Thomas Reinehr

Summary

Affiliation: University of Witten/Herdecke
Country: Germany

Publications

  1. doi request reprint Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 93:4479-85. 2008
  2. doi request reprint Lifestyle intervention in childhood obesity: changes and challenges
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr Friedrich Steiner Straße 5, D 45711 Datteln, Germany
    Nat Rev Endocrinol 9:607-14. 2013
  3. pmc Changes in self-reported and parent-reported health-related quality of life in overweight children and adolescents participating in an outpatient training: findings from a 12-month follow-up study
    Emily Finne
    Bielefeld University, School of Public Health, Bielefeld, Germany
    Health Qual Life Outcomes 11:1. 2013
  4. pmc Health-related quality of life in overweight German children and adolescents: do treatment-seeking youth have lower quality of life levels? Comparison of a clinical sample with the general population using a multilevel model approach
    Emily Finne
    School of Public Health, Bielefeld University, Universitätsstraße 25, Bielefeld, D 33615, Germany
    BMC Public Health 13:561. 2013
  5. pmc Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
    Anna Lena Volckmar
    Department of Child and Adolescent Psychiatry, University Duisburg Essen, Virchowstr, 171, D 45147, Essen, Germany
    BMC Med Genomics 5:65. 2012
  6. doi request reprint Relationship between carotid intima-media thickness and metabolic syndrome in adolescents
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    J Pediatr 163:327-32. 2013
  7. doi request reprint Steroid hormone profiles in prepubertal obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 98:E1022-30. 2013
  8. doi request reprint Comorbidities in overweight children and adolescents: do we treat them effectively?
    T Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Datteln, Germany
    Int J Obes (Lond) 37:493-9. 2013
  9. doi request reprint Calculating cardiac risk in obese adolescents before and after onset of lifestyle intervention
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, Datteln, D 45711, Germany
    Expert Rev Cardiovasc Ther 11:297-306. 2013
  10. doi request reprint Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Strasse 5, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 97:2143-50. 2012

Collaborators

Detail Information

Publications105 found, 100 shown here

  1. doi request reprint Fetuin-A and its relation to metabolic syndrome and fatty liver disease in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 93:4479-85. 2008
    ..There are very limited data available concerning the relationships between fetuin-A, weight status, nonalcoholic fatty liver disease (NAFLD), and features of the metabolic syndrome (MetS) in obese humans, and especially in children...
  2. doi request reprint Lifestyle intervention in childhood obesity: changes and challenges
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr Friedrich Steiner Straße 5, D 45711 Datteln, Germany
    Nat Rev Endocrinol 9:607-14. 2013
    ..If lifestyle interventions do not result in weight loss in a child with obesity, drug treatment to reduce cardiovascular risk factors should be initiated but is currently seldom performed. ..
  3. pmc Changes in self-reported and parent-reported health-related quality of life in overweight children and adolescents participating in an outpatient training: findings from a 12-month follow-up study
    Emily Finne
    Bielefeld University, School of Public Health, Bielefeld, Germany
    Health Qual Life Outcomes 11:1. 2013
    ..We studied the HRQoL of 74 overweight, but not obese participants (32.4% male, mean age = 11.61 ± 1.70 SD) of a comprehensive and effective six-month outpatient training at four time-points up to 12 months after end of treatment...
  4. pmc Health-related quality of life in overweight German children and adolescents: do treatment-seeking youth have lower quality of life levels? Comparison of a clinical sample with the general population using a multilevel model approach
    Emily Finne
    School of Public Health, Bielefeld University, Universitätsstraße 25, Bielefeld, D 33615, Germany
    BMC Public Health 13:561. 2013
    ....
  5. pmc Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants
    Anna Lena Volckmar
    Department of Child and Adolescent Psychiatry, University Duisburg Essen, Virchowstr, 171, D 45147, Essen, Germany
    BMC Med Genomics 5:65. 2012
    ..Large scale GWAS studies depicted markers in the vicinity of the gene; animal models suggest a potential relevance for human body weight regulation...
  6. doi request reprint Relationship between carotid intima-media thickness and metabolic syndrome in adolescents
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    J Pediatr 163:327-32. 2013
    ..To test the hypothesis that metabolic syndrome (MetS) is more predictive of carotid intima-media thickness (IMT) than the sum of the individual components of MetS...
  7. doi request reprint Steroid hormone profiles in prepubertal obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 98:E1022-30. 2013
    ..Little information is available on the steroid hormone profiles in obese children and their changes after weight loss...
  8. doi request reprint Comorbidities in overweight children and adolescents: do we treat them effectively?
    T Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Datteln, Germany
    Int J Obes (Lond) 37:493-9. 2013
    ..The aim was to analyze the effectiveness of treatment concerning obesity-associated comorbidities in clinical practice...
  9. doi request reprint Calculating cardiac risk in obese adolescents before and after onset of lifestyle intervention
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, Datteln, D 45711, Germany
    Expert Rev Cardiovasc Ther 11:297-306. 2013
    ..However, in clinical practice, the weight loss in lifestyle interventions is only moderate and drug treatment of CRFs is seldom performed...
