Robert Ringseis

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. doi request reprint Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Heinrich Buff Ring 26 32, 35392 Gießen, Germany
    Mol Endocrinol 27:781-800. 2013
  2. doi request reprint Regulation of genes involved in lipid metabolism by dietary oxidized fat
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Giesen, Germany
    Mol Nutr Food Res 55:109-21. 2011
  3. doi request reprint Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Giessen, Germany
    Mol Nutr Food Res 55:S193-202. 2011
  4. doi request reprint Genome-wide transcript profiling indicates induction of energy-generating pathways and an adaptive immune response in the liver of sows during lactation
    Susann Rosenbaum
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Giessen, Germany
    Comp Biochem Physiol Part D Genomics Proteomics 7:370-81. 2012
  5. doi request reprint Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University, Giessen, Germany
    J Nutr 143:125-31. 2013
  6. pmc Genes involved in carnitine synthesis and carnitine uptake are up-regulated in the liver of sows during lactation
    Susann Rosenbaum
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Heinrich Buff Ring 26 32, Giessen, 35392, Germany
    Acta Vet Scand 55:24. 2013
  7. pmc Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-κB and Nrf2 in the duodenal mucosa of pigs
    Denise K Gessner
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Heinrich Buff Ring 26 32, 35392, Giessen, Germany
    Acta Vet Scand 55:18. 2013
  8. pmc Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs
    Juliane Varady
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Giessen, Germany
    Lipids Health Dis 11:34. 2012
  9. pmc Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation
    Gloria Schlegel
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Giessen, Germany
    BMC Vet Res 8:28. 2012
  10. pmc Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
    Juliane Varady
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Giessen, Germany
    Lipids Health Dis 11:31. 2012

