Arndt Rolfs

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. ncbi request reprint Ih is maturing: implications for neuronal development
    Nino Rocha
    Neurobiological Laboratory, Department of Neurology, University of Rostock, Rostock, Germany
    Neurodegener Dis 3:27-31. 2006
  2. pmc Glucosylsphingosine is a highly sensitive and specific biomarker for primary diagnostic and follow-up monitoring in Gaucher disease in a non-Jewish, Caucasian cohort of Gaucher disease patients
    Arndt Rolfs
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany
    PLoS ONE 8:e79732. 2013
  3. pmc Functional characterisation of alpha-galactosidase a mutations as a basis for a new classification system in fabry disease
    Jan Lukas
    Albrecht Kossel Institute for Neuroregeneration, Centre for Mental Health, University of Rostock, Rostock, Germany
    PLoS Genet 9:e1003632. 2013
  4. ncbi request reprint Acute cerebrovascular disease in the young: the Stroke in Young Fabry Patients study
    Arndt Rolfs
    Albrecht Kossel Institute for Neuroregeneration, Medical Faculty, University of Rostock, Gehlsheimer St 20, 18147 Rostock, Germany
    Stroke 44:340-9. 2013
  5. doi request reprint Protocol and methodology of the Stroke in Young Fabry Patients (sifap1) study: a prospective multicenter European study of 5,024 young stroke patients aged 18-55 years
    Arndt Rolfs
    Albrecht Kossel Institute for Neuroregeneration, Medical Faculty, University of Rostock, Gehlsheimerstrasse 20, Rostock, Germany
    Cerebrovasc Dis 31:253-62. 2011
  6. ncbi request reprint Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
    Arndt Rolfs
    Department of Neurology, University of Rostock, Rostock, Germany
    Lancet 366:1794-6. 2005
  7. ncbi request reprint Wnt-5a expression in the rat neuronal progenitor cell line ST14A
    Sabine Peters
    Department of Neurology, University of Rostock, PO Box 100888, 18055 Rostock, Germany
    Exp Brain Res 158:189-95. 2004
  8. doi request reprint Interferon-beta modulates protein synthesis in the central nervous system
    Susanne Beyer
    Dept of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
    J Neuroimmunol 213:31-8. 2009
  9. ncbi request reprint 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    J Autoimmun 27:251-65. 2006
  10. ncbi request reprint Increasing extracellular potassium results in subthalamic neuron activity resembling that seen in a 6-hydroxydopamine lesion
    Ulf Strauss
    Neurobiology, Department of Neurology, University of Rostock, Rostock, Germany
    J Neurophysiol 99:2902-15. 2008

Detail Information

Publications80

  1. ncbi request reprint Ih is maturing: implications for neuronal development
    Nino Rocha
    Neurobiological Laboratory, Department of Neurology, University of Rostock, Rostock, Germany
    Neurodegener Dis 3:27-31. 2006
    ..Further, it outlines hypotheses on the contribution of Ih to neuronal and network maturation...
  2. pmc Glucosylsphingosine is a highly sensitive and specific biomarker for primary diagnostic and follow-up monitoring in Gaucher disease in a non-Jewish, Caucasian cohort of Gaucher disease patients
    Arndt Rolfs
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany
    PLoS ONE 8:e79732. 2013
    ..Additionally, chitotriosidase reflects the changes in the course of the disease belatedly. This further enhances the need for a reliable biomarker, especially for the monitoring of the disease and the impact of potential treatments...
  3. pmc Functional characterisation of alpha-galactosidase a mutations as a basis for a new classification system in fabry disease
    Jan Lukas
    Albrecht Kossel Institute for Neuroregeneration, Centre for Mental Health, University of Rostock, Rostock, Germany
    PLoS Genet 9:e1003632. 2013
    ..Finally, in order to generate reliable predictions of mutant GLA defects we compared the different data sets to reveal the most coherent system to reflect the clinical situation. ..
  4. ncbi request reprint Acute cerebrovascular disease in the young: the Stroke in Young Fabry Patients study
    Arndt Rolfs
    Albrecht Kossel Institute for Neuroregeneration, Medical Faculty, University of Rostock, Gehlsheimer St 20, 18147 Rostock, Germany
    Stroke 44:340-9. 2013
    ..We initiated the prospective, multinational European study Stroke in Young Fabry Patients (sifap) to characterize a cohort of young stroke patients...
