K Raile

Summary

Affiliation: University of Leipzig
Country: Germany

Publications

  1. ncbi request reprint Leptin and pregnancy outcome
    J Kratzsch
    Institute of Clinical Chemistry and Pathobiochemistry, University of Leipzig, Germany
    Curr Opin Obstet Gynecol 12:501-5. 2000
  2. doi request reprint Thyroid gland development and defects
    Juergen Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Paul List Str 13 15, D 04103 Leipzig, Germany
    Best Pract Res Clin Endocrinol Metab 22:57-75. 2008
  3. ncbi request reprint Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany
    Eur J Endocrinol 155:609-14. 2006
  4. ncbi request reprint New reference intervals for thyrotropin and thyroid hormones based on National Academy of Clinical Biochemistry criteria and regular ultrasonography of the thyroid
    Juergen Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Institute of Transfusion Medicines, Clinics for Nuclear Medicine, University Hospital Leipzig, Germany
    Clin Chem 51:1480-6. 2005
  5. ncbi request reprint Inverse changes in the serum levels of the soluble leptin receptor and leptin in neonates: relations to anthropometric data
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, Germany
    J Clin Endocrinol Metab 90:2212-7. 2005
  6. ncbi request reprint Increased serum soluble leptin receptor levels in children and adolescents with type 1 diabetes mellitus
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
    Eur J Endocrinol 151:475-81. 2004
  7. doi request reprint Reference intervals for TSH and thyroid hormones are mainly affected by age, body mass index and number of blood leucocytes, but hardly by gender and thyroid autoantibodies during the first decades of life
    J Kratzsch
    Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Paul List Str 13 15 D 04103 Leipzig, Germany
    Clin Biochem 41:1091-8. 2008
  8. ncbi request reprint Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 87:4587-94. 2002
  9. ncbi request reprint A rapid, quantitative immunofunctional assay for measuring human leptin
    Jurgen Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, University of Leipzig, Germany
    Horm Res 57:127-32. 2002
  10. ncbi request reprint The exon 3-retaining and the exon 3-deleted forms of the growth hormone-binding protein (GHBP) in human serum are regulated differently
    J Kratzsch
    Department of Clinical Chemistry, University of Leipzig, Liebigstr 27a, D 04103 Leipzig, Germany
    Clin Endocrinol (Oxf) 54:61-8. 2001

