F G Riepe

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. doi request reprint Pseudohypoaldosteronism
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
    Endocr Dev 24:86-95. 2013
  2. pmc Intrinsic androgen-dependent gene expression patterns revealed by comparison of genital fibroblasts from normal males and individuals with complete and partial androgen insensitivity syndrome
    Paul Martin Holterhus
    Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 20, Kiel, Germany
    BMC Genomics 8:376. 2007
  3. pmc Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes
    Paul Martin Holterhus
    Department of Pediatrics, Christian Albrechts University of Kiel, Germany
    BMC Genomics 10:292. 2009
  4. doi request reprint Clinical and molecular features of type 1 pseudohypoaldosteronism
    Felix G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts University, University Hospital Schleswig Holstein, Kiel, Germany
    Horm Res 72:1-9. 2009
  5. ncbi request reprint Autosomal-dominant pseudohypoaldosteronism type 1 in a Turkish family is associated with a novel nonsense mutation in the human mineralocorticoid receptor gene
    Felix G Riepe
    Department of Pediatrics, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 89:2150-2. 2004
  6. doi request reprint Revealing a subclinical salt-losing phenotype in heterozygous carriers of the novel S562P mutation in the alpha subunit of the epithelial sodium channel
    Felix G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Clin Endocrinol (Oxf) 70:252-8. 2009
  7. ncbi request reprint Recent advances in diagnosis, treatment, and outcome of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat Kiel, Schwanenweg 20, 24105, Kiel, Germany
    Rev Endocr Metab Disord 8:349-63. 2007
  8. ncbi request reprint Exclusion of serum- and glucocorticoid-induced kinase 1 (SGK1) as a candidate gene for genetically heterogeneous renal pseudohypoaldosteronism type I in eight families
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Am J Nephrol 27:164-9. 2007
  9. ncbi request reprint Elucidating the underlying molecular pathogenesis of NR3C2 mutants causing autosomal dominant pseudohypoaldosteronism type 1
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Schwanenweg 20, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 91:4552-61. 2006
  10. ncbi request reprint Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    F G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat Kiel, Kiel, Germany
    Exp Clin Endocrinol Diabetes 114:105-10. 2006

Collaborators

Detail Information

Publications42

  1. doi request reprint Pseudohypoaldosteronism
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Kiel, Germany
    Endocr Dev 24:86-95. 2013
    ..Urinary tract infections and obstructive uropathies are the most frequent cause. Contrary to PHA1 and PHA2, the glomerular filtration rate is decreased in PHA3...
  2. pmc Intrinsic androgen-dependent gene expression patterns revealed by comparison of genital fibroblasts from normal males and individuals with complete and partial androgen insensitivity syndrome
    Paul Martin Holterhus
    Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Schwanenweg 20, Kiel, Germany
    BMC Genomics 8:376. 2007
    ....
  3. pmc Disorders of sex development expose transcriptional autonomy of genetic sex and androgen-programmed hormonal sex in human blood leukocytes
    Paul Martin Holterhus
    Department of Pediatrics, Christian Albrechts University of Kiel, Germany
    BMC Genomics 10:292. 2009
    ..g., 46, XY-females due to defective androgen biosynthesis) compared to normal 46, XY-males and 46, XX-females...
  4. doi request reprint Clinical and molecular features of type 1 pseudohypoaldosteronism
    Felix G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts University, University Hospital Schleswig Holstein, Kiel, Germany
    Horm Res 72:1-9. 2009
    ..Some mutations are discussed in more detail to demonstrate some of these findings. A better clinical work-up of the patients suffering from PHA1 may delineate additional associations between the genotype and phenotype in the future...
  5. ncbi request reprint Autosomal-dominant pseudohypoaldosteronism type 1 in a Turkish family is associated with a novel nonsense mutation in the human mineralocorticoid receptor gene
    Felix G Riepe
    Department of Pediatrics, Christian Albrechts University Kiel, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 89:2150-2. 2004
    ..This shows the incomplete penetrance of the phenotype, although a mild salt loss might have been overlooked in the father's childhood...
  6. doi request reprint Revealing a subclinical salt-losing phenotype in heterozygous carriers of the novel S562P mutation in the alpha subunit of the epithelial sodium channel
    Felix G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts Universitat zu Kiel, Kiel, Germany
    Clin Endocrinol (Oxf) 70:252-8. 2009
    ..Mutations in the three coding genes of the epithelial sodium channel (ENaC) are responsible for the systemic autosomal recessive form. So far, no phenotype has been reported in heterozygous carriers...
