Hermann Reichenspurner

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Overview of tacrolimus-based immunosuppression after heart or lung transplantation
    Hermann Reichenspurner
    Department of Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 24:119-30. 2005
  2. doi request reprint Impact of patient-prosthesis mismatch after transcatheter aortic valve-in-valve implantation in degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany
    J Thorac Cardiovasc Surg 143:617-24. 2012
  3. doi request reprint Transcatheter mitral valve-in-valve implantation in patients with degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    JACC Cardiovasc Interv 5:341-9. 2012
  4. ncbi request reprint FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transpl Int 18:215-20. 2005
  5. ncbi request reprint Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Cardiology 108:128-37. 2007
  6. doi request reprint Six-month results of a repositionable and retrievable pericardial valve for transcatheter aortic valve replacement: the Direct Flow Medical aortic valve
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    J Thorac Cardiovasc Surg 140:897-903. 2010
  7. ncbi request reprint Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease
    Tobias Deuse
    Department of Cardiovascular Surgery, University Heart Center, University Hospital Hamburg Eppendorf, Martinistr, Germany
    Transpl Int 19:310-8. 2006
  8. ncbi request reprint FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy
    Sonja Schrepfer
    University Heart Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 26:70-7. 2007
  9. doi request reprint Ascending aortic aneurysm and aortic valve dysfunction in bicuspid aortic valve disease
    Ali Aydin
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Int J Cardiol 164:301-5. 2013
  10. doi request reprint Impact of MitraClip™ therapy on secondary mitral valve surgery in patients at high surgical risk
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cardiothorac Surg 40:1521-6. 2011

Detail Information

Publications98

  1. ncbi request reprint Overview of tacrolimus-based immunosuppression after heart or lung transplantation
    Hermann Reichenspurner
    Department of Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 24:119-30. 2005
    ..In particular, the lesser propensity of tacrolimus to cause hypertension and hyperlipidemia potentially offers decreased cardiovascular risk for heart and lung transplant recipients...
  2. doi request reprint Impact of patient-prosthesis mismatch after transcatheter aortic valve-in-valve implantation in degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany
    J Thorac Cardiovasc Surg 143:617-24. 2012
    ..Nevertheless, hemodynamic performance is limited by the previously implanted xenograft. We report our experience with patient-prosthesis mismatch (PPM) after valve-in-valve implantation in the aortic position...
  3. doi request reprint Transcatheter mitral valve-in-valve implantation in patients with degenerated bioprostheses
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    JACC Cardiovasc Interv 5:341-9. 2012
    ..This study reports the results of a series of transapical mitral valve-in-valve implantations and aims to offer guidance on technical aspects of the procedure...
  4. ncbi request reprint FK778, a novel immunosuppressive agent, reduces early adhesion molecule up-regulation and prolongs cardiac allograft survival
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transpl Int 18:215-20. 2005
    ..Therefore, FK778 is a novel, highly desirable immunosuppressive drug for transplantation medicine...
  5. ncbi request reprint Inhibition of restenosis development after mechanical injury: a new field of application for malononitrilamides?
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Cardiology 108:128-37. 2007
    ..To investigate the efficacy of the malononitrilamide FK778 to prevent vascular smooth muscle cell (SMC) migration/proliferation, and vascular fibrosis, the key events in restenosis development using in vivo and in vitro studies...
  6. doi request reprint Six-month results of a repositionable and retrievable pericardial valve for transcatheter aortic valve replacement: the Direct Flow Medical aortic valve
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    J Thorac Cardiovasc Surg 140:897-903. 2010
    ..The Direct Flow Medical aortic valve (Direct Flow Medical, Inc, Santa Rosa, Calif) is a nonmetallic tissue valve prosthesis intended to treat patients with severe aortic stenosis at high risk for surgery...
  7. ncbi request reprint Sirolimus and FK778: a comparison of two anti-proliferative immunosuppressants for prevention of experimental obliterative airway disease
    Tobias Deuse
    Department of Cardiovascular Surgery, University Heart Center, University Hospital Hamburg Eppendorf, Martinistr, Germany
    Transpl Int 19:310-8. 2006
    ..The anti-proliferative potency on SMCs seems to be an especially important mechanism for FK778. De novo combination regimens revealed no beneficial interaction and thus remain doubtful...
  8. ncbi request reprint FK778 in experimental xenotransplantation: a detailed analysis of drug efficacy
    Sonja Schrepfer
    University Heart Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 26:70-7. 2007
    ..This study examines the efficacy of FK778 regimens for prevention of different phases of xenograft rejection...
  9. doi request reprint Ascending aortic aneurysm and aortic valve dysfunction in bicuspid aortic valve disease
    Ali Aydin
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Int J Cardiol 164:301-5. 2013
    ..The relationship of aortic valve dysfunction and ascending aortic aneurysm is unclear in adults with bicuspid aortic valve disease...
