Boris B Quednow

Summary

Affiliation: University of Bonn
Country: Germany

Publications

  1. ncbi request reprint Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Biol Psychol 71:256-63. 2006
  2. ncbi request reprint Prepulse inhibition and habituation of acoustic startle response in male MDMA ('ecstasy') users, cannabis users, and healthy controls
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Neuropsychopharmacology 29:982-90. 2004
  3. ncbi request reprint Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 175:399-406. 2004
  4. ncbi request reprint Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 59:536-45. 2006
  5. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
  6. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
  7. doi request reprint Executive performance of depressed suicide attempters: the role of suicidal ideation
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:414-21. 2008
  8. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
  9. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
  10. doi request reprint Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:1473-81. 2013

Detail Information

Publications33

  1. ncbi request reprint Attenuation of the prepulse inhibition of the acoustic startle response within and between sessions
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, D 53105 Bonn, Germany
    Biol Psychol 71:256-63. 2006
    ..Nevertheless, PPI was reliable across three test sessions, indicating that the significant attenuation of PPI over time was a consistent phenomenon. These results suggest that PPI exhibits short- and long-term attenuation...
  2. ncbi request reprint Prepulse inhibition and habituation of acoustic startle response in male MDMA ('ecstasy') users, cannabis users, and healthy controls
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Neuropsychopharmacology 29:982-90. 2004
    ..Use of cannabis does not lead to alterations of amplitude, habituation, or PPI of ASR...
  3. ncbi request reprint Effects of serotonergic and noradrenergic antidepressants on auditory startle response in patients with major depression
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Sigmund Freud Strasse 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 175:399-406. 2004
    ..Studies with rodents suggest that an increase or decrease in serotonin level in the brain alters several modalities of the ASR. So far, little is known about serotonergic and noradrenergic startle modulation in humans...
  4. ncbi request reprint Sensorimotor gating and habituation of the startle response in schizophrenic patients randomly treated with amisulpride or olanzapine
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 59:536-45. 2006
    ..Thus, we compared the effects of a combined 5-HT2A/D2 and a pure D2/D3 antagonist on PPI and habituation of ASR in patients with schizophrenia...
  5. pmc Sensorimotor gating is associated with CHRNA3 polymorphisms in schizophrenia and healthy volunteers
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 35:1429-39. 2010
    ..These results suggest that sensorimotor gating is influenced by variations of the CHRNA3 gene, which might also have an impact on the course and severity of schizophrenia...
  6. pmc DAOA/G72 predicts the progression of prodromal syndromes to first episode psychosis
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, 53105, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 260:209-15. 2010
    ..This is one of the first studies to identify a specific genetic factor for the progression of prodromal syndromes to schizophrenia, and further underscores the importance of the DAOA/G72 gene for schizophrenia...
  7. doi request reprint Executive performance of depressed suicide attempters: the role of suicidal ideation
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:414-21. 2008
    ..Yet it remains unclear if a distinct cognitive suicidal phenotype does exist. The aim of the present study was to further investigate the role of suicidal thinking for the neuropsychological performance in depressive suicide attempters...
  8. doi request reprint Investigation of tryptophan hydroxylase 2 (TPH2) in schizophrenia and in the response to antipsychotics
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    J Psychiatr Res 46:1073-80. 2012
    ..We also investigated the association of the SNPs to treatment response, but did not get significant results. In sum, our results argue for only a minor role of TPH2 in schizophrenia...
  9. doi request reprint The functional coding variant Asn107Ile of the neuropeptide S receptor gene (NPSR1) is associated with schizophrenia and modulates verbal memory and the acoustic startle response
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Int J Neuropsychopharmacol 15:1205-15. 2012
