Research Topics
Genomes and Genes | Andrew RemppisSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Publications
The small EF-hand Ca2+ binding protein S100A1 increases contractility and Ca2+ cycling in rat cardiac myocytesAndrew Remppis
Basic Res Cardiol 97:I56-62. 2002....
Cardiac problems in the dialysis patient: beyond coronary diseaseAndrew Remppis
Medical Clinic III, Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Semin Dial 21:319-25. 2008..This short review will therefore go beyond coronary heart disease, focus on the specific cardiac pathology in renal failure, and summarize the contemporary therapeutic strategies in ESRD...- S100A1 gene transfer: a strategy to strengthen engineered cardiac graftsAndrew Remppis
Medizinische Klinik III, Universitat Heidelberg, 69115 Heidelberg, Germany
J Gene Med 6:387-94. 2004..Here, we explore a strategy to improve contractile properties of engineered heart tissue (EHT) by S100A1 gene transfer... - Primary ICD-therapy in patients with advanced heart failure: selection strategies and future trialsLutz Frankenstein
Department of Cardiology, University of Heidelberg, Heidelberg, Germany
Clin Res Cardiol 97:594-600. 2008..Furthermore, we sought to provide current survival data and a size-estimate for prospective trials based on real-life data for this high risk cohort... - S100A1 gene therapy preserves in vivo cardiac function after myocardial infarctionSven T Pleger
, Otto Meyerhof Zentrum, , INF 350, 69115 Heidelberg, Germany
Mol Ther 12:1120-9. 2005..Also, S100A1 overexpression reduced cardiac hypertrophy 1 week post-MI. Overall, our data indicate that S100A1 gene therapy provides a potential novel treatment strategy to maintain contractile performance of the post-MI heart... - Biological variation of high sensitive Troponin T in stable heart failure patients with ischemic or dilated cardiomyopathyLutz Frankenstein
Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany
Clin Res Cardiol 100:633-40. 2011..For these values, a difference between ischemic heart disease (IHD) and dilated cardiomyopathy (dCMP) appears conceivable... - Self-care and depression in patients with chronic heart failureNicole Holzapfel
Department of Psychosomatic and General Internal Medicine, Medical Hospital, University of Heidelberg, Germany
Heart Lung 38:392-7. 2009..Although chronic heart failure (CHF) is often complicated by comorbid depression and poor self-care, little is known about their specific association in patients with CHF... 
Prevalence and prognostic significance of adrenergic escape during chronic beta-blocker therapy in chronic heart failureLutz Frankenstein
Department of Cardiology, Angiology, Pulmology, University of Heidelberg, 69120 Heidelberg, Germany
Eur J Heart Fail 11:178-84. 2009..The aim of this study was to examine the prevalence and prognostic value of AE with respect to different beta-blocker agents and doses...- Extracellular S100A1 protein inhibits apoptosis in ventricular cardiomyocytes via activation of the extracellular signal-regulated protein kinase 1/2 (ERK1/2)Patrick Most
Innere Medizin III, Universitat Heidelberg, 69115 Heidelberg, Germany
J Biol Chem 278:48404-12. 2003..These findings warrant speculation that injury-dependent release of the S100A1 protein from cardiomyocytes may serve as an intrinsic mechanism to promote survival of the myocardium in vivo... - Relation of N-terminal pro-brain natriuretic peptide levels and their prognostic power in chronic stable heart failure to obesity statusLutz Frankenstein
Department of Cardiology, Angiology and Pulmonology, University of Heidelberg, INF 410, Heidelberg, Germany
Eur Heart J 29:2634-40. 2008..To investigate the relationship between body mass index (BMI) and N-terminal pro-brain natriuretic peptide (NTproBNP) level and resultant prognostic capacity in chronic heart failure (CHF) controlled for known confounders... - Reference change values and determinants of variability of NT-proANP and GDF15 in stable chronic heart failureLutz Frankenstein
Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Basic Res Cardiol 104:731-8. 2009..The extent of change in both markers is not related to baseline hormonal levels or other baseline variables. RCVs are high for NT-proANP and low for GDF15, while inter-individual variation is high in GDF15 and intermediate in NT-proANP... - Exploring potential associations of suicidal ideation and ideas of self-harm in patients with congestive heart failureNicole Lossnitzer
Department of Psychosomatic and General Internal Medicine, Medical Hospital, University of Heidelberg, Heidelberg, Germany
Depress Anxiety 26:764-8. 2009..To determine the factors, which are associated with suicidal ideation and ideas of self-harm in patients with congestive heart failure (CHF)... - Staged heart transplantation and chemotherapy as a treatment option in patients with severe cardiac light-chain amyloidosisArnt V Kristen
Department of Cardiology, Angiology, and Respiratory Medicine, University Hospital Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
Eur J Heart Fail 11:1014-20. 2009..The prognosis of advanced cardiac light-chain amyloidosis is poor. Heart transplantation might enable causative therapy and ultimately improve prognosis... - Is serial determination of inspiratory muscle strength a useful prognostic marker in chronic heart failure?Lutz Frankenstein
Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Heidelberg, Germany
Eur J Cardiovasc Prev Rehabil 15:156-61. 2008..Training studies, however, frequently use it as a therapeutic target and surrogate marker for prognosis. The prognostic value of changes of PImax that allow this extrapolation is unknown... - HMGB1: the missing link between diabetes mellitus and heart failureH Christian Volz
Department of Medicine III, University of Heidelberg, INF 410, 69120, Heidelberg, Germany
Basic Res Cardiol 105:805-20. 2010..Therefore, blockage of HMGB1 might represent a therapeutic strategy to reduce post-ischemic remodeling in DM... - Panic disorder in patients with chronic heart failureThomas Müller-Tasch
Department of Psychosomatic and General Internal Medicine, University of Heidelberg, Heidelberg, Germany
J Psychosom Res 64:299-303. 2008..Our objective was to assess the prevalence of panic disorder, its influence on quality of life (QoL), and the presence of further anxiety and depressive comorbid disorders in outpatients with chronic heart failure (CHF)... - S100A1 decreases calcium spark frequency and alters their spatial characteristics in permeabilized adult ventricular cardiomyocytesMirko Völkers
Department of Internal Medicine III, Laboratory for Cardiac Stem Cell and Gene Therapy, Division of Cardiology, INF 350, University of Heidelberg, 69120 Heidelberg, Germany
Cell Calcium 41:135-43. 2007..6) remained unaltered by S100A1. Hence, we propose S100A1 as a novel inhibitory modulator of RyR2 function at diastolic Ca2+-concentrations in rabbit ventricular cardiomyocytes... - Expression of platelet-derived growth factor and fibroblast growth factor in cryopreserved endomyocardial biopsies early and late after heart transplantAchim Koch
Department of Cardiac Surgery, University of Heidelberg, Heidelberg, Germany
Ann Thorac Surg 81:1372-8. 2006..The aim of the present study was, therefore, to examine the growth factor expression in the early and later periods, up to three years after transplant in the same patient cohort... - High-mobility group box-1 in ischemia-reperfusion injury of the heartMartin Andrassy
Department of Medicine III, University of Heidelberg, Heidelberg, Germany