  10. doi request reprint Impact of MitraClip™ therapy on secondary mitral valve surgery in patients at high surgical risk
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Eur J Cardiothorac Surg 40:1521-6. 2011
    ..We report our experience with failed MitraClip™ therapy and its impact on subsequent surgical strategies, such as the feasibility of MVR in high-risk patients...
  11. ncbi request reprint FK778 and tacrolimus prevent the development of obliterative airway disease after heterotopic rat tracheal transplantation
    Tobias Deuse
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 24:1844-54. 2005
    ..The effectiveness of the novel immunosuppressive agent FK778 and of tacrolimus to prevent the development of obliterative airway disease (OAD) was investigated in an animal model...
  12. doi request reprint A heart team's perspective on interventional mitral valve repair: percutaneous clip implantation as an important adjunct to a surgical mitral valve program for treatment of high-risk patients
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    J Thorac Cardiovasc Surg 143:78-84. 2012
    ..We sought to assess the feasibility of catheter-based mitral valve repair using a clip-based percutaneous edge-to-edge repair system in selected patients at high surgical risk with mitral regurgitation grade 3 or worse...
  13. doi request reprint Echocardiographic and clinical outcomes of MitraClip therapy in patients not amenable to surgery
    Volker Rudolph
    Department of General and Interventional Cardiology, University Heart Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Am Coll Cardiol 58:2190-5. 2011
    ..The aim of this study was to assess the outcomes of patients at prohibitive surgical risk undergoing MitraClip therapy (Abbott Vascular, Redwood City, California) for severe mitral regurgitation (MR)...
  14. doi request reprint Series of transcatheter valve-in-valve implantations in high-risk patients with degenerated bioprostheses in aortic and mitral position
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Germany
    Catheter Cardiovasc Interv 76:608-15. 2010
    ..We report our experience with transcatheter valve-in-valve implantations in patients with degenerated bioprostheses in aortic and mitral position...
  15. ncbi request reprint The phytoestrogen biochaninA weakens acute cardiac allograft rejection without affecting the reproductive system
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Transpl Immunol 15:45-53. 2005
    ....
  16. doi request reprint Significant reduction of acute cardiac allograft rejection by selective janus kinase-1/3 inhibition using R507 and R545
    Tobias Deuse
    Transplant and Stem Cell Immunobiology Laboratory, University Heart Center Hamburg, Hamburg, Germany
    Transplantation 94:695-702. 2012
    ..This is the first report on the novel Janus kinase (JAK)1/3 inhibitors R507 and R545 for prevention of acute allograft rejection...
  17. doi request reprint Comparison of aortic root replacement in patients with Marfan syndrome
    Alexander M J Bernhardt
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    Eur J Cardiothorac Surg 40:1052-7. 2011
    ....
  18. doi request reprint Transcatheter aortic valve implantation versus surgical aortic valve replacement: a propensity score analysis in patients at high surgical risk
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    J Thorac Cardiovasc Surg 143:64-71. 2012
    ..In this propensity-score analysis we compared outcomes after TAVI to those after surgical aortic valve replacement (AVR)...
  19. ncbi request reprint The interaction between FK778 and tacrolimus in the prevention of rat cardiac allograft rejection is dose dependent
    Tobias Deuse
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplantation 77:509-13. 2004
    ..The aim of this study was to evaluate the combination of FK778 and tacrolimus in a high-responder rat cardiac transplantation model...
  20. doi request reprint First experience with transcatheter aortic valve implantation and concomitant percutaneous coronary intervention
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrasse 52, Hamburg, Germany
    Clin Res Cardiol 100:311-6. 2011
    ..We investigated our experience with combined transcatheter aortic valve implantation (TAVI) and percutaneous coronary intervention (PCI) as an alternative strategy in high-risk patients...
  21. doi request reprint Predictors of outcome of mitral valve prolapse in patients with the Marfan syndrome
    Meike Rybczynski
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Am J Cardiol 107:268-74. 2011
    ..In conclusion, the same clinical determinants that predict outcomes in idiopathic mitral valve prolapse also predict outcomes in mitral valve prolapse associated with Marfan syndrome...
  22. pmc The potassium channel KCa3.1 as new therapeutic target for the prevention of obliterative airway disease
    Xiaoqin Hua
    University of Hamburg, University Heart Center Hamburg, Transplant and Stem Cell Immunobiology Lab TSI, Cardiovascular Research Center Hamburg CVRC, Hamburg, Germany
    Transplantation 95:285-92. 2013
    ..We sought to investigate whether KCa3.1 contributes to the pathogenesis of obliterative airway disease (OAD) and whether knockout or pharmacologic blockade would prevent the development of OAD...
