Rolf Postina

Summary

Affiliation: University of Mainz
Country: Germany

Publications

  1. pmc Induction of RAGE shedding by activation of G protein-coupled receptors
    Verena V Metz
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 7:e41823. 2012
  2. doi request reprint Activation of α-secretase cleavage
    Rolf Postina
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Johann Joachim Becherweg 30, Mainz, Germany
    J Neurochem 120:46-54. 2012
  3. ncbi request reprint A closer look at alpha-secretase
    Rolf Postina
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Becherweg 30, 55099 Mainz, Germany
    Curr Alzheimer Res 5:179-86. 2008
  4. ncbi request reprint Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Germany
    FEBS J 272:5808-20. 2005
  5. ncbi request reprint The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg, Mainz, Germany
    FASEB J 20:512-4. 2006
  6. doi request reprint Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
  7. ncbi request reprint Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases
    Ling Zhang
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, Mainz D 55099, Germany
    J Biol Chem 283:35507-16. 2008
  8. pmc Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
    Claudia Prinzen
    Johannes Gutenberg University, Institute of Biochemistry, Mainz, Mainz, Germany
    BMC Genomics 10:66. 2009
  9. pmc Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice
    Dorothea Rat
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FASEB J 25:3208-18. 2011
  10. pmc Statins stimulate the production of a soluble form of the receptor for advanced glycation end products
    Patricia Quade-Lyssy
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, D 55128 Mainz, Germany
    J Lipid Res 54:3052-61. 2013

