K T Preissner

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. ncbi request reprint Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension
    Fotini M Kouri
    Department of Medicine II, University of Giessen Lung Center UGLC, Justus Liebig University, Giessen, Germany
    Int J Biochem Cell Biol 40:1872-82. 2008
  2. pmc Hyperglycemia impairs proteasome function by methylglyoxal
    Markus A Queisser
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    Diabetes 59:670-8. 2010
  3. pmc Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones
    Mona Saffarzadeh
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    PLoS ONE 7:e32366. 2012
  4. ncbi request reprint [Physiology of blood coagulation and fibrinolysis: biochemistry]
    K T Preissner
    Institut fur Biochemie, Fachbereich Medizin, Justus Liebig Universitat, Friedrichstr 24, 35392 Giessen
    Hamostaseologie 28:259-71. 2008
  5. ncbi request reprint [Biochemistry and physiology of blood coagulation and fibrinolysis]
    K T Preissner
    Institut fur Biochemie, Fachbereich Medizin, Justus Liebig Universitat, Friedrichstrasse 24, 35392 Giessen
    Hamostaseologie 24:84-93. 2004
  6. ncbi request reprint Extracellular RNA. A new player in blood coagulation and vascular permeability
    K T Preissner
    Institut fur Biochemie, Fachbereich Medizin, Justus Liebig Universitat, Friedrichstrasse 24, 35392 Giessen, Germany
    Hamostaseologie 27:373-7. 2007
  7. ncbi request reprint Hemostatic protease receptors and endothelial cell function: insights from gene targeting in mice
    K T Preissner
    Institute for Biochemistry, Fachbereich Humanmedizin, Justus Liebig Universitat, Giessen, Germany
    Semin Thromb Hemost 26:451-62. 2000
  8. ncbi request reprint Urokinase receptor: a molecular organizer in cellular communication
    K T Preissner
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, Friedrichstrasse 24, D 35392, Giessen, Germany
    Curr Opin Cell Biol 12:621-8. 2000
  9. ncbi request reprint The role of multifunctional adhesion molecules in spermatogenesis and sperm function: Lessons from hemostasis and defense?
    Klaus T Preissner
    Department of Biochemistry, Medical School, Justus Liebig University, Giessen, Germany
    Semin Thromb Hemost 33:100-10. 2007
  10. ncbi request reprint Vascular protease receptors: integrating haemostasis and endothelial cell functions
    K T Preissner
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, D 35392 Giessen, Germany
    J Pathol 190:360-72. 2000

Detail Information

Publications106 found, 100 shown here

  1. ncbi request reprint Plasminogen activator inhibitor type 1 inhibits smooth muscle cell proliferation in pulmonary arterial hypertension
    Fotini M Kouri
    Department of Medicine II, University of Giessen Lung Center UGLC, Justus Liebig University, Giessen, Germany
    Int J Biochem Cell Biol 40:1872-82. 2008
    ....
  2. pmc Hyperglycemia impairs proteasome function by methylglyoxal
    Markus A Queisser
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    Diabetes 59:670-8. 2010
    ..In this study, the influence of MGO-derived advanced glycation end product (AGE) formation on the activity of the proteasome was investigated in vitro and in vivo...
  3. pmc Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones
    Mona Saffarzadeh
    School of Medicine, Institute of Biochemistry, Justus Liebig University, Giessen, Germany
    PLoS ONE 7:e32366. 2012
    ..These data reveal the important role of protein components in NET, particularly histones, which may lead to host cell cytotoxicity and may be involved in lung tissue destruction...
  4. ncbi request reprint [Physiology of blood coagulation and fibrinolysis: biochemistry]
    K T Preissner
    Institut fur Biochemie, Fachbereich Medizin, Justus Liebig Universitat, Friedrichstr 24, 35392 Giessen
    Hamostaseologie 28:259-71. 2008
    ..The understanding of these relationships in complications of haemostasis has lead to different strategies for the therapeutic intervention with pro- and anticoagulant substances...
  5. ncbi request reprint [Biochemistry and physiology of blood coagulation and fibrinolysis]
    K T Preissner
    Institut fur Biochemie, Fachbereich Medizin, Justus Liebig Universitat, Friedrichstrasse 24, 35392 Giessen
    Hamostaseologie 24:84-93. 2004
    ..The understanding of these relationships in complications of haemostasis has led to different available strategies for the therapeutic intervention with pro- and anticoagulant substances...
  6. ncbi request reprint Extracellular RNA. A new player in blood coagulation and vascular permeability
    K T Preissner
    Institut fur Biochemie, Fachbereich Medizin, Justus Liebig Universitat, Friedrichstrasse 24, 35392 Giessen, Germany
    Hamostaseologie 27:373-7. 2007
    ....
  7. ncbi request reprint Hemostatic protease receptors and endothelial cell function: insights from gene targeting in mice
    K T Preissner
    Institute for Biochemistry, Fachbereich Humanmedizin, Justus Liebig Universitat, Giessen, Germany
    Semin Thromb Hemost 26:451-62. 2000
    ....
  8. ncbi request reprint Urokinase receptor: a molecular organizer in cellular communication
    K T Preissner
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, Friedrichstrasse 24, D 35392, Giessen, Germany
    Curr Opin Cell Biol 12:621-8. 2000
    ....
  9. ncbi request reprint The role of multifunctional adhesion molecules in spermatogenesis and sperm function: Lessons from hemostasis and defense?