  23. doi request reprint Midterm stability and hemodynamic performance of a transfemorally implantable nonmetallic, retrievable, and repositionable aortic valve in patients with severe aortic stenosis. Up to 2-year follow-up of the direct-flow medical valve: a pilot study
    Klaudija Bijuklic
    Medical Care Center Prof Mathey, Prof Schofer, Hamburg University Cardiovascular Center, Hamburg University Heart Center, and Radiologische Allianz, Hamburg, Germany
    Circ Cardiovasc Interv 4:595-601. 2011
    ..We, therefore, analyzed the midterm stability of the position, shape, and hemodynamic performance of the DFM percutaneous aortic valve...
  24. doi request reprint Acute outcomes of MitraClip therapy for mitral regurgitation in high-surgical-risk patients: emphasis on adverse valve morphology and severe left ventricular dysfunction
    Olaf Franzen
    Department of General and Interventional Cardiology, University Heart Centre, Hamburg, Germany
    Eur Heart J 31:1373-81. 2010
    ..We sought to assess the feasibility of catheter-based mitral valve repair using the MitraClip system in high-surgical-risk patients with mitral regurgitation (MR) > or =grade 3+...
  25. ncbi request reprint The selective estrogen receptor-beta agonist biochanin A shows vasculoprotective effects without uterotrophic activity
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    Menopause 13:489-99. 2006
    ....
  26. ncbi request reprint Identification and characterization of cells with high angiogenic potential and transitional phenotype in calcific aortic valve
    Fariba Chalajour
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, Hamburg, Germany
    Exp Cell Res 313:2326-35. 2007
    ..Hence, our findings might provide new insights into the process of pathological angiogenesis in cardiac valves...
  27. doi request reprint Bivalvular transcatheter treatment of high-surgical-risk patients with coexisting severe aortic stenosis and significant mitral regurgitation
    Volker Rudolph
    Department of General and Interventional Cardiology, University Heart Center, Hamburg, Germany
    Int J Cardiol 167:716-20. 2013
    ..We sought to assess the feasibility and effectiveness of bivalvular transcatheter therapy in patients with coexisting aortic stenosis and mitral regurgitation...
  28. doi request reprint Tacrolimus and cyclosporine have differential effects on the risk of development of bronchiolitis obliterans syndrome: results of a prospective, randomized international trial in lung transplantation
    Hendrik Treede
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistrasse 52, Hamburg, Germany
    J Heart Lung Transplant 31:797-804. 2012
    ..In this study we assessed the efficacy and safety of two de novo immunosuppression protocols to prevent BOS...
  29. doi request reprint Antibody response after a single dose of an AS03-adjuvanted split-virion influenza A (H1N1) vaccine in heart transplant recipients
    Sven Meyer
    Department of General and Interventional Cardiology, University Heart Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Transplantation 91:1031-5. 2011
    ..Vaccination against the novel influenza A (H1N1) virus has generally been advocated. There is limited experience with AS03-adjuvanted A/H1N1 pandemic influenza vaccines in immunosuppressed patients...
  30. ncbi request reprint FK778 attenuates lymphocyte-endothelium interaction after cardiac transplantation: in vivo and in vitro studies
    Tobias Deuse
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Transplantation 78:71-7. 2004
    ..We investigated the effects of FK778 upon acute cardiac allograft rejection and upon adhesion molecule upregulation in experimental transplantation and by using in vitro cell culture...
  31. doi request reprint FBN1 gene mutation characteristics and clinical features for the prediction of mitral valve disease progression
    Kristin Kühne
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Int J Cardiol 168:953-9. 2013
    ..Until today, FBN1 gene mutation characteristics were not compared with clinical features for the prediction of mitral valve disease progression...
  32. doi request reprint Severe intraprocedural complications after transcatheter aortic valve implantation: calling for a heart team approach
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 44:478-84; discussion 484. 2013
    ..We sought to characterize severe intraprocedural complications during TAVI requiring immediate surgical or interventional bailout manoeuvres and evaluate outcomes...
  33. doi request reprint Transapical implantation of a second-generation transcatheter heart valve in patients with noncalcified aortic regurgitation
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    JACC Cardiovasc Interv 6:590-7. 2013
    ..This study sought to report on the feasibility and early results of transcatheter aortic valve implantation employing a second-generation device in a series of patients with pure aortic regurgitation...
  34. doi request reprint Towards an integrated approach to mitral valve disease: implementation of an interventional mitral valve programme and its impact on surgical activity
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Cardiothorac Surg 44:324-8; discussion 328-9. 2013
    ..We sought to evaluate the impact of an interventional mitral valve programme on surgical mitral valve activity and to assess the risk profiles of the respective patient populations...
  35. doi request reprint The best of both worlds: staged hybrid approach to complex cardiac disease in a patient at high surgical risk
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Thorac Cardiovasc Surg 61:421-4. 2013
    ..For the future, increasing clinical importance of interventional valve therapies either for stand-alone or hybrid procedures can be anticipated. ..