Circulation 117:3216-26. 2008..Although HMGB1 has been implicated in ischemia/reperfusion (I/R) injury of the liver and lung, its role in I/R injury of the heart remains unclear... - Ezetimibe effectively lowers LDL-cholesterol in cardiac allograft recipients on stable statin therapyMathias H Konstandin
Department of Cardiology, Internal Medicine, Ruprecht Karls University, Heidelberg, Germany
Clin Transplant 22:639-44. 2008..Extent of pre-treatment LDL-C and cardiac disorder prior to transplantation appear to correlate with the efficacy of ezetimibe therapy... - Sex-specific predictive power of 6-minute walk test in chronic heart failure is not enhanced using percent achieved of published reference equationsLutz Frankenstein
Department of Cardiology, Angiology, and Pneumology, University of Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 27:427-34. 2008..The strong influence of height, weight, age, and sex on 6MWT distance may be accounted for by using percentage achieved of predicted value rather than uncorrected 6MWT values... - The association between long-term longitudinal trends in guideline adherence and mortality in relation to age and sexLutz Frankenstein
Department of Cardiology, Angiology, Pulmonology, University of Heidelberg, Im Neuenheimer Feld 410, Heidelberg D 69120, Germany
Eur J Heart Fail 12:574-80. 2010..Using a large clinical multi-site prospective chronic heart failure registry, we sought to determine (i) implementation of guidelines over time and (ii) adjusted survival benefit there from... - Rhizoma Coptidis inhibits LPS-induced MCP-1/CCL2 production in murine macrophages via an AP-1 and NFkappaB-dependent pathwayAndrew Remppis
Medizinische Klinik III, Universitat Heidelberg, 69120 Heidelberg, Germany
Mediators Inflamm 2010:194896. 2010..The Chinese extract Rhizoma coptidis is well known for its anti-inflammatory, antioxidative, antiviral, and antimicrobial activity. The exact mechanisms of action are not fully understood... - Osteopontin, a new prognostic biomarker in patients with chronic heart failureMark Rosenberg
Department of Internal Medicine III, University of Heidelberg, Heidelberg, Germany
Circ Heart Fail 1:43-9. 2008..We therefore tested whether osteopontin plasma levels are elevated in patients with chronic heart failure and whether they provide independent prognostic information... - The C terminus (amino acids 75-94) and the linker region (amino acids 42-54) of the Ca2+-binding protein S100A1 differentially enhance sarcoplasmic Ca2+ release in murine skinned skeletal muscle fibersPatrick Most
Abteilung Innere Medizin III Kardiologie, Universitat Heidelberg, 69115 Heidelberg, Germany
J Biol Chem 278:26356-64. 2003..Thus, our data suggest that S100A1 may serve as an endogenous enhancer of SR Ca2+ release and might therefore be of physiological relevance in the process of excitation-contraction coupling in skeletal muscle... - Variability of N-terminal probrain natriuretic peptide in stable chronic heart failure and its relation to changes in clinical variablesLutz Frankenstein
Department of Cardiology, Angiology, and Pulmonology University of Heidelberg, Heidelberg, Germany
Clin Chem 55:923-9. 2009..We investigated the variability of N-terminal probrain natriuretic peptide (NT-proBNP) and its relation to known confounding variables in patients with stable chronic heart failure who were on a stable optimized medication regimen... - A comparison of measured trough levels and abbreviated AUC estimation by limited sampling strategies for monitoring mycophenolic acid exposure in stable heart transplant patients receiving cyclosporin A-containing and cyclosporin A-free immunosuppressive Andreas O Dösch
Department of Cardiology, University Hospital, University of Heidelberg, Heidelberg, Germany
Clin Ther 28:893-905. 2006..A reliable method of achieving effective and well-tolerated levels of NIMF-based immunosuppression would be of eminent interest... 
