M Rietschel

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls
    M Rietschel
    Department of Psychiatry, University of Bonn, Germany
    Am J Med Genet 96:310-1. 2000
  2. ncbi request reprint Dopamine D3 receptor variant and tardive dyskinesia
    M Rietschel
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 250:31-5. 2000
  3. ncbi request reprint Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 4:76-84. 1999
  4. ncbi request reprint Familial occurrence of tardive dyskinesia
    D J Muller
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Acta Psychiatr Scand 104:375-9. 2001
  5. ncbi request reprint The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder
    J Erdmann
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 1:392-7. 1996
  6. ncbi request reprint A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
    Hum Mol Genet 10:2933-44. 2001
  7. ncbi request reprint A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Mol Psychiatry 6:342-9. 2001
  8. ncbi request reprint Affective symptomatology in schizophrenia: a risk factor for tardive dyskinesia?
    T G Schulze
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, Germany
    Eur Psychiatry 16:71-4. 2001
  9. ncbi request reprint hSKCa3: no association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia
    T Rohrmeier
    Department of Psychiatry, University of Regensburg, Germany
    Psychiatr Genet 9:169-75. 1999
  10. ncbi request reprint Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder
    R Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Mol Psychiatry 13:277-84. 2008

Detail Information

Publications47

  1. ncbi request reprint Association study of the tryptophan hydroxylase gene and bipolar affective disorder using family-based internal controls
    M Rietschel
    Department of Psychiatry, University of Bonn, Germany
    Am J Med Genet 96:310-1. 2000
    ..Neither allele 218A nor allele 218C were preferentially transmitted from heterozygous parents to bipolar offspring. Our results, therefore, do not support the hypothesis that the TPH gene is involved in the etiology of bipolar disorder...
  2. ncbi request reprint Dopamine D3 receptor variant and tardive dyskinesia
    M Rietschel
    Department of Psychiatry, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 250:31-5. 2000
    ..However, we found no evidence that the dopamine D3 receptor gene is likely to confer susceptibility to the development of tardive dyskinesia...
  3. ncbi request reprint Evaluation of linkage of bipolar affective disorder to chromosome 18 in a sample of 57 German families
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 4:76-84. 1999
    ..2 and 18q22-23 support prior evidence for susceptibility loci in these regions. The parent-of-origin effect on 18p11.2 is confirmed in our sample. The delineation of characteristics of 'either' families requires further study...
  4. ncbi request reprint Familial occurrence of tardive dyskinesia
    D J Muller
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Acta Psychiatr Scand 104:375-9. 2001
    ..We investigated these hypotheses in a large patient sample applying standardized methods for phenotype characterization...
  5. ncbi request reprint The human serotonin 7 (5-HT7) receptor gene: genomic organization and systematic mutation screening in schizophrenia and bipolar affective disorder
    J Erdmann
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 1:392-7. 1996
    ..Our data suggests that genetic variation of the 5-HT7 receptor does not play a major role in the development of bipolar affective disorder and schizophrenia...
  6. ncbi request reprint A genome screen for genes predisposing to bipolar affective disorder detects a new susceptibility locus on 8q
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, D 53111 Bonn, Germany
    Hum Mol Genet 10:2933-44. 2001
    ..Putative paternally imprinted loci were identified in chromosomal regions 2p24-p21 and 2q31-q32. Maternally imprinted susceptibility genes may be located on 14q32 and 16q21-q23...
  7. ncbi request reprint A possible susceptibility locus for bipolar affective disorder in chromosomal region 10q25--q26
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstr 31, D 53111 Bonn, Germany
    Mol Psychiatry 6:342-9. 2001
    ..12 (P = 0.0013). Positive linkage findings that have been reported by two independent studies further support the hypothesis of a susceptibility gene for bipolar affective disorder on 10q25-q26...
  8. ncbi request reprint Affective symptomatology in schizophrenia: a risk factor for tardive dyskinesia?
    T G Schulze
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, Germany
    Eur Psychiatry 16:71-4. 2001
    ..Thus, our data suggest that affective symptomatology cannot unambiguously be considered to predispose to TD...
  9. ncbi request reprint hSKCa3: no association of the polymorphic CAG repeat with bipolar affective disorder and schizophrenia
    T Rohrmeier
    Department of Psychiatry, University of Regensburg, Germany
    Psychiatr Genet 9:169-75. 1999
    ..Thus, our data do not support the hypothesis that longer CAG repeats in the hSkCa3 gene contribute to the susceptibility for bipolar disorder and schizophrenia...
  10. ncbi request reprint Genetic variation of the FAT gene at 4q35 is associated with bipolar affective disorder
    R Abou Jamra
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Mol Psychiatry 13:277-84. 2008
    ....