Collaborators

Detail Information

Publications22

  1. pmc Induction of RAGE shedding by activation of G protein-coupled receptors
    Verena V Metz
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    PLoS ONE 7:e41823. 2012
    ..Our findings suggest that pharmacological stimulation of RAGE shedding might open alternative treatment strategies for Alzheimers disease and diabetes-induced inflammation...
  2. doi request reprint Activation of α-secretase cleavage
    Rolf Postina
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University Mainz, Johann Joachim Becherweg 30, Mainz, Germany
    J Neurochem 120:46-54. 2012
    ..Excessive activation of ADAM10 should be avoided because ADAM10 and also ADAM17 are not APP-specific. Both ADAM proteins cleave various substrates, and therefore have been associated with tumorigenesis and tumor progression...
  3. ncbi request reprint A closer look at alpha-secretase
    Rolf Postina
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Becherweg 30, 55099 Mainz, Germany
    Curr Alzheimer Res 5:179-86. 2008
    ..Agonists for M1 muscarinic acetylcholine receptors and serotonin 5-HT4 receptors are currently in clinical trials to test their efficiency in the treatment of AD...
  4. ncbi request reprint Shedding of the amyloid precursor protein-like protein APLP2 by disintegrin-metalloproteinases
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Germany
    FEBS J 272:5808-20. 2005
    ..Retinoic acid treatment of two neuroblastoma cell lines upregulated the expression of both APLP2 and ADAM10, thus leading to an increased release of soluble APLP2...
  5. ncbi request reprint The neuropeptide PACAP promotes the alpha-secretase pathway for processing the Alzheimer amyloid precursor protein
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University, Becherweg, Mainz, Germany
    FASEB J 20:512-4. 2006
    ..Our findings provide evidence for a role of the neuropeptide PACAP in stimulation of the nonamyloidogenic pathway, which might be related to its neuroprotective properties...
  6. doi request reprint Statins and the squalene synthase inhibitor zaragozic acid stimulate the non-amyloidogenic pathway of amyloid-beta protein precursor processing by suppression of cholesterol synthesis
    Elzbieta Kojro
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    J Alzheimers Dis 20:1215-31. 2010
    ..Our results indicate that inhibition of cholesterol biosynthesis by a low lovastatin concentration is sufficient for alpha-secretase activation...
  7. ncbi request reprint Receptor for advanced glycation end products is subjected to protein ectodomain shedding by metalloproteinases
    Ling Zhang
    Institute of Biochemistry, Johannes Gutenberg University of Mainz, Becherweg 30, Mainz D 55099, Germany
    J Biol Chem 283:35507-16. 2008
    ..Identification of these novel mechanisms involved in regulating the availability of cell surface-located RAGE and its soluble ectodomain may influence further research in RAGE-mediated processes in cell biology and pathophysiology...
  8. pmc Differential gene expression in ADAM10 and mutant ADAM10 transgenic mice
    Claudia Prinzen
    Johannes Gutenberg University, Institute of Biochemistry, Mainz, Mainz, Germany
    BMC Genomics 10:66. 2009
    ..Furthermore, ADAM10 overexpression increased the cortical synaptogenesis. These results suggest that upregulation of ADAM10 in the brain has beneficial effects on AD pathology...
  9. pmc Neuropeptide pituitary adenylate cyclase-activating polypeptide (PACAP) slows down Alzheimer's disease-like pathology in amyloid precursor protein-transgenic mice
    Dorothea Rat
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, Mainz, Germany
    FASEB J 25:3208-18. 2011
    ..Thus, nasal application of PACAP was effective, and our results indicate that PACAP could be of therapeutic value in treating AD...
  10. pmc Statins stimulate the production of a soluble form of the receptor for advanced glycation end products
    Patricia Quade-Lyssy
    Institute of Pharmacy and Biochemistry, Johannes Gutenberg University, D 55128 Mainz, Germany
    J Lipid Res 54:3052-61. 2013
    ..Our results show that statins, due to their cholesterol-lowering effects, increase the soluble RAGE level by inducing RAGE shedding, and by doing this, might prevent the development of RAGE-mediated pathogenesis. ..
  11. pmc A disintegrin-metalloproteinase prevents amyloid plaque formation and hippocampal defects in an Alzheimer disease mouse model
    Rolf Postina
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    J Clin Invest 113:1456-64. 2004
    ....
  12. ncbi request reprint Genomic structure and functional characterization of the human ADAM10 promoter
    Claudia Prinzen
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    FASEB J 19:1522-4. 2005
    ..This finding suggests that pharmacologic targeting of RA receptors may increase the expression of the alpha-secretase ADAM10 with beneficial effects on AD pathology...
  13. ncbi request reprint Tumor necrosis factor-alpha converting enzyme is processed by proprotein-convertases to its mature form which is degraded upon phorbol ester stimulation
    Kristina Endres
    Institute of Biochemistry, Johannes Gutenberg University, Mainz, Germany
    Eur J Biochem 270:2386-93. 2003
    ....
  14. ncbi request reprint Synthesis of maleimide-functionalyzed HPMA-copolymers and in vitro characterization of the aRAGE- and human immunoglobulin (huIgG)-polymer conjugates
    Kristof Tappertzhofen
    Johannes Gutenberg Universitat Mainz, Institute of Organic Chemistry, Mainz, Germany
    Macromol Biosci 13:203-14. 2013
    ..Modification of the antibody and conjugation is monitored by SDS-PAGE electrophoresis. Preserved affinity is demonstrated by Western Blott and cell-uptake analysis, for example, to cells of the immune system...
  15. pmc The substrate degradome of meprin metalloproteases reveals an unexpected proteolytic link between meprin β and ADAM10
    Tamara Jefferson
    Institute of Biochemistry, Christian Albrechts University, 24118, Kiel, Germany
    Cell Mol Life Sci 70:309-33. 2013
    ..Our finding of cystatin C, elafin and fetuin-A as substrates and natural inhibitors for meprins reveal new mechanisms in the regulation of protease activity important for understanding pathophysiological processes...
  16. doi request reprint Regulated proteolysis of RAGE and AbetaPP as possible link between type 2 diabetes mellitus and Alzheimer's disease
    Elzbieta Kojro
    Institute of Biochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
    J Alzheimers Dis 16:865-78. 2009
    ..Current data suggest that the sequential proteolysis of RAGE is homologous to AbetaPP processing...
  17. ncbi request reprint Alpha-secretase activation--an approach to Alzheimer's disease therapy
    Falk Fahrenholz
    Institute of Biochemistry, University of Mainz, Mainz, Germany
    Neurodegener Dis 3:255-61. 2006
    ..Our results suggest medications and dietary regiments which enhance the nonamyloidogenic pathway of APP processing to be a valuable approach to Alzheimer's disease therapy...
  18. doi request reprint Unfolded protein response signaling by transcription factor XBP-1 regulates ADAM10 and is affected in Alzheimer's disease
    Sven Reinhardt
    1Department of Psychiatry and Psychotherapy, University Medical Center of the Johannes Gutenberg University Mainz, Untere Zahlbacher Strasse 8, 55131 Mainz, Germany
    FASEB J 28:978-97. 2014
    ..Our results demonstrate that XBP-1 is a driver of ADAM10 gene expression and that disturbance of this pathway might contribute to development or progression of AD...
  19. doi request reprint Amphiphilic HPMA-LMA copolymers increase the transport of Rhodamine 123 across a BBB model without harming its barrier integrity
    Mirjam Hemmelmann
    Institute of Organic Chemistry, Johannes Gutenberg University Mainz, Duesbergweg 10 14, 55099 Mainz, Germany
    J Control Release 163:170-7. 2012
    ..According to our results, p(HPMA)-co-p(LMA) copolymers are a promising delivery system for neurological therapeutics and their application might open alternative treatment strategies...
  20. ncbi request reprint Binding domains of the oxytocin receptor for the selective oxytocin receptor antagonist barusiban in comparison to the agonists oxytocin and carbetocin
    Gerald Gimpl
    Institut fur Biochemie, Becherweg 30, 55099 Mainz, Germany
    Eur J Pharmacol 510:9-16. 2005
    ..Overall, the data supported the concept of a central pocket site within the oxytocin receptor...
  21. ncbi request reprint The disintegrin ADAM9 indirectly contributes to the physiological processing of cellular prion by modulating ADAM10 activity
    Moustapha Alfa Cisse
    Institut de Pharmacologie Moleculaire et Cellulaire, du CNRS, UMR6097, Sophia Antipolis, 06560 Valbonne, France
    J Biol Chem 280:40624-31. 2005
    ..ADAM9 could therefore represent, besides ADAM10, another potential therapeutic target to enhance the breakdown of the 106-126 and Abeta toxic domains of the prion and betaAPP proteins...
  22. ncbi request reprint The disintegrin-like metalloproteinase ADAM10 is involved in constitutive cleavage of CX3CL1 (fractalkine) and regulates CX3CL1-mediated cell-cell adhesion
    Christian Hundhausen
    Institute for Biochemistry, Christian Albrechts University, Kiel, Germany
    Blood 102:1186-95. 2003
    ..Our data demonstrate that ADAM10 is involved in the constitutive cleavage of CX3CL1 and thereby may regulate the recruitment of monocytic cells to CX3CL1-expressing cell layers...