Research Topics
| F RatjenSummaryAffiliation: University of Essen Country: Germany Publications
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Detail Information
Publications
Effect of inhaled nitric oxide on pulmonary function in cystic fibrosisF Ratjen
Children s Hospital, University of Essen, Germany
Respir Med 93:579-83. 1999....- Dornase in non-CFFelix Ratjen
Department of Pediatrics, Children's Hospital, University of Essen, Germany
Pediatr Pulmonol Suppl 26:154-5. 2004 - Cystic fibrosisFelix Ratjen
Department of Paediatrics, University of Essen, Essen, Germany
Lancet 361:681-9. 2003..Here, we summarise advances in understanding and treatment of cystic fibrosis, focusing on pulmonary disease, which accounts for most morbidity and deaths... - Bronchoalveolar lavage fluid findings in children with hypersensitivity pneumonitisF Ratjen
Dept of Paediatrics, University of Essen, Germany
Eur Respir J 21:144-8. 2003..Assessing natural killer cells and human leukocyte antigen-DR expression appears to be a helpful adjunct in the diagnosis of paediatric patients with this disorder... - DNA concentrations in BAL fluid of cystic fibrosis patients with early lung disease: influence of treatment with dornase alphaF Ratjen
Children s Hospital, University of Essen, Essen, Germany
Pediatr Pulmonol 39:1-4. 2005..01, Fisher's test). Therefore, treatment with dornase alpha over 18 months reduces DNA load in BAL fluid, which may have a positive effect on the clearance of lower airway secretions... 
Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alphaF Ratjen
Children s Hospital, University of Essen, D 45122 Essen, Germany
Thorax 57:930-4. 2002..Matrix metalloproteinases (MMPs) are involved in the remodelling and degradation of extracellular matrix and may play a role in pulmonary tissue destruction in cystic fibrosis (CF)...- High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in childrenF Ratjen
Department of Paediatrics, Children s Hospital, University of Essen, Essen, Germany
Bone Marrow Transplant 36:135-8. 2005..These data would suggest that anti-inflammatory therapy may be a valuable treatment option in paediatric patients with bronchiolitis obliterans after BMT... - Early interventions in CFFelix Ratjen
Department of Pediatrics, Children's Hospital, University of Essen, Germany
Pediatr Pulmonol Suppl 26:88-90. 2004 - Airway nitric oxide in infants with acute wheezy bronchitisF Ratjen
Children s Hospital, University of Essen, Germany
Pediatr Allergy Immunol 11:230-5. 2000..Whether this reflects a different inflammatory reaction to upper airway infections in acutely wheezy infants or pathophysiologic differences in airway response remains to be determined... - Changes in strategies for optimal antibacterial therapy in cystic fibrosisF Ratjen
Children s Hospital, University of Essen Hufelandstr 55, D 45122, Essen, Germany
Int J Antimicrob Agents 17:93-6. 2001..Inhaled antibiotics such as tobramycin have been shown to improve lung function and reduce sputum density of P. aeruginosa, but both the optimal dose and the duration of therapy are unclear at the present time... - Effect of continuous antistaphylococcal therapy on the rate of P. aeruginosa acquisition in patients with cystic fibrosisF Ratjen
Children s Hospital, University of Essen, Hufelandstr 55, D 45122 Essen, Germany
Pediatr Pulmonol 31:13-6. 2001..aureus increases the risk of colonization with P. aeruginosa. How this affects the clinical outcome of these patients remains to be determined... - Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase geneH Grasemann
Children s Hospital and Ruhrlandklinik, University of Essen, Essen, Germany
Am J Respir Crit Care Med 162:2172-6. 2000..aeruginosa (p = 0.0147) and Aspergillus fumigatus (p = 0.0221). These data provide evidence that the NOS1 gene is not only associated with the variability of FENO, but also with P. aeruginosa colonization of airways in CF patients... - Inhaled glutathione decreases PGE2 and increases lymphocytes in cystic fibrosis lungsD Hartl
Department of Pediatrics, Ludwig Maximilians University, Munich, Germany