  7. ncbi request reprint Recent advances in diagnosis, treatment, and outcome of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat Kiel, Schwanenweg 20, 24105, Kiel, Germany
    Rev Endocr Metab Disord 8:349-63. 2007
    ..However, many issues are still unresolved, and novel questions, which will have to be answered in the future, arise with every new finding...
  8. ncbi request reprint Exclusion of serum- and glucocorticoid-induced kinase 1 (SGK1) as a candidate gene for genetically heterogeneous renal pseudohypoaldosteronism type I in eight families
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Am J Nephrol 27:164-9. 2007
    ..Therefore variations in the SGK1 gene may aggravate renal salt loss or cause PHA1...
  9. ncbi request reprint Elucidating the underlying molecular pathogenesis of NR3C2 mutants causing autosomal dominant pseudohypoaldosteronism type 1
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Schwanenweg 20, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 91:4552-61. 2006
    ..Pseudohypoaldosteronism type 1 (PHA1) is a rare salt-wasting syndrome. Mutations in the NR3C2 gene coding for the mineralocorticoid receptor (MR) cause autosomal dominant PHA1...
  10. ncbi request reprint Absence of exercise-induced leptin suppression associated with insufficient epinephrine reserve in patients with classic congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    F G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat Kiel, Kiel, Germany
    Exp Clin Endocrinol Diabetes 114:105-10. 2006
    ..In healthy subjects, an inhibitory effect of acute catecholamine elevation on the leptin plasma concentrations has been reported. However, it is not yet known how leptin levels respond to exercise in CAH patients...
  11. doi request reprint Functional and structural consequences of a novel point mutation in the CYP21A2 gene causing congenital adrenal hyperplasia: potential relevance of helix C for P450 oxidoreductase-21-hydroxylase interaction
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Schwanenweg 20, Kiel, Germany
    J Clin Endocrinol Metab 93:2891-5. 2008
    ..Congenital adrenal hyperplasia is caused by insufficient adrenal steroid biosynthesis due to impaired steroidogenic enzymes. The majority of patients suffer from deficiency of 21-hydroxylase (CYP21) coded by the CYP21A2 gene...
  12. ncbi request reprint Three novel point mutations of the CYP21 gene detected in classical forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    N Krone
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts Universitat zu Kiel, Universitätsklinikum Schleswig Holstein Campus Kiel, Kiel, Germany
    Exp Clin Endocrinol Diabetes 114:111-7. 2006
    ..Knowledge of the residual 21-hydroxylase function improves both genetic counselling and individual clinical management in CAH patients...
  13. ncbi request reprint Functional characterization of naturally occurring NR3C2 gene mutations in Italian patients suffering from pseudohypoaldosteronism type 1
    Antonio Balsamo
    Division of Pediatric Endocrinology, Department of Pediatrics, Policlinico S Orsola Malpighi, University of Bologna, Via Massarenti 11, 40138 Bologna, Italy
    Eur J Endocrinol 156:249-56. 2007
    ..The renal form of pseudohypoaldosteronism type 1 (PHA1) is a rare disease caused by mutations in the human mineralocorticoid receptor gene (NR3C2)...
  14. doi request reprint No correlation between androgen receptor CAG and GGN repeat length and the degree of genital virilization in females with 21-hydroxylase deficiency
    M Welzel
    Department of Pediatrics, Division of Pediatric Endocrinology and Diabetes, Christian Albrechts University, Schwanenweg 20, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 95:2443-50. 2010
    ..However, genital virilization in affected females correlates only weakly with CYP21A2 mutation groups, suggesting the influence of genetic modifiers...
  15. doi request reprint Testosterone synthesis in patients with 17β-hydroxysteroid dehydrogenase 3 deficiency
    R Werner
    Division of Pediatric Endocrinology, Department of Pediatric and Adolescent Medicine, University of Lubeck, Lubeck, Germany
    Sex Dev 6:161-8. 2012
    ..After gonadectomy, both androstenedione and testosterone decline rapidly in vivo. In 17β-HSD 3 deficiency, relevant amounts of testosterone are synthesized most probably through AKR1C3 in the testis and not peripherally in GSF...