    Klaus T Preissner
    Department of Biochemistry, Medical School, Justus Liebig University, Giessen, Germany
    Semin Thromb Hemost 33:100-10. 2007
    ..We explore the multifunctional roles of junctional adhesion molecules, nectins, integrins, ECM proteins, and others beyond their role in defense and hemostasis as important contributors in spermatogenesis and sperm function...
  10. ncbi request reprint Vascular protease receptors: integrating haemostasis and endothelial cell functions
    K T Preissner
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, D 35392 Giessen, Germany
    J Pathol 190:360-72. 2000
    ....
  11. doi request reprint From molecules to medicine: new horizons in vascular biology and thrombosis
    Klaus T Preissner
    Institute for Biochemistry, Justus Liebig University, Friedrichstrasse 24, Giessen, D 35392 Germany E mail
    Thromb Haemost 99:251-2. 2008
  12. doi request reprint Vitronectin in vascular context: facets of a multitalented matricellular protein
    Klaus T Preissner
    Department of Biochemistry, Medical School, Justus Liebig University, Giessen, Germany
    Semin Thromb Hemost 37:408-24. 2011
    ....
  13. ncbi request reprint Regulation of leukocyte recruitment by polypeptides derived from high molecular weight kininogen
    T Chavakis
    Institute for Biochemistry, and, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
    FASEB J 15:2365-76. 2001
    ....
  14. ncbi request reprint Haemostatic factors occupy new territory: the role of the urokinase receptor system and kininogen in inflammation
    T Chavakis
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, Friedrichstrasse 24, D 35392 Giessen, Germany
    Biochem Soc Trans 30:168-73. 2002
    ..Targeting the uPAR system may allow specific therapeutic intervention in vascular pathologies...
  15. ncbi request reprint Role of coagulation and fibrinolysis in lung and renal fibrosis
    C Ruppert
    University of Giessen Lung Center, Klinikstrasse 36, 35392 Giessen, Germany
    Hamostaseologie 28:30-2, 34-6. 2008
    ..In view of experiments obtained in animal models of lung and renal fibrosis, the potential therapeutic usefulness of anticoagulant or profibrinolytic strategies is discussed...
  16. ncbi request reprint Regulation of neovascularization by human neutrophil peptides (alpha-defensins): a link between inflammation and angiogenesis
    Triantafyllos Chavakis
    Institute for Biochemistry, Justus Liebig Universitat, Giessen, Germany
    FASEB J 18:1306-8. 2004
    ..These findings provide new insight into the role of inflammatory cells in angiogenesis and might provide a platform for developing a novel class of anti-angiogenesis drugs...
  17. ncbi request reprint The neutrophil-specific antigen CD177 is a counter-receptor for platelet endothelial cell adhesion molecule-1 (CD31)
    Ulrich J H Sachs
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, Langhansstrasse 7, Giessen D 35392, Germany
    J Biol Chem 282:23603-12. 2007
    ..Our findings provide direct evidence that neutrophil-specific CD177 is a heterophilic binding partner of PECAM-1. This interaction may constitute a new pathway that participates in neutrophil transmigration...
  18. pmc The G534E polymorphism of the gene encoding the factor VII-activating protease is associated with cardiovascular risk due to increased neointima formation
    Daniel Sedding
    Institute for Biochemistry, Justus Liebig University, 35392 Giessen, Germany
    J Exp Med 203:2801-7. 2006
    ..Hence, FSAP has a protective function in the vasculature, and analysis of MI polymorphism is likely to be clinically relevant in restenosis...
  19. ncbi request reprint Release of soluble urokinase receptor from vascular cells
    T Chavakis
    Biochemisches Institut, Fachbereich Humanmedizin, Giessen, Germany
    Thromb Haemost 86:686-93. 2001
    ....
  20. ncbi request reprint Molecular interactions and functional interference between vitronectin and transforming growth factor-beta
    Michael Schoppet
    Department of Biochemistry, Justus Liebig University, Friedrichstrasse 24, D 35392 Giessen, Germany
    Lab Invest 82:37-46. 2002
    ..These findings describe VN as a new binding protein for TGF-beta, whereby specific functions of both factors become modulated by this interaction...
  21. ncbi request reprint The functional role of blood platelet components in angiogenesis
    Joong Sup Rhee
    Biochemisches Institut, Fachbereich Medizin, Justus Liebig Universitat, Giessen, Germany
    Thromb Haemost 92:394-402. 2004
    ..Based on this proangiogenic role of platelets in neovascularization, anti-platelet substances can be considered as potent inhibitors of angiogenesis...
  22. ncbi request reprint Induction of apoptosis in vascular cells by plasminogen activator inhibitor-1 and high molecular weight kininogen correlates with their anti-adhesive properties
    Nadia Al-Fakhri
    Institute of Clinical Chemistry and Pathobiochemistry, Justus Liebig University, Gaffkystrasse 11, D 35392 Giessen, Germany
    Biol Chem 384:423-35. 2003
    ..Co-distribution of apoptosis with plasminogen activation system components in atherosclerosis exemplifies the significance of anti-adhesive mechanisms and apoptosis for tissue remodeling, such as in neointima development...
  23. ncbi request reprint New aspects of integrin-mediated leukocyte adhesion in inflammation: regulation by haemostatic factors and bacterial products
    Joong Sup Rhee
    Institute for Biochemistry, Medical Faculty, Justus Liebig University, Giessen, Germany
    Curr Mol Med 3:387-92. 2003
    ..The better understanding of the interactions between vascular cells and particularly of integrin-dependent leukocyte adhesion may lead to the development of novel therapeutical concepts in inflammatory vascular disorders...