  5. doi request reprint Protocol and methodology of the Stroke in Young Fabry Patients (sifap1) study: a prospective multicenter European study of 5,024 young stroke patients aged 18-55 years
    Arndt Rolfs
    Albrecht Kossel Institute for Neuroregeneration, Medical Faculty, University of Rostock, Gehlsheimerstrasse 20, Rostock, Germany
    Cerebrovasc Dis 31:253-62. 2011
    ..The primary aim of our study was to determine the prevalence of Fabry disease in young stroke patients, while the secondary aim was to describe patterns of stroke in young patients...
  6. ncbi request reprint Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
    Arndt Rolfs
    Department of Neurology, University of Rostock, Rostock, Germany
    Lancet 366:1794-6. 2005
    ..To determine the importance of Fabry disease in young people with stroke, we measured the frequency of unrecognised Fabry disease in a cohort of acute stroke patients...
  7. ncbi request reprint Wnt-5a expression in the rat neuronal progenitor cell line ST14A
    Sabine Peters
    Department of Neurology, University of Rostock, PO Box 100888, 18055 Rostock, Germany
    Exp Brain Res 158:189-95. 2004
    ..However, they raise the possibility that neuronal progenitor cells that might be used to treat neurodegenerative diseases express Wnt-5a, thus promoting their potential for dopaminergic differentiation...
  8. doi request reprint Interferon-beta modulates protein synthesis in the central nervous system
    Susanne Beyer
    Dept of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
    J Neuroimmunol 213:31-8. 2009
    ..This study presents novel effects of IFN-beta in the central nervous system and begins to unravel the mechanism behind the known excitability changes in neurons...
  9. ncbi request reprint 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    J Autoimmun 27:251-65. 2006
    ..Monitoring of expression of the newly identified candidate genes and patterns of lymphocyte subpopulations might predict the responsiveness of multiple sclerosis patients to statin treatment...
  10. ncbi request reprint Increasing extracellular potassium results in subthalamic neuron activity resembling that seen in a 6-hydroxydopamine lesion
    Ulf Strauss
    Neurobiology, Department of Neurology, University of Rostock, Rostock, Germany
    J Neurophysiol 99:2902-15. 2008
    ..Our data suggest that changed potassium sensitivity due to conductivity alterations and delayed clearance may be critical for shaping STN activity in parkinsonian states...
  11. doi request reprint Differential astroglial activation in 6-hydroxydopamine models of Parkinson's disease
    Jeannette Henning
    Department of Neurology, University of Rostock, Germany
    Neurosci Res 62:246-53. 2008
    ....
  12. ncbi request reprint Functional significance of HCN2/3-mediated I(h) in striatal cells at early developmental stages
    Rika Bajorat
    Neurobiological Laboratory, Clinic for Neurology, University of Rostock, Rostock, Germany
    J Neurosci Res 82:206-13. 2005
    ..These results suggest the potential importance of ST14A cells in defining the molecular mechanisms regulating I(h) expression and function...
  13. pmc Corneal alterations during combined therapy with cyclodextrin/allopregnanolone and miglustat in a knock-out mouse model of NPC1 disease
    Marine Hovakimyan
    Department of Ophthalmology, University of Rostock, Rostock, Germany
    PLoS ONE 6:e28418. 2011
    ..The purpose of the present study was to clarify if these inclusions regress during combined substrate reduction- and by-product therapy (SRT and BPT)...
  14. doi request reprint Novel indolylmaleimide acts as GSK-3beta inhibitor in human neural progenitor cells
    Anne Caroline Schmöle
    Albrecht Kossel Institute for Neuroregeneration AKos, Center for Mental Health, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    Bioorg Med Chem 18:6785-95. 2010
    ..Therefore we conclude that indolylmaleimides act via the canonical Wnt signalling pathway by inhibition of the key enzyme GSK-3beta...