  16. doi request reprint Congenital lipoid adrenal hyperplasia: functional characterization of three novel mutations in the STAR gene
    Susanne Bens
    Division of Pediatric Endocrinology, Department of Pediatrics, University Hospital Schleswig Holstein, Schwanenweg 20, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 95:1301-8. 2010
    ..We speculate that the substitution of hydrophilic glutamine with basic arginine at the surface of the molecule may accelerate cholesterol transfer...
  17. ncbi request reprint Congenital adrenal hyperplasia: the molecular basis of 21-hydroxylase deficiency in H-2(aw18) mice
    Felix G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts University of Kiel, Schwanenweg 20, D 24105 Kiel, Germany
    Endocrinology 146:2563-74. 2005
    ..The underlying genetic mechanisms are also known to be responsible for 21-OHD in humans, so rodent 21-OHD turns out to be an excellent genetic model for studying the human disease...
  18. ncbi request reprint Identification of a novel mutation in the human mineralocorticoid receptor gene in a german family with autosomal-dominant pseudohypoaldosteronism type 1: further evidence for marked interindividual clinical heterogeneity
    Felix G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts University Kiel, Germany
    J Clin Endocrinol Metab 88:1683-6. 2003
    ..It remains to be elucidated whether other defects or polymorphisms in genes coding for regulatory proteins participating in sodium homeostasis are a cause of the heterogeneity of the clinical manifestations in autosomal dominant PHA1...
  19. ncbi request reprint Congenital adrenal hyperplasia - how to improve the transition from adolescence to adult life
    B Kruse
    Department of Medicine I, Endocrine and Diabetes Unit, Universitätsklinikum Schleswig Holstein Campus Kiel, Christian Albrechts Universitat zu Kiel, Germany
    Exp Clin Endocrinol Diabetes 112:343-55. 2004
    ..For practical purposes, we here provide charts for follow-up of CAH patients that can be adapted for use in any endocrine outpatient clinic...
  20. doi request reprint Principles and clinical applications of liquid chromatography - tandem mass spectrometry for the determination of adrenal and gonadal steroid hormones
    A E Kulle
    Department of Pediatrics, University Hospital Schleswig Holstein, Christian Albrechts University of Kiel, Kiel, Germany
    J Endocrinol Invest 34:702-8. 2011
    ....
  21. ncbi request reprint Serum cortisol and cortisone levels in newborns with congenital adrenal hyperplasia before the start of therapy
    J Dotsch
    Department of Pediatrics, University of Kiel, Kiel, Germany
    J Endocrinol Invest 28:413-6. 2005
    ..While declining plasma aldosterone levels precede the onset of SW in CAH patients, plasma cortisol concentrations are kept normal in SW-CAH infants, temporarily maintaining sufficient mineralocorticoid activity...
  22. ncbi request reprint Functional characterization of two novel point mutations in the CYP21 gene causing simple virilizing forms of congenital adrenal hyperplasia due to 21-hydroxylase deficiency
    Nils Krone
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat zu Kiel, Universitatskinderklinik, Schwanenweg 20, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 90:445-54. 2005
    ..Studying the enzyme function in vitro helps to understand the phenotypical expression and disease severity of 21-hydroxylase deficiency and also provides new insights into cytochrome P450 structure-function relationships...
  23. ncbi request reprint Chromatographic system for the simultaneous measurement of plasma 18-hydroxy-11-deoxycorticosterone and 18-hydroxycorticosterone by radioimmunoassay: reference data for neonates and infants and its application in aldosterone-synthase deficiency
    F G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts University Kiel, Schwanenweg 20, 24105 Kiel, Germany
    J Chromatogr B Analyt Technol Biomed Life Sci 785:293-301. 2003
    ..Its application for the diagnosis of aldosterone synthase deficiency is demonstrated in two patients with homozygous mutation/deletion in the encoding CYP11B2 gene...
  24. ncbi request reprint Automated chromatographic system for the simultaneous measurement of plasma pregnenolone and 17-hydroxypregnenolone by radioimmunoassay
    F G Riepe
    Department of Paediatrics, Division of Paediatric Endocrinology, Christian Albrechts University Kiel, Germany
    J Chromatogr B Biomed Sci Appl 763:99-106. 2001
    ..Normal values for this assay in young male adults, in adult females, and in prepubertal boys and girls were established as a basis for the functional diagnosis of androgen excess syndromes/steroidogenesis defects...