  24. pmc Nucleic acids potentiate Factor VII-activating protease (FSAP)-mediated cleavage of platelet-derived growth factor-BB and inhibition of vascular smooth muscle cell proliferation
    Aya Shibamiya
    Institute for Biochemistry, Medical Faculty, Justus Liebig University, 35392 Giessen, Germany
    Biochem J 404:45-50. 2007
    ..These data are relevant to situations where extracellular nucleic acids released from necrotic or apoptotic cells could activate local FSAP, leading to inhibition of PDGF-BB...
  25. ncbi request reprint Angiogenic capacity of endothelial cells in islets of Langerhans
    T Linn
    Medical Clinic and Policlinic 3, Justus Liebig University Giessen, Rodthohl 6, 35392 Giessen, Germany
    FASEB J 17:881-3. 2003
    ..These graft-related endothelia persist after islet transplantation and are integrated within newly formed microvessels...
  26. ncbi request reprint Endothelial survival factors and spatial completion, but not pericyte coverage of retinal capillaries determine vessel plasticity
    J Hoffmann
    Medical Clinic and Policlinic 3, Justus Liebig University Giessen, Giessen, Germany
    FASEB J 19:2035-6. 2005
    ....
  27. pmc A positively charged cluster in the epidermal growth factor-like domain of Factor VII-activating protease (FSAP) is essential for polyanion binding
    Boran Altincicek
    Biochemisches Institut, Justus Liebig Universitat Giessen, Friedrichstrasse 24, D 35392 Giessen, Germany
    Biochem J 394:687-92. 2006
    ..The identification of polyanion-binding sites will help to define the role of FSAP in the vasculature...
  28. doi request reprint High negative charge-to-size ratio in polyphosphates and heparin regulates factor VII-activating protease
    Lars Muhl
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    FEBS J 276:4828-39. 2009
    ..Hence, negatively charged polymers with a high charge-to-size ratio are responsible for the activation of FSAP, and also act as co-factors for its inhibition by serine protease inhibitors...
  29. doi request reprint Enolase-1 promotes plasminogen-mediated recruitment of monocytes to the acutely inflamed lung
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Giessen, Germany
    Blood 113:5588-98. 2009
    ..These data suggest an important mechanism of inflammatory cell invasion mediated by increased cell-surface expression of ENO-1...
  30. ncbi request reprint The dual role of the urokinase receptor system in pericellular proteolysis and cell adhesion: implications for cardiovascular function
    K T Preissner
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, Giessen, Germany
    Basic Res Cardiol 94:315-21. 1999
    ..This article will focus on the molecular and functional interactions between the uPAR system and vascular integrins and discuss implications for cardiovascular function...
  31. ncbi request reprint Different mechanisms define the antiadhesive function of high molecular weight kininogen in integrin- and urokinase receptor-dependent interactions
    T Chavakis
    Institute for Biochemistry and the Department of Internal Medicine, Justus Liebig University, Giessen, Germany
    Blood 96:514-22. 2000
    ..Blood. 2000;96:514-522)..
  32. doi request reprint Expression and localisation of vascular ribonucleases in endothelial cells
    Silvia Fischer
    Department of Biochemistry, Justus Liebig University, Giessen, Germany
    Thromb Haemost 105:345-55. 2011
    ..Our results indicate that vascular RNase1 and RNase5 are mainly produced by vascular endothelial cells and can serve, depending on the vascular bed, different functions in vascular homeostasis and endothelial cell responses...
  33. ncbi request reprint Recombinant production of a hybrid plasminogen activator composed of surfactant protein B and low-molecular-weight urokinase
    Clemens Ruppert
    Department of Internal Medicine, University of Giessen Lung Center, Giessen, Germany
    Thromb Haemost 100:1185-92. 2008
    ..We conclude that recombinant production of a fusion protein consisting of mature SP-B and uPA is feasible, when the SP-B moiety is fused to the C-terminus of urokinase...
  34. ncbi request reprint Binding of urokinase plasminogen activator to gp130 via a putative urokinase-binding consensus sequence
    Olin D Liang
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, Friedrichstr 24, D 35392 Giessen, Germany
    Biol Chem 384:229-36. 2003
    ..The association of gp130 with uPA may link the uPA-uPAR system to various signal transduction pathways...
  35. ncbi request reprint Factor VII-activating protease (FSAP) inhibits growth factor-mediated cell proliferation and migration of vascular smooth muscle cells
    Christian Kannemeier
    Institute for Biochemistry, Justus Liebig University Giessen, Giessen, Germany
    FASEB J 18:728-30. 2004
    ..These results unravel a new function of FSAP as an inhibitor of the proatherogenic phenotype of vascular smooth muscle...
  36. ncbi request reprint Cellular origin of pro-coagulant and (anti)-fibrinolytic factors in bleomycin-injured lungs
    M Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Klinikstr 36, 35392 Giessen, Germany
    Eur Respir J 29:1105-14. 2007
    ..Alveolar macrophages and, to a lesser extent, alveolar type II cells are the main sources of locally produced pro-coagulant and anti-fibrinolytic factors in bleomycin-injured lungs...
  37. ncbi request reprint Identification of CML-modified proteins in hemofiltrate of diabetic patients by proteome analysis
    S Schmitt
    Department of Biochemistry, Justus Liebig University, Medical Faculty, Giessen, Germany
    Exp Clin Endocrinol Diabetes 116:26-34. 2008
    ....
