D Rosskopf

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. pmc Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, D 45122 Essen, Germany
    Biochem J 371:223-32. 2003
  2. ncbi request reprint The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstr 55, Germany
    FEBS Lett 544:27-32. 2003
  3. ncbi request reprint More hints on Wnts: gene profiling by beta2-adrenergic receptor-frizzled chimeras
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Essen, Germany
    Mol Pharmacol 65:12-4. 2004
  4. ncbi request reprint Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Essen, Germany
    Pharmacogenetics 12:209-20. 2002
  5. ncbi request reprint Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstr 55, D 45147, Essen, Germany
    Biochim Biophys Acta 1626:33-42. 2003
  6. ncbi request reprint G protein beta 3 gene: structure, promoter, and additional polymorphisms
    D Rosskopf
    Institut für Pharmakologie Universitätsklinikum Essen, Essen, Germany
    Hypertension 36:33-41. 2000
  7. ncbi request reprint Sodium-hydrogen exchange and platelet function
    D Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    J Thromb Thrombolysis 8:15-24. 1999
  8. ncbi request reprint Interaction of Gbeta3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteins
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Cell Signal 15:479-88. 2003
  9. ncbi request reprint The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache
    M Schurks
    Department of Neurology, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Cephalalgia 27:363-7. 2007
  10. ncbi request reprint G protein beta3 polymorphism and triptan response in cluster headache
    M Schurks
    Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Clin Pharmacol Ther 82:396-401. 2007

Collaborators

Detail Information

Publications36

  1. pmc Identification and characterization of G beta 3s2, a novel splice variant of the G-protein beta 3 subunit
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, D 45122 Essen, Germany
    Biochem J 371:223-32. 2003
    ..Together, these results suggest that G beta 3s2 is a biologically active G beta variant which may play a role in the manifestation of the complex phenotype associated with the 825T-allele...
  2. ncbi request reprint The human G protein beta4 subunit: gene structure, expression, Ggamma and effector interaction
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstr 55, Germany
    FEBS Lett 544:27-32. 2003
    ....
  3. ncbi request reprint More hints on Wnts: gene profiling by beta2-adrenergic receptor-frizzled chimeras
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Essen, Germany
    Mol Pharmacol 65:12-4. 2004
  4. ncbi request reprint Identification and ethnic distribution of major haplotypes in the gene GNB3 encoding the G-protein beta3 subunit
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Essen, Germany
    Pharmacogenetics 12:209-20. 2002
    ..Furthermore, they will contribute to the understanding of GNB3-related population-specific pharmacogenetic differences in the response to major drugs, as already shown for diuretics and antidepressants...
  5. ncbi request reprint Characterization of the splice variant Gbeta3v of the human G-protein Gbeta3 subunit
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstr 55, D 45147, Essen, Germany
    Biochim Biophys Acta 1626:33-42. 2003
    ..However, there is no association with an allele of the GNB3 C825T polymorphism, which suggests that Gbeta3v does not contribute to the complex phenotype observed in association with the 825T-allele...
  6. ncbi request reprint G protein beta 3 gene: structure, promoter, and additional polymorphisms
    D Rosskopf
    Institut für Pharmakologie Universitätsklinikum Essen, Essen, Germany
    Hypertension 36:33-41. 2000
    ..This is the first complete characterization of the human GNB3 gene and its promoter region, which will enable refined epidemiological and biochemical investigations of GNB3 in hypertension and obesity...
  7. ncbi request reprint Sodium-hydrogen exchange and platelet function
    D Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    J Thromb Thrombolysis 8:15-24. 1999
    ..Blockade of platelet NHE1 can inhibit platelet activation. With the development of highly specific NHE1 inhibitors, detailed investigation of the relationships between NHE1 activity and platelet activation now becomes feasible...
