Ehrhardt Proksch

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi request reprint The management of dry skin with topical emollients--recent perspectives
    Ehrhardt Proksch
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitäts Hautklinik Kiel
    J Dtsch Dermatol Ges 3:768-74. 2005
  2. doi request reprint [New insights into the pathogenesis of sensitive skin]
    E Proksch
    Klinik fur Dermatologie, Venerologie und Allergologie, Univ Hautklinik, Universitatsklinikum Schleswig Holstein, Kiel, Deutschland
    Hautarzt 62:900-5. 2011
  3. doi request reprint [Aged-related principles of topical therapy]
    E Proksch
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 7, 24105, Kiel, Deutschland
    Hautarzt 65:192-6. 2014
  4. doi request reprint Abnormal epidermal barrier in the pathogenesis of contact dermatitis
    Ehrhardt Proksch
    Department of Dermatology, University of Kiel, Schittenhelmstr 7, Kiel 24105, Germany
    Clin Dermatol 30:335-44. 2012
  5. doi request reprint Presumptive frequency of, and review of reports on, allergies to household gloves
    E Proksch
    Department of Dermatology, University of Kiel, Germany
    J Eur Acad Dermatol Venereol 23:388-93. 2009
  6. ncbi request reprint Skin barrier function, epidermal proliferation and differentiation in eczema
    Ehrhardt Proksch
    Department of Dermatology, University of Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    J Dermatol Sci 43:159-69. 2006
  7. ncbi request reprint [Rational treatment of first-degree burns]
    E Proksch
    Universitäts Hautklinik, Schittenhelmstrasse 7, 24105 Kiel, Germany
    Hautarzt 58:604-10. 2007
  8. doi request reprint The role of emollients in the management of diseases with chronic dry skin
    E Proksch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Skin Pharmacol Physiol 21:75-80. 2008
  9. doi request reprint Protection against dryness of facial skin: a rational approach
    E Proksch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Skin Pharmacol Physiol 22:3-7. 2009
  10. ncbi request reprint The skin: an indispensable barrier
    Ehrhardt Proksch
    Department of Dermatology, University Hospitals of Schleswig Holstein, Kiel, Germany
    Exp Dermatol 17:1063-72. 2008

Collaborators

Detail Information

Publications48

  1. ncbi request reprint The management of dry skin with topical emollients--recent perspectives
    Ehrhardt Proksch
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitäts Hautklinik Kiel
    J Dtsch Dermatol Ges 3:768-74. 2005
    ..The ideal emollient will include these ingredients plus an agent to support epidermal differentiation. Selecting the correct emollient product and using it regularly are vital factors in the management of xerosis...
  2. doi request reprint [New insights into the pathogenesis of sensitive skin]
    E Proksch
    Klinik fur Dermatologie, Venerologie und Allergologie, Univ Hautklinik, Universitatsklinikum Schleswig Holstein, Kiel, Deutschland
    Hautarzt 62:900-5. 2011
    ..Of further importance for the pathogenesis are neurogenic factors including stress and hyper-excitability. Mechanisms in signal transduction involve cytokines and neurotransmitters, but the exact pathways are unknown...
  3. doi request reprint [Aged-related principles of topical therapy]
    E Proksch
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitatsklinikum Schleswig Holstein, Campus Kiel, Schittenhelmstr 7, 24105, Kiel, Deutschland
    Hautarzt 65:192-6. 2014
    ..In addition, range and cause of diseases varies considerably within age groups. Finally, the penetration of the active substance from creams and ointments may also change with age. ..
  4. doi request reprint Abnormal epidermal barrier in the pathogenesis of contact dermatitis
    Ehrhardt Proksch
    Department of Dermatology, University of Kiel, Schittenhelmstr 7, Kiel 24105, Germany
    Clin Dermatol 30:335-44. 2012
    ..Skin barrier repair is more complete after treatment with calcineurin inhibitors and bland lipid-based emollient; therefore, these preparations should be preferred for long-term treatment of contact dermatitis...