  15. doi request reprint Small molecule GSK-3 inhibitors increase neurogenesis of human neural progenitor cells
    Christian Lange
    Neurobiological Laboratory, Department of Neurology, University of Rostock, Germany
    Neurosci Lett 488:36-40. 2011
    ..Small molecule inhibitors of GSK-3 enhance neurogenesis of human neural progenitor cells and may be used to direct the differentiation of neural stem and progenitor cells in therapeutic applications...
  16. ncbi request reprint 2-DE profiling of GDNF overexpression-related proteome changes in differentiating ST14A rat progenitor cells
    Raimund Hoffrogge
    Department of Neurology, Medical Faculty, Neurobiological Laboratory, University of Rostock, Rostock, Germany
    Proteomics 7:33-46. 2007
    ..The results reflect the large rearrangements of the proteome during the differentiation process of NPCs and their strong modification by neurotrophic factors like GDNF...
  17. ncbi request reprint Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation
    Tobias Böttcher
    Department of Neurology, University of Rostock, Rostock, Germany
    J Neurosci Res 73:42-53. 2003
    ..g., of Huntington's disease...
  18. doi request reprint Specific properties of sodium currents in multipotent striatal progenitor cells
    Ulrike Wasner
    Department of Neurology, University of Rostock, Rostock, Germany
    Eur J Neurosci 28:1068-79. 2008
    ..We conclude that multipotent neural progenitor cells express Na(+) channels in their membrane irrespective of their fate but these channels have little effect due to their subunit composition, which is regulated by alternative splicing...
  19. ncbi request reprint Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression
    Jeannette Henning
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
    Eur J Neurosci 25:239-50. 2007
    ..Furthermore, a downregulation of calcium/calmodulin-dependent protein kinase type IIA and Homer1 was observed. This downregulation could result in a reduced sensitivity towards glutamate in basal ganglia downstream of STN...
  20. pmc Erythropoietin and the effect of oxygen during proliferation and differentiation of human neural progenitor cells
    Anne Katrin Giese
    Albrecht Kossel Institute for Neuroregeneration, Centre for Mental Health Disease, University of Rostock, Germany
    BMC Cell Biol 11:94. 2010
    ..In the present study, we explored the impact of lowered oxygen on the differentiation potential of human neural progenitor cells, and the role of erythropoietin in the differentiation process...
  21. ncbi request reprint Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, Rostock D 18055, Germany
    J Neuroimmunol 151:158-70. 2004
    ..Thus, monitoring of the expression of these new candidate genes may serve as a tool for the disease progression and the pharmaceutical treatment...
  22. doi request reprint Decreased expression of myelin gene regulatory factor in Niemann-Pick type C 1 mouse
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, School of Medicine, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Metab Brain Dis 26:299-306. 2011
    ....
  23. doi request reprint Quantitative and kinetic profile of Wnt/β-catenin signaling components during human neural progenitor cell differentiation
    Orianne Mazemondet
    Albrecht Kossel Institute for Neuroregeneration, Centre for Mental Health Disease, University of Rostock, Gehlsheimer Strasse 20, 18147, Rostock, Germany
    Cell Mol Biol Lett 16:515-38. 2011
    ..This detailed temporal profile of the Wnt/β-catenin pathway is a first step to understand, control and to orientate, in vitro, human neural progenitor cell differentiation...
  24. doi request reprint In vitro characterization of embryionic ST14A-cells
    Marine Hovakimyan
    Institute of Anatomy, University of Rostock, Rostock, Germany
    Int J Neurosci 118:1489-501. 2008
    ..In serum-free medium the process of neuronal differentiation became more obvious, indicating the potential to use these cells for experimental restorative therapies...
  25. doi request reprint Human neural progenitor cells show functional neuronal differentiation and regional preference after engraftment onto hippocampal slice cultures
    Peter J Morgan
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany
    Stem Cells Dev 21:1501-12. 2012
    ....
  26. doi request reprint Morphological alterations of the cornea in the mouse model of niemann-pick disease type c1
    Marine Hovakimyan
    Department of Ophthalmology, University of Rostock, Rostock, Germany
    Cornea 30:796-803. 2011
    ..A knockout mouse model (NPC1) is an important tool for the study of pathogenesis and treatment strategies. In the present study, NPC1 mice were examined for pathological changes in the cornea...
