F Ratjen

Summary

Affiliation: University of Essen
Country: Germany

Publications

  1. ncbi request reprint Dornase in non-CF
    Felix Ratjen
    Department of Pediatrics, Children s Hospital, University of Essen, Germany
    Pediatr Pulmonol Suppl 26:154-5. 2004
  2. ncbi request reprint Effect of inhaled nitric oxide on pulmonary function in cystic fibrosis
    F Ratjen
    Children s Hospital, University of Essen, Germany
    Respir Med 93:579-83. 1999
  3. ncbi request reprint Cystic fibrosis
    Felix Ratjen
    Department of Paediatrics, University of Essen, Essen, Germany
    Lancet 361:681-9. 2003
  4. ncbi request reprint Bronchoalveolar lavage fluid findings in children with hypersensitivity pneumonitis
    F Ratjen
    Dept of Paediatrics, University of Essen, Germany
    Eur Respir J 21:144-8. 2003
  5. ncbi request reprint DNA concentrations in BAL fluid of cystic fibrosis patients with early lung disease: influence of treatment with dornase alpha
    F Ratjen
    Children s Hospital, University of Essen, Essen, Germany
    Pediatr Pulmonol 39:1-4. 2005
  6. pmc Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha
    F Ratjen
    Children s Hospital, University of Essen, D 45122 Essen, Germany
    Thorax 57:930-4. 2002
  7. ncbi request reprint High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children
    F Ratjen
    Department of Paediatrics, Children s Hospital, University of Essen, Essen, Germany
    Bone Marrow Transplant 36:135-8. 2005
  8. ncbi request reprint Early interventions in CF
    Felix Ratjen
    Department of Pediatrics, Children s Hospital, University of Essen, Germany
    Pediatr Pulmonol Suppl 26:88-90. 2004
  9. ncbi request reprint Airway nitric oxide in infants with acute wheezy bronchitis
    F Ratjen
    Children s Hospital, University of Essen, Germany
    Pediatr Allergy Immunol 11:230-5. 2000
  10. ncbi request reprint Changes in strategies for optimal antibacterial therapy in cystic fibrosis
    F Ratjen
    Children s Hospital, University of Essen Hufelandstr 55, D 45122, Essen, Germany
    Int J Antimicrob Agents 17:93-6. 2001

Collaborators

Detail Information

Publications60

  1. ncbi request reprint Dornase in non-CF
    Felix Ratjen
    Department of Pediatrics, Children s Hospital, University of Essen, Germany
    Pediatr Pulmonol Suppl 26:154-5. 2004
  2. ncbi request reprint Effect of inhaled nitric oxide on pulmonary function in cystic fibrosis
    F Ratjen
    Children s Hospital, University of Essen, Germany
    Respir Med 93:579-83. 1999
    ....
  3. ncbi request reprint Cystic fibrosis
    Felix Ratjen
    Department of Paediatrics, University of Essen, Essen, Germany
    Lancet 361:681-9. 2003
    ..Here, we summarise advances in understanding and treatment of cystic fibrosis, focusing on pulmonary disease, which accounts for most morbidity and deaths...
  4. ncbi request reprint Bronchoalveolar lavage fluid findings in children with hypersensitivity pneumonitis
    F Ratjen
    Dept of Paediatrics, University of Essen, Germany
    Eur Respir J 21:144-8. 2003
    ..Assessing natural killer cells and human leukocyte antigen-DR expression appears to be a helpful adjunct in the diagnosis of paediatric patients with this disorder...
  5. ncbi request reprint DNA concentrations in BAL fluid of cystic fibrosis patients with early lung disease: influence of treatment with dornase alpha
    F Ratjen
    Children s Hospital, University of Essen, Essen, Germany
    Pediatr Pulmonol 39:1-4. 2005
    ..01, Fisher's test). Therefore, treatment with dornase alpha over 18 months reduces DNA load in BAL fluid, which may have a positive effect on the clearance of lower airway secretions...
  6. pmc Matrix metalloproteases in BAL fluid of patients with cystic fibrosis and their modulation by treatment with dornase alpha
    F Ratjen
    Children s Hospital, University of Essen, D 45122 Essen, Germany
    Thorax 57:930-4. 2002
    ..Matrix metalloproteinases (MMPs) are involved in the remodelling and degradation of extracellular matrix and may play a role in pulmonary tissue destruction in cystic fibrosis (CF)...