  5. doi request reprint Presumptive frequency of, and review of reports on, allergies to household gloves
    E Proksch
    Department of Dermatology, University of Kiel, Germany
    J Eur Acad Dermatol Venereol 23:388-93. 2009
    ..In contrast, very few articles have reported on latex allergy (type I) or allergic contact sensitization to additives (type IV) associated with household gloves, in spite of some 44 million pairs sold in Germany in, e.g., 2006...
  6. ncbi request reprint Skin barrier function, epidermal proliferation and differentiation in eczema
    Ehrhardt Proksch
    Department of Dermatology, University of Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    J Dermatol Sci 43:159-69. 2006
    ..Common treatment strategies for eczema include the application of lipid-based creams and ointments, which aim toward the restoration of the defective permeability barrier, thus helping to normalize proliferation and differentiation...
  7. ncbi request reprint [Rational treatment of first-degree burns]
    E Proksch
    Universitäts Hautklinik, Schittenhelmstrasse 7, 24105 Kiel, Germany
    Hautarzt 58:604-10. 2007
    ..Foam sprays and lotions are ideal because they are easy and painless to apply. The use of topical corticosteroids is not recommended, as superiority to the vehicle has not been shown...
  8. doi request reprint The role of emollients in the management of diseases with chronic dry skin
    E Proksch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Skin Pharmacol Physiol 21:75-80. 2008
    ..This review will explain the role of emollients within the management of diseases with dry skin as a major symptom and the components of an ideal emollient...
  9. doi request reprint Protection against dryness of facial skin: a rational approach
    E Proksch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Skin Pharmacol Physiol 22:3-7. 2009
    ..This review critically examines the scientific basis, rationale and evidence for inclusion of these ingredients in products for protection of facial skin...
  10. ncbi request reprint The skin: an indispensable barrier
    Ehrhardt Proksch
    Department of Dermatology, University Hospitals of Schleswig Holstein, Kiel, Germany
    Exp Dermatol 17:1063-72. 2008
    ..A disturbed skin barrier is important for the pathogenesis of contact dermatitis, ichthyosis, psoriasis and atopic dermatitis...
  11. ncbi request reprint Dexpanthenol enhances skin barrier repair and reduces inflammation after sodium lauryl sulphate-induced irritation
    E Proksch
    Department of Dermatology, University of Kieh Kiel, Germany
    J Dermatolog Treat 13:173-8. 2002
    ..Coenzyme A catalyses early steps in the synthesis of fatty acids and sphingolipids which are of crucial importance for stratum corneum lipid bilayers and cell membrane integrity...
  12. ncbi request reprint Bathing in a magnesium-rich Dead Sea salt solution improves skin barrier function, enhances skin hydration, and reduces inflammation in atopic dry skin
    Ehrhardt Proksch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Int J Dermatol 44:151-7. 2005
    ..Magnesium salts are known to bind water, influence epidermal proliferation and differentiation, and enhance permeability barrier repair...
  13. ncbi request reprint Toxicological evaluation of nitrosamines in condoms
    E Proksch
    Klinik fur Dermatologie, Venerologie und Allergologie, Universitat Kiel, Schittenhelmstr 7, D 24105 Kiel, Germany
    Int J Hyg Environ Health 204:103-10. 2001
    ..In summary, the risk for the induction of tumors from nitrosamines in condoms is very low...
  14. ncbi request reprint Skin lipids and epidermal differentiation in atopic dermatitis
    Ehrhardt Proksch
    Department of Dermatology, University of Kiel, Kiel, Germany
    Clin Dermatol 21:134-44. 2003
  15. doi request reprint Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Allergy Clin Immunol 123:1124-33. 2009
    ..It is essential that drugs applied to patients with AD restore the impaired epidermal barrier to prevent sensitization by environmental allergens...
  16. ncbi request reprint Barrier function, epidermal differentiation, and human beta-defensin 2 expression in tinea corporis
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 127:1720-7. 2007
    ..Together, we describe profound changes in skin barrier structure and function, epidermal proliferation, and differentiation including pronounced protein expression of hBD-2 in tinea corporis...
  17. ncbi request reprint Impaired sphingomyelinase activity and epidermal differentiation in atopic dermatitis
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 122:1423-31. 2004
    ..In summary, reduction in SMase-generating ceramides and impaired differentiation are involved in the defective barrier function found in AD...
