Jonas Rosendahl

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. pmc Pre-study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis
    Gabriele Fluhr
    Central Endoscopy and Department of Medicine A, University Medicine Greifswald, Ferdinand Sauerbruch Straße, Greifswald, 17475, Germany
    BMC Gastroenterol 13:11. 2013
  2. doi request reprint When in doubt, take it out? Cholestasis and obstructive gastric outlet syndrome in a patient with suspected chronic pancreatitis
    Jonas Rosendahl
    Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany
    Pancreatology 13:458-60. 2013
  3. doi request reprint [Genetically determined pancreatic diseases]
    J Rosendahl
    Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitatsklinikum Leipzig, AöR, Liebigstr 20, 04103, Leipzig
    Internist (Berl) 53:384, 386-8, 390-1. 2012
  4. pmc A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis
    Jonas Rosendahl
    Division of Gastroenterology and Rheumatology, Department for Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e29433. 2012
  5. pmc Hereditary chronic pancreatitis
    Jonas Rosendahl
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Orphanet J Rare Dis 2:1. 2007
  6. pmc Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany
    Pancreatology 10:243-9. 2010
  7. pmc Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany
    Pancreatology 10:165-72. 2010
  8. pmc Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis
    Sebastian Weis
    Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e37981. 2012
  9. ncbi request reprint The course of genetically determined chronic pancreatitis
    Volker Keim
    Medizinische Klinik II, Universitatsklinikum Leipzig, Germany
    JOP 4:146-54. 2003
  10. ncbi request reprint Compound heterozygous mutations of the SBDS gene in a patient with Shwachman-Diamond syndrome, type 1 diabetes mellitus and osteoporosis
    Jonas Rosendahl
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Leipzig, Germany
    Pancreatology 6:549-54. 2006

