Marco Prinz

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    J Neuroimmunol 224:80-4. 2010
  2. doi Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
  3. doi Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    Marco Prinz
    Department of Neuropathology, University Hospital of Freiburg, Freiburg, Germany
    Nat Neurosci 14:1227-35. 2011
  4. ncbi Microglia: unique and common features with other tissue macrophages
    Marco Prinz
    Institute of Neuropathology, University of Freiburg, Breisacher Str 64, 79106, Freiburg, Germany
    Acta Neuropathol 128:319-31. 2014
  5. pmc Role of microglia in CNS autoimmunity
    Tobias Goldmann
    Institute of Neuropathology, University of Freiburg, Breisacher Straße 64, 79106 Freiburg, Germany
    Clin Dev Immunol 2013:208093. 2013
  6. pmc Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system
    Marco Prinz
    Department of Neuropathology, University Clinic Freiburg Freiburg, Germany
    Front Immunol 3:67. 2012
  7. pmc Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias
    Katrin Kierdorf
    Institute of Neuropathology, University of Freiburg, Freiburg, Germany
    PLoS ONE 8:e58544. 2013
  8. pmc Factors regulating microglia activation
    Katrin Kierdorf
    Institute of Neuropathology, University of Freiburg Freiburg, Germany Faculty of Biology, University of Freiburg Freiburg, Germany
    Front Cell Neurosci 7:44. 2013
  9. pmc Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex
    Dorothee Aydin
    Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    BMC Genomics 12:160. 2011
  10. doi New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Trends Mol Med 16:379-86. 2010