  36. doi request reprint Retrograde transarterial implantation of a nonmetallic aortic valve prosthesis in high-surgical-risk patients with severe aortic stenosis: a first-in-man feasibility and safety study
    Joachim Schofer
    Medical Care Center Prof Mathey, Prof Schofer and Hamburg University Cardiovascular Center, University Heart Center Hamburg, Hamburg, Germany
    Circ Cardiovasc Interv 1:126-33. 2008
    ....
  37. ncbi request reprint Angiogenic activation of valvular endothelial cells in aortic valve stenosis
    Fariba Chalajour
    Department of Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Exp Cell Res 298:455-64. 2004
    ..These data provide new insights into the mechanisms of valvular disorders and open new perspectives for prevention and early treatment of calcified aortic stenosis...
  38. doi request reprint Predictors and outcomes after transcatheter aortic valve implantation using different approaches according to the valve academic research consortium definitions
    Moritz Seiffert
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    Catheter Cardiovasc Interv 82:640-52. 2013
    ....
  39. pmc Initial experience of pacemaker and implantable cardioverter defibrillator lead extraction with the new GlideLight 80 Hz laser sheaths
    Samer Hakmi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg 18:56-60. 2014
    ..Use of new laser sheaths, which deliver a rate of 80 pulses per second, may probably reduce intraoperative adverse events by reduction of extraction force...
  40. pmc Concomitant surgical atrial fibrillation ablation and event recorder implantation: better monitoring, better outcome?
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg 16:465-9. 2013
    ..We analysed the influence of event recorder (ER) implantation and therapy guidance by the results of continuous rhythm monitoring of consecutive postoperative follow-up by our department of electrophysiology...
  41. doi request reprint Shock efficacy of subcutaneous implantable cardioverter-defibrillator for prevention of sudden cardiac death: initial multicenter experience
    Ali Aydin
    Department of Electrophysiology, University Heart Center, Hamburg, Germany
    Circ Arrhythm Electrophysiol 5:913-9. 2012
    ..Recently, subcutaneous implantable cardioverter-defibrillator (S-ICD) has become available. The aim of our study was to assess the efficacy of S-ICD in a clinical setting...
  42. ncbi request reprint Techniques for experimental heterotopic and orthotopic tracheal transplantations - When to use which model?
    Tobias Deuse
    University Heart Center Hamburg, Department of Cardiovascular Surgery, Martinistr 52, 20246, Hamburg, Germany
    Transpl Immunol 17:255-61. 2007
    ..Here we describe the techniques of heterotopic and orthotopic tracheal transplantations in the rat, comparing the kinetics of systemic host immune response and of histopathologic OAD development...
  43. doi request reprint Surgical or percutaneous mitral valve repair for secondary mitral regurgitation: comparison of patient characteristics and clinical outcomes
    Lenard Conradi
    University Heart Center Hamburg, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Cardiothorac Surg 44:490-6; discussion 496. 2013
    ..However, proof of a survival benefit for these patients is still pending. Percutaneous techniques of mitral valve repair (MVR) have become a viable treatment alternative for selected high-risk patients with severe secondary MR...
  44. doi request reprint MitraClip® therapy in patients with end-stage systolic heart failure
    Olaf Franzen
    Department of General and Interventional Cardiology, University Heart Centre, Hamburg, Germany
    Eur J Heart Fail 13:569-76. 2011
    ..To assess the feasibility, short-term durability and clinical outcomes of MitraClip® therapy for mitral regurgitation (MR) in patients with end-stage heart failure and a severely reduced left ventricular (LV) ejection fraction...
  45. doi request reprint Results of modern mitral valve repair in patients with marfan syndrome
    Alexander Martin Bernhardt
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Thorac Cardiovasc Surg 62:35-41. 2014
    ..Minimally invasive repairs are feasible even in deformed thoraces, lowering the risk for future aortic surgery. Because of excellent mid-term to long-term results, MVR may also be justified in asymptomatic Marfan patients. ..
  46. doi request reprint Immunological properties of extraembryonic human mesenchymal stromal cells derived from gestational tissue
    Mandy Stubbendorff
    1 Transplant and Stem Cell Immunobiology Lab, University Heart Center Hamburg, Hamburg, Germany
    Stem Cells Dev 22:2619-29. 2013
    ....
  47. doi request reprint Clinical outcomes through 12 months in patients with degenerative mitral regurgitation treated with the MitraClip® device in the ACCESS-EUrope Phase I trial
    Hermann Reichenspurner
    University Heart Center Hamburg, Hamburg, Germany
    Eur J Cardiothorac Surg 44:e280-8. 2013
    ..We describe 12-month outcomes following treatment with the MitraClip device in DMR patients...
  48. pmc Minimal access median sternotomy for aortic valve replacement in elderly patients
    Yousuf Alassar
    Department of Cardiovascular Surgery, Univeity Heart Center Hamburg, Martinistr, 52, Hamburg, 20246, Germany
    J Cardiothorac Surg 8:103. 2013
    ..It was especially performed in patients asking for an excellent cosmetic result, who did not qualifying for minimally-invasive AVR via partial upper sternotomy...