  38. ncbi request reprint Ligand binding regions in the receptor for urokinase-type plasminogen activator
    O D Liang
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Leipzig Universität, Giessen, Germany
    J Biol Chem 276:28946-53. 2001
    ..These results indicate that uPA binding can take place to particular part(s) on several uPAR molecules and that direct uPAR-uPAR contacts may contribute to receptor activation and ligand binding...
  39. ncbi request reprint Induction of vascular SMC proliferation by urokinase indicates a novel mechanism of action in vasoproliferative disorders
    S M Kanse
    Max Planck Institute, Kerckhoff Klinik, Bad Nauheim, Germany
    Arterioscler Thromb Vasc Biol 17:2848-54. 1997
    ....
  40. ncbi request reprint New autoantibodies in pediatric opsoclonus myoclonus syndrome
    A Kirsten
    Institute of Biochemistry, Faculty of Medicine, Friedrichstrasse 24, Justus Liebig University, D 35392 Giessen, Germany
    Ann N Y Acad Sci 1110:256-60. 2007
    ..Antiproliferative and proapoptotic effects of these autoantibodies on neuroblastoma cell lines were noted as well. These results support the concept of a humoral autoimmune process in the pathogenesis of OMS...
  41. doi request reprint Factor VII-activating protease (FSAP): vascular functions and role in atherosclerosis
    Sandip M Kanse
    Department of Biochemistry, Medical School, Justus Liebig University, Friedrichstrasse 24, Giessen, Germany
    Thromb Haemost 99:286-9. 2008
    ..In this review the contribution of FSAP to vascular fibroproliferative inflammatory diseases in the context of pericellular proteolysis of the extracellular matrix, growth factor activity and haemostasis will be highlighted...
  42. doi request reprint Current view on alveolar coagulation and fibrinolysis in acute inflammatory and chronic interstitial lung diseases
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Thromb Haemost 99:494-501. 2008
    ..In the current article, the role of the alveolar coagulation and fibrinolysis systems in acute inflammatory and chronic interstitial lung diseases is discussed with regard to pathomechanisms and modalities of intervention...
  43. ncbi request reprint Signaling mechanism of extracellular RNA in endothelial cells
    Silvia Fischer
    Department of Biochemistry, Medical School Justus Liebig Universität, Friedrichstrasse 24, D 35392 Giessen, Germany
    FASEB J 23:2100-9. 2009
    ....
  44. pmc Inhibition of PDGF-BB by Factor VII-activating protease (FSAP) is neutralized by protease nexin-1, and the FSAP-inhibitor complexes are internalized via LRP
    Lars Muhl
    Institute for Biochemistry, Justus Liebig University, 35392 Giessen, Germany
    Biochem J 404:191-6. 2007
    ..Hence, PN-1 inhibits the enzymatic activity of FSAP and neutralizes its effect on PDGF-BB-mediated VSMC proliferation. The FSAP-inhibitor complexes are internalized via LRP without influencing the PDGF-BB signal transduction pathway...
  45. pmc Raised protein levels and altered cellular expression of factor VII activating protease (FSAP) in the lungs of patients with acute respiratory distress syndrome (ARDS)
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, University of Giessen Lung Center, Friedrichstrasse 24, 35392 Giessen, Germany
    Thorax 62:880-8. 2007
    ..Factor VII activating protease (FSAP) is a recently described serine protease in plasma and tissues known to be involved in haemostasis, cell proliferation and migration...
  46. ncbi request reprint Plasminogen activator inhibitor-1 is an inhibitor of factor VII-activating protease in patients with acute respiratory distress syndrome
    Malgorzata Wygrecka
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University Giessen, Giessen, Germany
    J Biol Chem 282:21671-82. 2007
    ....
  47. ncbi request reprint Extracellular RNA mediates endothelial-cell permeability via vascular endothelial growth factor
    Silvia Fischer
    Department of Biochemistry Medical School, Justus Liebig University, Giessen, Germany
    Blood 110:2457-65. 2007
    ..Together, these results identify extracellular RNA as a novel natural permeability factor, upstream of VEGF, whereas counteracting RNase treatment may serve as new vessel-protective modality...
  48. ncbi request reprint Identification of autoantigens in pediatric opsoclonus-myoclonus syndrome
    Franz Blaes
    Justus Liebig University, Department of Neurology, Am Steg 14, 35385 Giessen, Germany
    Expert Rev Clin Immunol 3:975-82. 2007
    ..Taken together, OMS is associated with surface-binding autoantibodies with pathogenic effects, indicating a humoral immune-mediated process as the underlying cause for OMS...
  49. ncbi request reprint Urokinase receptor (CD87) clustering in detergent-insoluble adhesion patches leads to cell adhesion independently of integrins
    Jutta Petzinger
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    Cell Commun Adhes 14:137-55. 2007
    ..Hence, uPAR-mediated cell adhesion on VN relies on the formation of a unique cellular structure that we have termed "detergent-insoluble adhesion patch" (DIAP)...
  50. doi request reprint Altered factor VII activating protease expression in murine hepatic fibrosis and its influence on hepatic stellate cells
    Martin Roderfeld
    Department of Medicine II, Gastroenterology, Justus Liebig University Giessen, Giessen, Germany
    Liver Int 29:686-91. 2009
    ..The liver-derived serine protease factor VII activating protease (FSAP) regulates the activities of PDGF-BB in a cell-specific manner...