  8. ncbi request reprint Interaction of Gbeta3s, a splice variant of the G-protein Gbeta3, with Ggamma- and Galpha-proteins
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Cell Signal 15:479-88. 2003
    ..Together, these results indicate that Gbeta3s is a biologically active Gbeta-protein that may mediate the enhanced signal transduction observed in cells with the 825T-allele...
  9. ncbi request reprint The G1246A polymorphism in the hypocretin receptor 2 gene is not associated with treatment response in cluster headache
    M Schurks
    Department of Neurology, University Hospital Essen, University Duisburg Essen, Essen, Germany
    Cephalalgia 27:363-7. 2007
    ..Our results do not support a role of the HCRTR2 G1246A polymorphism in drug responses in CH...
  10. ncbi request reprint G protein beta3 polymorphism and triptan response in cluster headache
    M Schurks
    Department of Neurology, University Hospital Essen, University of Duisburg Essen, Essen, Germany
    Clin Pharmacol Ther 82:396-401. 2007
    ..e., drugs not directly affecting G proteins. We conclude that pain relief by triptans is significantly modulated by a common genetic GNB3 variant...
  11. ncbi request reprint Worldwide ethnic distribution of the G protein beta3 subunit 825T allele and its association with obesity in Caucasian, Chinese, and Black African individuals
    W Siffert
    Institute für Pharmakologie, Universitatsklinikum Essen, Germany
    J Am Soc Nephrol 10:1921-30. 1999
    ..It is anticipated that high frequencies of the 825T allele in Africans and Asians may contribute to an obesity and hypertension epidemic if Westernization of lifestyles continues...
  12. ncbi request reprint [Genetic polymorphism of the G-protein beta3 subunit, obesity and essential hypertension]
    W Siffert
    Institut fur Pharmakologie, Universitatsklinikum Essen
    Herz 25:26-33. 2000
    ..In individuals with borderline hypertension genotyping can facilitate the decision for medical treatment as a positive test result confirms an inherited form of hypertension...
  13. ncbi request reprint Expression, functional characterization and tissue distribution of a Na+/H+ exchanger cloned from Xenopus laevis oocytes (XL-NHE)
    S Busch
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstr 55, D 45122 Essen, Germany
    Pflugers Arch 436:828-33. 1998
    ..Using reverse transcription polymerase chain reaction, XL-NHE message could be detected in various Xenopus tissues including heart, brain, skeletal muscle, reticulocytes, A6-kidney cells and oocytes...
  14. ncbi request reprint Enhanced epinephrine-induced platelet aggregation in individuals carrying the G protein beta3 subunit 825T allele
    C Naber
    Abteilung fur Kardiologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Germany
    FEBS Lett 484:199-201. 2000
    ..This effect was more pronounced after inhibition of the cyclooxygenase-2 pathway by acetylsalicylic acid. This phenomenon appeared independent of platelet secretion, or inhibition of the adenylyl cyclase...
  15. ncbi request reprint Glucose and lipid metabolism in young lean normotensive males with the G protein beta3 825T-allele
    B Saller
    Abteilung für Endokrinologie, Zentrum fur Innere Medizin, Universitatsklinikum Essen, Germany
    Eur J Med Res 8:91-7. 2003
    ..Furthermore, fasting cholesterol was significantly higher in TC compared to CC genotype (4.71 versus 3.96 mmol/l; p = 0.007) suggesting that enhanced G protein signalling might be associated with alterations of cholesterol metabolism...
  16. ncbi request reprint Association of a human G-protein beta3 subunit variant with hypertension
    W Siffert
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Nat Genet 18:45-8. 1998
    ..Genotype analysis of 427 normotensive and 426 hypertensive subjects suggests a significant association of the T allele with essential hypertension...
  17. ncbi request reprint The G protein beta3 subunit splice variant Gbeta3-s causes enhanced chemotaxis of human neutrophils in response to interleukin-8
    S Virchow
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    Naunyn Schmiedebergs Arch Pharmacol 360:27-32. 1999
    ....