  49. ncbi request reprint [3-year results of the SYNTAX trial--stent or surgery? A surgeon's perspective]
    Lenard Conradi
    Klinik und Poliklinik für Herz und Gefäßchirurgie, Universitäres Herzzentrum Hamburg, Martinistrasse 52, Hamburg, Germany
    Clin Res Cardiol Suppl 6:43-8. 2011
    ..Final decision making should be a formal process as recommended in the recently updated guidelines on myocardial revascularization by the European Society of Cardiology...
  50. doi request reprint Surgical technique of lower lobe lung transplantation
    Tobias Deuse
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Ann Thorac Surg 92:e39-42. 2011
    ..Here we describe our surgical technique and discuss the benefits and risks of this procedure...
  51. doi request reprint Asymptomatic infection with novel influenza A/H1N1 virus in a heart transplant recipient
    Sven Meyer
    Department of General and Interventional Cardiology, University Heart Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Heart Lung Transplant 29:585-6. 2010
    ..We present the first case of a young heart transplant recipient who remained asymptomatic despite positive polymerase chain reaction (PCR) after exposure to individuals with influenza A/H1N1...
  52. ncbi request reprint Functional and biochemical analysis of endothelial (dys)function and NO/cGMP signaling in human blood vessels with and without nitroglycerin pretreatment
    Eberhard Schulz
    University Hospital Eppendorf, Division of Cardiology, Hamburg, Germany
    Circulation 105:1170-5. 2002
    ..However, it is still controversial whether nitrate tolerance in humans is associated with both endothelial dysfunction and impaired vascular response to nitrovasodilator-derived NO...
  53. ncbi request reprint How to guide stent-graft implantation in type B aortic dissection? Comparison of angiography, transesophageal echocardiography, and intravascular ultrasound
    Dietmar H Koschyk
    Department of Cardiology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Circulation 112:I260-4. 2005
    ..Despite growing interest in stent-graft implantation for type-B aortic dissection, there are no established recommendations to prepare and perform an implantation procedure...
  54. ncbi request reprint Multidetector computed tomography (MDCT) in coronary surgery: first experiences with a new tool for diagnosis of coronary artery disease
    Hendrik Treede
    Department of Cardiac Surgery, Ludwig Maximilians University Munich, Germany
    Ann Thorac Surg 74:S1398-402. 2002
    ..Patients underwent CT scans in addition to SCA; findings were compared regarding location and degree of coronary artery stenosis...
  55. ncbi request reprint New technique for chest opening in mice: U-sternotomy
    Sonja Schrepfer
    Department of Thoracic and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Microsurgery 23:274-5. 2003
    ..This U-sternotomy reduces the risk of animal death and therefore the amount of quite expensive virus solutions needed...
  56. ncbi request reprint Robotically-assisted coronary artery surgery with and without cardiopulmonary bypass - from first clinical use to endoscopic operation
    Christian Detter
    Department of Thoracic and Cardiovascular Surgery, University Hospital Grosshadern, Munich, Germany
    Med Sci Monit 8:MT118-23. 2002
    ..Recently, the ZEUS(tm) Robotic Surgical System has been introduced to increase the precision of endoscopic cardiac surgery. This study investigated its clinical use for endoscopic coronary artery bypass grafting...
  57. ncbi request reprint Minimally invasive valve surgery: different techniques and approaches
    Christian Detter
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Martinistr 52, D 20246 Hamburg, Germany
    Expert Rev Cardiovasc Ther 2:239-51. 2004
    ..This article will review the different minimally invasive techniques and approaches, as well as early results and outcomes for aortic and mitral valve surgery...
  58. ncbi request reprint Experimental orthotopic tracheal transplantation: The Stanford technique
    Sonja Schrepfer
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, Stanford, CA 94305 5407, USA
    Microsurgery 27:187-9. 2007
    ..The technique is easy to learn, the procedure is well tolerated by the animals, and the grafts develop OAD lesions similar to those of human obliterative bronchiolitis...
  59. ncbi request reprint Minimally invasive direct coronary artery bypass grafting (MIDCAB) and off-pump coronary artery bypass grafting (OPCAB): two techniques for beating heart surgery
    Christian Detter
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilian University, Munich, Germany
    Heart Surg Forum 5:157-62. 2002
    ..Coronary bypass surgery can be performed less invasively by avoiding cardiopulmonary bypass (CPB). We present our experiences with beating heart bypass surgery performed through a minithoracotomy or sternotomy...
  60. ncbi request reprint Comparison of two stabilizer concepts for off-pump coronary artery bypass grafting
    Christian Detter
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwig Maximilian University, Munich, Germany
    Ann Thorac Surg 74:497-501. 2002
    ..This study was designed to evaluate the efficacy of two different stabilizer concepts for off-pump coronary artery bypass grafting...