  27. pmc Effect of 3D-scaffold formation on differentiation and survival in human neural progenitor cells
    Stefanie Ortinau
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Gehlsheimerstrasse 20, 18147 Rostock, Germany
    Biomed Eng Online 9:70. 2010
    ....
  28. pmc Elucidating the sources of β-catenin dynamics in human neural progenitor cells
    Orianne Mazemondet
    Modelling and Simulation Group, Institute of Computer Science, University of Rostock, Rostock, Germany
    PLoS ONE 7:e42792. 2012
    ..We further report on significant stochastic effects that directly result from model parameters provided in literature and contradict experimental observations...
  29. doi request reprint Increased excitability and compromised long-term potentiation in the neocortex of NPC1(-/-) mice
    Yosef Avchalumov
    Oscar Langendorff Institute of Physiology, University of Rostock, Germany
    Brain Res 1444:20-6. 2012
    ..However, neocortical excitability was significantly enhanced while LTP was abolished. These results suggest that at least in the somatosensory neocortex NPC1 protein is instrumental in synaptic function...
  30. doi request reprint Expression patterns of ADAMs in the developing chicken lens
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, School of Medicine University of Rostock, Gehlsheimer Strasse 20, 18147, Rostock, Germany
    J Mol Histol 43:121-35. 2012
    ..At E16, only weak ADAM9, ADAM10 and ADAM17 signals are found in the anterior lens epithelium. The changing spatiotemporal expression of the seven ADAMs suggests a regulatory role for these molecules during chicken lens development...
  31. doi request reprint Quantitative and dynamic expression profile of premature and active forms of the regional ADAM proteins during chicken brain development
    Annett Markus
    Albrecht Kossel Institute for Neuroregeneration, Centre for Mental Health Disease, University of Rostock, Gehlsheimer Strasse 20, 18147, Rostock, Germany
    Cell Mol Biol Lett 16:431-51. 2011
    ....
  32. pmc Lessons from everyday stroke care for clinical research and vice versa: comparison of a comprehensive and a research population of young stroke patients
    Christian Tanislav
    Department of Neurology, Justus Liebig University, Klinikstrasse 33, 35392 Giessen, Germany
    BMC Neurol 14:45. 2014
    ..Therefore we compared baseline data of patients included in a recent large study addressing young stroke in comparison to a large representative stroke registry...
  33. ncbi request reprint Interference of a novel indolylmaleimide with microtubules induces mitotic arrest and apoptosis in human progenitor and cancer cells
    Christian Eisenlöffel
    Albrecht Kossel Institute for Neuroregeneration, Center for Mental Health, University of Rostock, Germany
    Biochem Pharmacol 85:763-71. 2013
    ..Thus PDA-66 is a new anti-mitotic compound with an indole-core with the potential to be used for cancer therapy...
  34. doi request reprint Investigating function and connectivity of morphometric findings--exemplified on cerebellar atrophy in spinocerebellar ataxia 17 (SCA17)
    Kathrin Reetz
    Department of Neurology, RWTH Aachen University, Pauwelsstrasse 30, D 52074 Aachen, Germany
    Neuroimage 62:1354-66. 2012
    ....
  35. ncbi request reprint Dopamine exerts no acute effects on Kv1.3 in activated encephalitogenic T cells
    Ulf Strauss
    Neurobiological Laboratory, Department of Neurology, University of Rostock, Rostock, Germany
    Neuroimmunomodulation 12:45-53. 2005
    ..Nevertheless, care should be taken when using the dopamine-protecting anti-oxidant ascorbic acid, since we found that it markedly inhibited both K+ currents and lymphocyte proliferation at higher concentrations...
  36. doi request reprint Differentiation of human neural progenitor cells regulated by Wnt-3a
    Rayk Hübner
    Albrecht Kossel Institute for Neuroregeneration AKos, School of Medicine, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Biochem Biophys Res Commun 400:358-62. 2010
    ..Thus, our data suggest that neurogenesis induced by Wnt-3a is independent of the transcriptional activity of Wnt/β-catenin pathway in ReNcell VM cells...