  25. doi request reprint Androgen receptor mutations are associated with altered epigenomic programming as evidenced by HOXA5 methylation
    S Bens
    Institute of Human Genetics, Christian Albrechts University of Kiel and University Hospital Schleswig Holstein, Campus Kiel, Kiel, Germany
    Sex Dev 5:70-6. 2011
    ....
  26. ncbi request reprint Longitudinal imaging reveals pituitary enlargement preceding hypoplasia in two brothers with combined pituitary hormone deficiency attributable to PROP1 mutation
    F G Riepe
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts University, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 86:4353-7. 2001
    ....
  27. ncbi request reprint Analyzing the functional and structural consequences of two point mutations (P94L and A368D) in the CYP11B1 gene causing congenital adrenal hyperplasia resulting from 11-hydroxylase deficiency
    Nils Krone
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat zu Kiel, Universitätsklinikum Schleswig Holstein Campus Kiel, Schwanenweg 20, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 91:2682-8. 2006
    ..Congenital adrenal hyperplasia is a group of autosomal recessive inherited disorders of steroidogenesis. The deficiency of steroid 11-hydroxylase (CYP11B1) resulting from mutations in the CYP11B1 gene is the second most frequent cause...
  28. ncbi request reprint The residue E351 is essential for the activity of human 21-hydroxylase: evidence from a naturally occurring novel point mutation compared with artificial mutants generated by single amino acid substitutions
    Nils Krone
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat zu Kiel, Universitätsklinikum Schleswig Holstein Campus Kiel, Schwanenweg 20, 24105, Kiel, Germany
    J Mol Med (Berl) 83:561-8. 2005
    ..The combination of in vitro enzyme function and computerized protein analysis of the E351 residue of the CYP21 protein provides experimental evidence for the ERR triad being a fundamental structural element of cytochrome P450 enzymes...
  29. doi request reprint Hashimoto encephalopathy in a 15-year-old-girl: EEG findings and follow-up
    Hiltrud Muhle
    Department of Neuropediatrics, University Medical Center Schleswig Holstein, Christian Albrechts Universitat zu Kiel, 24105 Kiel, Germany
    Pediatr Neurol 41:301-4. 2009
    ..Laboratory findings were in accordance with Hashimoto encephalopathy, which was steroid-responsive...
  30. ncbi request reprint Congenital adrenal hyperplasia due to 11-hydroxylase deficiency: functional characterization of two novel point mutations and a three-base pair deletion in the CYP11B1 gene
    Nils Krone
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat zu Kiel, Universitatskinderklinik, Schwanenweg 20, D 24105 Kiel, Germany
    J Clin Endocrinol Metab 90:3724-30. 2005
    ..Moreover, the combination of in vitro enzyme function and molecular modeling provides new insights in cytochrome P450 structural-functional relationships...
  31. ncbi request reprint [Calcinosis cutis in Albright hereditary osteodystrophy: pseudohypoparathyroidism type Ia]
    R Fölster-Holst
    Dermatologie, Venerologie und Allergologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Germany
    Hautarzt 57:893-7. 2006
    ..The diagnosis was confirmed by biochemical and molecular analyses. An unusual feature was calcinosis cutis at such an early age, which led to extensive differential diagnostic procedures...
  32. doi request reprint Carboxyl-terminal mutations in 3beta-hydroxysteroid dehydrogenase type II cause severe salt-wasting congenital adrenal hyperplasia
    Maik Welzel
    Division of Pediatric Endocrinology, Department of Pediatrics, Christian Albrechts Universitat zu Kiel, 24105 Kiel, Germany
    J Clin Endocrinol Metab 93:1418-25. 2008
    ..Most mutations are located within domains regarded crucial for enzyme function. The function of the C terminus of the 3beta-HSD protein is not known...
  33. doi request reprint A novel ultrapressure liquid chromatography tandem mass spectrometry method for the simultaneous determination of androstenedione, testosterone, and dihydrotestosterone in pediatric blood samples: age- and sex-specific reference data
    A E Kulle
    Department of Pediatrics, Christian Albrechts University of Kiel, 24105 Kiel, Germany
    J Clin Endocrinol Metab 95:2399-409. 2010
    ..Mass spectrometry-based methods are available for individual steroids but need complex sample preparation and report only fragmentary reference data for the pediatric population...