  7. ncbi request reprint High-dose corticosteroid therapy for bronchiolitis obliterans after bone marrow transplantation in children
    F Ratjen
    Department of Paediatrics, Children s Hospital, University of Essen, Essen, Germany
    Bone Marrow Transplant 36:135-8. 2005
    ..These data would suggest that anti-inflammatory therapy may be a valuable treatment option in paediatric patients with bronchiolitis obliterans after BMT...
  8. ncbi request reprint Early interventions in CF
    Felix Ratjen
    Department of Pediatrics, Children s Hospital, University of Essen, Germany
    Pediatr Pulmonol Suppl 26:88-90. 2004
  9. ncbi request reprint Airway nitric oxide in infants with acute wheezy bronchitis
    F Ratjen
    Children s Hospital, University of Essen, Germany
    Pediatr Allergy Immunol 11:230-5. 2000
    ..Whether this reflects a different inflammatory reaction to upper airway infections in acutely wheezy infants or pathophysiologic differences in airway response remains to be determined...
  10. ncbi request reprint Changes in strategies for optimal antibacterial therapy in cystic fibrosis
    F Ratjen
    Children s Hospital, University of Essen Hufelandstr 55, D 45122, Essen, Germany
    Int J Antimicrob Agents 17:93-6. 2001
    ..Inhaled antibiotics such as tobramycin have been shown to improve lung function and reduce sputum density of P. aeruginosa, but both the optimal dose and the duration of therapy are unclear at the present time...
  11. ncbi request reprint Effect of continuous antistaphylococcal therapy on the rate of P. aeruginosa acquisition in patients with cystic fibrosis
    F Ratjen
    Children s Hospital, University of Essen, Hufelandstr 55, D 45122 Essen, Germany
    Pediatr Pulmonol 31:13-6. 2001
    ..aureus increases the risk of colonization with P. aeruginosa. How this affects the clinical outcome of these patients remains to be determined...
  12. ncbi request reprint Airway nitric oxide levels in cystic fibrosis patients are related to a polymorphism in the neuronal nitric oxide synthase gene
    H Grasemann
    Children s Hospital and Ruhrlandklinik, University of Essen, Essen, Germany
    Am J Respir Crit Care Med 162:2172-6. 2000
    ..aeruginosa (p = 0.0147) and Aspergillus fumigatus (p = 0.0221). These data provide evidence that the NOS1 gene is not only associated with the variability of FENO, but also with P. aeruginosa colonization of airways in CF patients...
  13. ncbi request reprint Pharmacokinetics of inhaled colistin in patients with cystic fibrosis
    F Ratjen
    Children s Hospital, University of Duisburg Essen, Essen, Germany
    J Antimicrob Chemother 57:306-11. 2006
    ..Inhaled colistin is commonly used in patients with cystic fibrosis (CF), but only limited data are available to define its pharmacokinetic profile...
  14. ncbi request reprint Effect of growth hormone therapy on nitric oxide formation in cystic fibrosis patients
    C Grasemann
    Children s Hospital, University of Duisburg Essen, Germany
    Eur Respir J 31:815-21. 2008
    ..Treatment with growth hormone in children with cystic fibrosis decreases exhaled nitric oxide by reducing the concentration of l-arginine in the airways...
  15. ncbi request reprint Inhaled glutathione decreases PGE2 and increases lymphocytes in cystic fibrosis lungs
    D Hartl
    Department of Pediatrics, Ludwig Maximilians University, Munich, Germany
    Free Radic Biol Med 39:463-72. 2005
    ..Thus, GSH primarily affected the pulmonary immune response rather than the oxidative status in CF patients. The effect of GSH inhalation on PGE2 levels and lymphocytes in CF warrants further investigation...
  16. ncbi request reprint Ciprofloxacin-induced acute renal failure in a patient with cystic fibrosis
    M Bald
    University Children's Hospital, University of Essen, Germany
    Pediatr Infect Dis J 20:320-1. 2001
    ..Withdrawal of the drug led to normalization of renal function after 10 days...