  18. ncbi request reprint Human G protein beta3 subunit variant does not alter hypercarbic or hypoxic ventilatory response
    H J Exner
    , , Hufeland Strasse 55, D-45122 Essen, Germany
    Clin Physiol 21:612-20. 2001
    ..Whilst respiratory control may still be influenced by G-protein aberration, other mechanisms seem to have a more important role in controlling ventilation...
  19. ncbi request reprint Cluster headache is associated with the G1246A polymorphism in the hypocretin receptor 2 gene
    M Schurks
    Department of Neurology, University Hospital Essen, Hufelandstrasse 55, 45122 Essen, Germany
    Neurology 66:1917-9. 2006
    ..The genotype and allele distribution varied significantly between patients and controls. Homozygous carriers of the G-allele had a twofold increase in risk for CH (OR 1.97; 95% CI 1.32 to 2.92; p = 0.0007)...
  20. ncbi request reprint Alcohol consumption is associated with an interaction between DRD2 exon 8 A/A genotype and self-directedness in males
    Michael Lucht
    Department of Psychiatry and Psychotherapy, HANSE Klinikum Stralsund, Stralsund, Germany
    Neuropsychobiology 56:24-31. 2007
    ..We examined for interactions between DRD2 exon 8(rs6276), a polymorphism which has been associated with various alcohol-related phenotypes, SDD and alcohol consumption...
  21. ncbi request reprint Association between migraine and the G1246A polymorphism in the hypocretin receptor 2 gene
    Markus Schürks
    Department of Neurology, University of Duisberg Essen, Essen, Germany
    Headache 47:1195-9. 2007
    ....
  22. ncbi request reprint Comment on "A common genetic variant is associated with adult and childhood obesity"
    Dieter Rosskopf
    Institute of Pharmacology, Ernst Moritz Arndt University of Greifswald, Germany
    Science 315:187; author reply 187. 2007
    ..A subgroup analysis, however, revealed that this allele significantly increased the risk for obesity in already overweight individuals...
  23. doi request reprint Comment on "Genetically determined differences in learning from errors"
    Michael Lucht
    Hospital for Psychiatry and Psychotherapy, Haus 30, Ernst Moritz Arndt University, Greifswald, Stralsund 18437, Germany
    Science 321:200; author reply 200. 2008
    ..We raise the concern that this polymorphism resides in the gene for the kinase ANKK1, where it causes a nonconservative amino acid exchange...
  24. ncbi request reprint Association study of the G-protein beta3 subunit C825T polymorphism with disease progression in patients with bladder cancer
    Andreas Eisenhardt
    Institut fur Pharmakologie, Universitatsklinikum Essen, Germany
    World J Urol 23:279-86. 2005
    ..The genotype of the GNB3 C825T polymorphism appears to influence the biological behavior of tumor disease in non-smoking TCC patients...
  25. ncbi request reprint Expression analysis and potential functional role of the CXCR4 chemokine receptor in bladder cancer
    Andreas Eisenhardt
    Department of Pharmacology, University Hospital Essen, Hufelandstr 55, 45122 Essen, Germany
    Eur Urol 47:111-7. 2005
    ....
  26. pmc Rap2B-dependent stimulation of phospholipase C-epsilon by epidermal growth factor receptor mediated by c-Src phosphorylation of RasGRP3
    Matthias B Stope
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Mol Cell Biol 24:4664-76. 2004
    ..Collectively, these data suggest that the EGF receptor triggers activation of Rap2B via PLC-gamma1 activation and tyrosine phosphorylation of RasGRP3 by c-Src, finally resulting in stimulation of PLC-epsilon...
  27. ncbi request reprint Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1
    Stefan Oswald
    Department of Clinical Pharmacology, University of Greifswald, Greifswald, Germany
    Pharmacogenet Genomics 18:559-68. 2008
    ....