  11. ncbi request reprint Moclobemide response in depressed patients: association study with a functional polymorphism in the monoamine oxidase A promoter
    Daniel J Muller
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Pharmacopsychiatry 35:157-8. 2002
  12. ncbi request reprint Lack of association between a functional polymorphism of the cytochrome P450 1A2 (CYP1A2) gene and tardive dyskinesia in schizophrenia
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 105:498-501. 2001
    ..Thus, our results do not support the hypothesis that the C-->A polymorphism in the CYP1A2 gene is involved in the etiology of TD in the German population...
  13. ncbi request reprint Cloning, genomic organization, alternative transcripts and mutational analysis of the gene responsible for autosomal recessive universal congenital alopecia
    S Cichon
    Institute of Human Genetics, University of Bonn, Wilhelmstrasse 31, 53111 Bonn, Germany
    Hum Mol Genet 7:1671-9. 1998
    ..We speculate that this tissue-specific difference in the proportion of hairless transcripts lacking exon 17 sequences could contribute to the tissue-specific disease phenotype observed in individuals with isolated congenital alopecia...
  14. ncbi request reprint CYP2D6 polymorphism and tardive dyskinesia in schizophrenic patients
    P L Lohmann
    Department of Psychiatry, University of Bonn, Germany
    Pharmacopsychiatry 36:73-8. 2003
    ..In conclusion, our results provide no evidence for the contribution of CYP2D6 genotype to the development of TD in schizophrenic patients receiving long-term antipsychotic medication...
  15. ncbi request reprint Caught in the trio trap? Potential selection bias inherent to association studies using parent-offspring trios
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 105:351-3. 2001
    ..Thus, giving up case control designs for the sake of family-based association studies could be at the risk of selecting against several genetically determined factors...
  16. ncbi request reprint Examination of G72 and D-amino-acid oxidase as genetic risk factors for schizophrenia and bipolar affective disorder
    J Schumacher
    Institute of Human Genetics, University of Bonn, Germany
    Mol Psychiatry 9:203-7. 2004
    ..The association of variation at G72 with schizophrenia as well as BPAD provides molecular support for the hypothesis that these two major psychiatric disorders share some of their etiologic background...
  17. ncbi request reprint Genetics of schizophrenia and affective disorders
    W Maier
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Pharmacopsychiatry 36:S195-202. 2003
    ....
  18. pmc A gene for universal congenital alopecia maps to chromosome 8p21-22
    M M Nöthen
    Institute of Human Genetics, University of Bonn, Bonn, Germany
    Am J Hum Genet 62:386-90. 1998
    ..This will aid future identification of the responsible gene, which will be extremely useful for the understanding of the biochemistry of hair development...
  19. ncbi request reprint Association between a functional polymorphism in the monoamine oxidase A gene promoter and major depressive disorder
    T G Schulze
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Am J Med Genet 96:801-3. 2000
    ..Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:801-803, 2000...
  20. doi request reprint Genome-wide survey implicates the influence of copy number variants (CNVs) in the development of early-onset bipolar disorder
    L Priebe
    Department of Genomics, Life and Brain Center, University of Bonn, Bonn, Germany
    Mol Psychiatry 17:421-32. 2012
    ..These data suggest that CNVs have an influence on the development of early-onset, but not later-onset BD. Our study provides further support for previous hypotheses of an etiological difference between early-onset and later-onset BD...
  21. ncbi request reprint Systematic screening for mutations in the human serotonin-2A (5-HT2A) receptor gene: identification of two naturally occurring receptor variants and association analysis in schizophrenia
    J Erdmann
    Institute of Human Genetics, University of Bonn, Germany
    Hum Genet 97:614-9. 1996
    ..However, the reported association of the non-coding polymorphism 102T/C with the disease has also been detected in our sample (P=0.041, odds ratio=1.28, 95% confidence interval 1.012-1.623)...
  22. ncbi request reprint Maternal transmission disequilibrium of the glutamate receptor GRIK2 in schizophrenia
    J Bah
    Human Genetics and Cognitive Functions, Universite Paris 7, Institut Pasteur, 25, rue du Docteur Roux, 75724 Paris Cedex 15, France
    Neuroreport 15:1987-91. 2004
    ..05). These results are similar to the maternal GRIK2 transmission disequilibrium previously reported for autism, and support the presence of a susceptibility gene for schizophrenia at 6q16...
  23. ncbi request reprint Investigation of the DAOA/G30 locus in panic disorder
    J Schumacher
    Mol Psychiatry 10:428-9. 2005
  24. ncbi request reprint Association between COMT (Val158Met) functional polymorphism and early onset in patients with major depressive disorder in a European multicenter genetic association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 10:598-605. 2005
    ..The COMT gene may have complex and pleiotropic effects on susceptibility and symptomatology of neuropsychiatric disorders...
