Matthias W Riepe

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. pmc Quality of life as an outcome in Alzheimer's disease and other dementias--obstacles and goals
    Matthias W Riepe
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Neurol 9:47. 2009
  2. pmc Bupropion and Citalopram in the APP23 Mouse Model of Alzheimer's Disease: A Study in a Dry-Land Maze
    Katharina L Neumeister
    Division of Mental Health and Old Age Psychiatry, Psychiatry II, Ulm University, 89312 Günzburg, Germany
    Int J Alzheimers Dis 2012:673584. 2012
  3. doi request reprint [Dementia guidelines: what should come to general practice--an interdisciplinary consensus of physicians in private practice]
    M W Riepe
    Klinik für Psychiatrie II, Sektion Gerontopsychiatrie, Universitat Ulm
    Dtsch Med Wochenschr 137:1499-504. 2012
  4. pmc Additive scales in degenerative disease--calculation of effect sizes and clinical judgment
    Matthias W Riepe
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Med Res Methodol 11:169. 2011
  5. doi request reprint Measuring therapeutic efficacy in patients with Alzheimer's disease: role of instruments
    Matthias W Riepe
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ludwig Heilmeyer Strasse 2, Gunzburg, Germany
    Dement Geriatr Cogn Disord 31:233-8. 2011
  6. doi request reprint Efficacy of short-term inpatient rehabilitation for dementia patients and caregivers: prospective cohort study
    Claudia Schiffczyk
    Division of Mental Health and Old Age Psychiatry, Department of Psychiatry and Psychotherapy II, Ulm University, Ulm, Germany
    Dement Geriatr Cogn Disord 35:300-12. 2013
  7. pmc Appraising the need for care in Alzheimer's disease
    Claudia Schiffczyk
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Psychiatry 13:73. 2013
  8. pmc Gender-dependence of substituted judgment on quality of life in patients with dementia
    Claudia Schiffczyk
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Neurol 11:118. 2011
  9. doi request reprint Staging dementia using proxy-reported activities of daily living
    Christina Jonas
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Germany
    Dement Geriatr Cogn Disord 32:111-7. 2011
  10. doi request reprint Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease
    Katharina L Neumeister
    Mental Health and Old Age Psychiatry, Psychiatry II, Ulm University, Gunzburg, Germany
    J Alzheimers Dis 30:245-51. 2012

