Steffen Rex

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi Intraoperative management of severe pulmonary hypertension during cardiac surgery with inhaled iloprost
    Steffen Rex
    Department of Anesthesiology, University Hospital, Technical University Aachen, Germany
    Anesthesiology 99:745-7. 2003
  2. ncbi Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial
    S Rex
    Department of Anaesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 52:65-72. 2008
  3. doi [Postoperative management of patients undergoing left ventricular assist device implantation]
    Steffen Rex
    Klinik für Anästhesiologie am Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen
    Anasthesiol Intensivmed Notfallmed Schmerzther 46:424-31; quiz 432. 2011
  4. ncbi Positron emission tomography study of regional cerebral metabolism during general anesthesia with xenon in humans
    Steffen Rex
    Department of Anesthesiology, University Hospital, RWTH Aachen, Aachen, Germany
    Anesthesiology 105:936-43. 2006
  5. ncbi Normothermic beating heart surgery with assistance of miniaturized bypass systems: the effects on intraoperative hemodynamics and inflammatory response
    Steffen Rex
    Department of Anesthesiology, Universitätsklinikum der RWTH, Aachen, Germany
    Anesth Analg 102:352-62. 2006
  6. doi Positron emission tomography study of regional cerebral blood flow and flow-metabolism coupling during general anaesthesia with xenon in humans
    S Rex
    Department of Anaesthesiology, University Hospital, Technical University Aachen, Aachen, Germany
    Br J Anaesth 100:667-75. 2008
  7. ncbi Prediction of fluid responsiveness in patients during cardiac surgery
    S Rex
    Department of Anaesthesiology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Br J Anaesth 93:782-8. 2004
  8. pmc Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension
    Steffen Rex
    Department of Acute Medical Sciences, Centre for Experimental Anaesthesiology, Emergency and Intensive Care Medicine, Catholic University Leuven, Minderbroedersstraat, 3000 Leuven, Belgium
    Crit Care 12:R113. 2008
  9. ncbi Limitations of arterial pulse pressure variation and left ventricular stroke volume variation in estimating cardiac pre-load during open heart surgery
    S Rex
    Department of Anaesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 51:1258-67. 2007
  10. ncbi Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction
    Carlo Missant
    Center for Experimental Anesthesiology, Emergency and Intensive Care Medicine, Department of Acute Medical Sciences, Katholieke Universiteit Leuven, Belgium
    Crit Care Med 35:707-15. 2007

Collaborators

Detail Information

Publications45

  1. ncbi Intraoperative management of severe pulmonary hypertension during cardiac surgery with inhaled iloprost
    Steffen Rex
    Department of Anesthesiology, University Hospital, Technical University Aachen, Germany
    Anesthesiology 99:745-7. 2003
  2. ncbi Inhaled iloprost to control pulmonary artery hypertension in patients undergoing mitral valve surgery: a prospective, randomized-controlled trial
    S Rex
    Department of Anaesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 52:65-72. 2008
    ..We therefore compared the effects of inhaled iloprost vs. intravenous standard therapy in cardiac surgical patients with chronic PHT...
  3. doi [Postoperative management of patients undergoing left ventricular assist device implantation]
    Steffen Rex
    Klinik für Anästhesiologie am Universitätsklinikum der Rheinisch Westfälischen Technischen Hochschule Aachen
    Anasthesiol Intensivmed Notfallmed Schmerzther 46:424-31; quiz 432. 2011
    ..The present overview summarizes current strategies for preoperative risk estimation and for the prevention and treatment of frequently occurring perioperative complications...
  4. ncbi Positron emission tomography study of regional cerebral metabolism during general anesthesia with xenon in humans
    Steffen Rex
    Department of Anesthesiology, University Hospital, RWTH Aachen, Aachen, Germany
    Anesthesiology 105:936-43. 2006
    ..Therefore, the authors hypothesized that xenon, similar to ketamine and nitrous oxide, increases global and regional cerebral metabolism in humans...
  5. ncbi Normothermic beating heart surgery with assistance of miniaturized bypass systems: the effects on intraoperative hemodynamics and inflammatory response
    Steffen Rex
    Department of Anesthesiology, Universitätsklinikum der RWTH, Aachen, Germany
    Anesth Analg 102:352-62. 2006
    ..We conclude that in our study, miniaturizing bypass systems and avoidance of cardioplegic arrest were not effective in improving hemodynamic performance and in attenuating the proinflammatory immune response after CPB...