  51. doi request reprint 3-Deazaadenosine prevents smooth muscle cell proliferation and neointima formation by interfering with Ras signaling
    Daniel G Sedding
    Department of Internal Medicine I Cardiology, Giessen University, Klinikstrasse 36, 35392 Giessen, Germany
    Circ Res 104:1192-200. 2009
    ..Thus, therapeutic inhibition of S-adenosylhomocysteine hydrolase by c3Ado may represent a save and effective novel approach to prevent vascular proliferative disease...
  52. ncbi request reprint Reciprocal regulation of urokinase receptor (CD87)-mediated cell adhesion by plasminogen activator inhibitor-1 and protease nexin-1
    Sandip M Kanse
    Institute for Biochemistry, Justus Liebig University, 35392 Giessen, Germany
    J Cell Sci 117:477-85. 2004
    ..These results indicate a novel function of PN-1 linked to complex formation with uPA that leads to the regulation of VN-dependent adhesion of leukocytes...
  53. ncbi request reprint Intermolecular contact regions in urokinase plasminogen activator receptor
    Olin D Liang
    Institut fur Biochemie, Fachbereich Humanmedizin, Justus Liebig Universitat, Friedrichstr 24, D 35392 Giessen, Germany
    J Biochem 134:661-6. 2003
    ..We propose that multiple uPAR-uPAR ectodomain interactions contribute considerably to the regulation of various cellular functions of uPAR...
  54. ncbi request reprint Surface-binding autoantibodies to cerebellar neurons in opsoclonus syndrome
    Franz Blaes
    Department of Neurology, Justus Liebig University, Giessen, Germany
    Ann Neurol 58:313-7. 2005
    ..Therefore, we hypothesize that opsoclonus-myoclonus syndrome may be the result of an autoimmune process against a neuronal surface protein...
  55. ncbi request reprint Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes
    Triantafyllos Chavakis
    Institute for Biochemistry, Third Department of Internal Medicine, Justus Liebig Universitat, Giessen, Germany
    Nat Med 8:687-93. 2002
    ....
  56. ncbi request reprint Characterization of human chorionic gonadotropin as a novel angiogenic factor
    Marek Zygmunt
    Department of Obstetrics and Gynecology, Justus Liebig University, Klinikstrasse 32, D 35385 Giessen, Germany
    J Clin Endocrinol Metab 87:5290-6. 2002
    ..Our data indicate a novel function for hCG in uterine adaptation to early pregnancy as well as in tumor development and underline the importance of hCG as an as yet unrecognized angiogenic factor...
  57. ncbi request reprint Variability in the expression of urokinase receptor (CD87) mutants on cells: relevance to cell adhesion
    Sandip M Kanse
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    Cell Biochem Funct 22:257-64. 2004
    ..Hence, any alterations in the domain structure of uPAR reduce its expression and only the intact receptor can sustain the direct cell adhesion on VN-rich matrices found at sites of inflammation and injury...
  58. pmc The junctional adhesion molecule 3 (JAM-3) on human platelets is a counterreceptor for the leukocyte integrin Mac-1
    Sentot Santoso
    Institute for Clinical Immunology and Transfusion Medicine, Justus Liebig University, D 35385 Giessen, Germany
    J Exp Med 196:679-91. 2002
    ..JAM-3 thereby provides a novel molecular target for antagonizing interactions between vascular cells that promote inflammatory vascular pathologies such as in atherothrombosis...
  59. ncbi request reprint Promotion of leukocyte adhesion by a novel interaction between vitronectin and the beta2 integrin Mac-1 (alphaMbeta2, CD11b/CD18)
    Sandip M Kanse
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    Arterioscler Thromb Vasc Biol 24:2251-6. 2004
    ..Until now, only an indirect interaction between Mac-1 and VN via the urokinase receptor (urokinase plasminogen activator receptor) was known. We now propose that Mac-1 and VN can directly interact with each other...
  60. ncbi request reprint A novel antithrombotic role for high molecular weight kininogen as inhibitor of plasminogen activator inhibitor-1 function
    Triantafyllos Chavakis
    Institute for Biochemistry, Third Department of Internal Medicine, Justus Liebig University, Giessen D 35392, Germany
    J Biol Chem 277:32677-82. 2002
    ..Based on these observations potential low molecular weight PAI-1 inhibitors could be designed for the use in therapeutic interventions against thromboembolic complications...
  61. ncbi request reprint Kinetics of integrin expression in the mouse model of proliferative retinopathy and success of secondary intervention with cyclic RGD peptides
    E Chavakis
    III Medical Department, Justus Liebig University, Giessen, Germany
    Diabetologia 45:262-7. 2002
    ..Specifically, it has been shown that ligation inhibition of the alpha(v)-type integrins with cyclic penta-peptid peptide inhibits proliferative retinopathy by almost 80 % in a hypoxia-induced mouse model...
  62. doi request reprint Structure-function analysis of factor VII activating protease (FSAP): sequence determinants for heparin binding and cellular functions
    Lars Muhl
    Institute for Biochemistry, Medical School, Justus Liebig University Giessen, Giessen, Germany
    FEBS Lett 583:1994-8. 2009
    ..The DeltaEGF-3 mutant showed diminished binding to and activation by heparin. Hence, regulation of FSAP activity is dependent on its EGF-3 domain and over-expression of active variants induces cell death...