Collaborators

Detail Information

Publications26

  1. pmc Quality of life as an outcome in Alzheimer's disease and other dementias--obstacles and goals
    Matthias W Riepe
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Neurol 9:47. 2009
    ..g. severity of symptoms or frequency of complications of a disease. However, this does not allow clear judgement on clinical relevance or comparison across different diseases...
  2. pmc Bupropion and Citalopram in the APP23 Mouse Model of Alzheimer's Disease: A Study in a Dry-Land Maze
    Katharina L Neumeister
    Division of Mental Health and Old Age Psychiatry, Psychiatry II, Ulm University, 89312 Günzburg, Germany
    Int J Alzheimers Dis 2012:673584. 2012
    ..Conclusion. Bupropion increases psychomotor activity in APP23 transgenic animals, while citalopram slightly reduces psychomotor activity. Spatial learning per se is unaffected by treatment with either bupropion or citalopram...
  3. doi request reprint [Dementia guidelines: what should come to general practice--an interdisciplinary consensus of physicians in private practice]
    M W Riepe
    Klinik für Psychiatrie II, Sektion Gerontopsychiatrie, Universitat Ulm
    Dtsch Med Wochenschr 137:1499-504. 2012
    ..Guidelines commonly do not account for regional specifics. Transfer of knowledge from guidelines to general practice, therefore, is incomplete...
  4. pmc Additive scales in degenerative disease--calculation of effect sizes and clinical judgment
    Matthias W Riepe
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Med Res Methodol 11:169. 2011
    ..Hence in an aim to overcome this pooling the results of clinical studies into a meta-analyses with a statistical calculus has been assumed to be a more definitive way of deciding of efficacy...
  5. doi request reprint Measuring therapeutic efficacy in patients with Alzheimer's disease: role of instruments
    Matthias W Riepe
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ludwig Heilmeyer Strasse 2, Gunzburg, Germany
    Dement Geriatr Cogn Disord 31:233-8. 2011
    ..Global cognitive scales and meta-analyses thereof are used to appraise therapeutic efficacy over a broad range of disease severity. Clinically, however, different aspects of cognition change in different stages of disease...
  6. doi request reprint Efficacy of short-term inpatient rehabilitation for dementia patients and caregivers: prospective cohort study
    Claudia Schiffczyk
    Division of Mental Health and Old Age Psychiatry, Department of Psychiatry and Psychotherapy II, Ulm University, Ulm, Germany
    Dement Geriatr Cogn Disord 35:300-12. 2013
    ..The efficacy of nonpharmacological and multicomponent treatments in patients with dementia is under discussion, as is the ongoing debate which endpoints best measure efficacy...
  7. pmc Appraising the need for care in Alzheimer's disease
    Claudia Schiffczyk
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Psychiatry 13:73. 2013
    ..Our aim was to investigate whether a reduced ability of the patient to perform ADL is sufficient to adequately assess the supportive needs of family caregivers...
  8. pmc Gender-dependence of substituted judgment on quality of life in patients with dementia
    Claudia Schiffczyk
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Neurol 11:118. 2011
    ..It is unclear whether substituted judgment of the patient's quality of life can serve as a surrogate measure in patients with dementia...
  9. doi request reprint Staging dementia using proxy-reported activities of daily living
    Christina Jonas
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Germany
    Dement Geriatr Cogn Disord 32:111-7. 2011
    ..Therefore, other instruments are used, such as scales of activities of daily living (ADL). Our goal was to analyze variables influencing the appraisal of ADL...
  10. doi request reprint Synergistic effects of antidementia drugs on spatial learning and recall in the APP23 transgenic mouse model of Alzheimer's disease
    Katharina L Neumeister
    Mental Health and Old Age Psychiatry, Psychiatry II, Ulm University, Gunzburg, Germany
    J Alzheimers Dis 30:245-51. 2012
    ..Combination treatment with donepezil and memantine exerts a synergistic effect improving both moving time and resting time and thus possibly both spatial learning and retrieval...
  11. pmc Generic quality of life assessment in dementia patients: a prospective cohort study
    Claudia Schiffczyk
    Department of Psychiatry and Psychotherapy II, Mental Health and Old Age Psychiatry, Ulm University, Ulm, Germany
    BMC Neurol 10:48. 2010
    ..Quality of life (QoL) is increasingly used to characterize the impact of disease and the efficacy of interventions...
  12. doi request reprint Everyday memory deficits in very mild Alzheimer's disease
    Catherine N Widmann
    Department of Psychiatry, Mental Health and Old Age Psychiatry, Charité Medical University, Berlin, Germany
    Neurobiol Aging 33:297-303. 2012
    ..In future, this may aid objective appraisal of interventions with regard to their everyday relevance...
  13. doi request reprint Tau-proteins as gender-specific state markers in amnestic mild cognitive impairment
    Matthias W Riepe
    Division of Mental Health and Old Age Psychiatry, Psychiatry II, University of Ulm, Ulm, Germany matthias riepe uni ulm de
    Dement Geriatr Cogn Disord 30:93-100. 2010
    ..Our purpose was to assess whether cerebrospinal fluid (CSF) markers of Alzheimer's disease (AD) reflect trait or state of disease in patients with AD and amnestic mild cognitive impairment (aMCI)...
