Patrick Johannes Riss

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. doi [(68)Ga]Ga-DO(2)A-(OBu-l-tyr)(2): synthesis, (68)Ga-radiolabeling and in vitro studies of a novel (68)Ga-DO(2)A-tyrosine conjugate as potential tumor tracer for PET
    Carsten Burchardt
    Johannes Gutenberg University Mainz, Institute of Nuclear Chemistry, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem Lett 19:3498-501. 2009
  2. doi [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
  3. doi Synthesis and monoamine uptake inhibition of conformationally constrained 2beta-carbomethoxy-3beta-phenyl tropanes
    Patrick Johannes Riss
    Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz Strassmann Weg 2, 55128, Mainz, Germany
    Org Biomol Chem 7:2688-98. 2009
  4. doi A convenient chemo-enzymatic synthesis and 18F-labelling of both enantiomers of trans-1-toluenesulfonyloxymethyl-2-fluoromethyl-cyclopropane
    Patrick Johannes Riss
    Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz Strassmann Weg 2, 55128, Mainz, Germany
    Org Biomol Chem 6:4567-74. 2008
  5. doi Ex vivo and in vivo evaluation of [18F]PR04.MZ in rodents: a selective dopamine transporter imaging agent
    Patrick J Riss
    Universität Mainz Institut für Kernchemie, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    ChemMedChem 4:1480-7. 2009
  6. doi Efficient microwave-assisted direct radiosynthesis of [(18)F]PR04.MZ and [(18)F]LBT999: selective dopamine transporter ligands for quantitative molecular imaging by means of PET
    Patrick J Riss
    Institute of Nuclear Chemistry, Johannes Gutenberg University, Fritz Strassmann Weg 2, D 55128 Mainz, Germany
    Bioorg Med Chem 17:7630-4. 2009
  7. doi Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET
    Matthias M Herth
    Institute of Nuclear Chemistry Johannes Gutenberg University Mainz, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem 17:2989-3002. 2009
  8. ncbi The renaissance of the ⁶⁸Ge/⁶⁸Ga radionuclide generator initiates new developments in ⁶⁸Ga radiopharmaceutical chemistry
    Frank Roesch
    Institute of Nuclear Chemistry, University of Mainz, Germany
    Curr Top Med Chem 10:1633-68. 2010
  9. doi NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging
    Patrick J Riss
    Institute of Nuclear Chemistry, University of Mainz, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem Lett 18:5364-7. 2008

Collaborators

Detail Information

Publications9

  1. doi [(68)Ga]Ga-DO(2)A-(OBu-l-tyr)(2): synthesis, (68)Ga-radiolabeling and in vitro studies of a novel (68)Ga-DO(2)A-tyrosine conjugate as potential tumor tracer for PET
    Carsten Burchardt
    Johannes Gutenberg University Mainz, Institute of Nuclear Chemistry, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem Lett 19:3498-501. 2009
    ..These promising results indicate a high potential of [(68)Ga]Ga-DO(2)A-(OBu-l-tyr)(2) for molecular imaging of tumor-driven amino acid uptake by PET...
  2. doi [(11)C]PR04.MZ, a promising DAT ligand for low concentration imaging: Synthesis, efficient (11)C-O-methylation and initial small animal PET studies
    Patrick J Riss
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973, USA
    Bioorg Med Chem Lett 19:4343-5. 2009
    ..A preliminary muPET-experiment demonstrates the reversible, highly specific binding of [(11)C]PR04.MZ in the brain of a male Sprague-Dawley rat...
  3. doi Synthesis and monoamine uptake inhibition of conformationally constrained 2beta-carbomethoxy-3beta-phenyl tropanes
    Patrick Johannes Riss
    Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz Strassmann Weg 2, 55128, Mainz, Germany
    Org Biomol Chem 7:2688-98. 2009
    ..A SAR-study was conducted to determine the contribution of extended, 4-fluorinated, conformationally constrained C4 chains at the tropane nitrogen to human monoamine transporter affinity and selectivity...
  4. doi A convenient chemo-enzymatic synthesis and 18F-labelling of both enantiomers of trans-1-toluenesulfonyloxymethyl-2-fluoromethyl-cyclopropane
    Patrick Johannes Riss
    Institute of Nuclear Chemistry, Johannes Gutenberg University Mainz, Fritz Strassmann Weg 2, 55128, Mainz, Germany
    Org Biomol Chem 6:4567-74. 2008
    ..Both enantiomers of 1 were prepared selectively in high overall yield over nine steps, starting from ethyl acrylate. The successful radiosynthesis of [18F]-1 and [18F]-ent-1 is also reported...
  5. doi Ex vivo and in vivo evaluation of [18F]PR04.MZ in rodents: a selective dopamine transporter imaging agent
    Patrick J Riss
    Universität Mainz Institut für Kernchemie, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    ChemMedChem 4:1480-7. 2009
    ..Furthermore, its ex vivo organ distribution, its binding profile in the rat brain and reversibility of binding were examined. A muPET study illuminates a fast kinetic profile and specific binding to rat DAT...
  6. doi Efficient microwave-assisted direct radiosynthesis of [(18)F]PR04.MZ and [(18)F]LBT999: selective dopamine transporter ligands for quantitative molecular imaging by means of PET
    Patrick J Riss
    Institute of Nuclear Chemistry, Johannes Gutenberg University, Fritz Strassmann Weg 2, D 55128 Mainz, Germany
    Bioorg Med Chem 17:7630-4. 2009
    ..MZ (0.95-1.09GBq, 42-135GBq/micromol) was obtained within 34-40min starting from 3.0GBq [(18)F]fluoride ion in 32-36% non-decay-corrected overall yield using K[(18)F]F(-)Kryptofix 222 cryptate in MeCN...
  7. doi Synthesis and in vitro affinities of various MDL 100907 derivatives as potential 18F-radioligands for 5-HT2A receptor imaging with PET
    Matthias M Herth
    Institute of Nuclear Chemistry Johannes Gutenberg University Mainz, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem 17:2989-3002. 2009
    ..The novel compounds MA-1 (53) and (R)-MH.MZ (56) thus appear to be promising high affine and selective tracers of (18)F-labelled analogues for 5-HT(2A) imaging with PET...
  8. ncbi The renaissance of the ⁶⁸Ge/⁶⁸Ga radionuclide generator initiates new developments in ⁶⁸Ga radiopharmaceutical chemistry
    Frank Roesch
    Institute of Nuclear Chemistry, University of Mainz, Germany
    Curr Top Med Chem 10:1633-68. 2010
    ....
  9. doi NODAPA-OH and NODAPA-(NCS)n: synthesis, 68Ga-radiolabelling and in vitro characterisation of novel versatile bifunctional chelators for molecular imaging
    Patrick J Riss
    Institute of Nuclear Chemistry, University of Mainz, Fritz Strassmann Weg 2, 55128 Mainz, Germany
    Bioorg Med Chem Lett 18:5364-7. 2008
    ..Protein binding and exemplified conjugation are also reported...