  6. doi Positron emission tomography study of regional cerebral blood flow and flow-metabolism coupling during general anaesthesia with xenon in humans
    S Rex
    Department of Anaesthesiology, University Hospital, Technical University Aachen, Aachen, Germany
    Br J Anaesth 100:667-75. 2008
    ..The effects of xenon on regional cerebral blood flow (rCBF) are controversial. Moreover, the precise sites of action at which xenon exerts its effects in the human brain remain to be established...
  7. ncbi Prediction of fluid responsiveness in patients during cardiac surgery
    S Rex
    Department of Anaesthesiology, Rheinisch Westfalische Technische Hochschule, Aachen, Germany
    Br J Anaesth 93:782-8. 2004
    ..Left ventricular stroke volume variation (SVV) has been shown to be a predictor of fluid responsiveness in various subsets of patients. However, the accuracy and reliability of SVV are unproven in patients ventilated with low tidal volumes...
  8. pmc Effects of inhaled iloprost on right ventricular contractility, right ventriculo-vascular coupling and ventricular interdependence: a randomized placebo-controlled trial in an experimental model of acute pulmonary hypertension
    Steffen Rex
    Department of Acute Medical Sciences, Centre for Experimental Anaesthesiology, Emergency and Intensive Care Medicine, Catholic University Leuven, Minderbroedersstraat, 3000 Leuven, Belgium
    Crit Care 12:R113. 2008
    ..We studied the role of these different mechanisms in the overall haemodynamic effects produced by iloprost inhalation in an experimental model of acute pulmonary hypertension...
  9. ncbi Limitations of arterial pulse pressure variation and left ventricular stroke volume variation in estimating cardiac pre-load during open heart surgery
    S Rex
    Department of Anaesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
    Acta Anaesthesiol Scand 51:1258-67. 2007
    ....
  10. ncbi Levosimendan improves right ventriculovascular coupling in a porcine model of right ventricular dysfunction
    Carlo Missant
    Center for Experimental Anesthesiology, Emergency and Intensive Care Medicine, Department of Acute Medical Sciences, Katholieke Universiteit Leuven, Belgium
    Crit Care Med 35:707-15. 2007
    ..To test this hypothesis, we developed an experimental model of right ventricular failure and analyzed the effects of levosimendan on ventriculovascular coupling between the right ventricle and pulmonary artery (PA)...
  11. pmc Does a 4 diagram manual enable laypersons to operate the Laryngeal Mask Supreme®? A pilot study in the manikin
    Gereon Schälte
    Department of Anesthesiology, University Hospital Aachen, Aachen, Germany
    Scand J Trauma Resusc Emerg Med 20:21. 2012
    ..The aim of this pilot study was to determine whether an instruction manual consisting of four diagrams enables laypersons to operate a Laryngeal Mask Supreme® (LMAS) in the manikin...
  12. ncbi Thoracic epidural anesthesia impairs the hemodynamic response to acute pulmonary hypertension by deteriorating right ventricular-pulmonary arterial coupling
    Steffen Rex
    Laboratory for Experimental Anesthesiology, Department of Acute Medical Sciences, Katholieke Universiteit Leuven, Leuven, Belgium
    Crit Care Med 35:222-9. 2007
    ..In the present study, we tested the hypothesis that thoracic epidural anesthesia decreases right ventricular contractility and limits its capacity to tolerate pulmonary hypertension...
  13. doi Thoracic epidural anaesthesia disrupts the protective mechanism of homeometric autoregulation during right ventricular pressure overload by cardiac sympathetic blockade: a randomised controlled animal study
    Carlo Missant
    Department of Acute Medical Sciences Anaesthesiology, Catholic University Leuven, Leuven, Belgium
    Eur J Anaesthesiol 28:535-43. 2011
    ..We recently demonstrated that TEA-mediated cardiac sympathicolysis prevents the native right ventricular positive inotropic response to the induction of acute pulmonary hypertension...
