D Prawitt

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. ncbi request reprint RNAi knock-down mice: an emerging technology for post-genomic functional genetics
    D Prawitt
    Children s Hospital, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Cytogenet Genome Res 105:412-21. 2004
  2. pmc Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor
    Dirk Prawitt
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Proc Natl Acad Sci U S A 102:4085-90. 2005
  3. ncbi request reprint Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family
    T Enklaar
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, Mainz, D 55101, Germany
    Genomics 67:179-87. 2000
  4. ncbi request reprint Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)
    A Cichutek
    Department of Pediatrics, University of Mainz, Mainz, Germany
    Cytogenet Cell Genet 93:277-83. 2001
  5. doi request reprint A family-based investigation of cold pain tolerance
    F Birklein
    Department of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Pain 138:111-8. 2008
  6. ncbi request reprint Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression
    D Prawitt
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Hum Mol Genet 9:203-16. 2000
  7. ncbi request reprint Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene
    A Bahn
    Zentrum für Physiologie und Pathophysiologie, Humboldtallee 23, Gottingen, 37073, Germany
    Biochem Biophys Res Commun 275:623-30. 2000
  8. pmc The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation
    J Kim
    Department of Biochemistry, Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 19:2289-99. 1999
  9. ncbi request reprint Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules
    M Reece
    Department of Biochemistry, McGill University, Montreal, Que, Canada
    FEBS Lett 433:245-50. 1998
  10. ncbi request reprint Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain
    P R Cooper
    Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genomics 49:38-51. 1998

Collaborators

Detail Information

Publications11

  1. ncbi request reprint RNAi knock-down mice: an emerging technology for post-genomic functional genetics
    D Prawitt
    Children s Hospital, Johannes Gutenberg Universitat Mainz, Mainz, Germany
    Cytogenet Genome Res 105:412-21. 2004
    ..Finally, we present prospective strategies as to how RNAi technology might be applied for generating conditional and tissue-restricted knock-down mice...
  2. pmc Microdeletion of target sites for insulator protein CTCF in a chromosome 11p15 imprinting center in Beckwith-Wiedemann syndrome and Wilms' tumor
    Dirk Prawitt
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Proc Natl Acad Sci U S A 102:4085-90. 2005
    ..Our results suggest that the combined effects of the H19/IGF2-imprinting center microdeletion and 11p15 chromosome duplication were necessary for manifestation of BWS...
  3. ncbi request reprint Mtr1, a novel biallelically expressed gene in the center of the mouse distal chromosome 7 imprinting cluster, is a member of the Trp gene family
    T Enklaar
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, Mainz, D 55101, Germany
    Genomics 67:179-87. 2000
    ..Imprinting analysis, using RT-PCR on RNA from reciprocal mouse crosses harboring a sequence polymorphism, revealed biallelic expression of Mtr1 transcripts at all stages and tissues examined...
  4. ncbi request reprint Comparative architectural aspects of regions of conserved synteny on human chromosome 11p15.3 and mouse chromosome 7 (including genes WEE1 and LMO1)
    A Cichutek
    Department of Pediatrics, University of Mainz, Mainz, Germany
    Cytogenet Cell Genet 93:277-83. 2001
    ..CpG islands were found conserved in putative promoter regions of the known genes but also in regions which so far have not been described as harboring expressed sequences...
  5. doi request reprint A family-based investigation of cold pain tolerance
    F Birklein
    Department of Neurology, Johannes Gutenberg University Mainz, Langenbeckstr 1, 55131 Mainz, Germany
    Pain 138:111-8. 2008
    ..In conclusion our results suggest that cold pain tolerance may be at least partially inherited. Genetic or environmental factors might explain family clustering of cold pain sensitivity...
  6. ncbi request reprint Identification and characterization of MTR1, a novel gene with homology to melastatin (MLSN1) and the trp gene family located in the BWS-WT2 critical region on chromosome 11p15.5 and showing allele-specific expression
    D Prawitt
    Children s Hospital, University of Mainz, Langenbeckstrasse 1, D 55101 Mainz, Germany
    Hum Mol Genet 9:203-16. 2000
    ....
  7. ncbi request reprint Genomic structure and in vivo expression of the human organic anion transporter 1 (hOAT1) gene
    A Bahn
    Zentrum für Physiologie und Pathophysiologie, Humboldtallee 23, Gottingen, 37073, Germany
    Biochem Biophys Res Commun 275:623-30. 2000
    ..1-q13.2. Additionally, 600 bp of the 5' flanking region was analyzed, illustrating the probable transcription start site at nt -280, a NF-kappaB-site at nt -397 and several putative transcription factor binding sites...
  8. pmc The Wilms' tumor suppressor gene (wt1) product regulates Dax-1 gene expression during gonadal differentiation
    J Kim
    Department of Biochemistry, Experimental Medicine, McGill University, Montreal, Quebec, Canada
    Mol Cell Biol 19:2289-99. 1999
    ..In addition, we demonstrate that WT1 can activate the endogenous Dax-1 promoter. Our results indicate that the WT1-DAX-1 pathway is an early event in the process of mammalian sex determination...
  9. ncbi request reprint Functional characterization of ORCTL2--an organic cation transporter expressed in the renal proximal tubules
    M Reece
    Department of Biochemistry, McGill University, Montreal, Que, Canada
    FEBS Lett 433:245-50. 1998
    ..These results suggest that ORCTL2 may play a role in the transport of chloroquine and quinidine related compounds in the kidney...
  10. ncbi request reprint Divergently transcribed overlapping genes expressed in liver and kidney and located in the 11p15.5 imprinted domain
    P R Cooper
    Department of Human Genetics, Roswell Park Cancer Institute, Buffalo, New York 14263, USA
    Genomics 49:38-51. 1998
    ....
  11. ncbi request reprint Functional characterization of human nucleosome assembly protein-2 (NAP1L4) suggests a role as a histone chaperone
    P Rodriguez
    Department of Biochemistry, McGill University, Montreal, Quebec, Canada
    Genomics 44:253-65. 1997
    ..Our results, coupled with tumor suppression assays in G401 WT cells, do not support a role for NAP-2 in the etiology of WT. A putative role for NAP-2 in regulating cellular differentiation is discussed...