  17. ncbi request reprint Surfactant in children with malignancies, immunosuppression, fever and pulmonary infiltrates
    M Griese
    Children s Hospital, Ludwig Maximilians University, Munich, Germany
    Eur Respir J 20:1284-91. 2002
    ..Increased surfactant protein A and C may also be responsible for the conserved biophysical activity of surfactant in children with malignancies, immunosuppression, pulmonary infiltrates and fever...
  18. ncbi request reprint Mycobacterium chelonae in a CF patient with anaplastic large cell lymphoma
    E Tschiedel
    Children s Hospital, University of Duisburg Essen, Essen, Germany
    J Cyst Fibros 5:133-6. 2006
    ..This case highlights the dilemma of differentiating between colonisation and infection if mycobacteria are found in CF sputum samples...
  19. ncbi request reprint Oral L-arginine supplementation in cystic fibrosis patients: a placebo-controlled study
    H Grasemann
    Children s Hospital, University of Essen, Hufeland Str 55, D 45122 Essen, Germany
    Eur Respir J 25:62-8. 2005
    ..An effect of L-arginine supplementation on forced expiratory volume in one second was not observed. These data indicate that airway nitric oxide formation in cystic fibrosis patients can be augmented with oral L-arginine supplementation...
  20. ncbi request reprint Bronchial reactions to the inhalation of high-dose tobramycin in cystic fibrosis
    W H Nikolaizik
    Dept of Paediatrics, University Hospital Essen, Germany
    Eur Respir J 20:122-6. 2002
    ..Assessment of bronchial response at the first nebulisation of high-dose tobramycin and, in case of significant obstruction, beta-agonists in combination with the antibiotic inhalation are recommended...
  21. ncbi request reprint Nasal nitric oxide levels in cystic fibrosis patients are associated with a neuronal NO synthase (NOS1) gene polymorphism
    H Grasemann
    Children s Hospital, University of Essen, Essen, Germany
    Nitric Oxide 6:236-41. 2002
    ..0022). We conclude that (1) the variability in CF nasal NO levels are related to naturally occurring variants in the NOS1 gene, and (2) that nasal NOS1-derived NO affects the susceptibility of CF airways to infection with P. aeruginosa...
  22. ncbi request reprint P2Y2 receptor polymorphisms and haplotypes in cystic fibrosis and their impact on Ca2+ influx
    Rainer Buscher
    Department of Pediatrics, University Children s Hospital, Hufelandstr 55, 45122 Essen, Germany
    Pharmacogenet Genomics 16:199-205. 2006
    ..We also assessed the impact of the genetic variants on Ca2+-influx of P2Y2-null cells transfected with several P2Y2 receptor haplotypes...
  23. ncbi request reprint beta2 adrenoceptor gene polymorphisms in cystic fibrosis lung disease
    Rainer Buscher
    Children s Hospital, University of Essen, Germany
    Pharmacogenetics 12:347-53. 2002
    ..These data provide the first evidence suggesting that polymorphisms of the beta2AR gene contribute to clinical severity and disease progression in cystic fibrosis...
  24. pmc A pilot study to compare tobramycin 80 mg injectable preparation with 300 mg solution for inhalation in cystic fibrosis patients
    Wilfried H Nikolaizik
    Department of Pediatrics, University Hospital Essen, Essen, Germany
    Can Respir J 15:259-62. 2008
    ..However, to date no comparative data are available for different dose regimens used in clinical practice...
  25. pmc Sequential analysis of surfactant, lung function and inflammation in cystic fibrosis patients
    Matthias Griese
    Children s Hospital, University of Munich, Lindwurmstr 4, 80337 München, Germany
    Respir Res 6:133. 2005
    ..So far, longitudinal measurements of surfactant function in CF patients are lacking and it remains unclear how these alterations relate to the progression of airway inflammation as well as decline in pulmonary function over time...
  26. ncbi request reprint Pulmonary surfactant, lung function, and endobronchial inflammation in cystic fibrosis
    Matthias Griese
    Children s Hospital, University of Munich, Munich, Germany
    Am J Respir Crit Care Med 170:1000-5. 2004
    ....