  37. ncbi request reprint Hyperactive glial cells contribute to axonal pathologies in the spinal cord of Npc1 mutant mice
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, Rostock University Medical Center, University of Rostock, Rostock, Germany
    Glia 62:1024-40. 2014
    ....
  38. ncbi request reprint Clinical, genetic, and brain sonographic features related to Parkinson's disease in Gaucher disease
    Tobias Böttcher
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany
    J Neurol 260:2523-31. 2013
    ..We conclude that the combined clinical, genetic, and transcranial sonographic assessment may improve the PD risk evaluation in Gaucher disease...
  39. pmc Fabry disease - underestimated in the differential diagnosis of multiple sclerosis?
    Tobias Böttcher
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany Department of Neurology, Dietrich Bonhoeffer Klinikum, Neubrandenburg, Germany
    PLoS ONE 8:e71894. 2013
    ..We present an overview of cases from Fabry centres in Germany initially misdiagnosed with multiple sclerosis and report the clinical, MR-tomographical, and laboratory findings...
  40. doi request reprint Spontaneous calcium transients in human neural progenitor cells mediated by transient receptor potential channels
    Peter J Morgan
    University of Rostock, Albrecht Kossel Institute for Neuroregeneration, Rostock, Germany
    Stem Cells Dev 22:2477-86. 2013
    ..Taken together, these results suggest a link between external K(+) concentration, spontaneous Ca(2+) transients, and cell cycle distribution, which is able to influence the fate of stem and progenitor cells. ..
  41. ncbi request reprint 2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM)
    Raimund Hoffrogge
    Neurobiological Laboratory, Department of Neurology, Medical Faculty, University of Rostock, Germany
    Proteomics 6:1833-47. 2006
    ....
  42. doi request reprint Prevalence of stenoses and occlusions of brain-supplying arteries in young stroke patients
    Bettina von Sarnowski
    Department of Neurology, University Medicine, Ernst Moritz Arndt University, Greifswald, Germany
    Neurology 80:1287-94. 2013
    ..However, data from large cohorts are limited. This study investigates the prevalence of extracranial and intracranial atherosclerosis in stroke and TIA patients aged 18-55 years in the multinational sifap1 study...
  43. ncbi request reprint Neuromodulation by a cytokine: interferon-beta differentially augments neocortical neuronal activity and excitability
    Gergana Hadjilambreva
    Department of Neurology, Neurobiological Laboratory, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    J Neurophysiol 93:843-52. 2005
    ....
  44. ncbi request reprint An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy
    Ulf Strauss
    Department of Neurology, University Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Eur J Neurosci 19:3048-58. 2004
    ..We suggest that the deficit in Ih-mediated functions may contribute to the development and onset of spontaneously occurring hyperexcitability in a rat model of absence seizures...
  45. doi request reprint Differential expression of the ADAMs in developing chicken retina
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, School of Medicine University of Rostock, D 18147 Rostock, Germany
    Dev Growth Differ 53:726-39. 2011
    ..Therefore, the differential expression of the investigated ADAMs in the developing retina suggests the contribution of them to the retina development...
  46. ncbi request reprint Representation of individual gene expression in completely pooled mRNA samples
    Anne Glass
    Institute for Medical Informatics and Biometry, University of Rostock, Medical Faculty, Germany
    Biosci Biotechnol Biochem 69:1098-103. 2005
    ..Our analysis reveals problems in cases of small complete pooling designs with less than six subjects pooled...
  47. doi request reprint Protection of neurons derived from human neural progenitor cells by veratridine
    Peter J Morgan
    Albrecht Kossel Institute for Neuroregeneration AKos, Centre for Mental Health Diseases, University of Rostock, Gehlsheimer Strasse, Rostock, Germany
    Neuroreport 20:1225-9. 2009
    ..Our results show that veratridine is neuroprotective in human fetal neural progenitor cells, which may benefit studies investigating neuronal development by reducing premature death amongst developing neurons...
  48. pmc The novel arylindolylmaleimide PDA-66 displays pronounced antiproliferative effects in acute lymphoblastic leukemia cells
    Christin Kretzschmar
    Department of Hematology Oncology Palliative Medicine, Division of Medicine, University of Rostock, Ernst Heydemann Str, 6, Rostock 18057, Germany
    BMC Cancer 14:71. 2014
    ..Herein, we evaluated the influence of a novel arylindolylmaleimide (PDA-66), a potential GSK3β inhibitor, on several ALL cell lines...