  18. doi request reprint Murine filaggrin-2 is involved in epithelial barrier function and down-regulated in metabolically induced skin barrier dysfunction
    Britta Hansmann
    Department of Dermatology, University Hospital Schleswig Holstein, Campus Kiel, Germany
    Exp Dermatol 21:271-6. 2012
    ..These results suggest that filaggrin-2 may contribute to epidermal barrier function and its regulation differs, at least in parts, from that of filaggrin...
  19. doi request reprint Differential suppression of epidermal antimicrobial protein expression in atopic dermatitis and in EFAD mice by pimecrolimus compared to corticosteroids
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    Exp Dermatol 20:783-8. 2011
    ..This result may explain the clinical observation that prolonged treatment with topical corticosteroids sometimes leads to bacterial infection...
  20. ncbi request reprint Acid and neutral sphingomyelinase, ceramide synthase, and acid ceramidase activities in cutaneous aging
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Germany
    Exp Dermatol 14:609-18. 2005
    ..In contrast, A-SMase activity in the outer epidermis was unchanged, indicating that this enzyme is crucially involved in basal permeability barrier homeostasis...
  21. doi request reprint The antimicrobial protein psoriasin (S100A7) is upregulated in atopic dermatitis and after experimental skin barrier disruption
    Regine Gläser
    Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, Germany
    J Invest Dermatol 129:641-9. 2009
    ..coli. This indicates that the antimicrobial response in AD is not generally impaired, but greatly differs according to the type of AMP produced by the skin...
  22. doi request reprint IL-12 and IL-23 affect photocarcinogenesis differently
    Christian Jantschitsch
    Department of Dermatology, Christian Albrechts University Kiel, Kiel, Germany
    J Invest Dermatol 132:1479-86. 2012
    ..This may have impact on the development of future strategies utilizing antibodies against IL-12 and IL-23, respectively, for the treatment of inflammatory dermatoses...
  23. ncbi request reprint The interleukin-6 cytokine system regulates epidermal permeability barrier homeostasis
    Xu Ping Wang
    Department of Dermatology, University of Kiel, Germany
    J Invest Dermatol 123:124-31. 2004
    ..Our results indicate that the IL-6 cytokine system, particularly transsignalling via the soluble IL-6R, is critically involved in barrier repair after skin injury...
  24. doi request reprint ADAM10-mediated E-cadherin release is regulated by proinflammatory cytokines and modulates keratinocyte cohesion in eczematous dermatitis
    Thorsten Maretzky
    Biochemical Institute, Christian Albrecht University Kiel, Kiel, Germany
    J Invest Dermatol 128:1737-46. 2008
    ....
  25. ncbi request reprint Artificial barrier repair in wounds by semi-occlusive foils reduced wound contraction and enhanced cell migration and reepithelization in mouse skin
    Michael Schunck
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 125:1063-71. 2005
    ..In summary, we found that artificial barrier repair with semi-occlusive foils in wounds reduced wound contraction and enhanced cell migration and reepithelization without irritation...
  26. ncbi request reprint Constitutive expression and regulated release of the transmembrane chemokine CXCL16 in human and murine skin
    Felix Scholz
    Department of Dermatology, Venerology and Allergology, UKSH, Kiel, Germany
    J Invest Dermatol 127:1444-55. 2007
    ..Thus, CXCL16 is constitutively expressed on the surface of human epidermal keratinocytes, released upon cell activation or photodamage and may then target CXCR6-expressing T cells in the dermis...
  27. ncbi request reprint Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis
    Jens Michael Jensen
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Allergy Clin Immunol 124:R19-28. 2009
    ..Because pimecrolimus improved the epidermal barrier and did not cause atrophy, it might be more suitable for long-term treatment of AD...
  28. doi request reprint Role of the epidermal barrier in atopic dermatitis
    Ehrhardt Proksch
    Department of Dermatology, Venerology, and Allergology, University Clinic of Schleswig Holstein, Campus Kiel, University of Kiel, Germany
    J Dtsch Dermatol Ges 7:899-910. 2009
    ....
