H Potschka

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Role of CNS efflux drug transporters in antiepileptic drug delivery: overcoming CNS efflux drug transport
    Heidrun Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Koeniginstr 16, D 80539 Munich, Germany
    Adv Drug Deliv Rev 64:943-52. 2012
  2. ncbi Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans
    Bernadette Unkrüer
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University Munich, Munich, Germany
    BMC Neurosci 10:28. 2009
  3. ncbi Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches
    Heidrun Potschka
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Koeniginstr 16, D 80539 Munich, Germany
    Pharmacogenomics 11:1427-38. 2010
  4. ncbi Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice
    Sarah Verena Fischborn
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilian University, Koeniginstr 16, D 80539 Munich, Germany
    Epilepsy Res 91:57-65. 2010
  5. ncbi Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies?
    Heidrun Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Epilepsia 51:1333-47. 2010
  6. ncbi Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach
    Heidrun Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Koeniginstr 16, D 80539 Munich, Germany
    Pharmacol Ther 125:118-27. 2010
  7. ncbi Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX
    H Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University Munich, Koeniginstr 16, 80539 Munich, Germany
    Neuroscience 152:1093-8. 2008
  8. ncbi Impact of seizure activity on free extracellular phenytoin concentrations in amygdala-kindled rats
    Heidrun Potschka
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Neuropharmacology 61:909-17. 2011
  9. ncbi Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus
    C Freichel
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, , D-30559 Hannover, Germany
    Neuroscience 141:2177-94. 2006
  10. ncbi Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain
    H Potschka
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, 30559 Hannover, Germany
    Neuroreport 12:2387-9. 2001

Collaborators

  • A Tipold
  • U Ebert
  • V M Stein
  • W Loscher
  • S Wagner
  • A Becker
  • J Chen
  • A Keller
  • P Wlaz
  • A Pekcec
  • W Baumgartner
  • C Brandt
  • M Jafari
  • E L von Rüden
  • J Schlichtiger
  • Sarah Verena Fischborn
  • J Soerensen
  • Bernadette Unkrüer
  • C Freichel
  • H A Volk
  • D Algermissen
  • P Bock
  • J Avemary
  • C Zellinger
  • H Wendt
  • A Beineke
  • M Glien
  • V Haist
  • E L Schneider
  • C Fuest
  • H Bartmann
  • Jonna Soerensen
  • P Winter
  • Anja Horn
  • J P Bankstahl
  • Christina Fuest
  • B Unkrüer
  • Anton Pekcec
  • Wolfgang Baumgartner
  • Maria S Balda
  • Andrea Wehmeyer
  • K Burkhardt
  • H Voigt