  49. ncbi request reprint Small molecules in stem cell research
    Anne Caroline Schmöle
    Albrecht Kossel Institute for Neuroregeneration, Centre for Mental Health Diseases, University of Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Curr Pharm Biotechnol 14:36-45. 2013
    ..In this review we will present the recent progress on the use of small molecules in embryonic and induced pluripotent stem cell research. In the final section we will give a short summary of the clinical approaches using these cells...
  50. ncbi request reprint Wnt signal pathways and neural stem cell differentiation
    Christian Lange
    Department of Neurology, University of Rostock, Rostock, Germany
    Neurodegener Dis 3:76-86. 2006
    ....
  51. pmc CAG repeats determine brain atrophy in spinocerebellar ataxia 17: a VBM study
    Kathrin Reetz
    Department of Neurology, RWTH Aachen University, Aachen, Germany
    PLoS ONE 6:e15125. 2011
    ..Abnormal repeat length has been associated with an earlier age of onset and more severe disease progression in the rare neurodegenerative disorder spinocerebellar ataxia 17 (SCA17)...
  52. ncbi request reprint HES5 Is a Key Mediator of Wnt-3a-Induced Neuronal Differentiation
    Carolin Mußmann
    Albrecht Kossel Institute for Neuroregeneration AKos, University of Rostock, Rostock, Germany
    Stem Cells Dev 23:1328-39. 2014
    ....
  53. doi request reprint Headache as a symptom at stroke onset in 4,431 young ischaemic stroke patients. Results from the "Stroke in Young Fabry Patients (SIFAP1) study"
    Peter Kropp
    Institute of Medical Psychology and Medical Sociology Medical Faculty, University of Rostock, Gehlsheimer, Straße 20, 18147, Rostock, Germany
    J Neural Transm 120:1433-40. 2013
    ..Headache is a leading symptom in specific combination of stroke factors. These factors should be taken into account when patients report headache during IS or TIA...
  54. pmc ADAM10 negatively regulates neuronal differentiation during spinal cord development
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, School of Medicine University of Rostock, Rostock, Germany
    PLoS ONE 9:e84617. 2014
    ..Taken together, our data suggest that ADAM10 negatively regulates neuronal differentiation, possibly via its proteolytic effect on the Notch signaling during development of the spinal cord. ..
  55. pmc Olfactory deficits in Niemann-Pick type C1 (NPC1) disease
    Marina Hovakimyan
    Institute of Anatomy, Rostock University Medical Center, Rostock, Germany
    PLoS ONE 8:e82216. 2013
    ....
  56. doi request reprint Neuroproteomics in stem cell differentiation
    Susanne Beyer
    Neurobiological Laboratory, Department of Neurology, Medical Faculty, University of Rostock, Rostock, Germany
    Proteomics Clin Appl 1:1513-23. 2007
    ..This review gives also an outlook on technical improvements and perspectives of application of neural stem cell proteomics...
  57. pmc Differentiation of human neural progenitor cells in functionalized hydrogel matrices
    Andrea Liedmann
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock, Rostock, Germany
    Biores Open Access 1:16-24. 2012
    ..We conclude that a combination of elevated neuronal differentiation and a protective effect of the modified matrices underlies the increased proportion of neuronal cells...
  58. ncbi request reprint Lifestyle risk factors for ischemic stroke and transient ischemic attack in young adults in the Stroke in Young Fabry Patients study
    Bettina von Sarnowski
    Department of Neurology, University Medicine, Ferdinand Sauerbruch Straße, D 17475 Greifswald, Germany
    Stroke 44:119-25. 2013
    ..Although many stroke patients are young or middle-aged, risk factor profiles in these age groups are poorly understood...
  59. ncbi request reprint 2-DE proteomic profiling of neuronal stem cells
    Raimund Hoffrogge
    Neurobiological Laboratory, Department of Neurology, Medical Faculty, Rostock, Germany
    Neurodegener Dis 3:112-21. 2006
    ....
