Olaf Prante

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Subtype-selective dopamine receptor radioligands for PET imaging: current status and recent developments
    A Banerjee
    Laboratory of Molecular Imaging and Radiochemistry, Nuclear Medicine Clinic, Friedrich Alexander University, Schwabachanlage 6, D 91054 Erlangen, Germany
    Curr Med Chem 19:3957-66. 2012
  2. doi request reprint Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen, Germany
    J Med Chem 51:1800-10. 2008
  3. doi request reprint 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor
    Carsten Hocke
    Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 3:788-93. 2008
  4. ncbi request reprint A series of 18F-labelled pyridinylphenyl amides as subtype-selective radioligands for the dopamine D3 receptor
    Carsten Hocke
    Friedrich Alexander University Erlangen Nurnberg, Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 5:941-8. 2010
  5. ncbi request reprint Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 15:4819-23. 2005
  6. doi request reprint Detection of tumour invasion into the pyramidal tract in glioma patients with sensorimotor deficits by correlation of (18)F-fluoroethyl-L: -tyrosine PET and magnetic resonance diffusion tensor imaging
    Andreas Stadlbauer
    Department of Neurosurgery, University Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Acta Neurochir (Wien) 151:1061-9. 2009
  7. ncbi request reprint Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands
    Ismail Salama
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, D 91052 Erlangen, Germany
    J Med Chem 50:489-500. 2007
  8. doi request reprint Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker
    Rainer Tietze
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Schwabachanlage 6, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 18:983-8. 2008
  9. doi request reprint Effects of recombinant human thyroid-stimulating hormone superagonists on thyroidal uptake of 18F-fluorodeoxyglucose and radioiodide
    Julia Reinfelder
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen, Germany
    Thyroid 21:783-92. 2011
  10. ncbi request reprint Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 14:3963-6. 2004