Detail Information

Publications22

  1. ncbi Role of CNS efflux drug transporters in antiepileptic drug delivery: overcoming CNS efflux drug transport
    Heidrun Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Koeniginstr 16, D 80539 Munich, Germany
    Adv Drug Deliv Rev 64:943-52. 2012
    ....
  2. ncbi Cellular localization of Y-box binding protein 1 in brain tissue of rats, macaques, and humans
    Bernadette Unkrüer
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University Munich, Munich, Germany
    BMC Neurosci 10:28. 2009
    ..The Y-box binding protein 1 (YB-1) is considered to be one of the key regulators of transcription and translation. However, so far only limited knowledge exists regarding its cellular distribution in the adult brain...
  3. ncbi Transporter hypothesis of drug-resistant epilepsy: challenges for pharmacogenetic approaches
    Heidrun Potschka
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Koeniginstr 16, D 80539 Munich, Germany
    Pharmacogenomics 11:1427-38. 2010
    ..In this article, the evidence for an impact of efflux transporters on the response to antiepileptic drugs is discussed, focusing in particular on the different issues presenting a challenge for pharmacogenetic approaches in this field...
  4. ncbi Targeting the prostaglandin E2 EP1 receptor and cyclooxygenase-2 in the amygdala kindling model in mice
    Sarah Verena Fischborn
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilian University, Koeniginstr 16, D 80539 Munich, Germany
    Epilepsy Res 91:57-65. 2010
    ..The contrasting impact of the EP1 receptor antagonist and agonist suggests that EP1 receptors can influence endogenous mechanisms involved in termination of seizure activity...
  5. ncbi Modulating P-glycoprotein regulation: future perspectives for pharmacoresistant epilepsies?
    Heidrun Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Epilepsia 51:1333-47. 2010
    ..In this context current efforts are discussed, including the development of imaging tools that allow an evaluation of P-glycoprotein function in individual patients...
  6. ncbi Targeting regulation of ABC efflux transporters in brain diseases: a novel therapeutic approach
    Heidrun Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Koeniginstr 16, D 80539 Munich, Germany
    Pharmacol Ther 125:118-27. 2010
    ....
  7. ncbi Deficiency of neural cell adhesion molecule or its polysialylation modulates pharmacological effects of the AMPA receptor antagonist NBQX
    H Potschka
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University Munich, Koeniginstr 16, 80539 Munich, Germany
    Neuroscience 152:1093-8. 2008
    ..Thus, disease-related changes in the polysialylation of NCAM are likely to be associated with effects on the efficacy and tolerability of AMPA receptor antagonists...
  8. ncbi Impact of seizure activity on free extracellular phenytoin concentrations in amygdala-kindled rats
    Heidrun Potschka
    Institute of Pharmacology, Toxicology and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Neuropharmacology 61:909-17. 2011
    ....
  9. ncbi Acute changes in the neuronal expression of GABA and glutamate decarboxylase isoforms in the rat piriform cortex following status epilepticus
    C Freichel
    Department of Pharmacology, Toxicology, and Pharmacy, University of Veterinary Medicine Hannover, , D-30559 Hannover, Germany
    Neuroscience 141:2177-94. 2006
    ..The data substantiate the particular susceptibility of the central PC to seizure-induced plasticity and indicate that this brain region provides an interesting tool to study the regulation of GAD isoenzymes...
  10. ncbi Multidrug resistance-associated protein is involved in the regulation of extracellular levels of phenytoin in the brain
    H Potschka
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, 30559 Hannover, Germany
    Neuroreport 12:2387-9. 2001
    ..The data indicate that MRP critically participates in the regulation of extracellular brain concentrations of the major antiepileptic drug phenytoin...
  11. ncbi Neuronal expression of the drug efflux transporter P-glycoprotein in the rat hippocampus after limbic seizures
    H A Volk
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559, Hannover, Germany
    Neuroscience 123:751-9. 2004
    ....
  12. ncbi Celecoxib treatment restores pharmacosensitivity in a rat model of pharmacoresistant epilepsy
    J Schlichtiger
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Br J Pharmacol 160:1062-71. 2010
    ..Based on these data, we hypothesized that blocking the appropriate signalling cascade by cyclooxygenase-2 inhibition should improve brain penetration of antiepileptic drugs and help to overcome drug resistance...
  13. ncbi N-methyl-D-aspartate receptor blockade after status epilepticus protects against limbic brain damage but not against epilepsy in the kainate model of temporal lobe epilepsy
    C Brandt
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
    Neuroscience 118:727-40. 2003
    ..E. is an effective means to reduce the damage produced by a sustained S.E. in several brain regions, including the hippocampus, but show that this partial neuroprotection of the limbic system does not prevent the development of epilepsy...
  14. ncbi Repeated low-dose treatment of rats with pilocarpine: low mortality but high proportion of rats developing epilepsy
    M Glien
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
    Epilepsy Res 46:111-9. 2001
    ..The present study demonstrates that systemic treatment of lithium-pretreated rats with several low doses of pilocarpine efficiently produces SE and chronic epilepsy with much lower mortality rates than single-dose pilocarpine...
  15. ncbi Distemper virus encephalitis exerts detrimental effects on hippocampal neurogenesis
    E L von Rüden
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Neuropathol Appl Neurobiol 38:426-42. 2012
    ..Canine distemper is considered an interesting model of virus encephalitis, which can be associated with a chronic progressing disease course and can cause symptomatic seizures...
  16. ncbi P-glycoprotein and multidrug resistance-associated protein are involved in the regulation of extracellular levels of the major antiepileptic drug carbamazepine in the brain
    H Potschka
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, , D-30559 Hannover, Germany
    Neuroreport 12:3557-60. 2001
    ..The data indicate that both PGP and MRP participate in the regulation of extracellular brain concentrations of the major AED carbamazepine...
  17. ncbi In vivo evidence for P-glycoprotein-mediated transport of phenytoin at the blood-brain barrier of rats
    H Potschka
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsia 42:1231-40. 2001
    ....
  18. ncbi Over-expression of P-glycoprotein in the canine brain following spontaneous status epilepticus
    A Pekcec
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University Munich, Munich, Germany
    Epilepsy Res 83:144-51. 2009
    ..Clinical studies with Pgp modulating compounds are currently envisaged in canine epilepsy...
  19. ncbi Age-dependent decline of blood-brain barrier P-glycoprotein expression in the canine brain
    A Pekcec
    Inst of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University Munich, Koeniginstr 16, 80539 Munich, Germany
    Neurobiol Aging 32:1477-85. 2011
    ..Future studies are necessary to further evaluate the correlation between Abeta deposits and P-glycoprotein expression in different phases of the disease...
  20. ncbi Frontal versus transcorneal stimulation to induce maximal electroshock seizures or kindling in mice and rats
    P Wlaz
    Department of Pharmacology, Toxicology and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Epilepsy Res 30:219-29. 1998
    ..Nevertheless, this type of stimulation cannot be used to produce minimal electroshock seizures and seems not to be useful to produce kindling in rats and mice...
  21. ncbi Impact of Theiler's virus infection on hippocampal neuronal progenitor cells: differential effects in two mouse strains
    M Jafari
    Institute of Pharmacology, Toxicology, and Pharmacy, Ludwig Maximilians University, Munich, Germany
    Neuropathol Appl Neurobiol 38:647-64. 2012
    ....
  22. ncbi Kindling-induced overexpression of Homer 1A and its functional implications for epileptogenesis
    H Potschka
    Department of Pharmacology, Toxicology, and Pharmacy, School of Veterinary Medicine, Hannover, Germany
    Eur J Neurosci 16:2157-65. 2002
    ....