  63. ncbi request reprint Inhibition of platelet adhesion and aggregation by a defined region (Gly-486-Lys-502) of high molecular weight kininogen
    Triantafyllos Chavakis
    Institute for Biochemistry, Justus Liebig University, D 35392 Giessen, Germany
    J Biol Chem 277:23157-64. 2002
    ..Taken together, our data emphasize the inhibitory role of HK domain 5 on platelet adhesion and aggregation; new anti-thrombotic compounds may become available on the basis of peptide Gly-486-Lys-502 of HK domain 5...
  64. ncbi request reprint Expression of transcription factor Oct-4 and other embryonic genes in CD133 positive cells from human umbilical cord blood
    Nelli Baal
    Department of Obstetrics, Justus Liebig University, Giessen, Germany
    Thromb Haemost 92:767-75. 2004
    ..Our results indicate that CD133(+) HSPC from umbilical cord blood may have a greater differentiation potential than previously recognized and give rise to proliferative endothelial cells participating in placental vasculogenesis...
  65. doi request reprint Extracellular nucleic acids as novel alarm signals in the vascular system. Mediators of defence and disease
    S Fischer
    Department of Biochemistry, Medical School, Justus Liebig Universitat, Friedrichstr 24, 35392 Giessen, Germany
    Hamostaseologie 33:37-42. 2013
    ..Thus, extracellular nucleic acids appear not only to function as host alarm signals that serve to amplify the defence response, but they also provide important links to thrombus formation as part of the innate immune system...
  66. doi request reprint Protease-activated receptors (PAR)-1 and -3 drive epithelial-mesenchymal transition of alveolar epithelial cells - potential role in lung fibrosis
    Malgorzata Wygrecka
    Department of Biochemistry, University of Giessen Lung Center, Friedrichstrasse 24, Giessen, Germany
    Thromb Haemost 110:295-307. 2013
    ....
  67. ncbi request reprint Host-derived extracellular nucleic acids enhance innate immune responses, induce coagulation, and prolong survival upon infection in insects
    Boran Altincicek
    Institute of Phytopathology and Applied Zoology, Justus Liebig University of Giessen, Heinrich Buff Ring 26 32, Giessen, Germany
    J Immunol 181:2705-12. 2008
    ....
  68. doi request reprint A key role for Toll-like receptor-3 in disrupting the hemostasis balance on endothelial cells
    Aya Shibamiya
    Institute for Biochemistry, Justus Liebig University, Giessen, Germany
    Blood 113:714-22. 2009
    ..Hence, the activation of TLR3 can induce the procoagulant state in the endothelium, and this could be relevant for understanding the mechanisms of viral stimulation of hemostasis...
  69. ncbi request reprint Oncodevelopmental alpha-fetoprotein acts as a selective proangiogenic factor on endothelial cell from the fetomaternal unit
    Olin D Liang
    Department of Obstetrics and Gynecology, Justus Liebig University, D 35385 Giessen, Germany
    J Clin Endocrinol Metab 89:1415-22. 2004
    ..These data indicate that AFP may act as a specific proangiogenic factor of endothelial cells within the fetomaternal unit during advanced stages in pregnancy...
  70. doi request reprint Loss of RAGE in pulmonary fibrosis: molecular relations to functional changes in pulmonary cell types
    Markus A Queisser
    Department of Biochemistry, University of Giessen Lung Center, Justus Liebig University, Giessen, Germany
    Am J Respir Cell Mol Biol 39:337-45. 2008
    ..These results indicate that RAGE serves a protective role in the lung, and that loss of the receptor is related to functional changes of pulmonary cell types, with the consequences of fibrotic disease...
  71. pmc Transforming growth factor-β1 induces expression of human coagulation factor XII via Smad3 and JNK signaling pathways in human lung fibroblasts
    Ewa Jablonska
    Department of Biochemistry, Faculty of Medicine, Justus Liebig University, 35392 Giessen, Germany
    J Biol Chem 285:11638-51. 2010
    ..Our results show that JNK/Smad3 pathway plays a critical role in TGF-beta1-induced FXII expression in human lung fibroblasts and implicate its possible involvement in pathological conditions characterized by elevated TGF-beta1 levels...
  72. doi request reprint In vitro spheroid model of placental vasculogenesis: does it work?
    Nelli Baal
    Department of Obstetrics and Gynecology, University of Giessen, Giessen, Germany
    Lab Invest 89:152-63. 2009
    ..Therefore, the three-dimensional spheroid model consisting of major placental cell types proved to be an appropriate system to investigate early placental vessel development under both physiological and pathological conditions...
  73. ncbi request reprint Isolated pancreatic islets in three-dimensional matrices are responsive to stimulators and inhibitors of angiogenesis
    Andre Kidszun
    Medical Clinic and Policlinic 3, Justus Liebig University, Rodthohl 6, 35392 Giessen, Germany
    Cell Transplant 15:489-97. 2006
    ..Isolated pancreatic islets are capable of forming new capillary structures and are susceptible to pro- and antiangiogenic stimuli...
  74. pmc Evidence for an RNA chaperone function of polypyrimidine tract-binding protein in picornavirus translation
    Yutong Song
    Institute of Biochemistry, Faculty of Medicine, Justus Liebig University, 35392 Giessen, Germany
    RNA 11:1809-24. 2005
    ..Thus, PTB most likely acts as an RNA chaperone to stabilize IRES structure and, in that way, augment IRES activity...
  75. ncbi request reprint Characterisation and partial purification of Schistosoma mansoni egg-derived pro-angiogenic factor
    Sandip M Kanse
    Institut fur Biochemie, Justus Liebig Universitat, Friedrichstrasse 24, D 35392 Giessen, Germany
    Mol Biochem Parasitol 144:76-85. 2005
    ..The S. mansoni egg-derived pro-angiogenic factor, described here, may directly contribute to vascular remodelling in the liver and illustrates how helminth parasites may modulate angiogenesis...