  14. doi request reprint Reduced benefit from mnemonic strategies in early-stage Alzheimer's disease: a brief testing-the-limits paradigm for clinical practice
    Ingo Uttner
    Neurologische Klinik der Universität Ulm, Oberer Eselsberg 45, 89081, Ulm, Germany
    J Neurol 257:1718-26. 2010
    ..Our data confirm the finding of an impaired cognitive plasticity already present in very early stages of AD and illustrate the efficiency of a dynamic test approach in identifying incipient dementia...
  15. ncbi request reprint Cholinergic enhancement of episodic memory in healthy young adults
    Georg Gron
    Department of Psychiatry, University of Ulm, Leimgrubenweg 12, 89075 Ulm, Germany
    Psychopharmacology (Berl) 182:170-9. 2005
    ..Acetylcholine esterase (AchE) inhibitors are known to remediate symptoms of Alzheimer's disease. However, only few systematic data exist on the effects of cholinergic treatment on cognitive functions in normal subjects...
  16. ncbi request reprint Chemical hypoxia facilitates alternative splicing of EAAT2 in presymptomatic APP23 transgenic mice
    Christoph Munch
    Department of Neurology, Jewish Hospital Berlin, Heinz Galinski Str 1, 13347 Berlin, Germany
    Neurochem Res 33:1005-10. 2008
    ..Our results demonstrate that hypoxia facilitates alternative splicing of EAAT2 in the APP23 model. This may be a molecular mechanism linking vascular factors to early pathophysiology of Alzheimer's disease...
  17. ncbi request reprint The stamp of ancestry: roots of behavioral and neuronal impairment in adulthood
    Peter Lohmann
    Department of Psychiatry, Mental Health and Old Age Psychiatry, Charité Medical University, Eschenallee 3, D 14050 Berlin, Germany
    Exp Neurol 200:104-11. 2006
    ..This finding may ultimately help to understand the causes of neuronal impairment or even neuropsychiatric disease in old age...
  18. ncbi request reprint Differential regulation of 5' splice variants of the glutamate transporter EAAT2 in an in vivo model of chemical hypoxia induced by 3-nitropropionic acid
    Christoph Munch
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurosci Res 71:819-25. 2003
    ..Our findings contribute to the hypothesis that RNA splicing events can serve as a molecular mechanism of posthypoxic gene regulation...
  19. doi request reprint Genetic variants in PSEN2 and correlation to CSF β-amyloid42 levels in AD
    Elena Lebedeva
    Institute of Pharmacology of Natural Products and Clinical Pharmacology, Ulm University, Ulm, Germany
    Neurobiol Aging 33:201.e9-18. 2012
    ..A better understanding of genetic influences on biomarkers like CSF Aβ42 might help to stratify patients and develop specific treatment strategies...
  20. doi request reprint Cognitive estimation in aged patients with major depressive disorder
    Agota Barabassy
    Department of Psychiatry, Mental Health and Old Age Psychiatry, Charité Medical University, Berlin, Germany
    Psychiatry Res 176:26-9. 2010
    ..We conclude that MDD patients in old age are impaired to some extent in cognitive estimation and in the ability to correct themselves, deficits that are likely to affect the performance of everyday activities...
  21. ncbi request reprint Secondary stroke prevention: inside the vessels and beyond
    Matthias W Riepe
    Department of Psychiatry and Psychotherapy, Mental Health and Old Age Psychiatry, Charité Medical University, Berlin, Germany
    CNS Drugs 22:113-21. 2008
    ..This neuroprotective mechanism is also shared with HMG-CoA reductase inhibitors...
  22. ncbi request reprint Graded reoxygenation with chemical inhibition of oxidative phosphorylation improves posthypoxic recovery in murine hippocampal slices
    Roman Huber
    Department of Neurology, University of Ulm, Ulm, Germany
    J Neurosci Res 75:441-9. 2004
    ..Thus, grading of reoxygenation with selective targeting of mitochondrial complex I or II but not of complex IV improves outcome upon reoxygenation in murine hippocampal slices...
  23. ncbi request reprint Screening for cognitive impairment in patients with acute stroke
    Matthias W Riepe
    Department of Neurology, University of Ulm, Ulm, Germany
    Dement Geriatr Cogn Disord 17:49-53. 2004
    ..Formal assessment of cognitive impairment is rare in acute stroke, yet. It was the goal to utilize easy-to-apply established screening tests to assess cognitive impairment from any cause in patients with acute ischemic stroke...
  24. ncbi request reprint Donepezil in Alzheimer's disease: a clinical observational study evaluating individual treatment response
    Matthias W Riepe
    Department of Psychiatry, Mental Health and Old Age Psychiatry, Charite Universitatsmedizin, Berlin, Germany
    Curr Med Res Opin 23:1829-35. 2007
    ..A post-marketing surveillance study evaluating the sensitivity of the Individual Symptom Score (IndiSS) in assessing the treatment benefits of donepezil in patients with Alzheimer's disease (AD) under everyday conditions...
  25. ncbi request reprint Trans-synaptic increase of hypoxic tolerance in hippocampus upon physical challenge with two-photon microscopy
    Maren Büchner
    Department of Neurology, University of Ulm, Ulm, Germany
    Hippocampus 12:765-73. 2002
    ..This is mediated in part through endogenous modulation by zinc. Mild zinc increase improves hypoxic tolerance while pronounced increase predicts neuronal cell death...