Free Radic Biol Med 39:463-72. 2005..Thus, GSH primarily affected the pulmonary immune response rather than the oxidative status in CF patients. The effect of GSH inhalation on PGE2 levels and lymphocytes in CF warrants further investigation... - Pharmacokinetics of inhaled colistin in patients with cystic fibrosisF Ratjen
Children s Hospital, University of Duisburg Essen, Essen, Germany
J Antimicrob Chemother 57:306-11. 2006..Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only limited data are available to define its pharmacokinetic profile... - Effect of growth hormone therapy on nitric oxide formation in cystic fibrosis patientsC Grasemann
Children s Hospital, University of Duisburg Essen, Germany
Eur Respir J 31:815-21. 2008..Treatment with growth hormone in children with cystic fibrosis decreases exhaled nitric oxide by reducing the concentration of l-arginine in the airways... - Ciprofloxacin-induced acute renal failure in a patient with cystic fibrosisM Bald
University Children's Hospital, University of Essen, Germany
Pediatr Infect Dis J 20:320-1. 2001..Withdrawal of the drug led to normalization of renal function after 10 days... - Surfactant in children with malignancies, immunosuppression, fever and pulmonary infiltratesM Griese
Children s Hospital, Ludwig Maximilians University, Munich, Germany
Eur Respir J 20:1284-91. 2002..Increased surfactant protein A and C may also be responsible for the conserved biophysical activity of surfactant in children with malignancies, immunosuppression, pulmonary infiltrates and fever... - Mycobacterium chelonae in a CF patient with anaplastic large cell lymphomaE Tschiedel
Children's Hospital, University of Duisburg-Essen, Essen, Germany
J Cyst Fibros 5:133-6. 2006..This case highlights the dilemma of differentiating between colonisation and infection if mycobacteria are found in CF sputum samples... - Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled studyH Grasemann
Children s Hospital, University of Essen, Hufeland Str 55, D 45122 Essen, Germany
Eur Respir J 25:62-8. 2005..An effect of L-arginine supplementation on forced expiratory volume in one second was not observed. These data indicate that airway nitric oxide formation in cystic fibrosis patients can be augmented with oral L-arginine supplementation... - Bronchial reactions to the inhalation of high-dose tobramycin in cystic fibrosisW H Nikolaizik
Dept of Paediatrics, University Hospital Essen, Germany
Eur Respir J 20:122-6. 2002..Assessment of bronchial response at the first nebulisation of high-dose tobramycin and, in case of significant obstruction, beta-agonists in combination with the antibiotic inhalation are recommended... - Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphismH Grasemann
Children s Hospital, University of Essen, Essen, Germany
Nitric Oxide 6:236-41. 2002..0022). We conclude that (1) the variability in CF nasal NO levels are related to naturally occurring variants in the NOS1 gene, and (2) that nasal NOS1-derived NO affects the susceptibility of CF airways to infection with P. aeruginosa... - P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influxRainer Buscher
Department of Pediatrics, University Children s Hospital, Hufelandstr 55, 45122 Essen, Germany
Pharmacogenet Genomics 16:199-205. 2006..We also assessed the impact of the genetic variants on Ca2+-influx of P2Y2-null cells transfected with several P2Y2 receptor haplotypes... - beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung diseaseRainer Buscher
Children s Hospital, University of Essen, Germany
Pharmacogenetics 12:347-53. 2002..These data provide the first evidence suggesting that polymorphisms of the beta2AR gene contribute to clinical severity and disease progression in cystic fibrosis... - A pilot study to compare tobramycin 80 mg injectable preparation with 300 mg solution for inhalation in cystic fibrosis patientsWilfried H Nikolaizik
Department of Pediatrics, University Hospital Essen, Essen, Germany
Can Respir J 15:259-62. 2008..However, to date no comparative data are available for different dose regimens used in clinical practice... 
Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patientsMatthias Griese
Children s Hospital, University of Munich, Lindwurmstr 4, 80337 München, Germany
Respir Res 6:133. 2005..So far, longitudinal measurements of surfactant function in CF patients are lacking and it remains unclear how these alterations relate to the progression of airway inflammation as well as decline in pulmonary function over time...- Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosisMatthias Griese
Children s Hospital, University of Munich, Munich, Germany
Am J Respir Crit Care Med 170:1000-5. 2004.... - Increased arginase activity in cystic fibrosis airwaysHartmut Grasemann
Children s Hospital, University of Duisburg Essen, Essen, Germany
Am J Respir Crit Care Med 172:1523-8. 2005..Airway nitric oxide concentrations are reduced in cystic fibrosis (CF). Arginases compete for L-arginine, the substrate of nitric oxide synthesis... - A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the metabolic and respiratory effects of growth hormone in children with cystic fibrosisDirk Schnabel
Department of Pediatric Endocrinology and Diabetology, Children s Hospital, Charite, Berlin, Germany
Pediatrics 119:e1230-8. 2007..This trial was designed as a multicenter, randomized, placebo-controlled, double-blind study to assess the efficacy and safety of 2 dosages of growth hormone in cystic fibrosis... - The infant with cystic fibrosis: inflammatory markersF Ratjen
Children's Hospital, University of Essen, Hufelandstr 55, 45122 Essen, Germany
Paediatr Respir Rev 5:S365-6. 2004 - Paediatric bronchoscopyF Ratjen
Children's Hospital, University of Essen, Hufelandstr. 55, 45122 Essen, Germany
Paediatr Respir Rev 5:S21-2. 2004 - Nodular pulmonary vasculitis in a twelve-year-old boyT Borchers
Children s Hospital, University of Essen, Essen, Germany
Pediatr Pulmonol 37:181-5. 2004..While nodular vasculitis is known to occur in Wegener's granulomatosis, to the best of our knowledge, this case represents the first c-ANCA negative primary pulmonary vasculitis in childhood... - High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolatesS Viazov
Institute of Virology, Essen University Hospital, D 45122 Essen, Germany
J Clin Microbiol 41:3043-5. 2003..Phylogenetic analysis of the amplified viral genome fragments confirmed the existence and simultaneous circulation within one epidemic season of HMPV isolates belonging to two genetic lineages... - Airway nitric oxide in Duchenne muscular dystrophyVolker Straub
Children's Hospital, University of Essen, Germany
J Pediatr 141:132-4. 2002..02) or 17 adult male control subjects (18.5 +/- 1.8 parts per billion, P <.001). These findings provide indirect evidence that NOS1 contributes significantly to fractional exhaled nitric oxide in healthy children... - Endothelial nitric oxide synthase variants in cystic fibrosis lung diseaseHartmut Grasemann
Children s Hospital, University of Essen, Essen, Germany
Am J Respir Crit Care Med 167:390-4. 2003..aeruginosa... - Inhalation of Moli1901 in patients with cystic fibrosisHartmut Grasemann
The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
Chest 131:1461-6. 2007..Moli1901 stimulates an alternative chloride channel and may thus compensate for the CFTR deficiency in the airway epithelium of CF patients... - Nitrogen redox balance in the cystic fibrosis airway: effects of antipseudomonal therapyBenjamin Gaston
Department of Pediatric Pulmonary Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
Am J Respir Crit Care Med 165:387-90. 2002..We speculate that normalization of airway nitrogen redox balance could contribute to the beneficial effects of antipseudomonal therapy on lung function in CF... - Pilot study of safety and tolerability of inhaled hypertonic saline in infants with cystic fibrosisPadmaja Subbarao
Division of Pediatric Respiratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada
Pediatr Pulmonol 42:471-6. 2007..There was no difference in microbiologic yield between pre- and post-HS throat swabs. In this pilot study, inhalation of HS was well tolerated in CF infants. These results support a study of the efficacy of HS in this age group... - Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosisKarl Paul
Department of Pediatric Pneumology and Immunology, Charit, Germany
Am J Respir Crit Care Med 169:719-25. 2004..We conclude that in patients with CF, an increase in neutrophilic airway inflammation is found that is positively influenced by rhDNase treatment... - Gender-specific disease modification by NOS3Hartmut Grasemann
Br J Haematol 126:160; author reply 161. 2004 - New pulmonary therapies for cystic fibrosisFelix Ratjen
Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Canada
Curr Opin Pulm Med 13:541-6. 2007..This review addresses recent therapeutic strategies that either target the underlying defect or early steps in cystic fibrosis pathophysiology... - Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosisFelix Ratjen
Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
Curr Opin Pulm Med 12:428-32. 2006..aeruginosa infection. There are also studies showing that early treatment can eradicate the organism in the majority of cases... - What's new in CF airway inflammation: an updateFelix Ratjen
Hospital for Sick Children, Toronto, Ontario, Canada
Paediatr Respir Rev 7:S70-2. 2006.... - Inhaled L-arginine improves exhaled nitric oxide and pulmonary function in patients with cystic fibrosisHartmut Grasemann
The Hospital for Sick Children, Division of Respiratory Medicine, 555 University Ave, Toronto, ON, M5G 1X8 Canada
Am J Respir Crit Care Med 174:208-12. 2006..Nitric oxide formation is deficient in airways of patients with cystic fibrosis (CF). Since nitric oxide has bronchodilatory effects, nitric oxide deficiency may contribute to airway obstruction in CF... - Reduced lung function in cystic fibrosis: a primary or secondary phenotype?Stephanie D Davis
Am J Respir Crit Care Med 178:2-3. 2008 - Improvement of alveolar glutathione and lung function but not oxidative state in cystic fibrosisMatthias Griese
Department of Pediatric Ludwig Maximilians University, Munich, Germany
Am J Respir Crit Care Med 169:822-8. 2004..Reversion of markers of oxidative injury may need longer treatment, higher doses, or different types of antioxidants... 