  10. doi request reprint Fibroblast growth factor 21 (FGF-21) and its relation to obesity, metabolic syndrome, and nonalcoholic fatty liver in children: a longitudinal analysis
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Strasse 5, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 97:2143-50. 2012
    ..Fibroblast growth factor 21 (FGF-21), a potent activator of glucose uptake, has been proposed to be related to insulin resistance, metabolic syndrome (MetS), nonalcoholic fatty liver disease (NAFLD), and weight status...
  11. pmc Health-related quality of life in overweight and obese youths: results of a multicenter study
    Nora Wille
    Research Section Child Public Health, Dept, of Psychosomatics in Children and Adolescents, University Clinic Hamburg Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    Health Qual Life Outcomes 8:36. 2010
    ..We examined treatment-seeking overweight and obese youths to better understand the gender, age, and treatment modality differences in generic and disease-specific health-related quality of life (HRQOL)...
  12. pmc Gastric inhibitory polypeptide receptor: association analyses for obesity of several polymorphisms in large study groups
    Carla I G Vogel
    Department of Child and Adolescent Psychiatry, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 10:19. 2009
    ..We genotyped three GIPR SNPs (rs8111428, rs2302382 and rs1800437) in German families with at least one obese index patient, two case-control studies and two cross-sectional population-based studies...
  13. pmc 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents
    Timo D Müller
    Department of Child and Adolescent Psychiatry and Psychotherapy, University of Duisburg Essen, Essen, Germany
    BMC Med Genet 9:85. 2008
    ..Additionally, we tested for association of rs9939609 alleles with fasting blood parameters indicative of glucose and lipid metabolism...
  14. ncbi request reprint Insulin-like growth factor-I, insulin-like growth factor binding protein-3 and growth in obese children before and after reduction of overweight
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    J Pediatr Endocrinol Metab 22:225-33. 2009
    ..Reduction of overweight was associated with a significant decrease of IGFBP-3 SDS, leptin, and insulin concentrations. IGF-I SDS and height SDS did not change after weight loss...
  15. doi request reprint Lifestyle intervention in obese children is associated with a decrease of the metabolic syndrome prevalence
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Germany
    Atherosclerosis 207:174-80. 2009
    ..Weight loss is the appropriate approach to reduce the obesity-related health risk. However, the effect of lifestyle interventions on the metabolic syndrome prevalence has been rarely studied in obese children...
  16. doi request reprint Association between leptin and transaminases: 1-year follow-up study in 180 overweight children
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, 45711 Datteln, Germany
    Metabolism 58:497-503. 2009
    ..These findings suggest that leptin may be involved in the pathogenesis of liver diseases. However, to test this hypothesis, careful histologic assessments in correlation to leptin levels are needed...
  17. doi request reprint Medical care of overweight children under real-life conditions: the German BZgA observation study
    T Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke Germany, Datteln, Germany
    Int J Obes (Lond) 33:418-23. 2009
    ..Current care for overweight children is controversial, and only few data are available concerning the process of care, as well as the outcome under real-life conditions...
  18. ncbi request reprint Peptide YY and glucagon-like peptide-1 in morbidly obese patients before and after surgically induced weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Obes Surg 17:1571-7. 2007
    ..The aim of this study was to analyze the relationships between fasting PYY, GLP-1, and weight status in morbidly obese patients before and after surgically induced weight loss...
  19. ncbi request reprint Type 2 diabetes in children and adolescents in a 2-year follow-up: insufficient adherence to diabetes centers
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Horm Res 69:107-13. 2008
    ..To study the 2-year course of children and adolescents with type 2 diabetes mellitus (T2DM) in general practice to present (1) the treatment modalities, (2) patient adherence, and (3) the occurrence of comorbidities...
  20. doi request reprint Lifestyle intervention in obese children with non-alcoholic fatty liver disease: 2-year follow-up study
    T Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Arch Dis Child 94:437-42. 2009
    ..Lifestyle intervention was demonstrated to improve NAFLD but follow-up studies after end of intervention are lacking. Furthermore the necessary degree of overweight reduction for improvement of NAFLD remains unknown...
  21. doi request reprint Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention
    T Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    Arch Dis Child 94:965-7. 2009
    ..Obesity is considered a polygenic and multifactorial disorder and different single nucleotide polymorphisms (SNP) are involved. Studies concerning their impact on weight loss in lifestyle intervention are scarce...
  22. pmc Retinol-binding protein 4 and its relation to insulin resistance in obese children before and after weight loss
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Strasse 5, Datteln, Germany
    J Clin Endocrinol Metab 93:2287-93. 2008
    ..There are limited and controversial data concerning the relationships between retinol-binding protein 4 (RBP4), weight status, and insulin resistance in obese humans and especially in children...
  23. doi request reprint Small for gestational age status is associated with metabolic syndrome in overweight children
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Eur J Endocrinol 160:579-84. 2009
    ..We hypothesized that overweight children with former SGA status had more present components of the MetS than overweight children with former appropriate for gestational age (AGA) status...