Collaborators

Detail Information

Publications30

  1. doi request reprint Sterol regulatory element-binding proteins are regulators of the NIS gene in thyroid cells
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Heinrich Buff Ring 26 32, 35392 Gießen, Germany
    Mol Endocrinol 27:781-800. 2013
    ..These findings show that TSH acts as a regulator of SREBP expression and maturation in thyroid epithelial cells and that SREBPs are novel transcriptional regulators of NIS...
  2. doi request reprint Regulation of genes involved in lipid metabolism by dietary oxidized fat
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Giesen, Germany
    Mol Nutr Food Res 55:109-21. 2011
    ....
  3. doi request reprint Regular endurance exercise improves the diminished hepatic carnitine status in mice fed a high-fat diet
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Giessen, Germany
    Mol Nutr Food Res 55:S193-202. 2011
    ..Herein, we tested the hypothesis that regular endurance exercise (EE) improves the HF diet-induced impairment of carnitine status through stimulating the expression of hepatic genes involved in carnitine synthesis and uptake...
  4. doi request reprint Genome-wide transcript profiling indicates induction of energy-generating pathways and an adaptive immune response in the liver of sows during lactation
    Susann Rosenbaum
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Giessen, Germany
    Comp Biochem Physiol Part D Genomics Proteomics 7:370-81. 2012
    ..The alterations of expression of genes encoding proteins involved in immune response suggest that lactation in sows may cause an adaptive immune response that possibly counteracts hepatic inflammation...
  5. doi request reprint Supplementing obese Zucker rats with niacin induces the transition of glycolytic to oxidative skeletal muscle fibers
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University, Giessen, Germany
    J Nutr 143:125-31. 2013
    ..The increased utilization of fatty acids by muscle might contribute to the strong TG-lowering effect of niacin treatment...
  6. pmc Genes involved in carnitine synthesis and carnitine uptake are up-regulated in the liver of sows during lactation
    Susann Rosenbaum
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Heinrich Buff Ring 26 32, Giessen, 35392, Germany
    Acta Vet Scand 55:24. 2013
    ..Sows are typically in a negative energy balance during peak lactation. We investigated the hypothesis that genes involved in carnitine synthesis and uptake in the liver of sows are up-regulated during peak lactation...
  7. pmc Supplementation of a grape seed and grape marc meal extract decreases activities of the oxidative stress-responsive transcription factors NF-κB and Nrf2 in the duodenal mucosa of pigs
    Denise K Gessner
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Heinrich Buff Ring 26 32, 35392, Giessen, Germany
    Acta Vet Scand 55:18. 2013
    ....
  8. pmc Dietary moderately oxidized oil induces expression of fibroblast growth factor 21 in the liver of pigs
    Juliane Varady
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Giessen, Germany
    Lipids Health Dis 11:34. 2012
    ..Therefore, the present study investigated the hypothesis that feeding of oxidized fats causes an induction of FGF21 in the liver...
  9. pmc Expression of genes involved in hepatic carnitine synthesis and uptake in dairy cows in the transition period and at different stages of lactation
    Gloria Schlegel
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Giessen, Germany
    BMC Vet Res 8:28. 2012
    ..Dairy cows are typically in a negative energy balance during early lactation. We investigated the hypothesis that genes of carnitine synthesis and uptake in dairy cows are enhanced during early lactation...
  10. pmc Dietary moderately oxidized oil activates the Nrf2 signaling pathway in the liver of pigs
    Juliane Varady
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Giessen, Germany
    Lipids Health Dis 11:31. 2012
    ....
  11. doi request reprint The mouse gene encoding the carnitine biosynthetic enzyme 4-N-trimethylaminobutyraldehyde dehydrogenase is regulated by peroxisome proliferator-activated receptor α
    Gaiping Wen
    Justus Liebig Universitat, Giessen, Germany
    Biochim Biophys Acta 1819:357-65. 2012
    ....
  12. doi request reprint Treatment with pharmacological PPARα agonists stimulates the ubiquitin proteasome pathway and myofibrillar protein breakdown in skeletal muscle of rodents
    Robert Ringseis
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Giessen, Germany
    Biochim Biophys Acta 1830:2105-17. 2013
    ..We tested the hypothesis that activation of PPARα leads to an up-regulation of the ubiquitin proteasome system (UPS) which plays a major role in protein degradation in muscle...
  13. doi request reprint Niacin supplementation induces type II to type I muscle fiber transition in skeletal muscle of sheep
    Muckta Khan
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, 35390 Giessen, Germany
    Acta Vet Scand 55:85. 2013
    ..For this purpose, 16 male, 11 wk old Rhoen sheep were randomly allocated to two groups of 8 sheep each administered either no (control group) or 1 g niacin per day (niacin group) for 4 wk...
  14. doi request reprint Increased plasma thyroid hormone concentrations in LDL receptor deficient mice may be explained by inhibition of aryl hydrocarbon receptor-dependent expression of hepatic UDP-glucuronosyltransferases
    Denise K Gessner
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Heinrich Buff Ring 26 32, 35392 Giessen, Germany
    Biochim Biophys Acta 1820:495-502. 2012
    ..We investigated the hypothesis that LDLR(-/-) mice have increased concentrations of thyroid hormones in plasma due to a reduced hepatic glucuronidation...
  15. doi request reprint Role of carnitine in the regulation of glucose homeostasis and insulin sensitivity: evidence from in vivo and in vitro studies with carnitine supplementation and carnitine deficiency