    ..Based on these findings, we consider NPS as a promising target for antipsychotic drug development...
  10. doi request reprint Nicotine enhances antisaccade performance in schizophrenia patients and healthy controls
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Int J Neuropsychopharmacol 16:1473-81. 2013
    ..Instead, the findings likely represent genuine nicotine-induced enhancement of cognitive performance. ..
  11. doi request reprint The schizophrenia risk gene ZNF804A influences the antipsychotic response of positive schizophrenia symptoms
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 262:193-7. 2012
    ..41 ± 0.71, P = 0.022). This provides further evidence that ZNF804A is of functional relevance to schizophrenia and indicates that ZNF804A may be a novel target for pharmacological interventions...
  12. doi request reprint Influence of 5-HT3 receptor subunit genes HTR3A, HTR3B, HTR3C, HTR3D and HTR3E on treatment response to antipsychotics in schizophrenia
    Anna Schuhmacher
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:843-51. 2009
    ..Moreover, many antipsychotic drugs are antagonists at 5-HT3 receptors. However, the role of 5-HT3 receptor variants on response to antipsychotic drugs in schizophrenic patients is still unclear...
  13. ncbi request reprint Cognitive improvement in schizophrenic patients does not require a serotonergic mechanism: randomized controlled trial of olanzapine vs amisulpride
    Michael Wagner
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Neuropsychopharmacology 30:381-90. 2005
    ..Importantly, amisulpride was not inferior to olanzapine for any cognitive domain. Combined 5-HT(2A)/D2 receptor blockade is probably not necessary for cognitive improvement by SGAs...
  14. doi request reprint Impact of TCF4 on the genetics of schizophrenia
    Leonhard Lennertz
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 261:S161-5. 2011
    ..This indicates that TCF4 influences key mechanisms of information processing, which may contribute to the pathogenesis of schizophrenia...
  15. doi request reprint Impaired sensorimotor gating of the acoustic startle response in the prodrome of schizophrenia
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 64:766-73. 2008
    ..To test this assumption, we investigated PPI of ASR in individuals with prodromal symptoms of schizophrenia and patients with first-episode schizophrenia...
  16. doi request reprint Sensorimotor gating of schizophrenia patients is influenced by 5-HT2A receptor polymorphisms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 64:434-7. 2008
    ..Moreover, both schizophrenia and PPI are thought to be inheritable. We investigated the impact of three 5-HT(2A)R polymorphisms (A-1438G, T102C, H452Y) on PPI in schizophrenia patients...
  17. ncbi request reprint Normal prepulse inhibition and habituation of acoustic startle response in suicidal depressive patients without psychotic symptoms
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    J Affect Disord 92:299-303. 2006
    ..Thus, we investigated PPI and habituation of ASR in suicidal patients with depressive disorders as potential biological markers for suicidal behavior...
  18. doi request reprint Functional serotonin 1A receptor variant influences treatment response to atypical antipsychotics in schizophrenia
    Rainald Mossner
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Pharmacogenet Genomics 19:91-4. 2009
    ..003). The functional variant of the 5-HT1A receptor thus influences the response of schizophrenia patients to atypical antipsychotics and may be useful in the future to predict the pharmacogenetics of negative symptoms...
  19. doi request reprint From genes to psychoses and back: the role of the 5HT2alpha-receptor and prepulse inhibition in schizophrenia
    Wolfgang Maier
    Klinik und Poliklinik fur Psychiatrie und Psychotherapie, der Universität Bonn, Sigmund Freud Strasse 25, Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 258:40-3. 2008
    ....
  20. doi request reprint Startle cue-reactivity differentiates between light and heavy smokers
    Anne K Rehme
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Addiction 104:1757-64. 2009
    ..The goal of the present study was to investigate (i) whether smoking scenes induce appetitive cue effects in smokers, and (ii) whether smoking intensity is related to cue-reactivity...
  21. doi request reprint Nicotine differentially modulates antisaccade performance in healthy male non-smoking volunteers stratified for low and high accuracy
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Psychopharmacology (Berl) 221:27-38. 2012
    ..The response to acute nicotine is heterogeneous across subjects and samples; however, only a few reliable predictors of response have been identified...