  27. ncbi request reprint Increased arginase activity in cystic fibrosis airways
    Hartmut Grasemann
    Children s Hospital, University of Duisburg Essen, Essen, Germany
    Am J Respir Crit Care Med 172:1523-8. 2005
    ..Airway nitric oxide concentrations are reduced in cystic fibrosis (CF). Arginases compete for L-arginine, the substrate of nitric oxide synthesis...
  28. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled trial to evaluate the metabolic and respiratory effects of growth hormone in children with cystic fibrosis
    Dirk Schnabel
    Department of Pediatric Endocrinology and Diabetology, Children s Hospital, Charite, Berlin, Germany
    Pediatrics 119:e1230-8. 2007
    ..This trial was designed as a multicenter, randomized, placebo-controlled, double-blind study to assess the efficacy and safety of 2 dosages of growth hormone in cystic fibrosis...
  29. ncbi request reprint The infant with cystic fibrosis: inflammatory markers
    F Ratjen
    Children s Hospital, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Paediatr Respir Rev 5:S365-6. 2004
  30. ncbi request reprint Paediatric bronchoscopy
    F Ratjen
    Children s Hospital, University of Essen, Hufelandstr 55, 45122 Essen, Germany
    Paediatr Respir Rev 5:S21-2. 2004
  31. ncbi request reprint Nodular pulmonary vasculitis in a twelve-year-old boy
    T Borchers
    Children s Hospital, University of Essen, Essen, Germany
    Pediatr Pulmonol 37:181-5. 2004
    ..While nodular vasculitis is known to occur in Wegener's granulomatosis, to the best of our knowledge, this case represents the first c-ANCA negative primary pulmonary vasculitis in childhood...
  32. pmc High prevalence of human metapneumovirus infection in young children and genetic heterogeneity of the viral isolates
    S Viazov
    Institute of Virology, Essen University Hospital, D 45122 Essen, Germany
    J Clin Microbiol 41:3043-5. 2003
    ..Phylogenetic analysis of the amplified viral genome fragments confirmed the existence and simultaneous circulation within one epidemic season of HMPV isolates belonging to two genetic lineages...
  33. ncbi request reprint Airway nitric oxide in Duchenne muscular dystrophy
    Volker Straub
    Children s Hospital, University of Essen, Germany
    J Pediatr 141:132-4. 2002
    ..02) or 17 adult male control subjects (18.5 +/- 1.8 parts per billion, P <.001). These findings provide indirect evidence that NOS1 contributes significantly to fractional exhaled nitric oxide in healthy children...
  34. ncbi request reprint Endothelial nitric oxide synthase variants in cystic fibrosis lung disease
    Hartmut Grasemann
    Children s Hospital, University of Essen, Essen, Germany
    Am J Respir Crit Care Med 167:390-4. 2003
    ..aeruginosa...
  35. ncbi request reprint Inhalation of Moli1901 in patients with cystic fibrosis
    Hartmut Grasemann
    The Hospital for Sick Children, 555 University Avenue, Toronto, Ontario, Canada
    Chest 131:1461-6. 2007
    ..Moli1901 stimulates an alternative chloride channel and may thus compensate for the CFTR deficiency in the airway epithelium of CF patients...
  36. ncbi request reprint Nitrogen redox balance in the cystic fibrosis airway: effects of antipseudomonal therapy
    Benjamin Gaston
    Department of Pediatric Pulmonary Medicine, University of Virginia School of Medicine, Charlottesville, VA 22908, USA
    Am J Respir Crit Care Med 165:387-90. 2002
    ..We speculate that normalization of airway nitrogen redox balance could contribute to the beneficial effects of antipseudomonal therapy on lung function in CF...
  37. ncbi request reprint Pilot study of safety and tolerability of inhaled hypertonic saline in infants with cystic fibrosis
    Padmaja Subbarao
    Division of Pediatric Respiratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada
    Pediatr Pulmonol 42:471-6. 2007
    ..There was no difference in microbiologic yield between pre- and post-HS throat swabs. In this pilot study, inhalation of HS was well tolerated in CF infants. These results support a study of the efficacy of HS in this age group...
  38. ncbi request reprint Effect of treatment with dornase alpha on airway inflammation in patients with cystic fibrosis
    Karl Paul
    Department of Pediatric Pneumology and Immunology, Charite, Germany
    Am J Respir Crit Care Med 169:719-25. 2004
    ..We conclude that in patients with CF, an increase in neutrophilic airway inflammation is found that is positively influenced by rhDNase treatment...