  14. pmc High postoperative blood levels of macrophage migration inhibitory factor are associated with less organ dysfunction in patients after cardiac surgery
    Christian Stoppe
    Department of Anesthesiology, University Hospital, RWTH Aachen, Germany
    Mol Med 18:843-50. 2012
    ..Moreover, MIF values on postoperative d 1 were related to the calculated cardiac power index (r = 0.420, p < 0.05). Elevated postoperative MIF levels are inversely correlated with organ dysfunction in patients after cardiac surgery...
  15. ncbi Epoprostenol treatment of acute pulmonary hypertension is associated with a paradoxical decrease in right ventricular contractility
    Steffen Rex
    Section Centre for Experimental Anesthesiology, Emergency and Intensive Care Medicine, Department of Acute Medical Sciences, Katholieke Universiteit Leuven, Minderbroederstraat 19 bus 7003, 3000 Leuven, Belgium
    Intensive Care Med 34:179-89. 2008
    ..Data on this subject are controversial, however, and vary with the experimental conditions. We studied the inotropic effects of epoprostenol at clinically recommended doses in an experimental model of acute PHT...
  16. doi Selenium blood concentrations in patients undergoing elective cardiac surgery and receiving perioperative sodium selenite
    Christian Stoppe
    Department of Anesthesiology, University Hospital, RWTH Aachen, Germany
    Nutrition 29:158-65. 2013
    ..The aim of this study was to assess the effects of perioperative high-dose sodium-selenite administration on selenium blood concentrations in cardiac surgical patients...
  17. pmc Dexmedetomidine is neuroprotective in an in vitro model for traumatic brain injury
    Marc Schoeler
    Department of Anesthesiology, University Hospital of the RWTH Aachen, Pauwelsstrase 30, 52074 Aachen, Germany
    BMC Neurol 12:20. 2012
    ..The α2-adrenoreceptor agonist dexmedetomidine is known to provide neuroprotection under ischemic conditions. In this study we investigated whether dexmedetomidine has a protective effect in an in vitro model for traumatic brain injury...
  18. doi Combining xenon and mild therapeutic hypothermia preserves neurological function after prolonged cardiac arrest in pigs
    Michael Fries
    Department of Surgical Intensive Care, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 40:1297-303. 2012
    ..Administering xenon may confer an additional neuroprotective effect after successful cardiopulmonary resuscitation due to its ability to stabilize cellular calcium homeostasis via N-methyl-D-aspartate-receptor antagonism...
  19. doi Myocardial blood flow during general anesthesia with xenon in humans: a positron emission tomography study
    Wolfgang Schaefer
    Department of Nuclear Medicine, University Hospital of the RWTH, Aachen, Germany
    Anesthesiology 114:1373-9. 2011
    ..However, little is known about the effects of xenon anesthesia on myocardial blood flow (MBF) and coronary vascular resistance in humans...
  20. doi Levosimendan but not norepinephrine improves microvascular oxygenation during experimental septic shock
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:1886-91. 2008
    ..To determine the effects of norepinephrine and levosimendan on microvascular perfusion and oxygenation in a rat model of septic shock...
  21. pmc What is the significance of perioperative release of macrophage migration inhibitory factor in cardiac surgery?
    Christian Stoppe
    Department of Anesthesiology, University Hospital of the RWTH Aachen, 52074 Aachen, Germany
    Antioxid Redox Signal 19:231-9. 2013
    ..Based on current observations, we hypothesize that intraoperative MIF secretion is due to I/R and enhances the antioxidant capacity in patients during cardiac surgery...
  22. pmc Propofol: neuroprotection in an in vitro model of traumatic brain injury
    Jan Rossaint
    Department of Anesthesiology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen, Germany
    Crit Care 13:R61. 2009
    ..We examined its neuroprotective properties in an in vitro model of traumatic brain injury...
  23. pmc Blood levels of macrophage migration inhibitory factor after successful resuscitation from cardiac arrest
    Christian Stoppe
    Department of Anaesthesiology, University Hospital of the RWTH Aachen, Aachen, Germany
    PLoS ONE 7:e33512. 2012
    ....
  24. pmc Early cognitive function, recovery and well-being after sevoflurane and xenon anaesthesia in the elderly: a double-blinded randomized controlled trial
    Jan Cremer
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstrase 30, D 52074 Aachen, Germany
    Med Gas Res 1:9. 2011
    ..abstract:..