Rapid pulmonary delivery of inhaled tobramycin for Pseudomonas infection in cystic fibrosis: a pilot projectAllan L Coates
Division of Nuclear Medicine, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada
Pediatr Pulmonol 43:753-9. 2008..Patients with cystic fibrosis spend as much 30 min a day inhaling tobramycin. Could a new rapid system deposit the equivalent amount of tobramycin faster?..- Pharmacokinetic modelling of a once-daily dosing regimen for intravenous tobramycin in paediatric cystic fibrosis patientsWallace Lam
Department of Pharmacy Services, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
J Antimicrob Chemother 59:1135-40. 2007..In addition, we aimed to assess whether certain patient characteristics affect tobramycin pharmacokinetics and, therefore, dosing... - Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosisGreg D Wells
Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
Pediatr Pulmonol 43:345-53. 2008..The Habitual Activity Estimation Scale (HAES) questionnaire has been shown to be a feasible tool to measure physical activity however the reliability and validity have yet to be determined in the CF population... - Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patientsSabine Ridder Schaphorn
Institute of Medical Microbiology, University of Muenster Hospital, Domagkstr 10, 48149 Muenster, Germany
J Clin Microbiol 45:2979-84. 2007..In CF patients, the oropharynx, and not the nose, was the predominant site of S. aureus infection and persistence. Hence, it is unlikely that CF patients will benefit from topical treatment strategies to eradicate nasal carriage... - Topsy-turvy heart with associated congenital tracheobronchial stenosis and airway compression requiring surgical reconstructionPatricio Herrera
Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
Ann Thorac Surg 86:282-3. 2008.... - Bronchoalveolar lavage protein patterns in children with malignancies, immunosuppression, fever and pulmonary infiltratesManfred Neumann
Kinderklinik and Kinderpoliklinik im Dr. von Haunerschen Kinderspital, Ludwig-Maximilians-University, Munich, Germany
Proteomics 2:683-9. 2002..Future target regions of interest were identified. Sample prefractionation and the selection of suitable narrow isoelectric point ranges will be necessary for optimized detection and separating conditions... - Mucolytics in cystic fibrosisMarkus O Henke
Department of Pulmonary Medicine, Philipps University Marburg, 35043 Marburg, Germany
Paediatr Respir Rev 8:24-9. 2007..Ultimately, drugs that are mucokinetic, which preserve viscoelasticity, rather than mucolytic may prove to be beneficial for CF lung disease in the future... - Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patientsFelix Ratjen
Division of Respiratory Medicine Hospital for Sick Children, Canada
Pediatr Pulmonol 42:249-55. 2007..However, because variability between patients is considerable, treatment decisions should not be based on P. aeruginosa antibody levels alone... - Beta2-agonists for asthma: the pediatric perspectivePadmaja Subbarao
Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
Clin Rev Allergy Immunol 31:209-18. 2006..Finally, the potential detrimental effects of long- and short-acting beta-agonists in infants and children are discussed... - Diagnosing and managing infection in CFFelix Ratjen
Hospital for Sick Children, Toronto, Ontario, Canada
Paediatr Respir Rev 7:S151-3. 2006..In addition, the optimal duration of therapy type of inhaled antibiotic as well as the optimal dose has not been clarified. Studies are currently ongoing to resolve these issues... - Microaspiration in infants with laryngomalaciaFabio Midulla
Servizio Speciale Fibrosi Cistica, Istituto di Clinica Pediatrica, Universita di Roma La Sapienza, Italy
Laryngoscope 114:1592-6. 2004..In this study, we evaluated whether infants with laryngomalacia have episodes of microaspiration by calculating the amount of lipids present in the alveolar macrophages... - Restoring airway surface liquid in cystic fibrosisFelix Ratjen
N Engl J Med 354:291-3. 2006 - Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosisChih-Min Tang
Department of Pharmacology, University of California-San Diego, 9500 Gilman Drive, La Jolla, CA 92093-0636, USA
Pharmacogenet Genomics 15:321-7. 2005..None of the SNPs identified in A2B receptors are likely to be modifiers in CF... - Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosisJacques Brouard
Inserm E213, Armand Trousseau Hospital, Paris, and the Department of Pediatrics, Georges Clemenceau Hospital, Caen, France
J Infect Dis 191:1988-91. 2005..fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF... - Multidrug-resistant organisms in cystic fibrosis: management and infection-control issuesValerie Waters
Division of Infectious Diseases, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
Expert Rev Anti Infect Ther 4:807-19. 2006..Until more is known about their pathogenicity and effect on clinical outcomes, physicians should be aware of the potential transmissibility of these organisms and implement adequate infection control strategies...