Collaborators

Detail Information

Publications26

  1. ncbi request reprint Subtype-selective dopamine receptor radioligands for PET imaging: current status and recent developments
    A Banerjee
    Laboratory of Molecular Imaging and Radiochemistry, Nuclear Medicine Clinic, Friedrich Alexander University, Schwabachanlage 6, D 91054 Erlangen, Germany
    Curr Med Chem 19:3957-66. 2012
    ....
  2. doi request reprint Synthesis, radiofluorination, and in vitro evaluation of pyrazolo[1,5-a]pyridine-based dopamine D4 receptor ligands: discovery of an inverse agonist radioligand for PET
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen, Germany
    J Med Chem 51:1800-10. 2008
    ..The observed binding pattern was mainly consistent with the known D 4R distribution in the rat brain. Thus, [(18)F]3h (FAUC F41) represents a potential radioligand for studying the D 4R in vivo by positron emission tomography (PET)...
  3. doi request reprint 18F-Labeled FAUC 346 and BP 897 derivatives as subtype-selective potential PET radioligands for the dopamine D3 receptor
    Carsten Hocke
    Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 3:788-93. 2008
    ..Optimization of the (18)F-labeling conditions led to radiochemical yields between 24 and 65 %...
  4. ncbi request reprint A series of 18F-labelled pyridinylphenyl amides as subtype-selective radioligands for the dopamine D3 receptor
    Carsten Hocke
    Friedrich Alexander University Erlangen Nurnberg, Clinic of Nuclear Medicine, Friedrich Alexander University, Krankenhausstrasse 12, 91054 Erlangen, Germany
    ChemMedChem 5:941-8. 2010
    ....
  5. ncbi request reprint Synthesis and evaluation of 18F-labeled dopamine D3 receptor ligands as potential PET imaging agents
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 15:4819-23. 2005
    ..The most promising ligand, [18F]8d, was used as imaging agent of the D3 receptor in vitro. However, due to the lack of specific binding, further studies should aim at the development of radioligands with improved D3 receptor selectivity...
  6. doi request reprint Detection of tumour invasion into the pyramidal tract in glioma patients with sensorimotor deficits by correlation of (18)F-fluoroethyl-L: -tyrosine PET and magnetic resonance diffusion tensor imaging
    Andreas Stadlbauer
    Department of Neurosurgery, University Erlangen Nuremberg, Schwabachanlage 6, 91054, Erlangen, Germany
    Acta Neurochir (Wien) 151:1061-9. 2009
    ..e. diffusion tensor imaging (DTI), fibre tracking and O-(2-[(18)F]-fluoroethyl)-L: -tyrosine ((18)F-FET) PET, for the detection of tumour invasion into white matter structures not visible in routine MRI...
  7. ncbi request reprint Structure-selectivity investigations of D2-like receptor ligands by CoMFA and CoMSIA guiding the discovery of D3 selective PET radioligands
    Ismail Salama
    Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstrasse 19, D 91052 Erlangen, Germany
    J Med Chem 50:489-500. 2007
    ....
  8. doi request reprint Discovery of a dopamine D4 selective PET ligand candidate taking advantage of a click chemistry based REM linker
    Rainer Tietze
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Schwabachanlage 6, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 18:983-8. 2008
    ..4) of 2.8 and was determined to be highly stable in human serum. Thus, [(18)F]7h represents a promising dopamine D4 selective radioligand for positron emission tomography (PET)...
  9. doi request reprint Effects of recombinant human thyroid-stimulating hormone superagonists on thyroidal uptake of 18F-fluorodeoxyglucose and radioiodide
    Julia Reinfelder
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen, Germany
    Thyroid 21:783-92. 2011
    ....
  10. ncbi request reprint Synthesis and radioiodination of selective ligands for the dopamine D3 receptor subtype
    Carsten Hocke
    Department of Nuclear Medicine, Krankenhausstrasse 12, D 91054 Erlangen, Germany
    Bioorg Med Chem Lett 14:3963-6. 2004
    ..Suitable precursors were radioiodinated with high radiochemical yields (53-85%) leading to potential imaging agents for the D3 receptor by SPET...
  11. doi request reprint Synthesis and evaluation of a (18)F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors
    Christopher Lang
    Department of Chemistry and Pharmacy, Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstraße 19, 91052 Erlangen, Germany
    J Med Chem 56:9361-5. 2013
    ..Thus, the tracer [(18)F]8 represents a highly promising candidate for PET imaging of NTS1-positive tumors. ..
  12. ncbi request reprint In vitro studies on the signal transduction of thyroidal uptake of 18F-FDG and 131I-Iodide
    Daniel Bläser
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen Nurnberg, Germany
    J Nucl Med 47:1382-8. 2006
    ....
  13. ncbi request reprint In vitro characterization of the thyroidal uptake of O-(2-[(18)F]fluoroethyl)-L-tyrosine
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, D 91054 Erlangen, Germany
    Nucl Med Biol 34:305-14. 2007
    ..We therefore studied several factors potentially governing the uptake of FET in the rat thyroid cell line FRTL-5 in comparison with thyroid tumor cell lines of human origin...
