Marco Prinz

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. doi Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    J Neuroimmunol 224:80-4. 2010
  2. doi Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
  3. doi Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    Marco Prinz
    Department of Neuropathology, University Hospital of Freiburg, Freiburg, Germany
    Nat Neurosci 14:1227-35. 2011
  4. pmc Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex
    Dorothee Aydin
    Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    BMC Genomics 12:160. 2011
  5. doi New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Trends Mol Med 16:379-86. 2010
  6. doi Microglia in the CNS: immigrants from another world
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Glia 59:177-87. 2011
  7. doi CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Brain 132:2487-500. 2009
  8. doi A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
    Tobias Goldmann
    1 Institute of Neuropathology, University of Freiburg, Freiburg, Germany 2
    Nat Neurosci 16:1618-26. 2013
  9. pmc Role of microglia in CNS autoimmunity
    Tobias Goldmann
    Institute of Neuropathology, University of Freiburg, Breisacher Straße 64, 79106 Freiburg, Germany
    Clin Dev Immunol 2013:208093. 2013
  10. doi Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to an increase in a CD133-positive cell population in human glioblastomas in vitro
    Ulf Dietrich Kahlert
    Division of Stereotactic Neurosurgery, University Freiburg Medical Center, Freiburg, Germany
    J Neuropathol Exp Neurol 71:1086-99. 2012

Collaborators

Detail Information

Publications24

  1. doi Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    J Neuroimmunol 224:80-4. 2010
    ..Therefore, these molecules present viable targets for therapeutic manipulations of myeloid cells destined for the CNS...
  2. doi Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
    ..In contrast, absence of IFNAR on myeloid cells led to severe disease with an enhanced effector phase and increased lethality, indicating a distinct protective function of type I IFNs during autoimmune inflammation of the CNS...
  3. doi Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    Marco Prinz
    Department of Neuropathology, University Hospital of Freiburg, Freiburg, Germany
    Nat Neurosci 14:1227-35. 2011
    ..On the basis of these new studies, we differentiate brain myeloid subtypes with regard to their origin, function and fate in the brain and illustrate the divergent features of these cells during neurodegeneration...
  4. pmc Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex
    Dorothee Aydin
    Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    BMC Genomics 12:160. 2011
    ..The γ-secretase-generated APP intracellular domain (AICD) functions as a transcriptional regulator in heterologous reporter assays although its role for endogenous gene regulation has remained controversial...
  5. doi New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Trends Mol Med 16:379-86. 2010
    ..The recent discovery of a novel T-cell subset, Th17 cells, sheds new light on type I IFNs in MS...
  6. doi Microglia in the CNS: immigrants from another world
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Glia 59:177-87. 2011
    ..These new aspects will be discussed in the present review...
  7. doi CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Brain 132:2487-500. 2009
    ..Collectively, these data indicate a disease-promoting role of CCR2+Ly-6Chi monocytes during autoimmune inflammation of the central nervous system...
  8. doi A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
    Tobias Goldmann
    1 Institute of Neuropathology, University of Freiburg, Freiburg, Germany 2
    Nat Neurosci 16:1618-26. 2013
    ..Thus, we found TAK1 to be pivotal in CNS autoimmunity, and we present a tool for future investigations of microglial function in the CNS. ..
  9. pmc Role of microglia in CNS autoimmunity
    Tobias Goldmann
    Institute of Neuropathology, University of Freiburg, Breisacher Straße 64, 79106 Freiburg, Germany
    Clin Dev Immunol 2013:208093. 2013
    ..Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention. ..
  10. doi Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to an increase in a CD133-positive cell population in human glioblastomas in vitro
    Ulf Dietrich Kahlert
    Division of Stereotactic Neurosurgery, University Freiburg Medical Center, Freiburg, Germany
    J Neuropathol Exp Neurol 71:1086-99. 2012
    ..These results suggest the possible efficacy of a novel therapy for glioblastoma focused on eradication of BTSCs by modifications of epigenetic regulation of gene expression...
  11. doi Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS
    Angela Dann
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 15:98-106. 2012
    ....
  12. doi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..Our data provide cellular and molecular insights into the origin and development of microglia...
  13. doi IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system
    Jenni Raasch
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Brain 134:1184-98. 2011
    ..Thus, therapies targeting IκB kinase 2 function in non-neuronal cells may represent a promising strategy for the treatment of distinct demyelinating central nervous system diseases...
  14. doi Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    J Neurosci 31:11159-71. 2011
    ..Together, our data advocate selective functions of CCR2-expressing myeloid subsets, which could be targeted specifically to modify disease burden in AD...
  15. ncbi Ly-6G+CCR2- myeloid cells rather than Ly-6ChighCCR2+ monocytes are required for the control of bacterial infection in the central nervous system
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    J Immunol 181:2713-22. 2008
    ....
  16. pmc Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias
    Katrin Kierdorf
    Institute of Neuropathology, University of Freiburg, Freiburg, Germany
    PLoS ONE 8:e58544. 2013
    ....
  17. doi Multi-focal occurrence of cortical dysplasia in epilepsy patients
    Susanne Fauser
    Epilepsy Center, Department of Neurosurgery, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 132:2079-90. 2009
    ..Based on genetic analysis and clinical features, multi-FCD in this patient series was not likely to be related to tuberous sclerosis...
  18. pmc Love and death: microglia, NLRP3 and the Alzheimer's brain
    Tobias Goldmann
    Institute of Neuropathology, University of Freiburg, Freiburg, Germany
    Cell Res 23:595-6. 2013
    ..A new report in Nature by the Heneka, Latz and Golenbock groups, however, sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration...
  19. doi How type I interferons shape myeloid cell function in CNS autoimmunity
    Stefanie M Brendecke
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    J Leukoc Biol 92:479-88. 2012
    ..This kind of approach would allow for replacing the current treatment strategy in MS of broadly and unselectively altering all immune responses, regardless of their beneficial or detrimental nature...
  20. doi Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
    Ulf D Kahlert
    Division of Stereotactic Neurosurgery, Department of General Neurosurgery, University Medical Center Freiburg, Freiburg, Germany
    Cancer Lett 325:42-53. 2012
    ..These findings suggest that canonical WNT/β-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target...
  21. doi Microglia as modulators of cognition and neuropsychiatric disorders
    Thomas Blank
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Glia 61:62-70. 2013
    ....
  22. doi IκB-ζ deficiency leaves epithelial cells high and dry
    Stefanie M Brendecke
    Institute of Neuropathology, University of Freiburg, 79100 Freiburg, Germany
    Immunity 38:404-6. 2013
    ..2013) demonstrate that tissue-specific dysfunction, namely deficiency of the transcriptional regulator IκB-ζ in epithelial cells, rather than hematopoietic cell pathology, is sufficient to elicit SS-like inflammation...
  23. pmc Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system
    Marco Prinz
    Department of Neuropathology, University Clinic Freiburg Freiburg, Germany
    Front Immunol 3:67. 2012
    ..Recently uncovered molecular and cellular mechanisms in the etiology of AGS and experimental autoimmune encephalomyelitis (EAE), the murine model of MS will be highlighted...
  24. doi mHERC6 is the essential ISG15 E3 ligase in the murine system
    Lars Ketscher
    University Clinic Freiburg, Department of Neuropathology, Freiburg im Breisgau, Germany
    Biochem Biophys Res Commun 417:135-40. 2012
    ..We demonstrate that mHERC6 is essential for endogenous murine ISGylation and thus represents the dominant ISG15 E3 ligase in mice. In contrast to its human homologue, mHERC6 is also capable to mediate conjugation of human ISG15...