  76. ncbi request reprint Extracellular RNA promotes leukocyte recruitment in the vascular system by mobilising proinflammatory cytokines
    Silvia Fischer
    Department of Biochemistry, Medical School, Justus Liebig University, Giessen, Germany
    Thromb Haemost 108:730-41. 2012
    ..Our findings present evidence that eRNA in connection with tissue/vascular damage provokes a potent inflammatory response by inducing leukocyte recruitment and by mobilising proinflammatory cytokines from monocytes...
  77. doi request reprint Elevated B-cell activating factor BAFF, but not APRIL, correlates with CSF cerebellar autoantibodies in pediatric opsoclonus-myoclonus syndrome
    V Fühlhuber
    Dept of Neurology, Justus Liebig University, Giessen, Germany
    J Neuroimmunol 210:87-91. 2009
    ..58, p<0.05). These data indicate that an activated B-cell system in the cerebrospinal fluid is involved in the pathogenesis of OMS, and BAFF may be a candidate parameter for the activation of B-cell immune system...
  78. pmc Microbial metalloproteinases mediate sensing of invading pathogens and activate innate immune responses in the lepidopteran model host Galleria mellonella
    Boran Altincicek
    Institute of Phytopathology and Applied Zoology, Justus Liebig University of Giessen, Heinrich Buff Ring 26 32, 35392 Giessen, Germany
    Infect Immun 75:175-83. 2007
    ..mellonella. The obtained results support the proposed danger model, which suggests that the immune system senses endogenous alarm signals during infection besides recognition of microbial pattern molecules...
  79. ncbi request reprint IgG subclass distribution of autoantibodies in pediatric opsoclonus-myoclonus syndrome
    S Beck
    Department of Neurology, Justus Liebig University, Giessen, 35385, Germany
    J Neuroimmunol 185:145-9. 2007
    ..These results support the autoimmune hypothesis and point to a protein autoantigen as antigenic target...
  80. pmc Potential role for ADAM15 in pathological neovascularization in mice
    Keisuke Horiuchi
    Cellular Biochemistry and Biophysics Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10021, USA
    Mol Cell Biol 23:5614-24. 2003
    ..Since ADAM15 does not appear to be required for developmental angiogenesis or for adult homeostasis, it may represent a novel target for the design of inhibitors of pathological neovascularization...
  81. ncbi request reprint Leukocyte trans-endothelial migration: JAMs add new pieces to the puzzle
    Triantafyllos Chavakis
    Department of Medicine 1, University Hospital, Heidelberg, Germany
    Thromb Haemost 89:13-7. 2003
    ..Deciphering their mechanisms of interaction will also allow to unravel novel strategies for therapeutic intervention in inflammatory or atherothrombotic diseases...
  82. ncbi request reprint The extracellular adherence protein from Staphylococcus aureus abrogates angiogenic responses of endothelial cells by blocking Ras activation
    Astrid C S Sobke
    Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, D 66421 Homburg Saar, Germany
    FASEB J 20:2621-3. 2006
    ..aureus infection but open new perspectives for therapeutic applications in pathological neovascularization...
  83. ncbi request reprint The role of junctional adhesion molecule-C (JAM-C) in oxidized LDL-mediated leukocyte recruitment
    Tanja Keiper
    Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    FASEB J 19:2078-80. 2005
    ..JAM-C may therefore provide a novel molecular target for antagonizing interactions between vascular cells in atherosclerosis...
  84. ncbi request reprint Fibronectin binding proteins contribute to the adherence of Staphylococcus aureus to intact endothelium in vivo
    Sylvain Kerdudou
    Institute of Medical Microbiology and Hygiene, University of Saarland Hospital, Homburg Saar, Germany
    Thromb Haemost 96:183-9. 2006
    ..Accordingly, this attribution of staphylococcal FnBPs provide a rationale for novel intervention strategies such as the use of anti-FnBP antibodies in endovascular S. aureus disease...
  85. ncbi request reprint Urokinase receptor surface expression regulates monocyte adhesion in acute myocardial infarction
    Andreas E May
    Medizinische Klinik des Klinikums Rechts der Isar und Deutsches Herzzentrum, Technische Universitat Munchen, Munich, Germany
    Blood 100:3611-7. 2002
    ..Thus, uPAR may be a novel target for prevention of unwanted monocyte recruitment as part of inflammatory cardiovascular processes...
  86. ncbi request reprint Functional characterisation of autoantibodies from patients with pediatric opsoclonus-myoclonus-syndrome
    Martina Korfei
    Department of Neurology, Am Steg 14, Justus Liebig University, D 35385 Giessen, Germany
    J Neuroimmunol 170:150-7. 2005
    ..These findings indicate that surface-binding autoantibodies are present in OMS patients and these autoantibodies cause inhibition of cell proliferation and induce apoptosis...
  87. ncbi request reprint Lipoprotein(a) in atherosclerotic plaques recruits inflammatory cells through interaction with Mac-1 integrin
    Sotirios N Sotiriou
    Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland 20892, USA
    FASEB J 20:559-61. 2006
    ..These observations suggest a novel mechanism for the atherogenic properties of Lp(a)...