  24. doi request reprint Parental diabetes, pubertal stage, and extreme obesity are the main risk factors for prediabetes in children and adolescents: a simple risk score to identify children at risk for prediabetes
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Pediatr Diabetes 10:395-400. 2009
    ..However, it is unclear that which children have an increased risk and should be screened for prediabetes...
  25. doi request reprint Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Datteln, Germany
    Obesity (Silver Spring) 17:382-9. 2009
    ....
  26. doi request reprint Thyroid hormones and their relation to weight status
    Thomas Reinehr
    Department of Pediatric Endocrinology, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Horm Res 70:51-7. 2008
    ..The aim of this study was to analyze thyroid hormones in female adolescents with obesity and anorexia nervosa (AN) before and after normalization of weight...
  27. doi request reprint Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity indices in overweight children and adolescents during a lifestyle intervention
    T Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Witten, Germany
    Int J Obes (Lond) 32:1521-4. 2008
    ..The aim of this study was to analyze whether there is an allele-dosage effect on changes of insulin resistance and sensitivity indices in overweight children participating in a lifestyle intervention...
  28. doi request reprint Obesity and thyroid function
    Thomas Reinehr
    Department of Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Mol Cell Endocrinol 316:165-71. 2010
    ..Leptin seems to be a promising link between obesity and alterations of thyroid hormones since leptin concentrations influence TSH release...
  29. doi request reprint Relationships between cardiovascular risk profile, ultrasonographic measurement of intra-abdominal adipose tissue, and waist circumference in obese children
    Thomas Reinehr
    Institute of Paediatric Nutrition Medicine, Vestische Kinder und Jugendklinik, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    Clin Nutr 29:24-30. 2010
    ..The aim of this study was to compare the relationship between waist circumference (WC), ultrasonographic measurements of intra-abdominal adipose tissue (UMA), and cardiovascular risk factors (CRF)...
  30. doi request reprint Effect of lifestyle intervention on features of polycystic ovarian syndrome, metabolic syndrome, and intima-media thickness in obese adolescent girls
    Nina Lass
    Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr F Steiner Strasse 5, D 45711 Datteln, Germany
    J Clin Endocrinol Metab 96:3533-40. 2011
    ..Polycystic ovarian syndrome (PCOS) is associated with cardiovascular risk factors (CRF). Lifestyle intervention is regarded as therapy of choice even if studies in adolescent girls with PCOS are scarce...
  31. doi request reprint Effectiveness of lifestyle intervention in overweight children
    Thomas Reinehr
    Department of Paediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr F Steiner Street, 545711 Datteln, Germany
    Proc Nutr Soc 70:494-505. 2011
    ..Studies under normal day-to-day circumstances are necessary to prove the benefit of this kind of intervention...
  32. doi request reprint [Practical implementation of treatment guidelines concerning obesity in children and adolescents]
    T Reinehr
    Abteilung für Pädiatrische Endokrinologie, Diabetes und Ernährungsmedizin, Vestische Kinder und Jugendklinik Datteln, Universitat Witten Herdecke, Datteln, Deutschland
    Bundesgesundheitsblatt Gesundheitsforschung Gesundheitsschutz 54:591-7. 2011
    ..Some subgroups (extreme obese adolescents, obese disabled children) have no meaningful and effective treatment options...
  33. doi request reprint Lack of association between apelin, insulin resistance, cardiovascular risk factors, and obesity in children: a longitudinal analysis
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    Metabolism 60:1349-54. 2011
    ..Our data do not support a significant relationship in childhood between apelin on one hand and leptin, HOMA, cardiovascular risk factors, or weight status on the other...
  34. doi request reprint Thyroid function in the nutritionally obese child and adolescent
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes, and Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Curr Opin Pediatr 23:415-20. 2011
    ..This review aimed to study the prevalence of disturbed thyroid hormone and TSH values in childhood obesity and the underlying pathophysiologic mechanisms linking obesity to thyroid function...
  35. doi request reprint Relationship between MTNR1B (melatonin receptor 1B gene) polymorphism rs10830963 and glucose levels in overweight children and adolescents
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    Pediatr Diabetes 12:435-41. 2011
    ..The aim of this study was to analyze whether there is an allele-dosage effect on glucose metabolism in overweight children and to explore if changes in glucose metabolism in a lifestyle intervention do also depend on genotype...
  36. doi request reprint Longitudinal association between IGFBP-1 levels and parameters of the metabolic syndrome in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    Int J Pediatr Obes 6:236-43. 2011
    ..Insulin-like growth factor binding protein 1 (IGFBP-1) is a marker of insulin resistance. We hypothesized that IGFBP-1 is associated with the metabolic syndrome (MetS), which is related to insulin resistance...