  34. ncbi request reprint Management of congenital adrenal hyperplasia: results of the ESPE questionnaire
    Felix G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts University, Kiel, Germany
    Horm Res 58:196-205. 2002
    ..All participating ESPE members feel the need for further improvement in prenatal diagnosis and treatment, compliance during puberty, screening programmes, psychological aspects, and corrective surgery...
  35. ncbi request reprint Early manifestation of calcinosis cutis in pseudohypoparathyroidism type Ia associated with a novel mutation in the GNAS gene
    Felix G Riepe
    Department of Pediatrics, Division of Pediatric Endocrinology, Universitatsklinikum Schleswig Holstein, Campus Kiel, Christian Albrechts Universitat, Germany
    Eur J Endocrinol 152:515-9. 2005
    ..To clarify the molecular defect for the clinical finding of congenital hypothyroidism combined with the manifestation of calcinosis cutis in infancy...
  36. ncbi request reprint Disproportionate stature but normal height in hypochondroplasia
    Felix G Riepe
    Division of Paediatric Endocrinology, Department of Paediatrics, Christian Albrechts University of Kiel, Schwanenweg 20, 24105, Kiel, Germany
    Eur J Pediatr 164:397-9. 2005
  37. pmc Human and mouse TPIT gene mutations cause early onset pituitary ACTH deficiency
    Anne Marie Pulichino
    Laboratoire de Genetique Moleculaire, Institut de recherches cliniques de Montreal IRCM, Montreal, Quebec, H2W 1R7 Canada
    Genes Dev 17:711-6. 2003
    ..This work defines congenital early onset IAD as a relatively homogeneous clinical entity caused by recessive transmission of loss-of-function mutations in the TPIT gene...
  38. ncbi request reprint Recurrence of the R947X mutation in unrelated families with autosomal dominant pseudohypoaldosteronism type 1: evidence for a mutational hot spot in the mineralocorticoid receptor gene
    Fabio L Fernandes-Rosa
    Department of Pediatrics, School of Medicine of Ribeirao Preto, Avenida Bandeirantes, 3900 Ribeirao Preto, 14049 900 Sao Paulo, Brazil
    J Clin Endocrinol Metab 91:3671-5. 2006
    ..Twenty-two different loss-of-function mutations in the mineralocorticoid receptor gene have been described in families with PHA1. These mutations were not recurrent and resulted in a large phenotypic variability...
  39. ncbi request reprint Four novel missense mutations in the CYP21A2 gene detected in Russian patients suffering from the classical form of congenital adrenal hyperplasia: identification, functional characterization, and structural analysis
    Yulia Grischuk
    Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, Moscow, Russia
    J Clin Endocrinol Metab 91:4976-80. 2006
    ..Congenital adrenal hyperplasia is a group of autosomal recessive inherited disorders of steroidogenesis. The most frequent cause is the deficiency of steroid 21-hydroxylase (CYP21) due to mutations in the CYP21A2 gene...
  40. ncbi request reprint Genetic heterogeneity in autosomal dominant pseudohypoaldosteronism type I: exclusion of claudin-8 as a candidate gene
    Catherine L Huey
    Division of Nephrology, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, Calif 90033, USA
    Am J Nephrol 24:483-7. 2004
    ..The aim of this study was to test the hypothesis that mutations in claudin-8, which would be expected to induce a distal tubule cation leak, can be a cause of PHAI...
  41. ncbi request reprint Congenital isolated adrenocorticotropin deficiency: an underestimated cause of neonatal death, explained by TPIT gene mutations
    Sophie Vallette-Kasic
    Laboratoire de Genetique Moleculaire, Institut de Recherches Cliniques de Montreal, 110 avenue des Pins Ouest, Montreal, Quebec, Canada
    J Clin Endocrinol Metab 90:1323-31. 2005
    ..Identification of TPIT gene mutations as the principal molecular cause of neonatal IAD permits prenatal diagnosis for families at risk for the purpose of early glucocorticoid replacement therapy...
  42. ncbi request reprint Long-term follow-up of spontaneous development in a boy with familial male precocious puberty
    Carl Joachim Partsch
    Children s Hospital, Städtische Kliniken Esslingen, Esslingen a N, Germany
    Horm Res 62:177-81. 2004
    ..We report on a boy with FMPP whose growth pattern and pubertal development was studied longitudinally without treatment...