pubmed
..This is the first complete characterization of the human GNB3 gene and its promoter region, which will enable refined epidemiological and biochemical investigations of GNB3 in hypertension and obesity. ..
Rosskopf D, Manthey I, Habich C, Kielbik M, Eisenhardt A, Nikula C, et al
. Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit. Biochem J. 2003;371:223-32 pubmed
..Together, these results suggest that G beta 3s2 is a biologically active G beta variant which may play a role in the manifestation of the complex phenotype associated with the 825T-allele. ..