  28. doi request reprint SLC2A9 influences uric acid concentrations with pronounced sex-specific effects
    Angela Doring
    Institute of Epidemiology, Helmholtz Zentrum Munchen, German Research Center for Environmental Health, 85764 Neuherberg, Germany
    Nat Genet 40:430-6. 2008
    ..The proportion of the variance of serum uric acid concentrations explained by genotypes was about 1.2% in men and 6% in women, and the percentage accounted for by expression levels was 3.5% in men and 15% in women...
  29. ncbi request reprint Signal transduction of somatostatin in human B lymphoblasts
    Dieter Rosskopf
    Institut fur Pharmakologie, Universitatsklinikum Essen, Hufelandstrasse 55, D 45122 Essen, Germany
    Am J Physiol Cell Physiol 284:C179-90. 2003
    ..5-fold stimulation of DNA synthesis and a 4.4-fold stimulation of B lymphoblast proliferation, which was accompanied by an enhanced immunoglobulin formation. Thus SST exerts a growth factor-like activity on human B lymphoblasts...
  30. pmc Direct stimulation of receptor-controlled phospholipase D1 by phospho-cofilin
    Li Han
    Institut fur Pharmakologie, Universitatsklinikum Essen, Essen, Germany
    EMBO J 26:4189-202. 2007
    ..These data indicate that till now designated inactive phospho-cofilin exhibits an active cellular function, and suggest that phospho-cofilin by its stimulatory effect on PLD1 may control a large variety of cellular functions...
  31. ncbi request reprint Investigation of the Lith6 candidate genes APOBEC1 and PPARG in human gallstone disease
    Clemens Schafmayer
    Department of General Surgery and Thoracic Surgery, Christian Albrechts University Kiel, Kiel, Germany
    Liver Int 27:910-9. 2007
    ..Two attractive positional and functional candidate genes in apolipoprotein B mRNA-editing protein (APOBEC1) and peroxisome proliferator-activated receptor gamma (PPARG) are located in this interval...
  32. ncbi request reprint A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
    Stephan Buch
    First Department of Medicine, University Hospital Schleswig Holstein, 24105 Kiel, Germany
    Nat Genet 39:995-9. 2007
    ..6, P = 1.4 x 10(-14)) in the full German sample. Association was stronger in subjects with cholesterol gallstones (odds ratio = 3.3), suggesting that His19 might be associated with a more efficient transport of cholesterol into the bile...
  33. ncbi request reprint Genetics of arterial hypertension and hypotension
    Dieter Rosskopf
    Department Pharmacology, Research Center for Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University Greifswald, Friedrich Loeffler Str 23d, 17487 Greifswald, Germany
    Naunyn Schmiedebergs Arch Pharmacol 374:429-69. 2007
    ..Together, this provides the basis for the identification of novel drug targets and, hopefully, innovative antihypertensive drugs...
  34. ncbi request reprint Uptake of cardiovascular drugs into the human heart: expression, regulation, and function of the carnitine transporter OCTN2 (SLC22A5)
    Markus Grube
    Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, Department of Pharmacology, Ernst Moritz Arndt University, Greifswald, Germany
    Circulation 113:1114-22. 2006
    ..We investigated expression and localization of OCTN2 in the human heart, uptake of drugs by OCTN2, and functional coupling of OCTN2 with the eliminating ATP-binding cassette (ABC) transporter ABCB1 (P-glycoprotein)...
  35. ncbi request reprint Disposition and sterol-lowering effect of ezetimibe are influenced by single-dose coadministration of rifampin, an inhibitor of multidrug transport proteins
    Stefan Oswald
    Department of Clinical Pharmacology, Ernst Moritz Arndt University of Greifswald, Greifswald, Germany
    Clin Pharmacol Ther 80:477-85. 2006
    ....
  36. ncbi request reprint Cyclic AMP-dependent and Epac-mediated activation of R-Ras by G protein-coupled receptors leads to phospholipase D stimulation
    Maider López de Jesús
    Institut fur Pharmakologie, Universitatsklinikum Essen, 45122 Essen, Germany
    J Biol Chem 281:21837-47. 2006
    ....