Collaborators

Detail Information

Publications34

  1. ncbi Tickets to the brain: role of CCR2 and CX3CR1 in myeloid cell entry in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    J Neuroimmunol 224:80-4. 2010
    ..Therefore, these molecules present viable targets for therapeutic manipulations of myeloid cells destined for the CNS...
  2. doi Distinct and nonredundant in vivo functions of IFNAR on myeloid cells limit autoimmunity in the central nervous system
    Marco Prinz
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    Immunity 28:675-86. 2008
    ..In contrast, absence of IFNAR on myeloid cells led to severe disease with an enhanced effector phase and increased lethality, indicating a distinct protective function of type I IFNs during autoimmune inflammation of the CNS...
  3. doi Heterogeneity of CNS myeloid cells and their roles in neurodegeneration
    Marco Prinz
    Department of Neuropathology, University Hospital of Freiburg, Freiburg, Germany
    Nat Neurosci 14:1227-35. 2011
    ..On the basis of these new studies, we differentiate brain myeloid subtypes with regard to their origin, function and fate in the brain and illustrate the divergent features of these cells during neurodegeneration...
  4. ncbi Microglia: unique and common features with other tissue macrophages
    Marco Prinz
    Institute of Neuropathology, University of Freiburg, Breisacher Str 64, 79106, Freiburg, Germany
    Acta Neuropathol 128:319-31. 2014
    ..Here, we discuss new aspects of myeloid cell biology in general with special emphasis on the brain-resident macrophages and microglia. ..
  5. pmc Role of microglia in CNS autoimmunity
    Tobias Goldmann
    Institute of Neuropathology, University of Freiburg, Breisacher Straße 64, 79106 Freiburg, Germany
    Clin Dev Immunol 2013:208093. 2013
    ..Hence, understanding microglia involvement in MS offers new exciting paths for therapeutic intervention. ..
  6. pmc Type I interferons as ambiguous modulators of chronic inflammation in the central nervous system
    Marco Prinz
    Department of Neuropathology, University Clinic Freiburg Freiburg, Germany
    Front Immunol 3:67. 2012
    ..Recently uncovered molecular and cellular mechanisms in the etiology of AGS and experimental autoimmune encephalomyelitis (EAE), the murine model of MS will be highlighted...
  7. pmc Bone marrow cell recruitment to the brain in the absence of irradiation or parabiosis bias
    Katrin Kierdorf
    Institute of Neuropathology, University of Freiburg, Freiburg, Germany
    PLoS ONE 8:e58544. 2013
    ....
  8. pmc Factors regulating microglia activation
    Katrin Kierdorf
    Institute of Neuropathology, University of Freiburg Freiburg, Germany Faculty of Biology, University of Freiburg Freiburg, Germany
    Front Cell Neurosci 7:44. 2013
    ..In this review, we discuss recent achievements that gave new insights into mechanisms that ensure microglia quiescence...
  9. pmc Comparative transcriptome profiling of amyloid precursor protein family members in the adult cortex
    Dorothee Aydin
    Department of Bioinformatics and Functional Genomics, Institute of Pharmacy and Molecular Biotechnology, Heidelberg University, Im Neuenheimer Feld 364, D 69120 Heidelberg, Germany
    BMC Genomics 12:160. 2011
    ..The γ-secretase-generated APP intracellular domain (AICD) functions as a transcriptional regulator in heterologous reporter assays although its role for endogenous gene regulation has remained controversial...
  10. doi New lessons about old molecules: how type I interferons shape Th1/Th17-mediated autoimmunity in the CNS
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Trends Mol Med 16:379-86. 2010
    ..The recent discovery of a novel T-cell subset, Th17 cells, sheds new light on type I IFNs in MS...
  11. doi Microglia in the CNS: immigrants from another world
    Marco Prinz
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Glia 59:177-87. 2011
    ..These new aspects will be discussed in the present review...
  12. ncbi CCR2+Ly-6Chi monocytes are crucial for the effector phase of autoimmunity in the central nervous system
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Brain 132:2487-500. 2009
    ..Collectively, these data indicate a disease-promoting role of CCR2+Ly-6Chi monocytes during autoimmune inflammation of the central nervous system...
  13. ncbi Microglia in the adult brain arise from Ly-6ChiCCR2+ monocytes only under defined host conditions
    Alexander Mildner
    Institute of Neuropathology, Georg August University, Gottingen, Germany
    Nat Neurosci 10:1544-53. 2007
    ..Our results identify Ly-6C(hi)CCR2(+) monocytes as direct precursors of microglia in the adult brain and establish the importance of local factors in the adult CNS for microglia engraftment...
  14. ncbi Ly-6G+CCR2- myeloid cells rather than Ly-6ChighCCR2+ monocytes are required for the control of bacterial infection in the central nervous system
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    J Immunol 181:2713-22. 2008
    ....
  15. doi Type I interferon receptor signalling is induced during demyelination while its function for myelin damage and repair is redundant
    Hauke Schmidt
    Institute of Neuropathology, University Medical Center, Georg August University, Gottingen, Germany
    Exp Neurol 216:306-11. 2009
    ..Finally, myelin recovery was found to be independent from endogenous IFNAR signalling, indicating a redundant role of this receptor for non-inflammatory myelin damage and repair...
  16. doi Distinct and non-redundant roles of microglia and myeloid subsets in mouse models of Alzheimer's disease
    Alexander Mildner
    Department of Neuropathology, University of Freiburg, D 79106 Freiburg, Germany
    J Neurosci 31:11159-71. 2011
    ..Together, our data advocate selective functions of CCR2-expressing myeloid subsets, which could be targeted specifically to modify disease burden in AD...
  17. doi Resistance to hypoxia-induced, BNIP3-mediated cell death contributes to an increase in a CD133-positive cell population in human glioblastomas in vitro
    Ulf Dietrich Kahlert
    Division of Stereotactic Neurosurgery, University Freiburg Medical Center, Freiburg, Germany
    J Neuropathol Exp Neurol 71:1086-99. 2012
    ..These results suggest the possible efficacy of a novel therapy for glioblastoma focused on eradication of BTSCs by modifications of epigenetic regulation of gene expression...
  18. doi A new type of microglia gene targeting shows TAK1 to be pivotal in CNS autoimmune inflammation