  22. ncbi request reprint Neuropsychological performance in partly remitted unipolar depressive patients: focus on executive functioning
    Jens Westheide
    Department of Psychiatry, University of Bonn, Sigmund Freud Str 25, 53105 Bonn, Germany
    Eur Arch Psychiatry Clin Neurosci 257:389-95. 2007
    ..The role of impulsivity/orbitofrontal associated executive functioning in remitted depression has not yet been examined...
  23. doi request reprint The effect of nicotine on sensorimotor gating is modulated by a CHRNA3 polymorphism
    Nadine Petrovsky
    Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany
    Psychopharmacology (Berl) 229:31-40. 2013
    ..Moreover, the TT genotype of the nicotinic acetylcholine receptor (nAChR) α3-subunit (CHRNA3) rs1051730 polymorphism has previously been associated with diminished PPI and nicotine dependence...
  24. pmc Sensorimotor gating depends on polymorphisms of the serotonin-2A receptor and catechol-O-methyltransferase, but not on neuregulin-1 Arg38Gln genotype: a replication study
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Germany
    Biol Psychiatry 66:614-20. 2009
    ..Therefore, we aimed to replicate these results and investigated the impact of the related polymorphisms on PPI in healthy human volunteers...
  25. ncbi request reprint Impaired prepulse inhibition of acoustic startle in obsessive-compulsive disorder
    Klaus Hoenig
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Biol Psychiatry 57:1153-8. 2005
    ..However, there is only preliminary evidence about impaired PPI in OCD so far...
  26. ncbi request reprint Memory deficits in abstinent MDMA (ecstasy) users: neuropsychological evidence of frontal dysfunction
    Boris B Quednow
    Department of Psychiatry, University of Bonn, Bonn, Germany
    J Psychopharmacol 20:373-84. 2006
    ..These results suggest that the memory deficits of MDMA users are not only the result of a temporal or hippocampal dysfunction, but also of a dysfunction of regions within the frontal cortex...
  27. ncbi request reprint Antidepressive treatment in patients with temporal lobe epilepsy and major depression: a prospective study with three different antidepressants
    Kai Uwe Kuhn
    Department of Psychiatry, University of Bonn, Bonn, Germany
    Epilepsy Behav 4:674-9. 2003
    ..At endpoint the dropout rate for mirtazapine was significantly higher than that for reboxetine or citalopram. Reboxetine showed a trend to be more efficacious than citalopram but not mirtazapine at Week 4...
  28. doi request reprint Sensorimotor gating and attentional set-shifting are improved by the mu-opioid receptor agonist morphine in healthy human volunteers
    Boris B Quednow
    University Hospital of Psychiatry, Experimental Psychopathology and Brain Imaging, University of Zurich, Switzerland
    Int J Neuropsychopharmacol 11:655-69. 2008
    ....
  29. ncbi request reprint The monotonic dependency of prepulse inhibition of the acoustic startle reflex on the intensity of the startle-eliciting stimulus
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Lenggstrasse 31, CH 8029 Zurich, Switzerland
    Behav Brain Res 174:143-50. 2006
    ....
  30. ncbi request reprint Elevated impulsivity and impaired decision-making cognition in heavy users of MDMA ("Ecstasy")
    Boris B Quednow
    Department of Psychiatry, University of Zurich, Lenggstrasse 31, CH 8008, Zurich, Switzerland
    Psychopharmacology (Berl) 189:517-30. 2007
    ..In fact, MDMA users have shown elevated impulsivity in two studies, but little is known about decision making in drug-free MDMA consumers...
  31. doi request reprint On the influence of baseline startle reactivity on the indexation of prepulse inhibition
    Philipp A Csomor
    Psychiatric University Hospital Zurich, Zurich, Switzerland
    Behav Neurosci 122:885-900. 2008
    ....
  32. ncbi request reprint The effects of the preferential 5-HT2A agonist psilocybin on prepulse inhibition of startle in healthy human volunteers depend on interstimulus interval
    Franz X Vollenweider
    University Hospital of Psychiatry, Neuropsychopharmacology and Brain Imaging and Heffter Research Center, Lenggstrasse 31, CH 8032 Zurich, Switzerland
    Neuropsychopharmacology 32:1876-87. 2007
    ....
  33. ncbi request reprint [Schizophrenia and religiousness--a comparative study at the time of the two German states]
    Michael Pfaff
    Klinik für Psychiatrie und Psychotherapie der Ruhr Universität Bochum, LWL Klinik Bochum
    Psychiatr Prax 35:240-6. 2008
    ..Religious delusions are prevalent symptoms in schizophrenia. It is unclear, however, whether religious delusions reflect illness- or culture-related factors...