Thomas Pusl

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. pmc Intrahepatic cholestasis of pregnancy
    Thomas Pusl
    Department of Gastroenterology and Hepatology, AMC, University of Amsterdam, The Netherlands
    Orphanet J Rare Dis 2:26. 2007
  2. ncbi request reprint Plasma separation and anion adsorption transiently relieve intractable pruritus in primary biliary cirrhosis
    Thomas Pusl
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany
    J Hepatol 45:887-91. 2006
  3. doi request reprint Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1
    Thomas Pusl
    Department of Medicine II Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Biochem Biophys Res Commun 367:208-12. 2008
  4. ncbi request reprint Ursodeoxycholic acid treatment of vanishing bile duct syndromes
    Thomas Pusl
    Department of Medicine II, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    World J Gastroenterol 12:3487-95. 2006
  5. doi request reprint Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators?
    Ulrich Beuers
    Department of Gastroenterology and Hepatology, G4 213, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100, DE, Amsterdam, The Netherlands
    Clin Rev Allergy Immunol 36:52-61. 2009
  6. ncbi request reprint ABCB4 deficiency: A family saga of early onset cholelithiasis, sclerosing cholangitis and cirrhosis and a novel mutation in the ABCB4 gene
    Gerald U Denk
    Department of Medicine II Großhadern, University of Munich, Munich
    Hepatol Res 40:937-41. 2010
  7. doi request reprint Long-term LDL apheresis does not stably improve hemorheology in hypercholesterolemic patients with coronary artery disease
    Thomas Pusl
    Department of Internal Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany
    Clin Hemorheol Microcirc 41:137-42. 2009
  8. ncbi request reprint Pathogenesis and treatment of pruritus in cholestasis
    Andreas E Kremer
    Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drugs 68:2163-82. 2008
  9. doi request reprint Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis
    Thomas Pusl
    Department of Medicine II Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Biochem Biophys Res Commun 371:441-5. 2008
  10. doi request reprint Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis
    Johannes Stallhofer
    Department of Medicine II, Biometry and Epidemiology, University Hospital Munich Grosshadern, Munich, Germany
    Digestion 84:29-35. 2011

Collaborators

Detail Information

Publications15

  1. pmc Intrahepatic cholestasis of pregnancy
    Thomas Pusl
    Department of Gastroenterology and Hepatology, AMC, University of Amsterdam, The Netherlands
    Orphanet J Rare Dis 2:26. 2007
    ..Delivery has been recommended in the 38th week when lung maturity has been established...
  2. ncbi request reprint Plasma separation and anion adsorption transiently relieve intractable pruritus in primary biliary cirrhosis
    Thomas Pusl
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany
    J Hepatol 45:887-91. 2006
    ..The aim of this study was to assess the clinical efficacy of plasma separation and anion adsorption in the treatment of intractable pruritus of cholestasis...
  3. doi request reprint Tauroursodeoxycholic acid reduces bile acid-induced apoptosis by modulation of AP-1
    Thomas Pusl
    Department of Medicine II Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Biochem Biophys Res Commun 367:208-12. 2008
    ..These data suggest that reversal of bile acid-induced AP-1 activation may be relevant for the antiapoptotic effect of TUDCA in liver cells...
  4. ncbi request reprint Ursodeoxycholic acid treatment of vanishing bile duct syndromes
    Thomas Pusl
    Department of Medicine II, Klinikum Grosshadern, Marchioninistrasse 15, 81377 Munich, Germany
    World J Gastroenterol 12:3487-95. 2006
    ..Several potential mechanisms of action of UDCA have been proposed including stimulation of hepatobiliary secretion, inhibition of apoptosis and protection of cholangiocytes against toxic effects of hydrophobic bile acids...
  5. doi request reprint Medical treatment of primary sclerosing cholangitis: a role for novel bile acids and other (post-)transcriptional modulators?
    Ulrich Beuers
    Department of Gastroenterology and Hepatology, G4 213, Academic Medical Center, University of Amsterdam, P O Box 22700, 1100, DE, Amsterdam, The Netherlands
    Clin Rev Allergy Immunol 36:52-61. 2009
    ..In our view, the novel bile acid norUDCA and agonists of PPARs, VDR, and PXR appear particularly attractive for further studies in PSC...
  6. ncbi request reprint ABCB4 deficiency: A family saga of early onset cholelithiasis, sclerosing cholangitis and cirrhosis and a novel mutation in the ABCB4 gene
    Gerald U Denk
    Department of Medicine II Großhadern, University of Munich, Munich
    Hepatol Res 40:937-41. 2010
    ..Here we report on a family with ABCB4 deficiency and LPAC syndrome associated with a novel mutation (c.3203T>A) in the ABCB4 gene...
  7. doi request reprint Long-term LDL apheresis does not stably improve hemorheology in hypercholesterolemic patients with coronary artery disease
    Thomas Pusl
    Department of Internal Medicine II, Klinikum Grosshadern, University of Munich, Munich, Germany
    Clin Hemorheol Microcirc 41:137-42. 2009
    ..However, long-term apheresis had no sustained effect on plasma and whole blood viscosity. Our data indicate that in contrast to its beneficial short-term effects, long-term LDL apheresis does not stably improve hemorheology...
  8. ncbi request reprint Pathogenesis and treatment of pruritus in cholestasis
    Andreas E Kremer
    Liver Center, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Drugs 68:2163-82. 2008
    ....
  9. doi request reprint Free fatty acids sensitize hepatocytes to bile acid-induced apoptosis
    Thomas Pusl
    Department of Medicine II Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Biochem Biophys Res Commun 371:441-5. 2008
    ..Thus, low levels of cholestasis normally not considered harmful could advance liver injury in patients with NAFLD...
  10. doi request reprint Analysis of IL2/IL21 gene variants in cholestatic liver diseases reveals an association with primary sclerosing cholangitis
    Johannes Stallhofer
    Department of Medicine II, Biometry and Epidemiology, University Hospital Munich Grosshadern, Munich, Germany
    Digestion 84:29-35. 2011
    ....
  11. doi request reprint Medical treatment of cholestatic liver disease
    Gustav Paumgartner
    Department of Medicine II, Klinikum Grosshadern, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Clin Liver Dis 12:53-80, viii. 2008
    ..New drugs are being designed and tested along these lines and may be regarded as treatment opportunities of the future...
  12. ncbi request reprint Extrahepatic manifestations of cholestatic liver diseases: pathogenesis and therapy
    Thomas Pusl
    Department of Medicine II, Klinikum of the University of Munich Grosshadern, Munich, Germany
    Clin Rev Allergy Immunol 28:147-57. 2005
    ..This article provides treatment recommendations for the complications of cholestasis based on putative pathomechanisms and summarizes recent experimental and clinical data involving management options...
  13. ncbi request reprint The role of inositol 1,4,5-trisphosphate receptors in the regulation of bile secretion in health and disease
    Thomas Pusl
    Department of Medicine II, Klinikum of the University of Munich Grosshadern, 81377 Munich, Germany
    Biochem Biophys Res Commun 322:1318-25. 2004
    ..In addition, we review evidence that the InsP3R is lost from cholangiocytes in cholestatic forms of liver disease, and discuss this as a possible final common pathway for cholestasis...
  14. ncbi request reprint Biliary drainage transiently relieves intractable pruritus in primary biliary cirrhosis
    Ulrich Beuers
    Hepatology 44:280-1. 2006
  15. ncbi request reprint Intrahepatic cholestasis of pregnancy--a heterogeneous group of pregnancy-related disorders?
    Ulrich Beuers
    Hepatology 43:647-9. 2006