Detail Information

Publications28

  1. ncbi request reprint Leptin and pregnancy outcome
    J Kratzsch
    Institute of Clinical Chemistry and Pathobiochemistry, University of Leipzig, Germany
    Curr Opin Obstet Gynecol 12:501-5. 2000
    ..In summary, leptin appears to be an important permissive factor that is involved in female reproduction...
  2. doi request reprint Thyroid gland development and defects
    Juergen Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Paul List Str 13 15, D 04103 Leipzig, Germany
    Best Pract Res Clin Endocrinol Metab 22:57-75. 2008
    ....
  3. ncbi request reprint Metabolic decompensation in children with type 1 diabetes mellitus associated with increased serum levels of the soluble leptin receptor
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Germany
    Eur J Endocrinol 155:609-14. 2006
    ..The aim of our study was to investigate potential metabolic factors that may be associated with the induction of the sOB-R release from its membrane receptor...
  4. ncbi request reprint New reference intervals for thyrotropin and thyroid hormones based on National Academy of Clinical Biochemistry criteria and regular ultrasonography of the thyroid
    Juergen Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, Institute of Transfusion Medicines, Clinics for Nuclear Medicine, University Hospital Leipzig, Germany
    Clin Chem 51:1480-6. 2005
    ..We also assessed the effect of potentially confounding factors to modulate the limits of these intervals...
  5. ncbi request reprint Inverse changes in the serum levels of the soluble leptin receptor and leptin in neonates: relations to anthropometric data
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostic, University Hospital Leipzig, Germany
    J Clin Endocrinol Metab 90:2212-7. 2005
    ..These suppressive effects may be an important stimulus for energy uptake in the first week of life or in other conditions with a high energy demand...
  6. ncbi request reprint Increased serum soluble leptin receptor levels in children and adolescents with type 1 diabetes mellitus
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, Leipzig, Germany
    Eur J Endocrinol 151:475-81. 2004
    ..We investigated whether or not serum levels of the soluble leptin receptor (sOB-R) and leptin are related to anthropometric and metabolic changes during pubertal development of children and adolescents with type 1 diabetes mellitus...
  7. doi request reprint Reference intervals for TSH and thyroid hormones are mainly affected by age, body mass index and number of blood leucocytes, but hardly by gender and thyroid autoantibodies during the first decades of life
    J Kratzsch
    Institute for Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, Paul List Str 13 15 D 04103 Leipzig, Germany
    Clin Biochem 41:1091-8. 2008
    ..The purpose of our study was to establish reference intervals for thyroid function tests in children and adolescents and to identify factors that may influence the limits of these intervals...
  8. ncbi request reprint Circulating soluble leptin receptor and free leptin index during childhood, puberty, and adolescence
    J Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University of Leipzig, 04103 Leipzig, Germany
    J Clin Endocrinol Metab 87:4587-94. 2002
    ..Furthermore, determinations of sOB-R and FLI are additional valuable tools to investigate the leptin axis during growth and sexual maturation...
  9. ncbi request reprint A rapid, quantitative immunofunctional assay for measuring human leptin
    Jurgen Kratzsch
    Institute of Laboratory Medicine, Clinical Chemistry and Molecular Diagnostics, University Hospital, University of Leipzig, Germany
    Horm Res 57:127-32. 2002
    ..Such an assay is theoretically capable of differentiating between physiologically active leptin molecules from those with modified, either enhanced or reduced, binding activity...
  10. ncbi request reprint The exon 3-retaining and the exon 3-deleted forms of the growth hormone-binding protein (GHBP) in human serum are regulated differently
    J Kratzsch
    Department of Clinical Chemistry, University of Leipzig, Liebigstr 27a, D 04103 Leipzig, Germany
    Clin Endocrinol (Oxf) 54:61-8. 2001
    ..The availability of assays for the determination of GHBP isoforms may be very important for the study of the GH receptor and its soluble extracellular domain, GHBP...
  11. ncbi request reprint The DSL analog free testosterone assay: serum levels are not related to sex hormone-binding globulin in normative data throughout childhood and adolescence
    J Kratzsch
    Institute of Clinical Chemistry and Pathobiochemistry, University of Leipzig, Germany
    Clin Lab 47:73-7. 2001
    ..In addition, SHBG levels in healthy children and adolescents are also given and may permit for studies of pathophysiologic states in this age group...
  12. ncbi request reprint Obesity in childhood and adolescence: clinical diagnosis and management
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Germany
    J Pediatr Endocrinol Metab 14:1431-40. 2001
    ..This review aims to increase awareness of the health burden and economic dimension of the epidemic of childhood obesity that is occurring around the globe...
  13. ncbi request reprint Clinical aspects of obesity in childhood and adolescence
    W Kiess
    Children s Hospital, University of Leipzig, Oststr 21 25, D 04317 Leipzig, Germany
    Obes Rev 2:29-36. 2001
    ..Finally, one should aim to increase public awareness of the ever increasing health burden and economic dimension of the childhood obesity epidemic that is present around the globe...
  14. ncbi request reprint Glucose regulates expression of the nerve growth factor (NGF) receptors TrkA and p75NTR in rat islets and INS-1E beta-cells
    K Raile
    Hospital for Children and Adolescents, Leipzig, Germany
    Regul Pept 135:30-8. 2006
    ..We therefore investigated whether or not glucose concentration influences expression of TrkA and p75NTR in rat islets and in INS-1E beta-cells at the mRNA and protein level (INS-1E)...