  61. ncbi request reprint Evaluation of acute traumatic changes of the coronary artery wall after robotically assisted endoscopic coronary artery bypass grafting
    Martin Arnold
    Department of Cardiac Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Heart Surg Forum 5:128-31. 2002
    ..Goleta, CA) in a laboratory setting...
  62. doi request reprint Mechanically Induced Ventricular Tachycardia by the HeartWare Ventricular Assist Device
    Yalin Yildirim
    From the Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    ASAIO J 60:124-6. 2014
    ..A mechanical irritation of the HVAD inflow touching the inferior-posterior wall was found to trigger these focal arrhythmias. The HVAD was explanted, and no further arrhythmias occurred. ..
  63. doi request reprint Transcutaneous lead implantation connected to an externalized pacemaker in patients with implantable cardiac defibrillator/pacemaker infection and pacemaker dependency
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, 20246 Hamburg, Germany
    Europace 15:1205-9. 2013
    ..In this study, a new therapy option with temporary pacing by ipsilateral implantation of a new active-fixation right ventricular (RV)-lead was evaluated...
  64. doi request reprint Isolated permanent right ventricular assistance using the HVAD continuous-flow pump
    Tobias Deuse
    University Heart Center Hamburg, Hamburg, Germany
    Ann Thorac Surg 95:1434-6. 2013
    ..No manipulations of the system were required to adapt the assist device to the pulmonary circulation...
  65. doi request reprint Concomitant transcatheter aortic valve and left ventricular assist device implantation
    Christina Baum
    University Heart Center Hamburg, 20246 Hamburg, Germany
    ASAIO J 59:90-2. 2013
    ..We believe concomitant transcatheter aortic valve implantation (TAVI) and LVAD implantation is a promising hybrid procedure, even in patients with pure AR...
  66. ncbi request reprint Prospective, randomized study comparing two different minimized versus conventional cardiopulmonary bypass systems
    Jeannette Schoenebeck
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Innovations (Phila) 5:270-7. 2010
    ..We aimed to assess the impact of two different minimized cardiopulmonary bypass systems (mini-CPB) with and without Bioline-coating compared with CCPB regarding organ function, inflammatory response, and early clinical outcome...
  67. doi request reprint Spontaneous coronary bypass rupture
    Jan Kaehler
    Department of Cardiology, University Hospital Hamburg, Hamburg, Germany
    Ann Thorac Surg 86:664. 2008
  68. ncbi request reprint Fluorescent cardiac imaging: a novel intraoperative method for quantitative assessment of myocardial perfusion during graded coronary artery stenosis
    Christian Detter
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    Circulation 116:1007-14. 2007
    ..FCI is a novel technology to visualize coronary vessels and myocardial perfusion intraoperatively using the indocyanine green dye with an infrared-sensitive imaging device...
  69. pmc Long-term follow-up after autologous skeletal myoblast transplantation in ischaemic heart disease
    Jens Brickwedel
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg 18:61-6. 2014
    ..Our study reports the longest long-term worldwide follow-up of a single-centre cohort, focusing on the safety and efficacy of ASM-Tx...
  70. pmc Successful extracorporeal membrane oxygenation weaning after cardiac resynchronization therapy device implantation in a patient with end-stage heart failure
    Simon Pecha
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Interact Cardiovasc Thorac Surg 15:922-3. 2012
    ..We decided to proceed with CRT-D implantation while still on ECMO support. With biventricular stimulation, cardiac function improved promptly and the patient could be weaned from ECMO the same day...
  71. pmc Impact of AT2 receptor deficiency on postnatal cardiovascular development
    Daniel Biermann
    Department of Cardiovascular Surgery, University Heart Center, Hamburg, Germany
    PLoS ONE 7:e47916. 2012
    ..The angiotensin II receptor subtype 2 (AT2 receptor) is ubiquitously and highly expressed in early postnatal life. However, its role in postnatal cardiac development remained unclear...
  72. ncbi request reprint Vascular wall resident progenitor cells: a source for postnatal vasculogenesis
    Elvin Zengin
    Center of Experimental Medicine, Institute of Anatomy I, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Development 133:1543-51. 2006
    ....
  73. ncbi request reprint Coincidence of aortic valve stenosis and regurgitation and multiple cardiac papillary fibroelastomas in a young male adult
    Karsten Sydow
    Department of Cardiology, Hamburg University Heart Center, Hamburg, Germany
    J Thorac Cardiovasc Surg 133:564-5. 2007
  74. doi request reprint Use of initial biventricular mechanical support in a case of postinfarction ventricular septal rupture as a bridge to surgery
    Lenard Conradi
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Ann Thorac Surg 87:e37-9. 2009
    ..This approach may represent a new treatment option restoring hemodynamic stability and avoiding surgery on freshly infarcted myocardium...