  25. ncbi request reprint A family-based and case-control association study of trace amine receptor genes on chromosome 6q23 in bipolar affective disorder
    R Abou Jamra
    Mol Psychiatry 10:618-20. 2005
  26. pmc Genome-wide scan for genes involved in bipolar affective disorder in 70 European families ascertained through a bipolar type I early-onset proband: supportive evidence for linkage at 3p14
    B Etain
    INSERM U513, Neurobiology and Psychiatry, Faculte de Medecine, Creteil, France
    Mol Psychiatry 11:685-94. 2006
    ..51 to 3.83. This study is the first to use early-onset bipolar type I probands in an attempt to increase sample homogeneity. These preliminary findings require confirmation in independent panels of families...
  27. ncbi request reprint Genetic association of the human corticotropin releasing hormone receptor 1 (CRHR1) with binge drinking and alcohol intake patterns in two independent samples
    J Treutlein
    Molecular Genetics Laboratory and Department of Addiction Medicine, Central Institute of Mental Health, Mannheim, Germany
    Mol Psychiatry 11:594-602. 2006
    ..Our findings support results from animal models, suggesting an importance of CRHR1 in integrating gene-environment effects in alcohol use disorders...
  28. ncbi request reprint Variation of the serotonin transporter gene SLC6A4 in the susceptibility to migraine with aura
    U Todt
    Institute of Human Genetics, Center for Molecular Medicine Cologne, University of Cologne, Cologne, Germany
    Neurology 67:1707-9. 2006
    ....
  29. pmc A genome-wide association study implicates diacylglycerol kinase eta (DGKH) and several other genes in the etiology of bipolar disorder
    A E Baum
    Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, US Department of Health and Human Services, National Institute of Mental Health, NIH, Bethesda, MD 20892, USA
    Mol Psychiatry 13:197-207. 2008
    ..This first genome-wide association study of bipolar disorder shows that several genes, each of modest effect, reproducibly influence disease risk. Bipolar disorder may be a polygenic disease...
  30. pmc Meta-analysis of two genome-wide association studies of bipolar disorder reveals important points of agreement
    A E Baum
    Mol Psychiatry 13:466-7. 2008
  31. ncbi request reprint Transmission disequilibrium and haplotype analyses of the G72/G30 locus: suggestive linkage to schizophrenia in Palestinian Arabs living in the North of Israel
    M Korostishevsky
    Department of Human Genetics and Molecular Medicine, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel 69978
    Am J Med Genet B Neuropsychiatr Genet 141:91-5. 2006
    ..These data suggest a common risk factor for schizophrenia susceptibility in the G72/G30 locus among Ashkenazi Jews and Palestinian Arabs. The results strengthen previous reports on the role of this locus in the etiology of schizophrenia...
  32. ncbi request reprint Family-based and case-control study of catechol-O-methyltransferase in schizophrenia among Palestinian Arabs
    I Kremer
    Emek Hospital, Afula, Israel
    Am J Med Genet B Neuropsychiatr Genet 119:35-9. 2003
    ..In summary, by case-control design but not by a family-based study, there is a weak effect in female patients of the high activity COMT allele in conferring risk for schizophrenia...
  33. ncbi request reprint No association between the dopamine D3 receptor Bal I polymorphism and schizophrenia in a family-based study of a Palestinian Arab population
    I Kremer
    Department of Psychiatry, Emek Hospital, Afula, Israel
    Am J Med Genet 96:778-80. 2000
    ..38, P > 0.1, n = 86 families) for association/linkage (or increased homozygosity) of the DRD3 Bal I polymorphism to schizophrenia in our sample. Am. J. Med. Genet. (Neuropsychiatr. Genet.) 96:778-780, 2000...
  34. ncbi request reprint Serotonin receptor gene HTR3A variants in schizophrenic and bipolar affective patients
    B Niesler
    Institute of Human Genetics, University of Heidelberg, Germany
    Pharmacogenetics 11:21-7. 2001
    ..Further studies are needed to support the hypothesis that HTR3A may contribute to the schizophrenia in these patients...
  35. ncbi request reprint No evidence for linkage by transmission disequilibrium test analysis of microsatellite marker D22S278 and schizophrenia in a Palestinian Arab and in a German population
    M Dobrusin
    Beersheva Mental Health Center, Beersheva, Israel
    Am J Med Genet 105:328-31. 2001
    ..11, P = 0.12, df = 9; Beersheva: chi-square = 7.04, P = 0.32, df = 6). Additionally, we examined D22S278 in a group of 114 schizophrenic German triads and failed to observe evidence for linkage (chi-square = 8.13, P = 0.42, df = 8df)...
  36. ncbi request reprint Association between the 5' UTR variant C178T of the serotonin receptor gene HTR3A and bipolar affective disorder
    B Niesler
    Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Pharmacogenetics 11:471-5. 2001
    ..These findings show that the C178T(Pro16Ser) variant in HTR3A may represent a functional variant and affect the susceptibility to bipolar disorder...