  37. pmc Obesity in disabled children and adolescents: an overlooked group of patients
    Thomas Reinehr
    Institut für Pädiatrische Ernährungsmedizin, Vestische Kinder und Jugendklinik Datteln, Universitat Witten Herdecke, 5711 Datteln, Germany
    Dtsch Arztebl Int 107:268-75. 2010
    ..There is an ongoing debate concerning the relationship between disability and obesity in childhood and adolescence...
  38. ncbi request reprint Changes of dipeptidyl peptidase IV (DPP-IV) in obese children with weight loss: relationships to peptide YY, pancreatic peptide, and insulin sensitivity
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    J Pediatr Endocrinol Metab 23:101-8. 2010
    ..We analyzed changes of DPP-IV after weight loss in obese children and its relationships to the GI hormones pancreatic peptide (PP), peptide YY (PYY), and insulin sensitivity...
  39. doi request reprint Body mass index patterns over 5 y in obese children motivated to participate in a 1-y lifestyle intervention: age as a predictor of long-term success
    Thomas Reinehr
    Vestische Kinderklinik Datteln, Institute of Pediatric Nutrition Medicine, University of Witten Herdecke, Datteln, Germany
    Am J Clin Nutr 91:1165-71. 2010
    ..Long-term outcome after lifestyle interventions in obese children is largely unknown but important to improving intervention...
  40. doi request reprint An effective lifestyle intervention in overweight children: findings from a randomized controlled trial on "Obeldicks light"
    T Reinehr
    Department of Paediatric Nutrition Medicine, Vestische Youth Hospital, University of Witten Herdecke, Dr F Steiner Str 5, Datteln, Germany
    Clin Nutr 29:331-6. 2010
    ..Randomized controlled trials (RCT) have demonstrated the effectiveness of lifestyle interventions in obese children. However, the effectiveness of interventions for overweight, but no obese children has not been demonstrated yet by RCTs...
  41. doi request reprint A new link between skeleton, obesity and insulin resistance: relationships between osteocalcin, leptin and insulin resistance in obese children before and after weight loss
    T Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    Int J Obes (Lond) 34:852-8. 2010
    ..However, there are very limited data available concerning the relationships between the osteoblast-derived hormone osteocalcin, weight status, adiponectin and leptin in obese humans, especially in children...
  42. doi request reprint Former small for gestational age (SGA) status is associated to changes of insulin resistance in obese children during weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Pediatr Diabetes 11:431-7. 2010
    ..We hypothesized that obese children with former appropriate for gestational age (AGA) status improve their insulin resistance during weight loss more effectively compared to obese children with former SGA status...
  43. doi request reprint Leptin concentrations are a predictor of overweight reduction in a lifestyle intervention
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Int J Pediatr Obes 4:215-23. 2009
    ..Leptin resistance is discussed to be involved in the genesis of obesity. Therefore, we hypothesized that leptin levels were negatively associated with degree of weight loss in obese children participating in a lifestyle intervention...
  44. doi request reprint Onset of puberty and cardiovascular risk factors in untreated obese children and adolescents: a 1-year follow-up study
    Thomas Reinehr
    Department of Pediatric Nutrition and Medicine, Vestische Hospital for Children and Adolescents, Witten Herdecke University, Dr F Steiner St 5, Datteln 45711, Germany
    Arch Pediatr Adolesc Med 163:709-15. 2009
    ..To determine the course of obesity-associated nonalcoholic fatty liver disease (NAFLD) and the cardiovascular risk factors of hypertension, dyslipidemia, and disturbed glucose metabolism in untreated obese children...
  45. doi request reprint Two-year follow-up in 21,784 overweight children and adolescents with lifestyle intervention
    Thomas Reinehr
    Department of Pediatric Nutrition Medicine, Vestische Children s Hospital, University of Witten Herdecke, Witten, Germany
    Obesity (Silver Spring) 17:1196-9. 2009
    ..To improve the effectiveness of lifestyle interventions in real-life studying, the process and structure quality as well as their long-term results is urgently needed...
  46. doi request reprint Intima media thickness-related risk factors in childhood obesity
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Int J Pediatr Obes 6:46-52. 2011
    ..Most importantly, these early changes are reversible if effective therapy of cardiovascular risk factors could be achieved...
  47. ncbi request reprint Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Diabetes 57:623-6. 2008
    ..The aim of this study was to analyze whether children homozygous for the C-allele lose less weight in an intervention than children with the GG- or GC-genotype...
  48. ncbi request reprint Circulating soluble leptin receptor, leptin, and insulin resistance before and after weight loss in obese children
    T Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Germany
    Int J Obes (Lond) 29:1230-5. 2005
    ..To study the relationships between leptin, soluble leptin receptor (sOB-R), and insulin resistance in obese children before and after weight reduction...
  49. ncbi request reprint Changes of cardiovascular risk factors in obese children effects of inpatient and outpatient interventions
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Witten, Germany
    J Pediatr Gastroenterol Nutr 43:506-11. 2006
    ..The aim of the study was to compare the benefits of 2 different therapeutic approaches on cardiovascular risk factors (CVRF) in obese children and adolescents...