  29. doi request reprint Distinct roles of JNK-1 and ERK-2 isoforms in permeability barrier repair and wound healing
    Kathrin Koehler
    Department of Dermatology, University of Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    Eur J Cell Biol 90:565-71. 2011
    ..In summary, superficial and deep wound healing depends on the differential activity of MAP kinases such as JNK1 in epidermal differentiation and ERK2 in proliferation...
  30. doi request reprint Mechanical and metabolic injury to the skin barrier leads to increased expression of murine β-defensin-1, -3, and -14
    Kerstin Ahrens
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 131:443-52. 2011
    ..In summary, we demonstrated upregulation of mBD1, -3, and -14 after mechanically and metabolically induced skin barrier disruption, which may be an attempt to increase defense in the case of permeability barrier dysfunction...
  31. ncbi request reprint Cathepsin D is involved in the regulation of transglutaminase 1 and epidermal differentiation
    Friederike Egberts
    Department of Dermatology, University Hospital of Schleswig Holstein, Campus Kiel, 24105 Kiel, Germany
    J Cell Sci 117:2295-307. 2004
    ..Our findings suggest a functional link between cathepsin D activation, transglutaminase 1 activity and protein expression of cornified envelope proteins during epidermal differentiation...
  32. doi request reprint Effects of pimecrolimus compared with triamcinolone acetonide cream on skin barrier structure in atopic dermatitis: a randomized, double-blind, right-left arm trial
    Jens Michael Jensen
    Department of Dermatology, University Hospitals of Schleswig Holstein, University of Kiel, Schittenhelmstrasse 7, Kiel, Germany
    Acta Derm Venereol 93:515-9. 2013
    ..05); however, significantly less than with PIM (p < 0.05). Clinical score and TEWL were more improved after treatment with TA, whereas the lamellar bodies were more normal after treatment with PIM. ..
  33. doi request reprint Induction of regulatory T cells by a murine β-defensin
    Fatemeh Navid
    Department of Dermatology and Allergology, University of Kiel, 24105 Kiel, Germany
    J Immunol 188:735-43. 2012
    ....
  34. doi request reprint Infrared radiation does not enhance the frequency of ultraviolet radiation-induced skin tumors, but their growth behaviour in mice
    Christian Jantschitsch
    Department of Dermatology, University Kiel, Schittenhelmstrasse 7, Kiel, Germany
    Exp Dermatol 20:346-50. 2011
    ..Although IR may delay the onset of UVR-induced tumors, it might contribute to a worse outcome by shifting these tumors into a more aggressive phenotype...
  35. doi request reprint Treatment of acute radiodermatitis with an oil-in-water emulsion following radiation therapy for breast cancer: a controlled, randomized trial
    Jens Michael Jensen
    Department of Dermatology, University Hospitals of Schleswig Holstein, University of Kiel, Germany
    Strahlenther Onkol 187:378-84. 2011
    ..Dry skin is characterized by scaliness, epidermal barrier dysfunction, and reduced stratum corneum hydration, and these signs and symptoms are reduced by treatment with an emulsion...
  36. ncbi request reprint Matrix metalloproteinase-19 expression in normal and diseased skin: dysregulation by epidermal proliferation
    Thorsten Sadowski
    Institute of Biochemistry, University of Kiel, Kiel, Germany
    J Invest Dermatol 121:989-96. 2003
    ..The dysregulation of MMP-19 expression in epidermis suggests its possible involvement in the perpetuation of cutaneous infections and proliferative disorders such as psoriasis...
  37. ncbi request reprint Trypsin induces epidermal proliferation and inflammation in murine skin
    Ulf Meyer-Hoffert
    Department of Dermatology, University Kiel, Kiel, Germany
    Exp Dermatol 13:234-41. 2004
    ..Proliferation seems not to be signaled by PAR activation, but PAR-2-induced KC chemokine expression may contribute in part to trypsin-induced inflammation...
  38. ncbi request reprint Intraoral lesions associated with sebaceous nevus syndrome
    P H Warnke
    Department of Oral and Maxillofacial Surgery, University of Kiel, Kiel, Germany
    J Cutan Pathol 33:175-80. 2006
    ..Awareness of the potential presence or development of significant intraoral lesions in association with the sebaceous nevus syndrome is important for those involved in the care of patients with this syndrome...
