A Roers

Summary

Affiliation: University of Cologne
Country: Germany

Publications

  1. pmc Mast cell-specific Cre/loxP-mediated recombination in vivo
    Julia Scholten
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Transgenic Res 17:307-15. 2008
  2. pmc Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    H Babbe
    Institute for Genetics, Institute for Pathology, University of Cologne, 50931 Cologne, Germany
    J Exp Med 192:393-404. 2000
  3. ncbi Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal
    A Roers
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 28:2424-31. 1998
  4. pmc T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    Axel Roers
    Dept of Dermatology, University of Cologne, Josef Stelzmann Str 9, 50931 Cologne, Germany
    J Exp Med 200:1289-97. 2004
  5. pmc Single-cell PCR analysis of T helper cells in human lymph node germinal centers
    A Roers
    Institute for Genetics, University of Cologne, Cologne University of Frankfurt, Frankfurt, Germany
    Am J Pathol 156:1067-71. 2000
  6. pmc Rare occurrence of classical Hodgkin's disease as a T cell lymphoma
    M MUSCHEN
    Institute for Genetics, Department of Immunology, Universitat zu Koln, Germany
    J Exp Med 191:387-94. 2000
  7. ncbi Spontaneous regression of HIV associated T-cell non-Hodgkin's lymphoma with highly active antiretroviral therapy
    G Fatkenheuer
    Klinik I fur Innere Medizin, Universitat zu Koln, D 50924 Koln, Germany
    Eur J Med Res 5:236-40. 2000
  8. ncbi Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
    Lisa Siewe
    Department of Dermatology, University of Cologne, Cologne, Germany
    Eur J Immunol 36:3248-55. 2006
  9. pmc Accelerated wound closure in mice deficient for interleukin-10
    Sabine A Eming
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 170:188-202. 2007
  10. doi Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008

Collaborators

Detail Information

Publications13

  1. pmc Mast cell-specific Cre/loxP-mediated recombination in vivo
    Julia Scholten
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937, Cologne, Germany
    Transgenic Res 17:307-15. 2008
    ..Our results show that the Mcpt5 promoter can drive Cre expression in a mast cell-specific fashion. We expect that our Mcpt5-Cre mice will be a useful tool for the investigation of mast cell biology...
  2. pmc Clonal expansions of CD8(+) T cells dominate the T cell infiltrate in active multiple sclerosis lesions as shown by micromanipulation and single cell polymerase chain reaction
    H Babbe
    Institute for Genetics, Institute for Pathology, University of Cologne, 50931 Cologne, Germany
    J Exp Med 192:393-404. 2000
    ..In case 2, two of the CD8(+) clones identified in brain tissue were also detected in peripheral blood. Investigation of the antigenic specificities of expanded clones may help to elucidate their functional properties...
  3. ncbi Amplification of TCRbeta gene rearrangements from micromanipulated single cells: T cells rosetting around Hodgkin and Reed-Sternberg cells in Hodgkin's disease are polyclonal
    A Roers
    Institute for Genetics, University of Cologne, Germany
    Eur J Immunol 28:2424-31. 1998
    ..These data suggest that the HRS cells attract CD4+ T cells nonspecifically...
  4. pmc T cell-specific inactivation of the interleukin 10 gene in mice results in enhanced T cell responses but normal innate responses to lipopolysaccharide or skin irritation
    Axel Roers
    Dept of Dermatology, University of Cologne, Josef Stelzmann Str 9, 50931 Cologne, Germany
    J Exp Med 200:1289-97. 2004
    ..Our data highlight the importance of T cell-derived IL-10 in the regulation of T cell responses and demonstrate that endotoxic shock and the irritant response of the skin are controlled by IL-10 from other cell types...
  5. pmc Single-cell PCR analysis of T helper cells in human lymph node germinal centers
    A Roers
    Institute for Genetics, University of Cologne, Cologne University of Frankfurt, Frankfurt, Germany
    Am J Pathol 156:1067-71. 2000
    ..The detection of clonal expansions accounting for more than half of the sampled B cells in addition to ongoing somatic hypermutation of Ig V region genes suggested that GC3 was a fully developed GC...
  6. pmc Rare occurrence of classical Hodgkin's disease as a T cell lymphoma
    M MUSCHEN
    Institute for Genetics, Department of Immunology, Universitat zu Koln, Germany
    J Exp Med 191:387-94. 2000
    ..In a third case, however, H/RS cells were derived from a T cell, demonstrating that cHD can also occur as a T cell lymphoma...
  7. ncbi Spontaneous regression of HIV associated T-cell non-Hodgkin's lymphoma with highly active antiretroviral therapy
    G Fatkenheuer
    Klinik I fur Innere Medizin, Universitat zu Koln, D 50924 Koln, Germany
    Eur J Med Res 5:236-40. 2000
    ..This hypothesis is supported by parallels to EBV associated polyclonal lymphoproliferation in allogeneic transplantat recipients where regression of lymphoma can be induced by reducing immunosuppressive therapy...
  8. ncbi Interleukin-10 derived from macrophages and/or neutrophils regulates the inflammatory response to LPS but not the response to CpG DNA
    Lisa Siewe
    Department of Dermatology, University of Cologne, Cologne, Germany
    Eur J Immunol 36:3248-55. 2006
    ..These results show that different innate immune responses can be subject to control by IL-10 from different cellular sources...
  9. pmc Accelerated wound closure in mice deficient for interleukin-10
    Sabine A Eming
    Department of Dermatology, University of Cologne, Joseph Stelzmann Str 9, 50931 Koln, Germany
    Am J Pathol 170:188-202. 2007
    ..These results show for the first time that IL-10 can impede wound repair...
  10. doi Regulatory T cell-derived interleukin-10 limits inflammation at environmental interfaces
    Yuri P Rubtsov
    Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA
    Immunity 28:546-58. 2008
    ..Furthermore, these mechanisms are likely to be nonredundant, in that a distinct suppressor mechanism most likely plays a prominent and identifiable role at a particular tissue and inflammatory setting...
  11. ncbi Tolerance without clonal expansion: self-antigen-expressing B cells program self-reactive T cells for future deletion
    Friederike Frommer
    I Medical Department, Johannes Gutenberg University Mainz, Obere Zahlbacher Str 63, Mainz, Germany
    J Immunol 181:5748-59. 2008
    ..In contrast, the T cells became sensitive to Ag-induced cell death. Our results demonstrate that B cells participate in the homeostasis of the immune system by ablation of conventional self-reactive T cells...
  12. pmc Clonal tracking of autoaggressive T cells in polymyositis by combining laser microdissection, single-cell PCR, and CDR3-spectratype analysis
    Monika Hofbauer
    Institute for Clinical Neuroimmunology, Ludwig Maximilians University, D 81377 Munich, Germany
    Proc Natl Acad Sci U S A 100:4090-5. 2003
    ..This approach should be applicable to other inflammatory and autoimmune disorders...
  13. ncbi Integrin alpha2beta1 deficiency does not affect contact hypersensitivity
    Manon C Zweers
    Department of Dermatology, University of Cologne, Kerpener Str 62, 50937 Cologne, Germany
    Arch Dermatol Res 298:201-5. 2006
    ..Our results suggest that the adhesive functions of integrin alpha2beta1 are dispensable for the CHS response; they may be compensated for by the collagen receptor alpha1beta1 or other collagen receptors...