  50. ncbi request reprint Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Am J Clin Nutr 84:490-6. 2006
    ..Data concerning the long-term improvement of cardiovascular disease (CVD) risk factors after an obesity intervention in children are limited...
  51. ncbi request reprint Insulin sensitivity among obese children and adolescents, according to degree of weight loss
    Thomas Reinehr
    Vestische Youth Hospital, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    Pediatrics 114:1569-73. 2004
    ..Insulin sensitivity is impaired among some obese children, reflecting an atherogenic risk factor profile for the affected subjects. This study was performed to examine the amount of weight reduction required to improve insulin sensitivity...
  52. ncbi request reprint Hyperthyrotropinemia in obese children is reversible after weight loss and is not related to lipids
    Thomas Reinehr
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    J Clin Endocrinol Metab 91:3088-91. 2006
    ..There is some controversy whether T(4) treatment is indicated in obese humans with hyperthyrotropinemia...
  53. pmc Beta-cell autoantibodies in children with type 2 diabetes mellitus: subgroup or misclassification?
    T Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Arch Dis Child 91:473-7. 2006
    ..The occurrence of beta-cell autoantibodies in European children and adolescents with T2DM has not been reported so far...
  54. ncbi request reprint Clinical presentation of type 2 diabetes mellitus in children and adolescents
    T Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    Int J Obes (Lond) 29:S105-10. 2005
    ..Therefore, it is essential that clinicians are aware of the clinical features of T2DM in these age groups...
  55. ncbi request reprint [Evaluation of the training program "OBELDICKS" for obese children and adolescents]
    T Reinehr
    Vestische Kinderklinik Datteln, Universitat Witten Herdecke
    Klin Padiatr 217:1-8. 2005
    ..The nutrition, exercise and eating habits (cognitive control and disinhibition of control) were significantly improved. Side effects were not found...
  56. ncbi request reprint Ghrelin levels before and after reduction of overweight due to a low-fat high-carbohydrate diet in obese children and adolescents
    T Reinehr
    Vestische Kinder und Jugendklinik Datteln, University of Witten Herdecke, Datteln, Germany
    Int J Obes (Lond) 29:362-8. 2005
    ..Increasing ghrelin levels in weight reduction are considered to be responsible for compensatory mechanisms that make the reduction of overweight unlikely to be sustained...
  57. ncbi request reprint Longitudinal analyses among overweight, insulin resistance, and cardiovascular risk factors in children
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    Obes Res 13:1824-33. 2005
    ..It has been questioned whether insulin resistance or obesity is the central abnormality contributing to the cardiovascular risk factors dyslipidemia and hypertension in obesity...
  58. ncbi request reprint Resistin concentrations before and after weight loss in obese children
    T Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Datteln, Germany
    Int J Obes (Lond) 30:297-301. 2006
    ..The influences of gender, puberty, and obesity on resistin levels and the longitudinal relationships between insulin resistance, weight loss, and resistin have not yet been studied in childhood...
  59. ncbi request reprint High-sensitive C-reactive protein, tumor necrosis factor alpha, and cardiovascular risk factors before and after weight loss in obese children
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, D 45711 Datteln, Germany
    Metabolism 54:1155-61. 2005
    ..The chronic inflammation markers TNF-alpha and hsCRP were independent of lipids, blood pressure, and insulin resistance index. Weight loss was associated with the significant decrease of hsCRP and triglyceride levels, and blood pressure...
  60. ncbi request reprint Androgens before and after weight loss in obese children
    Thomas Reinehr
    Vestische Kinderklinik und Jugendklinik, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    J Clin Endocrinol Metab 90:5588-95. 2005
    ..Little information is available on androgens in obese children, and it is unknown whether these hormones change after weight loss...
  61. ncbi request reprint Cardiovascular risk factors in overweight German children and adolescents: relation to gender, age and degree of overweight
    Thomas Reinehr
    Department of Pediatrics, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Nutr Metab Cardiovasc Dis 15:181-7. 2005
    ..So far in Europe, no large studies have been published on the frequencies of the cardiovascular risk factors hypertension and dyslipidaemia in overweight children...
  62. ncbi request reprint Relationships of IGF-I and andrrogens to skeletal maturation in obese children and adolescents
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    J Pediatr Endocrinol Metab 19:1133-40. 2006
    ..IGF-I and androgens are postulated to accelerate skeletal maturation in obese children...
  63. ncbi request reprint Adiponectin before and after weight loss in obese children
    T Reinehr
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, Datteln, Germany
    J Clin Endocrinol Metab 89:3790-4. 2004
    ..Significant weight loss led to an increase in adiponectin levels and an improvement of insulin resistance...
  64. ncbi request reprint Cortisol and its relation to insulin resistance before and after weight loss in obese children
    Thomas Reinehr
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, Datteln, Germany
    Horm Res 62:107-12. 2004
    ..Insulin resistance occurs both in obesity and in Cushing's syndrome suggesting a pathogenetic role of cortisol in insulin-resistant obese subjects...