  88. ncbi request reprint Tenilsetam prevents early diabetic retinopathy without correcting pericyte loss
    Jennifer Hoffmann
    3rd Medical Department, Justus Liebig University Giessen, Germany
    Thromb Haemost 95:689-95. 2006
    ..These data suggest that, independent of known properties, tenilsetam shows important rescue functions on endothelial cells which could be useful for the treatment of early diabetic retinopathy...
  89. pmc Suppression of experimental autoimmune encephalomyelitis by extracellular adherence protein of Staphylococcus aureus
    Changping Xie
    Experimental Immunology Branch, National Cancer Institute, National Institutes of Health, Bethesda, MD 20892, USA
    J Exp Med 203:985-94. 2006
    ..Strikingly, intervention with Eap after the onset of EAE suppressed the disease. Collectively, our findings indicate that Eap represents an attractive treatment for autoimmune neuroinflammatory disorders such as MS...
  90. ncbi request reprint High molecular weight kininogen regulates platelet-leukocyte interactions by bridging Mac-1 and glycoprotein Ib
    Triantafyllos Chavakis
    Department of Internal Medicine I, University Heidelberg, D 69115 Heidelberg, Germany
    J Biol Chem 278:45375-81. 2003
    ..These distinct molecular interactions of HK with leukocytes and platelets contribute to the regulation of the adhesive behavior of vascular cells and provide novel molecular targets for reducing atherothrombotic pathologies...
  91. ncbi request reprint Possible angiogenic roles of insulin-like growth factor II and its receptors in uterine vascular adaptation to pregnancy
    Friederike Herr
    Department of Obstetrics and Gynecology, Justus Liebig University of Giessen, D 35385 Giessen, Germany
    J Clin Endocrinol Metab 88:4811-7. 2003
    ..Our results suggest an important angiogenic role of IGF-II in the vascular adaptation to pregnancy...
  92. ncbi request reprint Angiostatin is a novel anti-inflammatory factor by inhibiting leukocyte recruitment
    Triantafyllos Chavakis
    Department of Internal Medicine, Universitat Heidelberg, Germany
    Blood 105:1036-43. 2005
    ..These observations could provide the basis for new therapeutic applications of angiostatin to target chronic inflammatory processes in different pathologic situations...
  93. ncbi request reprint Localization of osteoprotegerin, tumor necrosis factor-related apoptosis-inducing ligand, and receptor activator of nuclear factor-kappaB ligand in Mönckeberg's sclerosis and atherosclerosis
    Michael Schoppet
    Department of Internal Medicine, Philipps University, Baldingerstrasse, D 35033 Marburg, Germany
    J Clin Endocrinol Metab 89:4104-12. 2004
    ....
  94. pmc Extracellular RNA is a natural cofactor for the (auto-)activation of Factor VII-activating protease (FSAP)
    Fumie Nakazawa
    Graduate School of Allied Health Sciences, Tokyo Medical and Dental University, Bunkyo ku, Tokyo 113 8519, Japan
    Biochem J 385:831-8. 2005
    ....
  95. ncbi request reprint Fibrinolysis and proteolysis in a cellular context
    Klaus T Preissner
    Thromb Haemost 91:423-4. 2004
  96. ncbi request reprint Heparanase modulates heparinoids anticoagulant activities via non-enzymatic mechanisms
    Ben Zion Katz
    The Hematology Institute, Tel Aviv Sourasky Medical Center, Tel Aviv 64239, Israel
    Thromb Haemost 98:1193-9. 2007
    ..Altogether, heparanase pro-coagulant activities that were also demonstrated in plasma samples from patients under LMWH treatment, point to a possible use of this molecule as antagonist for heparinoid treatment...
  97. pmc Extracellular RNA constitutes a natural procoagulant cofactor in blood coagulation
    Christian Kannemeier
    Research Laboratories, Aventis Behring, D 35392 Marburg, Germany
    Proc Natl Acad Sci U S A 104:6388-93. 2007
    ..Extracellular RNA thereby reveals a yet unrecognized target for antithrombotic intervention, using RNase or related therapeutic strategies...
  98. pmc The extracellular adherence protein (Eap) of Staphylococcus aureus inhibits wound healing by interfering with host defense and repair mechanisms
    Athanasios N Athanasopoulos
    Experimental Immunology Branch, NCI, NIH, Center Dr, Rm 4B17, Bethesda, MD 20892, USA
    Blood 107:2720-7. 2006
    ..Eap may also serve as a lead compound for new anti-inflammatory and antiangiogenic therapies in several pathologies...
  99. ncbi request reprint Effect of high hydrostatic pressure on biological properties of extracellular bone matrix proteins
    Peter Diehl
    Department of Orthopedic Surgery, Technical University of Munich, Munich, Germany
    Int J Mol Med 16:285-9. 2005
    ..While during this treatment eukaryotic cells including tumor cells will be irreversibly impaired, the bone's biomechanical properties and the biological properties of the ECM proteins FN, VN, and Col-I, respectively, are preserved...
  100. doi request reprint From molecules to medicine: new horizons in vascular biology and thrombosis (Part II)
    Klaus T Preissner
    Thromb Haemost 99:465. 2008
  101. ncbi request reprint Staphylococcus aureus interactions with the endothelium: the role of bacterial "secretable expanded repertoire adhesive molecules" (SERAM) in disturbing host defense systems
    Triantafyllos Chavakis
    Experimental Immunology Branch, NCI, NIH, Bethesda, Maryland, USA
    Thromb Haemost 94:278-85. 2005
    ..aureus infection but can specify novel targets for preventive or therapeutic strategies...