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, 35390 Giessen, Germany
    Eur J Nutr 51:1-18. 2012
    ..More recent studies even point toward a causative role for carnitine insufficiency in developing insulin resistance during states of chronic metabolic stress, such as obesity, which can be reversed by carnitine supplementation...
  16. doi request reprint mRNA expression of genes involved in fatty acid utilization in skeletal muscle and white adipose tissues of sows during lactation
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, D 35392 Giessen, Germany
    Comp Biochem Physiol A Mol Integr Physiol 158:450-4. 2011
    ....
  17. pmc The stress signalling pathway nuclear factor E2-related factor 2 is activated in the liver of sows during lactation
    Susann Rosenbaum
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig University, Heinrich Buff Ring 26 32, Giessen 35392, Germany
    Acta Vet Scand 54:59. 2012
    ..The present study aimed to study whether the Nrf2 pathway is activated also in the liver of lactating sows...
  18. doi request reprint Mouse γ-butyrobetaine dioxygenase is regulated by peroxisome proliferator-activated receptor α through a PPRE located in the proximal promoter
    Gaiping Wen
    Institute of Animal Nutrition and Nutritional Physiology, Justus Liebig Universitat, Heinrich Buff Ring Giessen, Germany
    Biochem Pharmacol 82:175-83. 2011
    ..The results confirm emerging evidence from recent studies that PPARα plays a key role in the regulation of carnitine homeostasis by controlling genes involved in both, carnitine synthesis and carnitine uptake...
  19. pmc 13-hydroxy linoleic acid increases expression of the cholesterol transporters ABCA1, ABCG1 and SR-BI and stimulates apoA-I-dependent cholesterol efflux in RAW264.7 macrophages
    Ines Kämmerer
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, 35390 Giessen, Germany
    Lipids Health Dis 10:222. 2011
    ..The present study aimed to test the hypothesis that the hydroxylated derivative of linoleic acid (LA), 13-HODE, which is a natural PPAR agonist, has similar effects in RAW264.7 macrophages...
  20. pmc Effect of L-carnitine on the hepatic transcript profile in piglets as animal model
    Janine Keller
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Heinrich Buff Ring 26 32, 35392 Gießen, Germany
    Nutr Metab (Lond) 8:76. 2011
    ..abstract:..
  21. pmc Niacin supplementation increases the number of oxidative type I fibers in skeletal muscle of growing pigs
    Muckta Khan
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, Giessen 35390, Germany
    BMC Vet Res 9:177. 2013
    ..The aim of the present study was to investigate whether niacin supplementation causes type II to type I muscle and changes the metabolic phenotype of skeletal muscles in growing pigs...
  22. doi request reprint Dietary L-carnitine alters gene expression in skeletal muscle of piglets
    Janine Keller
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Giesen, Germany
    Mol Nutr Food Res 55:419-29. 2011
    ..Carnitine improves protein accretion, muscle mass, and protein:fat accretion in piglets. The underlying mechanisms, however, are largely unknown...
  23. doi request reprint Feeding a thermally oxidised fat inhibits atherosclerotic plaque formation in the aortic root of LDL receptor-deficient mice
    Ines Kämmerer
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universität Gießen, Heinrich Buff Ring 26 32, 35392 Gießen, Germany
    Br J Nutr 105:190-9. 2011
    ....
  24. pmc Functional and muscular adaptations in an experimental model for isometric strength training in mice
    Karsten Krüger
    Department of Sports Medicine, Institute of Sports Sciences, Justus Liebig University Giessen, Giessen, Germany
    PLoS ONE 8:e79069. 2013
    ..This approach seems also suitable to test for therapeutical effects of strength training. ..
  25. doi request reprint Dietary oxidized fat activates the oxidative stress-responsive transcription factors NF-κB and Nrf2 in intestinal mucosa of mice
    Juliane Varady
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giesen, Heinrich Buff Ring 26 32, 35392, Giesen, Germany
    Eur J Nutr 50:601-9. 2011
    ..The aim of this study, therefore, was to test the hypothesis that ingestion of an oxidized fat causes activation of these transcription factors in the small intestinal mucosa...
  26. doi request reprint Mechanisms underlying the anti-wasting effect of L-carnitine supplementation under pathologic conditions: evidence from experimental and clinical studies
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, 35390 Giessen, Germany
    Eur J Nutr 52:1421-42. 2013
    ....
  27. pmc Regulation of Genes Involved in Carnitine Homeostasis by PPARα across Different Species (Rat, Mouse, Pig, Cattle, Chicken, and Human)
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University Giessen, Heinrich Buff Ring 26 32, 35390 Giessen, Germany
    PPAR Res 2012:868317. 2012
    ....
  28. doi request reprint The role of peroxisome proliferator-activated receptor alpha in transcriptional regulation of novel organic cation transporters
    Klaus Eder
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Heinrich Buff Ring 26 32, Giessen, Germany
    Eur J Pharmacol 628:1-5. 2010
    ....
  29. pmc Low availability of carnitine precursors as a possible reason for the diminished plasma carnitine concentrations in pregnant women
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig University, Giessen, Germany
    BMC Pregnancy Childbirth 10:17. 2010
    ..It was moreover intended to find out whether low carnitine concentrations during pregnancy could be due to a reduced availability of precursors of carnitine synthesis, namely trimethyllysine (TML) and gamma-butyrobetaine (BB)...
  30. doi request reprint Fatty acids and signalling in endothelial cells
    Robert Ringseis
    Institute of Animal Nutrition and Nutrition Physiology, Justus Liebig Universitat Giessen, Giessen, Germany
    Prostaglandins Leukot Essent Fatty Acids 82:189-98. 2010
    ....