  39. ncbi request reprint Gender-specific disease modification by NOS3
    Hartmut Grasemann
    Br J Haematol 126:160; author reply 161. 2004
  40. ncbi request reprint New pulmonary therapies for cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Canada
    Curr Opin Pulm Med 13:541-6. 2007
    ..This review addresses recent therapeutic strategies that either target the underlying defect or early steps in cystic fibrosis pathophysiology...
  41. ncbi request reprint Treatment of early Pseudomonas aeruginosa infection in patients with cystic fibrosis
    Felix Ratjen
    Division of Respiratory Medicine, Hospital for Sick Children, Toronto, Ontario, Canada
    Curr Opin Pulm Med 12:428-32. 2006
    ..aeruginosa infection. There are also studies showing that early treatment can eradicate the organism in the majority of cases...
  42. ncbi request reprint What's new in CF airway inflammation: an update
    Felix Ratjen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Respir Rev 7:S70-2. 2006
    ....
  43. ncbi request reprint Inhaled L-arginine improves exhaled nitric oxide and pulmonary function in patients with cystic fibrosis
    Hartmut Grasemann
    The Hospital for Sick Children, Division of Respiratory Medicine, 555 University Ave, Toronto, ON, M5G 1X8 Canada
    Am J Respir Crit Care Med 174:208-12. 2006
    ..Nitric oxide formation is deficient in airways of patients with cystic fibrosis (CF). Since nitric oxide has bronchodilatory effects, nitric oxide deficiency may contribute to airway obstruction in CF...
  44. ncbi request reprint Reduced lung function in cystic fibrosis: a primary or secondary phenotype?
    Stephanie D Davis
    Am J Respir Crit Care Med 178:2-3. 2008
  45. ncbi request reprint Improvement of alveolar glutathione and lung function but not oxidative state in cystic fibrosis
    Matthias Griese
    Department of Pediatric Ludwig Maximilians University, Munich, Germany
    Am J Respir Crit Care Med 169:822-8. 2004
    ..Reversion of markers of oxidative injury may need longer treatment, higher doses, or different types of antioxidants...
  46. doi request reprint Rapid pulmonary delivery of inhaled tobramycin for Pseudomonas infection in cystic fibrosis: a pilot project
    Allan L Coates
    Division of Nuclear Medicine, Hospital for Sick Children Research Institute, University of Toronto, Toronto, Canada
    Pediatr Pulmonol 43:753-9. 2008
    ..Patients with cystic fibrosis spend as much 30 min a day inhaling tobramycin. Could a new rapid system deposit the equivalent amount of tobramycin faster?..
  47. ncbi request reprint Pharmacokinetic modelling of a once-daily dosing regimen for intravenous tobramycin in paediatric cystic fibrosis patients
    Wallace Lam
    Department of Pharmacy Services, Princess Margaret Hospital, University Health Network, Toronto, Ontario, Canada
    J Antimicrob Chemother 59:1135-40. 2007
    ..In addition, we aimed to assess whether certain patient characteristics affect tobramycin pharmacokinetics and, therefore, dosing...
  48. doi request reprint Reliability and validity of the habitual activity estimation scale (HAES) in patients with cystic fibrosis
    Greg D Wells
    Division of Respiratory Medicine, The Hospital for Sick Children, Toronto, Ontario, Canada
    Pediatr Pulmonol 43:345-53. 2008
    ..The Habitual Activity Estimation Scale (HAES) questionnaire has been shown to be a feasible tool to measure physical activity however the reliability and validity have yet to be determined in the CF population...
  49. pmc Nasal Staphylococcus aureus carriage is not a risk factor for lower-airway infection in young cystic fibrosis patients
    Sabine Ridder-Schaphorn
    Institute of Medical Microbiology, University of Muenster Hospital, Domagkstr 10, 48149 Muenster, Germany
    J Clin Microbiol 45:2979-84. 2007
    ..In CF patients, the oropharynx, and not the nose, was the predominant site of S. aureus infection and persistence. Hence, it is unlikely that CF patients will benefit from topical treatment strategies to eradicate nasal carriage...