  75. doi request reprint Prognostic value of perioperative near-infrared spectroscopy during neonatal and infant congenital heart surgery for adverse in-hospital clinical events
    Jannika Dodge-Khatami
    Division of Congenital Cardiovascular Surgery, University Heart Center, University Hospital Hamburg Eppendorf, Hamburg, Germany
    World J Pediatr Congenit Heart Surg 3:221-8. 2012
    ..Cerebral NIRS and lactate levels showed a strong inverse correlation during the first six postoperative hours. ..
  76. doi request reprint Gender effects on health care costs in cardiovascular medicine-a black box?
    Helmut Gulbins
    Department of Cardiovascular Surgery, University Heart Center Hamburg, Hamburg, Germany
    Thorac Cardiovasc Surg 61:74-8. 2013
    ..This manuscript deals with the possible economic implications of gender-related differences in cardiovascular medicine...
  77. ncbi request reprint Immunosuppression with FK778 and mycophenolate mofetil in a rat cardiac transplantation model
    Tobias Deuse
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Germany
    Transplantation 76:1627-9. 2003
    ..3 +/- 2.9 days; P<0.01; combination index=0.85). High-dose drug combination (mean survival time 24.0 +/- 1.4 days) showed antagonistic drug interaction (combination index=1.55) with increased toxic side effects...
  78. doi request reprint Which patients benefit from stentless aortic valve replacement?
    Helmut Gulbins
    Department of Cardiovascular Surgery, University Heart Center, University Hospital Eppendorf, Hamburg, Germany
    Ann Thorac Surg 88:2061-8. 2009
    ..Jude Medical, Minneapolis, MN) showed an increase in degeneration after 10 years of follow-up, whereas the Freestyle porcine stentless prostheses (Medtronic, Minneapolis, MN) still showed excellent results after this period...
  79. doi request reprint Frequency and age-related course of mitral valve dysfunction in the Marfan syndrome
    Meike Rybczynski
    Centre of Cardiology and Cardiovascular Surgery, University Hospital Eppendorf, Hamburg, Germany
    Am J Cardiol 106:1048-53. 2010
    ..006). In conclusion, MVP was comparatively frequent in patients with the Marfan syndrome and carries an increased risk of progression to severe MVR and endocarditis, especially in older adults...
  80. pmc The MLCK-mediated alpha1-adrenergic inotropic effect in atrial myocardium is negatively modulated by PKCepsilon signaling
    Michael Grimm
    Institute of Experimental and Clinical Pharmacology and Toxicology, University Medical Center, Hamburg, Germany
    Br J Pharmacol 148:991-1000. 2006
    ....
  81. pmc Myeloperoxidase acts as a profibrotic mediator of atrial fibrillation
    Volker Rudolph
    1Department of General and Interventional Cardiology and Cardiovascular Research Center, University Heart Center, Hamburg, Germany
    Nat Med 16:470-4. 2010
    ..Our data demonstrate that MPO is a crucial prerequisite for structural remodeling of the myocardium, leading to an increased vulnerability to atrial fibrillation...
  82. ncbi request reprint Video and robotic-assisted minimally invasive mitral valve surgery: a comparison of the Port-Access and transthoracic clamp techniques
    Hermann Reichenspurner
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Ann Thorac Surg 79:485-90; discussion 490-1. 2005
    ....
  83. ncbi request reprint Robotically assisted coronary artery bypass surgery with the ZEUS telemanipulator system
    Dieter H Boehm
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Semin Thorac Cardiovasc Surg 15:112-20. 2003
    ..This article summarizes the current worldwide experience with the ZEUS(TM) system in cardiac surgery and describes the steps from preclinical to endoscopic operation, focusing on the potential limitations of the procedure and the system...
  84. ncbi request reprint Successful resection of a symptomatic right ventricular lipoma
    Sonja Schrepfer
    Department of Cardiovascular Surgery, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Ann Thorac Surg 76:1305-7. 2003
    ..Histology confirmed diagnosis of a benign cardiac lipoma. The postoperative course was uneventful and the patient was discharged 7 days after surgery. There was no episode of ventricular tachycardias during the 6-month follow-up...
  85. ncbi request reprint Early and midterm results after coronary artery bypass grafting with and without cardiopulmonary bypass: which patient population benefits the most?
    Tobias Deuse
    Department of Cardiac Surgery, Grosshadern Medical Center, Ludwig Maximilians University, Munich, Germany
    Heart Surg Forum 6:77-83. 2003
    ..We present our early and midterm results with off-pump coronary artery bypass grafting (OPCAB) on the beating heart and with conventional coronary artery bypass grafting (CABG) and compare patient outcomes for both procedures...