  14. ncbi request reprint Characterization of uptake of 3-[(131)I]iodo-alpha-methyl-L-tyrosine in human monocyte-macrophages
    Olaf Prante
    Department of Nuclear Medicine, Laboratory of Molecular Imaging, Friedrich Alexander University, Erlangen, Germany
    Nucl Med Biol 31:365-72. 2004
    ....
  15. ncbi request reprint Regulation of uptake of 18F-FDG by a follicular human thyroid cancer cell line with mutation-activated K-ras
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, Erlangen, Germany
    J Nucl Med 50:1364-70. 2009
    ..The data obtained in ML-1 were compared with those of a well-differentiated thyroid cell line of rat origin (FRTL-5)...
  16. ncbi request reprint 3,4,6-Tri-O-acetyl-2-deoxy-2-[18F]fluoroglucopyranosyl phenylthiosulfonate: a thiol-reactive agent for the chemoselective 18F-glycosylation of peptides
    Olaf Prante
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University, 91054 Erlangen, Germany
    Bioconjug Chem 18:254-62. 2007
    ....
  17. doi request reprint 18Fluoroethyl-L-tyrosine-PET in long-term epilepsy associated glioneuronal tumors
    Burkhard S Kasper
    Department of Neurology, Epilepsy Center, Friedrich Alexander University Erlangen, Erlangen, Germany
    Epilepsia 52:35-44. 2011
    ..Herein we analyzed a large LEAT cohort investigated by 18fluoroethyl-L-tyrosine-positron emission tomography (FET-PET)...
  18. doi request reprint A series of 2-O-trifluoromethylsulfonyl-D-mannopyranosides as precursors for concomitant 18F-labeling and glycosylation by click chemistry
    Simone Maschauer
    Laboratory of Molecular Imaging, Clinic of Nuclear Medicine, Friedrich Alexander University Erlangen Nurnberg, Erlangen, Germany
    Carbohydr Res 344:753-61. 2009
    ....
  19. ncbi request reprint (18)F-glyco-RGD peptides for PET imaging of integrin expression: efficient radiosynthesis by click chemistry and modulation of biodistribution by glycosylation
    Simone Maschauer
    Department of Nuclear Medicine, Molecular Imaging and Radiochemistry, Friedrich Alexander University, 91054 Erlangen, Germany
    Mol Pharm 11:505-15. 2014
    ..Due to its favorable biodistribution and tissue clearance in vivo, [(18)F]Mlt-RGD represents a viable alternative radiotracer for imaging integrin expression in solid tumors by PET. ..
  20. doi request reprint Click chemistry based synthesis of dopamine D4 selective receptor ligands for the selection of potential PET tracers
    Ashutosh Banerjee
    Molecular Imaging and Radiochemistry, Department of Nuclear Medicine, Friedrich Alexander University, Schwabachanlage 6, D 91054 Erlangen, Germany Department of Medicinal Chemistry, Emil Fischer Center, Friedrich Alexander University, Schuhstraβe 19, D 91052 Erlangen, Germany
    Bioorg Med Chem Lett 23:6079-82. 2013
    ....
  21. doi request reprint Induction and repair of DNA double-strand breaks in blood lymphocytes of patients undergoing ¹⁸F-FDG PET/CT examinations
    Matthias S May
    Department of Radiology, University Hospital Erlangen, Erlangen, Germany
    Eur J Nucl Med Mol Imaging 39:1712-9. 2012
    ....
  22. pmc Radiosynthesis and validation of (18)F-FP-CMT, a phenyltropane with superior properties for imaging the dopamine transporter in living brain
    Paul Cumming
    Department of Nuclear Medicine, Laboratory of Molecular Imaging and Radiochemistry, Friedrich Alexander University, Erlangen, Germany
    J Cereb Blood Flow Metab 34:1148-56. 2014
    ..The pharmacological selectivity of (18)F-FP-CMT, rapid kinetic profile, and lack of problematic metabolites constitute optimal properties for quantitation of DAT in rat, and may also predict applicability in human PET studies. ..
  23. doi request reprint Radioligands for the dopamine receptor subtypes
    Olaf Prante
    Laboratory of Molecular Imaging and Radiochemistry, Friedrich Alexander University, Schwabachanlage 6, D 91054, Erlangen, Germany
    J Labelled Comp Radiopharm 56:130-48. 2013
    ....
  24. doi request reprint Metabolic imaging of cerebral gliomas: spatial correlation of changes in O-(2-18F-fluoroethyl)-L-tyrosine PET and proton magnetic resonance spectroscopic imaging
    Andreas Stadlbauer
    Department of Neurosurgery, University of Erlangen Nuremberg, Erlangen, Germany
    J Nucl Med 49:721-9. 2008
    ....
  25. ncbi request reprint Characterization of 18F-FDG uptake in human endothelial cells in vitro
    Simone Maschauer
    Department of Nuclear Medicine, Laboratory of Molecular Imaging, Friedrich Alexander University, Erlangen, Germany
    J Nucl Med 45:455-60. 2004
    ..The contribution of (18)F-FDG uptake by endothelial cells to uptake values measured by PET in various tissues is as yet unclear. We therefore sought to characterize (18)F-FDG uptake in an in vitro model of human endothelial cells...
  26. ncbi request reprint Uptake of [18F]fluorodeoxyglucose in human monocyte-macrophages in vitro
    Jan Thiess Deichen
    Nuklearmedizinische Klinik mit Poliklinik, Friedrich Alexander Universitat Erlangen Nurnberg, Krankenhausstrasse 12, 91054 Erlangen, Germany
    Eur J Nucl Med Mol Imaging 30:267-73. 2003
    ..By accumulating [(18)F]FDG in a manner analogous to uptake by tumour cells, activated HMMs may contribute to the [(18)F]FDG uptake values measured by PET in neoplasms...