  25. doi Bispectral index monitoring during balanced xenon or sevoflurane anaesthesia in elderly patients
    Astrid V Fahlenkamp
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Germany
    Eur J Anaesthesiol 27:906-11. 2010
    ..We evaluated the bispectral index (BIS) for monitoring depth of anaesthesia during clinically guided balanced xenon or sevoflurane anaesthesia in aged patients...
  26. ncbi Longitudinal but not circumferential deformation reflects global contractile function in the right ventricle with open pericardium
    H Alex Leather
    Department of Anesthesiology, University Hospitals, Katholieke Universiteit Leuven, Herestraat 49, B 3000 Leuven, Belgium
    Am J Physiol Heart Circ Physiol 290:H2369-75. 2006
    ....
  27. doi The intraoperative decrease of selenium is associated with the postoperative development of multiorgan dysfunction in cardiac surgical patients
    Christian Stoppe
    Department of Anaesthesiology, University Hospital, RWTH Aachen, Germany
    Crit Care Med 39:1879-85. 2011
    ..Cardiac surgery using cardiopulmonary bypass provokes ischemia-reperfusion-mediated oxidative stress. We hypothesized that an intraoperative decrease of circulating trace elements may be involved in this response...
  28. ncbi The role of macrophage migration inhibitory factor in anesthetic-induced myocardial preconditioning
    Andreas Goetzenich
    Department of Thoracic, Cardiac and Vascular Surgery, University Hospital, RWTH Aachen, Aachen, Germany
    PLoS ONE 9:e92827. 2014
    ..Therefore, we hypothesized that MIF could play a key role in the AIP response...
  29. pmc Laypersons can successfully place supraglottic airways with 3 minutes of training. A comparison of four different devices in the manikin
    Gereon Schälte
    Department of Anesthesiology, University Hospital Aachen, Aachen, Germany
    Scand J Trauma Resusc Emerg Med 19:60. 2011
    ..Limited data exists concerning laypersons without any medical or paramedical background. We hypothesized that even laymen would be able to operate supraglottic airway devices after a brief training session...
  30. doi Xenon reduces neurohistopathological damage and improves the early neurological deficit after cardiac arrest in pigs
    Michael Fries
    Department of Anesthesiology, University Hospital RWTH Aachen, Aachen, Germany
    Crit Care Med 36:2420-6. 2008
    ..Treatment options to ameliorate brain damage following cardiopulmonary resuscitation from cardiac arrest are limited...
  31. ncbi Pulmono-atrial shunt and lung assist to treat right ventricular failure
    Jan Spillner
    Clinic for Cardiothoracic Surgery, University Hospital RWTH Aachen, Pauwelsstr 30, D 52074 Aachen, Germany
    Front Biosci (Landmark Ed) 16:2342-51. 2011
    ..3- 2.6 l/min and the animals recovered from cardiogenic shock. In conclusion a PA-shunt with a parallel lung assist can effectively reverse the deleterious effects of RVF...
  32. ncbi Outcome and mortality risk factors in long-term treated ICU patients: a retrospective analysis
    J Bickenbach
    Department of Intensive Care, University Hospital Aachen, RWTH Aachen University, Germany
    Minerva Anestesiol 77:427-38. 2011
    ..The aim of this study was to examine mortality and its risk factors in patients requiring intensive care therapy for more than 30 days...
  33. doi [Current developments in xenon research. Importance for anesthesia and intensive care medicine]
    A Brücken
    Klinik fur Anasthesiologie, Universitätsklinikum der RWTH Aachen, Pauwelsstr 30, 52074 Aachen
    Anaesthesist 59:883-95. 2010
    ..As the high cost of xenon will probably preclude its wider use as a routine anesthetic, data from extensive tests in large numbers of high risk patients is needed to confirm its possible superiority in this setting...
  34. ncbi [Airway management]
    G Schälte
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52074 Aachen
    Anaesthesist 56:837-55; quiz 856-7. 2007
    ....