  65. ncbi request reprint Long-term follow-up of overweight children: after training, after a single consultation session, and without treatment
    Thomas Reinehr
    Vestische Kinderklinik Datteln, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    J Pediatr Gastroenterol Nutr 37:72-4. 2003
    ..An individual consultation session is the usual practice while experts recommend an outpatient training program consisting of a combination of physical exercise, nutrition education, and behavior therapy...
  66. ncbi request reprint Amylin and its relation to insulin and lipids in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Obesity (Silver Spring) 15:2006-11. 2007
    ..There are limited data concerning the relationships between amylin, weight status, lipids, insulin, and insulin resistance in obese humans. Therefore, the aim was to study these relationships in cross-sectional and longitudinal analyses...
  67. ncbi request reprint Intima media thickness in childhood obesity: relations to inflammatory marker, glucose metabolism, and blood pressure
    Thomas Reinehr
    Department of Pediatrics, University of Witten Herdecke, 45711 Datteln, Germany
    Metabolism 55:113-8. 2006
    ..These changes are related to the cardiovascular risk factors of obesity, especially hypertension, chronic inflammation, and impaired glucose metabolism...
  68. ncbi request reprint Definable somatic disorders in overweight children and adolescents
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Datteln, Germany
    J Pediatr 150:618-22, 622.e1-5. 2007
    ..To analyze the frequencies and clinical presentation of definable somatic disorders in children who are overweight...
  69. pmc Changes in the atherogenic risk factor profile according to degree of weight loss
    T Reinehr
    Department of Vestische Kinderklinik, University of Witten Herdecke, Datteln, Germany
    Arch Dis Child 89:419-22. 2004
    ..The atherogenic risk factor profile in obese subjects is characterised by hypertension, reduced high density lipoprotein (HDL) cholesterol, increased low density lipoprotein (LDL) cholesterol and triglycerides, and insulin resistance...
  70. ncbi request reprint Four-year follow-up of children and adolescents participating in an obesity intervention program
    T Reinehr
    Department of Pediatric Endocrinology, Vestische Kinderklinik Datteln, University of Witten Herdecke, Witten Herdecke, Germany
    Int J Obes (Lond) 31:1074-7. 2007
    ..Since obesity affects children's health and social integration, treatment concepts with long-term efficiency are necessary...
  71. ncbi request reprint Fasting glucagon-like peptide-1 and its relation to insulin in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten, Germany
    J Pediatr Gastroenterol Nutr 44:608-12. 2007
    ..To study the relationships between glucagon-like peptide-1 (GLP-1), weight status, insulin, and insulin resistance in the fasting state...
  72. pmc Comparison of metabolic syndrome prevalence using eight different definitions: a critical approach
    Thomas Reinehr
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, Dr F Steiner Str 5, 45711 Datteln, Germany
    Arch Dis Child 92:1067-72. 2007
    ..The aim of this study was to analyse the variations in the MS prevalence using different definitions and to examine which factors influence the frequency of the MS in childhood and adolescence. Methods and..
  73. ncbi request reprint Adipocyte fatty acid-binding protein in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, 45711, Datteln, Germany
    Metabolism 56:1735-41. 2007
    ..Further longitudinal studies are necessary to study the relationship between A-FABP concentrations and parameters of the metabolic syndrome...
  74. ncbi request reprint Predictors to success in outpatient training in obese children and adolescents
    T Reinehr
    Vestische Kinderklinik Datteln, University of Witten Herdecke, Datteln, Germany
    Int J Obes Relat Metab Disord 27:1087-92. 2003
    ..The treatment of obese children and adolescents is not yet satisfactorily effective. It is not clear which participants can profit by a long-time outpatient therapy...
  75. doi request reprint Treatment of tall stature in boys: comparison of two different treatment regimens
    Thomas Reinehr
    Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Datteln, Germany
    Horm Res Paediatr 76:343-7. 2011
    ..High-dose testosterone treatment is a well-known, though still controversial, therapy in boys with tall stature...
  76. doi request reprint Lifestyle intervention "Obeldicks Mini" for obese children aged 4 to 7 years
    M Kleber
    Vestische Kinder und Jugendklinik, Universitat Witten Herdecke, Institut für Pädiatrische Ernährungsmedizin, Datteln, Germany
    Klin Padiatr 221:290-4. 2009
    ..Intima-media thickness as predictive factor for later atherosclerosis decreased significantly. Even 3 years after end of intervention, the achieved weight loss sustained...
  77. ncbi request reprint Peptide YY is a regulator of energy homeostasis in obese children before and after weight loss
    Christian L Roth
    Department of Pediatrics, University of Bonn, Adenauerallee 119, 53113 Bonn, Germany
    J Clin Endocrinol Metab 90:6386-91. 2005
    ..The gut hormone peptide YY(3-36) (PYY) reduces food intake via hypothalamic Y2 receptors in the brain. There is not much known about PYY in obese children...