  37. ncbi request reprint Variability of 5-HT2C receptor cys23ser polymorphism among European populations and vulnerability to affective disorder
    B Lerer
    Biological Psychiatry Laboratory, Hadassah Medical Organization, Jerusalem, Israel
    Mol Psychiatry 6:579-85. 2001
    ..34, df 1, P = 0.006) and BP (chi(2) = 5.45, df 1, P = 0.02) patients. These findings support a possible role for genetically based structural variation in 5-HT2C receptors in the pathogenesis of major affective disorder...
  38. ncbi request reprint An association study of debrisoquine hydroxylase (CYP2D6) polymorphisms in schizophrenia
    E Dawson
    Department of Neuroscience, Institute of Psychiatry, London, UK
    Psychiatr Genet 4:215-8. 1994
    ..The patient and control samples showed no significant deviation from Hardy-Weinberg equilibrium and the frequency of each mutant allele (CYP2D6A and CYP2D6B) did not differ between patients and controls...
  39. ncbi request reprint [Genetics of bipolar affective disorders. Current status of research for identification of susceptibility genes]
    J Schumacher
    Institut fur Humangenetik, Universitatsklinikum Bonn
    Nervenarzt 73:581-92; quiz 593-4. 2002
    ..New methods are being developed for linkage disequilibrium mapping and candidate gene approaches. One can be optimistic that over the next few years bipolar susceptibility genes will be identified...
  40. ncbi request reprint Analysis of a polymorphism in the tuberous sclerosis (TSC2) gene does not predispose to schizophrenia
    R Przkora
    Department of Neuropathology, University of Bonn Medical Center, Germany
    Eur Arch Psychiatry Clin Neurosci 248:314-5. 1998
    ..A 222-bp fragment of genomic DNA containing the TSC2 variant was analyzed by SSCP. The analysis revealed that there is no association with schizophrenia...
  41. ncbi request reprint Excess of allele1 for alpha3 subunit GABA receptor gene (GABRA3) in bipolar patients: a multicentric association study
    I Massat
    Department of Psychiatry, University Clinics of Brussels, Erasme Hospital, Free University of Brussels, Belgium
    Mol Psychiatry 7:201-7. 2002
    ..00002). Our findings suggest that the GABRA3 polymorphism may confer susceptibility to or may be in linkage disequilibrium with another gene involved in the genetic etiology of BPAD...
  42. ncbi request reprint Etiopathogenetic mechanisms in long-term course of schizophrenia
    P Falkai
    Department of Psychiatry and Psychotherapy, University of the Saarland, 66421 Homburg Saar, Germany
    Pharmacopsychiatry 37:S136-40. 2004
    ..The attempt is made to connect prefrontal grey matter loss with post-mortem findings of reduced neuropil but preserved cytoarchitecture leading to recently described candidate genes and their function...
  43. ncbi request reprint Measuring depression: comparison and integration of three scales in the GENDEP study
    R Uher
    Medical Research Council, Social, Genetic and Developmental Psychiatry Research Centre, Institute of Psychiatry, King s College London, UK
    Psychol Med 38:289-300. 2008
    ..In this study we examined and integrated the psychometric properties of three commonly used rating scales...
  44. ncbi request reprint A family-based study of the Cys23Ser 5HT2C serotonin receptor polymorphism in schizophrenia
    I Murad
    Dr. Kemal Psychiatric Hospital, Bethlehem, Palestine
    Am J Med Genet 105:236-8. 2001
    ..No evidence was obtained for preferential transmission of the Cys23Ser 5HT2C alleles in schizophrenia in either of the two main ethnic groups examined (German and Palestinian Arab) or in the combined cohort (TDT chi-square = 0.00, NS)...
  45. ncbi request reprint [Attitudes towards predictive genetic testing for Alzheimer's disease]
    F Illes
    Zentralinstitut fur Seelische Gesundheit, Abteilungen Gerontopsychiatrie sowie Genetische Epidemiologie in der Psychiatrie, J5, 68159, Mannheim, Germany
    Z Gerontol Geriatr 39:233-9. 2006
    ..From a medical perspective, the prevailing approach of professional associations to genetic testing appears reasonable and therefore should not be changed at present...
  46. ncbi request reprint [Pharmacogenetic strategies]
    M Rietschel
    , Bonn
    Fortschr Neurol Psychiatr 69:S62-4. 2001
    ..These 'guidelines' and study results will be presented...
  47. ncbi request reprint A dopamine transporter mutation associated with bipolar affective disorder causes inhibition of transporter cell surface expression
    S Horschitz
    Biochemical Laboratory, Central Institute of Mental Health, Mannheim, Germany
    Mol Psychiatry 10:1104-9. 2005
    ....