Increased proinflammatory endothelial response to S100A8/A9 after preactivation through advanced glycation end productsPhilipp Ehlermann
Universitat Heidelberg, Abteilung Innere Medizin III, Heidelberg, Germany
Cardiovasc Diabetol 5:6. 2006..As recently S100 proteins have been identified as ligands of RAGE, we sought to determine the effects of the proinflammatory heterodimer of S100A8/S100A9 on the RAGE-NFkappaB mediated induction of proinflammatory gene expression...- Determinants of B-type natriuretic peptide plasma levels in the chronic phase after heart transplantationRoland Klingenberg
Department of Cardiology, University Hospital Heidelberg, Heidelberg, Germany
Transpl Int 18:169-76. 2005..In order to determine the value of BNP as a potential surrogate marker of TVP serial intraindividual measurements appear appropriate... - Influence of different implantation techniques on AV valve competence after orthotopic heart transplantationAchim Koch
Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany
Eur J Cardiothorac Surg 28:717-23. 2005..We used this technique regularly since the year 1993 and report about our 10 years experience... - Posttranslationally modified proteins as mediators of sustained intestinal inflammationMartin Andrassy
Department of Medicine I, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Am J Pathol 169:1223-37. 2006..Thus, CML-mps generated in inflammatory lesions have the capacity to elicit a RAGE-dependent intestinal inflammatory response... - Immediate and chronic effects of AV-delay optimization in patients with cardiac resynchronization therapyStefan E Hardt
Department of Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Int J Cardiol 115:318-25. 2007..However, the chronic functional effects of AV-delay optimization have not been systematically examined despite of their potential role for chronic functional improvement... - Absence of auto-antibodies against cardiac troponin I predicts improvement of left ventricular function after acute myocardial infarctionFlorian Leuschner
Department of Internal Medicine III, Cardiology, University of Heidelberg, Im Neuenheimer Feld 410, 69120 Heidelberg, Germany
Eur Heart J 29:1949-55. 2008..Others have shown that auto-antibodies to cTnI are present in patients with acute coronary syndrome, but little is known about the clinical relevance of detected cTnI-Ab... - Beta-blockers influence the short-term and long-term prognostic information of natriuretic peptides and catecholamines in chronic heart failure independent from specific agentsLutz Frankenstein
Department of Cardiology, Angiology, Pneumology, University of Heidelberg, Heidelberg, Germany
J Heart Lung Transplant 26:1033-9. 2007..Data on the short-term and long-term predictive power comparing these biomarkers as well as accounting for the influence of beta-blocker treatment both on the marker or the resultant prognostic information are scarce... - Who needs 'bridge' to transplantation in the presence of the Eurotransplant high-urgency heart transplantation program?Hiroyuki Kamiya
Department of Cardiac Surgery, University of Heidelberg, Im Neuenheimer Feld 110, Heidelberg 69120, Germany
Eur J Cardiothorac Surg 34:1129-33; discussion 1134-5. 2008..The purposes of this study are to identify a patient cohort that would benefit from the use of mechanical circulatory support (MCS) in the presence of the Eurotransplant high-urgency (HU) program... - Orange flavonoid hesperetin modulates cardiac hERG potassium channel via binding to amino acid F656Eberhard P Scholz
Department of Cardiology, Medical University Hospital Heidelberg, Im Neuenheimer Feld 410, D 69120 Heidelberg, Germany
Nutr Metab Cardiovasc Dis 17:666-75. 2007..HERG potassium channels play a major role in cardiac repolarisation and represent the most important pharmacologic target of both antiarrhythmic and proarrhythmic drugs... - Differential effect of Rhizoma coptidis and its main alkaloid compound berberine on TNF-alpha induced NFkappaB translocation in human keratinocytesRonny Enk
Medizinische Klinik III, Universitat Heidelberg, Germany
J Ethnopharmacol 109:170-5. 2007..Rhizoma coptidis extract therefore appears to be a potent inhibitor of TNF-alpha induced inflammation in dermatological conditions... - Predictive value of inflammatory and hemostatic parameters, atherosclerotic risk factors, and chest x-ray for aortic arch atheromatosisPhilipp Ehlermann
Medizinische Klinik, Abt Innere Medizin III- Kardiologie, , Heidelberg, Germany
Stroke 35:34-9. 2004..Further prospective studies are now warranted to establish a risk score to identify patients in whom TEE screening should be undertaken... - Reduced hemoglobin after heart transplantation is no independent risk factor for survival but is associated closely with impaired renal functionChristian A Gleissner
Department of Cardiology, Angiology and Pneumonology, University of Heidelberg, Heidelberg, Germany
Transplantation 77:710-7. 2004..Further studies will be required to investigate the role of post-HTX anemia as a sensitive indicator of functional renal impairment and the effects of anemia treatment on long-term survival...