  78. doi request reprint Association between androgens, intima-media thickness and the metabolic syndrome in obese adolescent girls
    Gideon de Sousa
    Institute of Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Witten
    Clin Endocrinol (Oxf) 72:770-4. 2010
    ..Therefore, we analysed the relationships between androgens, MS and intima-media thickness (IMT) in this age-group...
  79. doi request reprint Hemodynamic responses to exercise in obese children and adolescents before and after overweight reduction
    G de Sousa
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, Datteln, Germany
    Klin Padiatr 221:237-40. 2009
    ..To determine the change of hemodynamic parameters in graded bicycle exercise testing in obese children before and after overweight reduction...
  80. ncbi request reprint Insulin resistance in children and adolescents with type 1 diabetes mellitus: relation to obesity
    Thomas Reinehr
    Department of Endocrinology and Diabetes, Vestische Youth Hospital, University of Witten Herdecke, Datteln, Germany
    Pediatr Diabetes 6:5-12. 2005
    ..Insulin resistance is well recognized both in type 1 diabetes mellitus (T1DM) and in obesity. Studies concerning the relation between insulin resistance and overweight in T1DM have not yet been carried out...
  81. ncbi request reprint Medical care of obese children and adolescents. APV: a standardised multicentre documentation derived to study initial presentation and cardiovascular risk factors in patients transferred to specialised treatment institutions
    Thomas Reinehr
    Vest Youth Hospital, University of Witten Herdecke, Dr Friedrich Steiner Strasse 5, 45711 Datteln, Germany
    Eur J Pediatr 163:308-12. 2004
    ....
  82. doi request reprint The German Working Group of Obesity in Childhood and Adolescence (AGA): improving the quality of care for overweight and obese children in Germany
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Datteln, Germany
    Obes Facts 1:26-32. 2008
    ..For example, the APV quality program demonstrated an increase of diagnostic procedures such as blood pressure measurement in the last 4 years...
  83. ncbi request reprint Relationship between metabolic syndrome definitions for children and adolescents and intima-media thickness
    Thomas Reinehr
    Department of Pediatric Endocrinology, Vestische Hospital for Children s and Adolescents, University of Witten Herdecke, Germany
    Atherosclerosis 199:193-200. 2008
    ..The aim of this study was to analyse whether these definitions are linked to intima-media thickness (IMT), which is predictive for atherosclerosis and later cardiovascular disease...
  84. ncbi request reprint Obestatin and ghrelin levels in obese children and adolescents before and after reduction of overweight
    Thomas Reinehr
    Vestische Kinder und Jugendklinik Datteln, University of Witten Herdecke, Germany
    Clin Endocrinol (Oxf) 68:304-10. 2008
    ..The aims of this study were to compare obestatin concentrations in obese and normal-weight children and to analyse the effect of weight loss on obestatin and ghrelin levels...
  85. ncbi request reprint Vitamin D status and parathyroid hormone in obese children before and after weight loss
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Dr F Steiner Strasse 5, 45711 Datteln, Germany
    Eur J Endocrinol 157:225-32. 2007
    ..Therefore, we studied the relationships between PTH, 1,25-dihydroxy-vitamin D (1,25-OH Vit D), 25-hydroxy-vitamin D (25-OH Vit D), weight status, and insulin sensitivity before and after weight loss in obese children...
  86. doi request reprint A comparison of polysomnographic variables between obese adolescents with polycystic ovarian syndrome and healthy, normal-weight and obese adolescents
    Gideon de Sousa
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, 45711, Datteln, Germany
    Sleep Breath 14:33-8. 2010
    ....
  87. ncbi request reprint Pancreatic polypeptide in obese children before and after weight loss
    T Reinehr
    Vestische Hospital for Children and Adolescents Datteln, University of Witten Herdecke, Datteln, Germany
    Int J Obes (Lond) 30:1476-81. 2006
    ..Little is known concerning pancreatic polypeptide (PP) in weight loss and in childhood obesity...
  88. ncbi request reprint Comparison of coenzyme Q10 plasma levels in obese and normal weight children
    Thomas Menke
    Vestische Kinderklinik Datteln, Universitat Witten Herdecke, Dr Friedrich Steiner Str 5, D 45711 Datteln, Germany
    Clin Chim Acta 349:121-7. 2004
    ..The lipophilic antioxidant coenzyme Q10 (CoQ10) is known as an effective inhibitor of oxidative damage in LDL as well. The aim of the present study was to compare the CoQ10 levels in obese and normal weight children...
  89. ncbi request reprint Insulin sensitivity indices of glucose and free fatty acid metabolism in obese children and adolescents in relation to serum lipids
    Thomas Reinehr
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, D 45711 Datteln, Germany
    Metabolism 54:397-402. 2005
    ..Most studies concerning the association between insulin resistance and the features of metabolic syndrome in obese children are based on measurement of insulin sensitivity indices (ISI) of glucose metabolism and not of fat metabolism...