  60. doi request reprint Regional expression of ADAM19 during chicken embryonic development
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, School of Medicine University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Dev Growth Differ 53:333-46. 2011
    ..All these data suggest that ADAM19 plays an important role in the embryonic development of chicken...
  61. ncbi request reprint Cadherin-20 expression by motor neurons is regulated by Sonic hedgehog during spinal cord development
    Jiankai Luo
    Institute of Anatomy I, Friedrich Schiller University Jena, Germany
    Neuroreport 20:365-70. 2009
    ..Blockage of Shh signaling inhibits cadherin-20 expression in the motor column. Therefore, cadherin-20 expression in motor neurons is regulated by Shh in a time-dependent manner...
  62. pmc Niemann-Pick type C1 patient-specific induced pluripotent stem cells display disease specific hallmarks
    Michaela Trilck
    Albrecht Kossel Institute for Neuroregeneration AKos, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Orphanet J Rare Dis 8:144. 2013
    ..Therefore, a human model using patient-specific induced pluripotent stem cells provides a promising approach...
  63. ncbi request reprint Identification of quantitative trait loci controlling cortical motor evoked potentials in experimental autoimmune encephalomyelitis: correlation with incidence, onset and severity of disease
    Ignacio Mazón Peláez
    Department of Immunology, University of Rostock, Germany
    Hum Mol Genet 14:1977-89. 2005
    ..There were no alterations in the morphological appearance of the myelin sheaths. Our findings suggest a possible role of myelin composition and/or synaptic transmission in susceptibility to EAE...
  64. pmc Persistent increase in cardiac troponin I in Fabry disease: a case report
    Christian Tanislav
    Department of Neurology, Justus Liebig University, Giessen, Germany
    BMC Cardiovasc Disord 11:6. 2011
    ..In diagnosing acute myocardial infarction cTNI is considered the most reliable parameter...
  65. doi request reprint Orexinergic innervation of the extended amygdala and basal ganglia in the rat
    Oliver Schmitt
    Institute of Anatomy, University of Rostock, P O Box 100888, 18055, Rostock, Germany
    Brain Struct Funct 217:233-56. 2012
    ..These results suggest that subdivisions and subnuclei of the extended amygdala are specific targets of the orexinergic system...
  66. ncbi request reprint Lymphocyte subpopulations, oxidative burst and apoptosis in peripheral blood cells of patients with multiple sclerosis-effect of interferon-beta
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, P O Box 100888, 18055 Rostock, Germany
    Autoimmunity 36:291-305. 2003
    ..Re-examination of the altered blood cell parameters after long-term IFN-beta therapy is warranted...
  67. ncbi request reprint Regional expression of the ADAMs in developing chicken cochlea
    Xin Yan
    Albrecht Kossel Institute for Neuroregeneration, School of Medicine, University of Rostock, D 18147 Rostock, Germany
    Dev Dyn 239:2256-65. 2010
    ..The expression of the ADAMs in the developing cochlea suggests a contribution of the ADAMs to the development of distinct cochlear structures...
  68. pmc Cultivation of Human Neural Progenitor Cells in a 3-dimensional Self-assembling Peptide Hydrogel
    Andrea Liedmann
    Albrecht Kossel Institute for Neuroregeneration, University of Rostock
    J Vis Exp . 2012
    ..g. immunocytochemical studies and subsequently analysed by flow cytometry. This speeds up the analysis and more over, the obtained data rest upon a wider base, improving the reliability of the data...
  69. doi request reprint A new facile synthesis of 3-amidoindole derivatives and their evaluation as potential GSK-3beta inhibitors
    Anahit Pews-Davtyan
    Leibniz Institut fur Katalyse e V an der Universitat Rostock, Albert Einstein Str 29a, D 18059, Rostock, Germany
    Org Biomol Chem 8:1149-53. 2010
    ..3-Amidoindoles were synthesized from commercially available arylhydrazines and propargylamines over Zn-salt mediated one pot procedure in excellent regioselectivity and up to 94% yield...
  70. doi request reprint Structural changes associated with progression of motor deficits in spinocerebellar ataxia 17
    Kathrin Reetz
    Department of Neurology, RWTH Aachen University, Germany
    Cerebellum 9:210-7. 2010
    ....