  39. ncbi request reprint The skin's barrier
    J M Jensen
    Department of Dermatology, University Hospitals of Schleswig Holstein, University of Kiel, Kiel, Germany
    G Ital Dermatol Venereol 144:689-700. 2009
    ..A disturbed skin barrier is an important component in the pathogenesis of contact dermatitis, ichthyosis, psoriasis, and atopic dermatitis...
  40. pmc Mouse beta-defensin-14, an antimicrobial ortholog of human beta-defensin-3
    Kerstin Hinrichsen
    University Hospital Schleswig Holstein, Department of Dermatology, Campus Kiel, Schittenhelmstr 7, 24105 Kiel, Germany
    Antimicrob Agents Chemother 52:1876-9. 2008
    ..Treatment of keratinocytes with gamma interferon or transforming growth factor alpha increased mBD-14 gene expression. These data suggest that mBD-14 is the functional ortholog of hBD-3...
  41. pmc Impaired neutral sphingomyelinase activation and cutaneous barrier repair in FAN-deficient mice
    D Kreder
    Institute of Immunology, University of Kiel, Brunswiker Strasse 4, 24105 Kiel, Germany
    EMBO J 18:2472-9. 1999
    ..Although FAN exhibits striking structural homologies with the CHS/Beige proteins, FAN-deficient mice did not reproduce the phenotype of beige mice...
  42. ncbi request reprint Human leukocyte elastase induces keratinocyte proliferation in vitro and in vivo
    Christina Rogalski
    Department of Dermatology, University of Kiel, Kiel, Germany
    J Invest Dermatol 118:49-54. 2002
    ..These results may provide an explanation for the epidermal hyperproliferation observed in psoriasis...
  43. pmc Roles for tumor necrosis factor receptor p55 and sphingomyelinase in repairing the cutaneous permeability barrier
    J M Jensen
    Department of Dermatology, and Institute of Immunology, University of Kiel, 24105 Kiel, Germany
    J Clin Invest 104:1761-70. 1999
    ..Together, these results suggest that TNF-R55 signaling pathways contribute to cutaneous permeability barrier repair through SMase-mediated generation of ceramide...
  44. ncbi request reprint Matrix metalloproteinase 19 processes the laminin 5 gamma 2 chain and induces epithelial cell migration
    T Sadowski
    Institute of Biochemistry, University of Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
    Cell Mol Life Sci 62:870-80. 2005
    ..These data suggest that the MMP-19-dependent processing of the gamma2 chains leads to the integrin switch favoring epithelial migration and that MMP-19 actively participates in the early stages of SCC invasion...
  45. ncbi request reprint Impaired cutaneous permeability barrier function, skin hydration, and sphingomyelinase activity in keratin 10 deficient mice
    J M Jensen
    Department of Dermatology and Institute of Immunology, University of Kiel, Germany
    J Invest Dermatol 115:708-13. 2000
    ..In summary, our results demonstrate the crucial role of the keratin filament for permeability barrier function and stratum corneum hydration...
  46. ncbi request reprint Current epidemiological data from the German Registry of Adamantiades-Behçet's disease
    Ch C Zouboulis
    German Registry of Adamantiades Behçet s Disease, Department of Dermatology, University Medical Center Benjamin Franklin, The Free University of Berlin, Berlin, Germany
    Adv Exp Med Biol 528:43-8. 2003
  47. ncbi request reprint Epidemiological features of Adamantiades-Behçet's disease in Germany and in Europe
    C C Zouboulis
    German Registry of Adamantiades Behçet s Disease, Department of Dermatology, University Medical Center Benjamin Franklin, Free University of Berlin, Germany
    Yonsei Med J 38:411-22. 1997
    ..HLA-B5 was confirmed as a marker of severe prognosis. Cardiolipin autoantibodies were associated with cutaneous vasculitis and superficial thrombophlebitis was correlated with systemic vessel involvement...
  48. ncbi request reprint Disseminated porokeratosis palmaris and plantaris treated with imiquimod cream to prevent malignancy
    Jens Michael Jensen
    Acta Derm Venereol 85:550-1. 2005