  90. ncbi request reprint [Prospective comparison of different ultrasound modalities to measure thicknesses less than 1 mm]
    R Wunsch
    Kinderradiologie, Vestische Kinderklinik, Datteln
    Rofo 179:65-71. 2007
    ..g. the measurement of the "Intima-Media Thickness" (IMT), it is not clear if better visualization comes at the price of incorrect measurement values. We checked different modalities for accuracy and visualization quality...
  91. doi request reprint One-year follow-up of untreated obese white children and adolescents with impaired glucose tolerance: high conversion rate to normal glucose tolerance
    M Kleber
    Vestische Hospital for Children and Adolescents, University of Witten Herdecke, Ulm, Germany
    Diabet Med 27:516-21. 2010
    ..Impaired glucose tolerance (IGT) is regarded at risk factor for later diabetes. The aim of this study was to identify predictive factors for outcome of IGT in obese children and adolescents...
  92. ncbi request reprint Clinical characteristics of type 2 diabetes mellitus in overweight European caucasian adolescents
    T Reinehr
    Vestische Kinder und Jugendklinik, University of Witten Herdecke, Datteln, Germany
    Exp Clin Endocrinol Diabetes 113:167-70. 2005
    ..To present the clinical features of Type 2 diabetes mellitus (T2DM) in overweight European Caucasian children and adolescents...
  93. doi request reprint [Comparative ultrasound visualization of clinically relevant structures for evaluating the infant hip joint utilizing trapezoidal vs. parallel transducers]
    R Wunsch
    Abt Pädiatrische Radiologie, Vestische Kinderklinik, Datteln
    Ultraschall Med 32:S102-9. 2011
    ..Our approach was both theoretical via a mathematical model and practical with in-vivo measurements in neonates...
  94. ncbi request reprint [Ambulant training programs for obese children. Criterions of comparison for the development of valid therapy recommendations]
    T Reinehr
    Vestische Kinderklinik Datteln, Universitat Witten Herdecke, Germany
    Klin Padiatr 214:83-8. 2002
    ..The schedule of criterions facilitates the comparison of programs to develop valid ambulant training programs for obese children...
  95. ncbi request reprint Intima-media thickness in obese children before and after weight loss
    Rainer Wunsch
    Department of Pediatrics, University of Witten Herdecke, Datteln, Germany
    Pediatrics 118:2334-40. 2006
    ..The objective of this study was to analyze the changes of intima-media thickness in obese children with weight loss...
  96. pmc Thyroid hormones before and after weight loss in obesity
    T Reinehr
    Vestische Kinderklinik, University of Witten Herdecke, Datteln, Germany
    Arch Dis Child 87:320-3. 2002
    ..Little is known about changes in thyroid function in obese children. An influence of leptin on thyroid hormone synthesis has been proposed...
  97. ncbi request reprint [Autoimmune thyroiditis in children and adolescents: clinical and laboratory findings in 34 patients]
    B Doeker
    Vestische Kinderklinik Datteln, Universitat Witten Herdecke
    Klin Padiatr 212:103-7. 2000
    ..The high degree of obviously hypothyroid patients at the time of diagnosis reflects a delay of diagnosis. Early recognition and treatment of the disease should be achieved for a preventive care of hypothyroidism...
  98. ncbi request reprint Plasma levels of coenzyme Q10 in children with hyperthyroidism
    Thomas Menke
    Vestische Kinderklinik Datteln, Universitat Witten Herdecke, Dr Friedrich Steiner Strasse 5, DE 45711 Datteln, Germany
    Horm Res 61:153-8. 2004
    ..The aim of this study was to determine whether there is a correlation between an increased respiratory chain activity and the state of CoQ10 in children with hyperthyroidism...
  99. doi request reprint Cardiovascular risk in 26,008 European overweight children as established by a multicenter database
    Dagmar I'Allemand
    Children s Hospital of Eastern Switzerland, St Gallen, Switzerland
    Obesity (Silver Spring) 16:1672-9. 2008
    ..Therefore, weight-related risk factors, their interrelationship, and association with biological parameters were assessed in a large group of overweight (OW) children, documented by an electronic database...
  100. doi request reprint Daily insulin requirement of children and adolescents with type 1 diabetes: effect of age, gender, body mass index and mode of therapy
    Susanna Wiegand
    Department of Pediatric Endocrinology and Diabetology, Charite Children s Hospital, Universitatsmedizin Berlin, Augustenburger Platz 1, 13353 Berlin, Germany
    Eur J Endocrinol 158:543-9. 2008
    ..The purpose of this study was to generate insulin dose (ID) percentiles for children and adolescents with type 1 diabetes mellitus (DM1) having the opportunity to assess this important parameter in relation to age and sex...
  101. doi request reprint Different anthropometric index changes in relation to cardiovascular risk profile change
    Andre Michael Toschke
    Department of Public Health Sciences, Division of Health and Social Care Research, King s College London, Floor 7 Capital House, 42 Weston Street, London SE1 3QD, UK
    Clin Nutr 27:457-63. 2008
    ..Different anthropometric indices were proposed to assess adiposity and its change in overweight children. The aim of this study was to identify the anthropometric index change that correlates best with cardiovascular risk factor change...