  86. ncbi request reprint Stent-based approach for ventricle-to-coronary artery bypass
    Peter Boekstegers
    Department of Internal Medicine I, Grosshadern University Hospital, Munich, Germany
    Circulation 106:1000-6. 2002
    ..Ventricle-to-coronary artery bypass (VCAB) is an experimental revascularization procedure that provides predominantly systolic instead of diastolic blood flow to a coronary artery...
  87. ncbi request reprint [Mitral valve reconstruction without cardiopulmonary bypass. Border zone between cardiac surgery and interventional cardiology]
    Thilo Tübler
    Universitäres Herz und Gefässzentrum Hamburg GmbH, Hamburg
    Herz 31:406-12. 2006
    ..In this article, the authors focus on the available data as well as on the advantages and disadvantages of the different approaches...
  88. ncbi request reprint International experience with conversion from cyclosporine to tacrolimus for acute and chronic lung allograft rejection
    Kambiz Sarahrudi
    Department of Cardithoracic Surgery, University of Vienna, Austria
    J Thorac Cardiovasc Surg 127:1126-32. 2004
    ..A retrospective study involving 13 institutions was performed to assess the efficacy of conversion from cyclosporine (INN: ciclosporin) to tacrolimus...
  89. ncbi request reprint Retroinfusion-supported stenting in high-risk patients for percutaneous intervention and bypass surgery: results of the prospective randomized myoprotect I study
    Tilmann Pohl
    Department of Internal Medicine I, Grosshadern University Hospital, Munich, Germany
    Catheter Cardiovasc Interv 62:323-30. 2004
    ....
  90. ncbi request reprint Myoblasts survive intracardiac transfer and divide further after transplantation
    Helmut Gulbins
    Department of Cardiac Surgery, University Hospital Grosshadern, LMU Munich, D 81366 Munich, Germany
    Heart Surg Forum 5:340-4. 2002
    ..In addition, an intravital fluorescence dye for marking these cells was evaluated...
  91. ncbi request reprint Cyclosporine A versus tacrolimus in combination with mycophenolate mofetil and steroids as primary immunosuppression after lung transplantation: one-year results of a 2-center prospective randomized trial
    Andreas Zuckermann
    Department of Cardiothoracic Surgery, University of Vienna, Austria
    J Thorac Cardiovasc Surg 125:891-900. 2003
    ..Benefit or risk deriving from the combination with mycophenolate mofetil are yet unknown...
  92. doi request reprint Review on balloon aortic valvuloplasty: a surgeon's perspective in 2008
    Lenard Conradi
    Clin Res Cardiol 97:285-7. 2008
    ..In the rare case of real contraindications to surgical AVR transcatheter valve implantation techniques seem to be the more adequate alternative today...
  93. doi request reprint Introducing the first polymer-free leflunomide eluting stent
    Tobias Deuse
    Department of Cardiothoracic Surgery, Stanford University School of Medicine, 300 Pasteur Dr, CVRB MC 5407, Stanford, CA, USA
    Atherosclerosis 200:126-34. 2008
    ..We here describe the pharmacological characteristic, in vivo efficacy, and in vitro mechanisms of a polymer-free leflunomide eluting stent in comparison to its rapamycin-coated equivalent...
  94. ncbi request reprint Heart transplantation: an approach to treating primary cardiac sarcoma?
    Peter Uberfuhr
    Division of Cardiac Surgery, Klinikum Grosshadern, University of Munich, Munich, Germany
    J Heart Lung Transplant 21:1135-9. 2002
    ..However, pre-operative chemotherapy can regress tumors in chemosensitive C-STS and potentially eradicate early micrometastases. Consecutive HTx for responders may then offer a chance of long-term survival...
  95. ncbi request reprint The Cardica C-Port System: clinical and angiographic evaluation of a new device for automated, compliant distal anastomoses in coronary artery bypass grafting surgery--a multicenter prospective clinical trial
    Klaus E Matschke
    Department of Cardiac Surgery, University of Technology Dresden, Dresden, Germany
    J Thorac Cardiovasc Surg 130:1645-52. 2005
    ..The goal of this prospective, nonrandomized, and multicenter study is to determine the safety and efficacy of this novel anastomotic system...
  96. ncbi request reprint [Myoblasts from the leg into the heart: can infarct damage be rectified in this manner? (interview by Dr. Judith Neumaier)]
    Hermann Reichenspurner
    MMW Fortschr Med 147:22. 2005
  97. ncbi request reprint Improved results after heart-lung transplantation: a 17-year experience
    Bruno Reichart
    Department of Cardiac Surgery, University Hospital Grosshadern, Ludwigs Maximilians University, Munich, Germany
    Transplantation 75:127-32. 2003
    ..In selected patients with severe end-stage combined cardiopulmonary diseases, heart-lung transplantation (HLTx) remains the only therapeutical option for improving survival and quality of life...
  98. ncbi request reprint Diagnosis of perioperative myocardial infarction after coronary artery bypass surgery
    Hermann Reichenspurner
    Herz 29:656-7. 2004