    Tobias Goldmann
    1 Institute of Neuropathology, University of Freiburg, Freiburg, Germany 2
    Nat Neurosci 16:1618-26. 2013
    ..Thus, we found TAK1 to be pivotal in CNS autoimmunity, and we present a tool for future investigations of microglial function in the CNS. ..
  19. ncbi Microglia emerge from erythromyeloid precursors via Pu.1- and Irf8-dependent pathways
    Katrin Kierdorf
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 16:273-80. 2013
    ..Our data provide cellular and molecular insights into the origin and development of microglia...
  20. pmc IkappaB kinase 2 determines oligodendrocyte loss by non-cell-autonomous activation of NF-kappaB in the central nervous system
    Jenni Raasch
    Department of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106 Freiburg, Germany
    Brain 134:1184-98. 2011
    ..Thus, therapies targeting IκB kinase 2 function in non-neuronal cells may represent a promising strategy for the treatment of distinct demyelinating central nervous system diseases...
  21. doi Cytosolic RIG-I-like helicases act as negative regulators of sterile inflammation in the CNS
    Angela Dann
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Nat Neurosci 15:98-106. 2012
    ....
  22. doi CD14 and TRIF govern distinct responsiveness and responses in mouse microglial TLR4 challenges by structural variants of LPS
    Tommy Regen
    Institute of Neuropathology, University of Gottingen, Germany
    Brain Behav Immun 25:957-70. 2011
    ..It thus proves as a sophisticated decision maker in infectious and non-infectious CNS challenges...
  23. pmc Love and death: microglia, NLRP3 and the Alzheimer's brain
    Tobias Goldmann
    Institute of Neuropathology, University of Freiburg, Freiburg, Germany
    Cell Res 23:595-6. 2013
    ..A new report in Nature by the Heneka, Latz and Golenbock groups, however, sheds new light on these distinct myeloid cells by revealing their deadly nature for mature neurons during neurodegeneration...
  24. pmc Innate immunity mediated by TLR9 modulates pathogenicity in an animal model of multiple sclerosis
    Marco Prinz
    Institute of Neuropathology, Georg August University, Gottingen, Germany
    J Clin Invest 116:456-64. 2006
    ..Our data clearly demonstrate that both TLR9 and MyD88 are essential modulators of the autoimmune process during the effector phase of disease and suggest that endogenous "danger signals" modulate the disease pathogenesis...
  25. ncbi Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease
    Marco Prinz
    1 Institute of Neuropathology, University of Freiburg, Breisacherstraße 64, 79106 Freiburg, Germany 2 BIOSS Centre for Biological Signalling Studies, University of Freiburg, 79104 Freiburg, Germany
    Nat Rev Neurosci 15:300-12. 2014
    ....
  26. ncbi Multi-focal occurrence of cortical dysplasia in epilepsy patients
    Susanne Fauser
    Epilepsy Center, Department of Neurosurgery, University of Freiburg, Breisacher Strasse 64, 79106 Freiburg, Germany
    Brain 132:2079-90. 2009
    ..Based on genetic analysis and clinical features, multi-FCD in this patient series was not likely to be related to tuberous sclerosis...
  27. ncbi Activation of canonical WNT/β-catenin signaling enhances in vitro motility of glioblastoma cells by activation of ZEB1 and other activators of epithelial-to-mesenchymal transition
    Ulf D Kahlert
    Division of Stereotactic Neurosurgery, Department of General Neurosurgery, University Medical Center Freiburg, Freiburg, Germany
    Cancer Lett 325:42-53. 2012
    ..These findings suggest that canonical WNT/β-catenin pathway is a critical regulator of GBM invasion and may represent a potential therapeutic target...
  28. ncbi How type I interferons shape myeloid cell function in CNS autoimmunity
    Stefanie M Brendecke
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    J Leukoc Biol 92:479-88. 2012
    ..This kind of approach would allow for replacing the current treatment strategy in MS of broadly and unselectively altering all immune responses, regardless of their beneficial or detrimental nature...
  29. doi mHERC6 is the essential ISG15 E3 ligase in the murine system
    Lars Ketscher
    University Clinic Freiburg, Department of Neuropathology, Freiburg im Breisgau, Germany
    Biochem Biophys Res Commun 417:135-40. 2012
    ..We demonstrate that mHERC6 is essential for endogenous murine ISGylation and thus represents the dominant ISG15 E3 ligase in mice. In contrast to its human homologue, mHERC6 is also capable to mediate conjugation of human ISG15...
  30. ncbi Microglia fuel the learning brain
    Thomas Blank
    Institute of Neuropathology, University of Freiburg, Breisacher Straße 64, 79106 Freiburg, Germany
    Trends Immunol 35:139-40. 2014
    ..A recent paper in Cell shows that the specific depletion of microglia causes deficits in learning-induced synaptic remodeling through paucity of the microglial neurotrophin brain-derived neurotrophic factor (BDNF). ..
  31. ncbi Glial epigenetics in neuroinflammation and neurodegeneration
    Ori Staszewski
    Institute of Neuropathology, University of Freiburg, Breisacher Str 64, D 79106, Freiburg, Germany
    Cell Tissue Res 356:609-16. 2014
    ..This review offers an overview of the current understanding of epigenetic regulation in glial cells in CNS disease...
  32. doi To be or not to be accepted: the role of immunogenicity of neural stem cells following transplantation into the brain in animal and human studies
    Philipp Capetian
    Laboratory of Molecular Neurosurgery, Department of Stereotactic and Functional Neurosurgery, Neurocenter, University Medical Center Freiburg, Breisacher Str 64, 79106, Freiburg, Germany
    Semin Immunopathol 33:619-26. 2011
    ..Implications of these findings on neural grafting and potential new therapeutic applications are discussed...
  33. doi Microglia as modulators of cognition and neuropsychiatric disorders
    Thomas Blank
    Department of Neuropathology, University of Freiburg, Freiburg, Germany
    Glia 61:62-70. 2013
    ....
  34. doi IκB-ζ deficiency leaves epithelial cells high and dry
    Stefanie M Brendecke
    Institute of Neuropathology, University of Freiburg, 79100 Freiburg, Germany
    Immunity 38:404-6. 2013
    ..2013) demonstrate that tissue-specific dysfunction, namely deficiency of the transcriptional regulator IκB-ζ in epithelial cells, rather than hematopoietic cell pathology, is sufficient to elicit SS-like inflammation...