  15. ncbi request reprint Apoptosis: live or die--hard work either way!
    B W Gallaher
    Children s Hospital, University of Leipzig, Oststrasse 21 25, 04317 Leipzig, Germany
    Horm Metab Res 33:511-9. 2001
    ..Finally, further understanding of signalling systems that are involved in proliferation or in apoptosis might provide novel tools to treat or even heal disorders like type I diabetes...
  16. ncbi request reprint Clinical examples of disturbed IGF signaling: intrauterine and postnatal growth retardation due to mutations of the insulin-like growth factor I receptor (IGF-IR) gene
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Oststr 21 25, D 04317, Leipzig, Germany
    Rev Endocr Metab Disord 6:183-7. 2005
  17. ncbi request reprint Type 2 diabetes mellitus in children and adolescents: a review from a European perspective
    W Kiess
    Hospital for Children and Adolescents, University of Leipzig, Germany
    Horm Res 59:77-84. 2003
    ....
  18. ncbi request reprint Insulin-like growth factor I (IGF-I) stimulates proliferation but also increases caspase-3 activity, Annexin-V binding, and DNA-fragmentation in human MG63 osteosarcoma cells: co-activation of pro- and anti-apoptotic pathways by IGF-I
    K Raile
    Research Laboratory, Hospital for Children and Adolescents, Faculty of Medicine, University of Leipzig, Leipzig, Germany
    Horm Metab Res 35:786-93. 2003
    ..Furthermore, in sarcomas or carcinomas showing clinical association to IGF-I levels and malignancy, IGF-I dependent apoptosis and proliferation could be a significant mechanism of malignant tumour growth...
  19. ncbi request reprint Weight in adolescents with type 1 diabetes mellitus during continuous subcutaneous insulin infusion (CSII) therapy
    K Raile
    Division of Endocrinology and Diabetes, Children s Hospital, Ludwig Maximilians University of Munich, Germany
    J Pediatr Endocrinol Metab 15:607-12. 2002
    ..The general threat of weight gain in patients who switch to insulin pump therapy must be pointed out, and the role of eating habits and caloric content of food should play a central role in insulin pump educational programs...
  20. ncbi request reprint A new heterozygous mutation of the FOXL2 gene is associated with a large ovarian cyst and ovarian dysfunction in an adolescent girl with blepharophimosis/ptosis/epicanthus inversus syndrome
    K Raile
    Hospital for Children and Adolescents and
    Eur J Endocrinol 153:353-8. 2005
    ....
  21. ncbi request reprint Glucose concentration and AMP-dependent kinase activation regulate expression of insulin receptor family members in rat islets and INS-1E beta cells
    K Raile
    University Hospital for Children and Adolescents, Oststr 21 25, 04317 Leipzig, Germany
    Diabetologia 48:1798-809. 2005
    ..Glucose and the peptide growth factors insulin, IGF-I and IGF-II strongly regulate beta cell mass. Furthermore, beta cell expression of IGF-I receptor (Igf1r) and insulin receptor (Insr) is mandatory for several steps of insulin secretion...
  22. ncbi request reprint Insulin antibodies are associated with lipoatrophy but also with lipohypertrophy in children and adolescents with type 1 diabetes
    K Raile
    Children s Hospital, Ludwig Maximilians University of Munich, Munich, Germany
    Exp Clin Endocrinol Diabetes 109:393-6. 2001
    ..To evaluate clinical and immunological factors that are associated with lipodystrophy, i.e. lipoatrophy and lipohypertrophy, in diabetic children and adolescents...
  23. ncbi request reprint [Treatment of adolescents with type 2 diabetes]
    T M Kapellen
    Universitätsklinik und Poliklinik für Kinder und Jugendliche, Leipzig
    Klin Padiatr 216:57-61. 2004
    ..Only few substances are available for treatment of adolescents with type 2 diabetes. We report on our experience of treatment in the diabetes centre in Leipzig, Germany...
  24. ncbi request reprint Fathers of children with diabetes mellitus and their role in coping strategies in the family
    W Kiess
    Children s Hospital, University of Leipzig, Germany
    J Pediatr Endocrinol Metab 14:639-43. 2001
    ..Special educational programs targeted towards the fathers of children with DM and towards improving parental interactive strategies are urgently needed to better use parental resources of coping and support...
  25. ncbi request reprint IGFs, basic FGF, and glucose modulate proliferation and apoptosis induced by IFNgamma but not by IL-1beta in rat INS-1E beta-cells
    K Raile
    Research Laboratory, Hospital for Children and Adolescents, University of Leipzig, Leipzig, Germany
    Horm Metab Res 35:407-14. 2003
    ..Cytokines IFNg and IL-1beta differentially interfere with intracellular signaling cascades stimulated by IGFs and bFGF or glucose, respectively...
  26. ncbi request reprint Clinical and functional characteristics of the human Arg59Ter insulin-like growth factor i receptor (IGF1R) mutation: implications for a gene dosage effect of the human IGF1R
    K Raile
    Pediatric Endocrinology and Diabetes, Charite Universitatsmedizin Berlin, Augustenburgerplatz 1, D 13353 Berlin, Germany
    J Clin Endocrinol Metab 91:2264-71. 2006
    ..Signaling via the IGF-I receptor (IGF-IR) is crucial for normal prenatal and postnatal growth. The heterozygous IGF-IR mutation Arg59Ter resulted in reduced IGF-IR expression and represents haploinsufficiency of the human IGF1R gene...
  27. doi request reprint Insulin allergy: clinical manifestations and management strategies
    L Heinzerling
    Department of Dermatology and Allergy, Charite Universitatsmedizin, Berlin, Germany
    Allergy 63:148-55. 2008
    ..It can be managed well in close cooperation between the diabetologist and the allergologist. Specific immunotherapy is efficient and should be considered...
  28. pmc Mutational spectrum of COH1 and clinical heterogeneity in Cohen syndrome
    W Seifert
    J Med Genet 43:e22. 2006
    ..Our data confirm the broad clinical spectrum of CS with some patients lacking even the characteristic facial gestalt and pigmentary retinopathy at school age...