  35. ncbi Xenon: recent developments and future perspectives
    M Derwall
    Department of Anesthesiology, University Hospital Aachen, RWTH Aachen, Germany
    Minerva Anestesiol 75:37-45. 2009
    ..Future studies will have to prove whether the high costs of xenon administration might be outweighed by its ability to substantially reduce the sequelae of myocardial and cerebral ischemia...
  36. doi [Intensive care medicine as a component of the compulsory medical curriculum. Evaluation of a pilot curriculum at the University Hospital Aachen]
    S K Beckers
    Klinik fur Anasthesiologie, Universitatsklinikum Aachen, Rheinisch Westfälische Technische Hochschule RWTH, Aachen
    Anaesthesist 58:273-9, 282-4. 2009
    ..This course was evaluated by both students and teaching staff in a written, anonymous form as a quality control...
  37. ncbi Xenon and isoflurane differentially modulate lipopolysaccharide-induced activation of the nuclear transcription factor KB and production of tumor necrosis factor-alpha and interleukin-6 in monocytes
    Lothar W de Rossi
    Department of Anesthesiology, University Hospital, Rheinisch Westfälische Technische Hochschule Aachen, Germany
    Anesth Analg 98:1007-12, table of contents. 2004
    ..Furthermore, xenon increases, whereas isoflurane inhibits the activation of NF-kappaB, providing a possible molecular mechanism for the different effects on monocyte TNF-alpha and IL-6 production...
  38. doi Anesthesia for transcatheter aortic valve implantation: an update
    Steffen Rex
    Department of Anesthesiology, University Hospitals Leuven, KU Leuven, Leuven, Belgium
    Curr Opin Anaesthesiol 26:456-66. 2013
    ..To summarize and highlight recent advances in the periprocedural management of patients undergoing transcatheter aortic valve implantation (TAVI)...
  39. doi Differential effects of lumbar and thoracic epidural anaesthesia on the haemodynamic response to acute right ventricular pressure overload
    C Missant
    Centre for Experimental Anaesthesiology, Emergency and Intensive Care Medicine, Department of Acute Medical Sciences, Catholic University Leuven, Belgium
    Br J Anaesth 104:143-9. 2010
    ....
  40. doi Burn injuries
    Steffen Rex
    Department of Anesthesiology, University Hospitals of the Catholic University Leuven, Leuven, Belgium
    Curr Opin Crit Care 18:671-6. 2012
    ..To summarize and highlight recent advances in the understanding and management of burn injuries...
  41. doi Comparison of early cognitive function and recovery after desflurane or sevoflurane anaesthesia in the elderly: a double-blinded randomized controlled trial
    D Rörtgen
    Department of Anaesthesiology, University Hospital Aachen of the RWTH Aachen, Pauwelsstreet 30, D 52072 Aachen, Germany
    Br J Anaesth 104:167-74. 2010
    ..We hypothesized that the use of the shorter-acting volatile anaesthetic desflurane would be associated with less incidence of POCD when compared with sevoflurane...
  42. ncbi Load-sensitivity of regional tissue deformation in the right ventricle: isovolumic versus ejection-phase indices of contractility
    C Missant
    Center for Experimental Anaesthesiology, Emergency and Intensive Care Medicine, Department of Acute Medical Sciences, Katholieke Universiteit Leuven, Belgium
    Heart 94:e15. 2008
    ....
  43. ncbi Validation of a new arterial pulse contour-based cardiac output device
    Eric E C de Waal
    Division of Perioperative and Emergency Care, University Medical Center, Utrecht, The Netherlands
    Crit Care Med 35:1904-9. 2007
    ..Vigileo cardiac output (VigileoCO) was compared with intermittent transpulmonary thermodilution cardiac output (TPCO) and an established arterial pulse contour-based cardiac output (PCCO)...
  44. ncbi Is continuous really continuous?
    Wolfgang Buhre
    Crit Care Med 36:628-30. 2008
  45. ncbi Experimental testing of a new left ventricular assist device--the microdiagonal blood pump
    Stefan Christiansen
    Department of Cardiothoracic Surgery, University of Aachen, Pauwelsstr 30, 52074 Aachen, Germany
    ASAIO J 50:200-4. 2004
    ..These results demonstrate that the microdiagonal pump may be a promising alternative to the currently used ventricular assist devices, if long-term trials support these results...