  50. doi request reprint Topsy-turvy heart with associated congenital tracheobronchial stenosis and airway compression requiring surgical reconstruction
    Patricio Herrera
    Division of Cardiovascular Surgery, Hospital for Sick Children, Toronto, Ontario, Canada
    Ann Thorac Surg 86:282-3. 2008
    ....
  51. ncbi request reprint Bronchoalveolar lavage protein patterns in children with malignancies, immunosuppression, fever and pulmonary infiltrates
    Manfred Neumann
    Kinderklinik and Kinderpoliklinik im Dr von Haunerschen Kinderspital, Ludwig Maximilians University, Munich, Germany
    Proteomics 2:683-9. 2002
    ..Future target regions of interest were identified. Sample prefractionation and the selection of suitable narrow isoelectric point ranges will be necessary for optimized detection and separating conditions...
  52. ncbi request reprint Mucolytics in cystic fibrosis
    Markus O Henke
    Department of Pulmonary Medicine, Philipps University Marburg, 35043 Marburg, Germany
    Paediatr Respir Rev 8:24-9. 2007
    ..Ultimately, drugs that are mucokinetic, which preserve viscoelasticity, rather than mucolytic may prove to be beneficial for CF lung disease in the future...
  53. ncbi request reprint Diagnostic value of serum antibodies in early Pseudomonas aeruginosa infection in cystic fibrosis patients
    Felix Ratjen
    Division of Respiratory Medicine Hospital for Sick Children, Canada
    Pediatr Pulmonol 42:249-55. 2007
    ..However, because variability between patients is considerable, treatment decisions should not be based on P. aeruginosa antibody levels alone...
  54. ncbi request reprint Beta2-agonists for asthma: the pediatric perspective
    Padmaja Subbarao
    Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    Clin Rev Allergy Immunol 31:209-18. 2006
    ..Finally, the potential detrimental effects of long- and short-acting beta-agonists in infants and children are discussed...
  55. ncbi request reprint Diagnosing and managing infection in CF
    Felix Ratjen
    Hospital for Sick Children, Toronto, Ontario, Canada
    Paediatr Respir Rev 7:S151-3. 2006
    ..In addition, the optimal duration of therapy type of inhaled antibiotic as well as the optimal dose has not been clarified. Studies are currently ongoing to resolve these issues...
  56. ncbi request reprint Microaspiration in infants with laryngomalacia
    Fabio Midulla
    Servizio Speciale Fibrosi Cistica, Istituto di Clinica Pediatrica, Universita di Roma La Sapienza, Italy
    Laryngoscope 114:1592-6. 2004
    ..In this study, we evaluated whether infants with laryngomalacia have episodes of microaspiration by calculating the amount of lipids present in the alveolar macrophages...
  57. ncbi request reprint Restoring airway surface liquid in cystic fibrosis
    Felix Ratjen
    N Engl J Med 354:291-3. 2006
  58. ncbi request reprint Human adenosine 2B receptor: SNP discovery and evaluation of expression in patients with cystic fibrosis
    Chih Min Tang
    Department of Pharmacology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093 0636, USA
    Pharmacogenet Genomics 15:321-7. 2005
    ..Using PCR and restriction fragment length polymorphism (RFLP) analysis, we assessed 53 American subjects of mixed ethnicity, 64 European Caucasian control subjects and 148 Caucasian patients with CF for A2B SNPs...
  59. ncbi request reprint Influence of interleukin-10 on Aspergillus fumigatus infection in patients with cystic fibrosis
    Jacques Brouard
    Inserm E213, Armand Trousseau Hospital, Paris, and the Department of Pediatrics, Georges Clemenceau Hospital, Caen, France
    J Infect Dis 191:1988-91. 2005
    ..fumigatus. These results suggest that polymorphisms in the promoter region of the IL-10 gene may influence the host response to A. fumigatus in the context of CF...
  60. ncbi request reprint Multidrug-resistant organisms in cystic fibrosis: management and infection-control issues
    Valerie Waters
    Division of Infectious Diseases, The Hospital for Sick Children, 555 University Avenue, Toronto, ON, M5G 1X8 Canada
    Expert Rev Anti Infect Ther 4:807-19. 2006
    ..Until more is known about their pathogenicity and effect on clinical outcomes, physicians should be aware of the potential transmissibility of these organisms and implement adequate infection control strategies...