Collaborators

Detail Information

Publications18

  1. pmc Pre-study protocol MagPEP: a multicentre randomized controlled trial of magnesium sulphate in the prevention of post-ERCP pancreatitis
    Gabriele Fluhr
    Central Endoscopy and Department of Medicine A, University Medicine Greifswald, Ferdinand Sauerbruch Straße, Greifswald, 17475, Germany
    BMC Gastroenterol 13:11. 2013
    ..It can thereby attenuate the intracellular activation of proteolytic digestive enzymes in the pancreas and reduces the severity of experimental pancreatitis when administered either intravenously or as a food supplement...
  2. doi request reprint When in doubt, take it out? Cholestasis and obstructive gastric outlet syndrome in a patient with suspected chronic pancreatitis
    Jonas Rosendahl
    Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany
    Pancreatology 13:458-60. 2013
    ..However, in rare cases, like the one presented here, an uncommon non-malignant entity like a periampullary hamartoma may be only diagnosed after surgical resection. ..
  3. doi request reprint [Genetically determined pancreatic diseases]
    J Rosendahl
    Klinik und Poliklinik für Gastroenterologie und Rheumatologie, Department für Innere Medizin, Neurologie und Dermatologie, Universitatsklinikum Leipzig, AöR, Liebigstr 20, 04103, Leipzig
    Internist (Berl) 53:384, 386-8, 390-1. 2012
    ....
  4. pmc A common variant of PNPLA3 (p.I148M) is not associated with alcoholic chronic pancreatitis
    Jonas Rosendahl
    Division of Gastroenterology and Rheumatology, Department for Internal Medicine, Neurology and Dermatology, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e29433. 2012
    ..I148M) is associated with the development of alcoholic liver cirrhosis (ALC). Since, alcoholic CP and ALC share the same aetiology PNPLA3 variant (p.I148M) possibly influences the development of alcoholic CP...
  5. pmc Hereditary chronic pancreatitis
    Jonas Rosendahl
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Orphanet J Rare Dis 2:1. 2007
    ..The disease course and prognosis of patients with HCP is unpredictable. Pancreatic cancer risk is elevated. Therefore, HCP patients should strongly avoid environmental risk factors for pancreatic cancer...
  6. pmc Complete analysis of the human mesotrypsinogen gene (PRSS3) in patients with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany
    Pancreatology 10:243-9. 2010
    ..Mesotrypsin (PRSS3) can degrade intrapancreatic trypsin inhibitors that protect against CP. Genetic variants that cause higher mesotrypsin activity might increase the risk for CP...
  7. pmc Sequence analysis of the human tyrosylprotein sulfotransferase-2 gene in subjects with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Leipzig, Germany
    Pancreatology 10:165-72. 2010
    ..Because increased trypsinogen autoactivation has been implicated as a pathogenic mechanism in chronic pancreatitis, we hypothesized that genetic variants of TPST2 might alter the risk for the disease...
  8. pmc Genetic analyses of heme oxygenase 1 (HMOX1) in different forms of pancreatitis
    Sebastian Weis
    Department of Internal Medicine, Neurology and Dermatology, Division of Gastroenterology and Rheumatology, University of Leipzig, Leipzig, Germany
    PLoS ONE 7:e37981. 2012
    ..Transcription of HMOX1 in humans is influenced by a GT-repeat located in the promoter. As such, HMOX1 variants might be of importance in the pathogenesis of pancreatitis...
  9. ncbi request reprint The course of genetically determined chronic pancreatitis
    Volker Keim
    Medizinische Klinik II, Universitatsklinikum Leipzig, Germany
    JOP 4:146-54. 2003
    ..The clinical course of chronic pancreatitis in patients with mutations of cationic trypsinogen and the trypsin inhibitor SPINK1 has not yet been characterized...
  10. ncbi request reprint Compound heterozygous mutations of the SBDS gene in a patient with Shwachman-Diamond syndrome, type 1 diabetes mellitus and osteoporosis
    Jonas Rosendahl
    Medizinische Klinik und Poliklinik II, Universitatsklinikum Leipzig, Leipzig, Germany
    Pancreatology 6:549-54. 2006
    ....
  11. pmc Chymotrypsin C (CTRC) variants that diminish activity or secretion are associated with chronic pancreatitis
    Jonas Rosendahl
    Department of Gastroenterology and Hepatology, University of Leipzig, Philipp Rosenthal Strasse 27, 04103 Leipzig, Germany
    Nat Genet 40:78-82. 2008
    ..The results indicate that loss-of-function alterations in CTRC predispose to pancreatitis by diminishing its protective trypsin-degrading activity...
  12. pmc Mutations of human cationic trypsinogen (PRSS1) and chronic pancreatitis
    Niels Teich
    Medizinische Klinik und Poliklinik II, Universitat Leipzig, Germany
    Hum Mutat 27:721-30. 2006
    ..The clinical presentation is highly variable, but most affected mutation carriers have relatively mild disease. In this review, we summarize the current knowledge on trypsinogen mutations and their role in pancreatic diseases...
  13. doi request reprint Genetic and biochemical evidence for a functional role of BACE1 in the regulation of insulin mRNA expression
    Albrecht Hoffmeister
    Department of Medicine, Gastroenterology, University of Leipzig, Germany
    Obesity (Silver Spring) 21:E626-33. 2013
    ..Beta-site amyloid precursor protein cleaving enzyme (BACE1) is highly expressed in pancreatic β-cells. The BACE1 gene is located in a region associated with a high diabetes risk in PIMA Indians...
  14. pmc The inverse starving test is not a suitable provocation test for Gilbert's syndrome
    Niels Teich
    Internistische Gemeinschaftspraxis für Verdauungs und Stoffwechselerkrankungen, Leipzig, Germany
    BMC Res Notes 1:35. 2008
    ..However, these tests cause considerable side effects or require hospital admission. In single GS patients, we observed rapid serum bilirubin normalization after a standard European lunch (the "inverse starving test")...
  15. ncbi request reprint HFE genotypes in patients with chronic pancreatitis and pancreatic adenocarcinoma
    Tomas Hucl
    Department of Medicine II, University of Heidelberg, Mannheim, Germany
    Genet Med 9:479-83. 2007
    ..C282Y and p.H63D may increase susceptibility to chronic liver and pancreatic disease. This study determines the frequencies of p.C282Y and p.H63D alterations in patients with chronic pancreatitis and pancreatic adenocarcinoma...
  16. ncbi request reprint Keratin 8 sequence variants in patients with pancreatitis and pancreatic cancer
    Matthias Treiber
    Department of Hepatology and Gastroenterology, Charite, Campus Virchow Klinikum, Universitatsmedizin Berlin, Berlin, Germany
    J Mol Med (Berl) 84:1015-22. 2006
    ..6%) control subjects of African descent. Our data suggest that the KRT8 alterations, Y54H and G62C, do not predispose patients to the development of pancreatitis or pancreatic cancer...
  17. pmc A degradation-sensitive anionic trypsinogen (PRSS2) variant protects against chronic pancreatitis
    Heiko Witt
    Department of Hepatology and Gastroenterology, Charite University Hospital, Augustenburger Platz 1, 13353 Berlin, Germany
    Nat Genet 38:668-73. 2006
    ..In conclusion, the G191R variant of PRSS2 mitigates intrapancreatic trypsin activity and thereby protects against chronic pancreatitis...
  18. pmc Signal peptide variants that impair secretion of pancreatic secretory trypsin inhibitor (SPINK1) cause autosomal dominant hereditary pancreatitis
    Orsolya Kiraly
    Department of Molecular and Cell Biology, Boston University, Goldman School of Dental Medicine, Boston, Massachusetts, USA
    Hum Mutat 28:469-76. 2007
    ..Therefore, these variants should be classified as severe and regarded as disease-causing rather than disease-modifiers...