A Richter

Summary

Affiliation: University of Veterinary Medicine
Country: Germany

Publications

  1. pmc Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Br J Pharmacol 134:343-52. 2001
  2. ncbi request reprint Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus?
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Pharmacol 332:133-41. 1997
  3. ncbi request reprint Pathology of idiopathic dystonia: findings from genetic animal models
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Prog Neurobiol 54:633-77. 1998
  4. ncbi request reprint Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Pharmacol 369:335-8. 1999
  5. pmc Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 131:921-6. 2000
  6. ncbi request reprint CGS 21680 exerts marked antidystonic effects in a genetic model of paroxysmal dyskinesia
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine Hannover, Bunteweg 17, 30559, Hannover, Germany
    Eur J Pharmacol 404:299-302. 2000
  7. ncbi request reprint Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Eur J Pharmacol 397:343-50. 2000
  8. ncbi request reprint Subconvulsive dose of pentylenetetrazole increases the firing rate of substantia nigra pars reticulata neurons in dystonic but not in nondystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Synapse 33:259-67. 1999
  9. ncbi request reprint Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Brain Res 821:277-85. 1999
  10. ncbi request reprint A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions
    A Lessenich
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neuroscience 107:615-28. 2001

Collaborators

  • W Loscher
  • M Hamann
  • M Gernert
  • S E Sander
  • M Bennay
  • A Lessenich
  • S Lindemann
  • D Wedekind
  • H J Hedrich
  • A Kaiser

Detail Information

Publications15

  1. pmc Effects of adenosine receptor agonists and antagonists in a genetic animal model of primary paroxysmal dystonia
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine Hannover, Bunteweg 17, 30559 Hannover, Germany
    Br J Pharmacol 134:343-52. 2001
    ....
  2. ncbi request reprint Prodystonic effects of riluzole in an animal model of idiopathic dystonia related to decreased total power in the red nucleus?
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Pharmacol 332:133-41. 1997
    ....
  3. ncbi request reprint Pathology of idiopathic dystonia: findings from genetic animal models
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Prog Neurobiol 54:633-77. 1998
    ..In addition to increasing our understanding of the pathophysiology of idiopathic dystonia, animal models may help to improve therapeutic strategies for this movement disorder...
  4. ncbi request reprint Gabapentin decreases the severity of dystonia at low doses in a genetic animal model of paroxysmal dystonic choreoathetosis
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Pharmacol 369:335-8. 1999
    ..The GABApotentiating activity of gabapentin could explain the antidystonic effects of low doses, while the loss of efficacy at higher doses may be due to other mechanisms of gabapentin...
  5. pmc Antidystonic efficacy of nitric oxide synthase inhibitors in a rodent model of primary paroxysmal dystonia
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Br J Pharmacol 131:921-6. 2000
    ..Peripheral side effects may limit the clinical use of NO synthase inhibitors, but more selective inhibitors of the neuronal NO synthase should be considered as interesting candidates for the treatment of paroxysmal dystonia...
  6. ncbi request reprint CGS 21680 exerts marked antidystonic effects in a genetic model of paroxysmal dyskinesia
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine Hannover, Bunteweg 17, 30559, Hannover, Germany
    Eur J Pharmacol 404:299-302. 2000
    ..Furthermore, the present data indicate that the precipitating effect of caffeine in patients with paroxysmal dystonia is probably due to its adenosine receptor antagonistic action...
  7. ncbi request reprint Paradoxical aggravation of paroxysmal dystonia during chronic treatment with phenobarbital in a genetic rodent model
    A Richter
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Eur J Pharmacol 397:343-50. 2000
    ..Tentatively, activity-dependent GABA-mediated excitation caused by chronic treatment with phenobarbital may be important for the prodystonic effects under pathological conditions in dt(sz) hamsters...
  8. ncbi request reprint Subconvulsive dose of pentylenetetrazole increases the firing rate of substantia nigra pars reticulata neurons in dystonic but not in nondystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Synapse 33:259-67. 1999
    ....
  9. ncbi request reprint Alterations in spontaneous single unit activity of striatal subdivisions during ontogenesis in mutant dystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Brain Res 821:277-85. 1999
    ....
  10. ncbi request reprint A novel black-hooded mutant rat (ci3) with spontaneous circling behavior but normal auditory and vestibular functions
    A Lessenich
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Neuroscience 107:615-28. 2001
    ..Apart from the use of ci3 rats for studying the functional lateralization of brain functions, the ci3 mutant may serve as a new model for movement disorders with abnormal lateralization...
  11. ncbi request reprint In vivo extracellular electrophysiology of pallidal neurons in dystonic and nondystonic hamsters
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    J Neurosci Res 57:894-905. 1999
    ..In view of recent findings, we assume that GABAergic dysfunctions in dystonic hamsters are of regionally different extent...
  12. ncbi request reprint Spontaneous remission of paroxysmal dystonia coincides with normalization of entopeduncular activity in dt(SZ) mutants
    M Bennay
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine Hannover, 30559 Hannover, Germany
    J Neurosci 21:RC153. 2001
    ..The present data clearly demonstrate the fundamental importance of a decreased basal ganglia output for the expression of paroxysmal dystonia...
  13. ncbi request reprint The electrical activity is impaired in the red nucleus of dt(sz) mutant hamsters with paroxysmal dystonia: an EEG power spectrum analysis of depth electrode recordings
    M Gernert
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Brain Res 760:102-8. 1997
    ..Although the observed changes of neural activity in the RN are probably based on a primary dysfunction in related structures, the present data demonstrate its importance in the expression of dystonic movements...
  14. ncbi request reprint Age-related changes in striatal nitric oxide synthase-immunoreactive interneurones in the dystonic dtsz mutant hamster
    S E Sander
    Institute of Pharmacology and Toxicology and Pharmacy, School of Veterinary Medicine, Freie Universitat, FU, Berlin, Germany
    Neuropathol Appl Neurobiol 32:74-82. 2006
    ..The age-related deficit of NOS-reactive interneurones may at least in part contribute to an abnormal activity of striatal GABAergic projection neurones and thereby to the age-dependent dystonic syndrome in the dt(sz) mutant...
  15. ncbi request reprint Piracetam and levetiracetam, two pyrrolidone derivatives, exert antidystonic activity in a hamster model of paroxysmal dystonia
    W Loscher
    Department of Pharmacology, School of Veterinary Medicine, Bunteweg 17, D 30559, Hannover, Germany
    Eur J Pharmacol 391:251-4. 2000
    ..The antidystonic activity of piracetam and levetiracetam was not associated with any behavioral side effects. The data indicate that piracetam and levetiracetam are interesting novel treatments for idiopathic dystonia...