  71. ncbi request reprint Clinical features and neuropathology of autosomal dominant spinocerebellar ataxia (SCA17)
    Arndt Rolfs
    Department of Neurology, University of Rostock, Rostock, Germany
    Ann Neurol 54:367-75. 2003
    ..Based on clinical and genetic data, we conclude that SCA17 is rare among white SCA patients. SCA17 should be considered in sporadic and familial cases of ataxia with accompanying psychiatric symptoms and dementia...
  72. ncbi request reprint Ciliary neurotrophic factor overexpression in neural progenitor cells (ST14A) increases proliferation, metabolic activity, and resistance to stress during differentiation
    Sabine Weinelt
    Neurobiological Laboratory, Department of Neurology, University of Rostock, Rostock, Germany
    J Neurosci Res 71:228-36. 2003
    ....
  73. doi request reprint Heterozygous S44L missense change of the spastin gene in amyotrophic lateral sclerosis
    Christoph Munch
    Department of Neurology, Jewish Hospital Berlin, Berlin, Germany
    Amyotroph Lateral Scler 9:251-3. 2008
    ..This unusual phenotype shows that allelic variants of spastin may predispose bearers to a greater spectrum of motor neuron disorders including ALS...
  74. ncbi request reprint NPC1: Complete genomic sequence, mutation analysis, and characterization of haplotypes
    Peter Bauer
    Universitat Rostock, Klinik für Neurologie und Poliklinik, Neurobiologisches Labor, Rostock, Germany
    Hum Mutat 19:30-8. 2002
    ..007; 2-sided Fisher exact test) suggesting the possibility of an influence of the haplotypic background on expression of missense mutations in NPC1...
  75. ncbi request reprint The microstructure of cornea verticillata in Fabry disease and amiodarone-induced keratopathy: a confocal laser-scanning microscopy study
    Karen Falke
    Department of Ophthalmology, University of Rostock, Rostock, Germany
    Graefes Arch Clin Exp Ophthalmol 247:523-34. 2009
    ..The purpose of this study is to describe cornea verticillata in Fabry disease and in amiodarone-induced keratopathy and to compare the corneal microstructure of both types...
  76. ncbi request reprint Disorganization of the desmin cytoskeleton and mitochondrial dysfunction in plectin-related epidermolysis bullosa simplex with muscular dystrophy
    Rolf Schroder
    Department of Neurology, University of Bonn, Germany
    J Neuropathol Exp Neurol 61:520-30. 2002
    ..Beyond EBS-MD, our data may contribute to the understanding of other myopathies characterized by sarcoplasmic IF accumulations such as desminopathies or alpha-B-crystallinopathies...
  77. ncbi request reprint Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells
    Jens Pahnke
    Department of Pathology, University Hospital Zurich, Switzerland
    Exp Cell Res 297:484-94. 2004
    ..Many proteins are anchored by farnesyl-derivates at the cell membrane. The identification of these GDNF-regulated genes may open new opportunities for directly influencing differentiation and developmental processes of neurons...
  78. ncbi request reprint Efferent connections of the parabigeminal nucleus to the amygdala and the superior colliculus in the rat: a double-labeling fluorescent retrograde tracing study
    Kamen G Usunoff
    Department of Anatomy and Histology, Faculty of Medicine, Medical University, Sofia 1431, Bulgaria
    Brain Res 1133:87-91. 2007
    ..The ipsilateral projections arise from separate cell populations, whilst the contralaterally projecting Pbg neurons emit branching axons that simultaneously innervate Am and SC...
  79. ncbi request reprint A rare manifestation of Fabry's disease
    Zsanett Fricska Nagy
    Swiss Med Wkly 137:130. 2007
  80. ncbi request reprint Residual galactosylsphingosine (psychosine) beta-galactosidase activities and associated GALC mutations in late and very late onset Krabbe disease
    Klaus Harzer
    Institut für Hirnforschung, Universitat Tubingen, Calwer Strasse 3, D 72076, Tubingen, Germany
    Clin Chim Acta 317:77-84. 2002
    ..About 90% of GLD patients have an infantile course by fatal cerebral demyelination, but 10% have a later onset (LOGLD) of symptoms and survive for one or several decades...