Ernst Poschl

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. pmc DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage
    E Poschl
    Department of Experimental Medicine, University of Erlangen Nurnberg, Glückstr 6, 91054 Erlangen, Germany
    Ann Rheum Dis 64:477-80. 2005
  2. ncbi Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
    Ernst Poschl
    Department of Experimental Medicine I, University Erlangen Nurnberg, 91054 Erlangen, Germany
    Development 131:1619-28. 2004
  3. pmc BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054, Erlangen, Germany
    Histochem Cell Biol 127:183-94. 2007
  4. ncbi Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo
    Martina Schmidl
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 281:31790-800. 2006
  5. ncbi Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms
    Helga von der Mark
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuernberg, 91054 Erlangen, Germany
    J Mol Biol 371:1188-203. 2007
  6. ncbi A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, D 91054, Germany
    Matrix Biol 23:309-22. 2004
  7. ncbi Differential gene expression in pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:3742-52. 2005
  8. ncbi The NC1 domain of human collagen IV is necessary to initiate triple helix formation
    Stephan Soder
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Germany
    Biochem Biophys Res Commun 325:276-80. 2004
  9. ncbi Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer
    Silvia Riemer
    Department of Experimental Medicine I, University of Erlangen Nuremberg, Germany
    J Cell Biochem 86:688-99. 2002
  10. ncbi SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes
    Thomas Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, Erlangen 91504, Germany
    Matrix Biol 22:363-72. 2003

Collaborators

Detail Information

Publications13

  1. pmc DNA methylation is not likely to be responsible for aggrecan down regulation in aged or osteoarthritic cartilage
    E Poschl
    Department of Experimental Medicine, University of Erlangen Nurnberg, Glückstr 6, 91054 Erlangen, Germany
    Ann Rheum Dis 64:477-80. 2005
    ..Expression of aggrecan is reduced during aging and osteoarthritic cartilage degeneration. CpG methylation may have a role in the down regulation of aggrecan transcriptions...
  2. ncbi Collagen IV is essential for basement membrane stability but dispensable for initiation of its assembly during early development
    Ernst Poschl
    Department of Experimental Medicine I, University Erlangen Nurnberg, 91054 Erlangen, Germany
    Development 131:1619-28. 2004
    ....
  3. pmc BAC constructs in transgenic reporter mouse lines control efficient and specific LacZ expression in hypertrophic chondrocytes under the complete Col10a1 promoter
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, 91054, Erlangen, Germany
    Histochem Cell Biol 127:183-94. 2007
    ..The Col10a1 specific BAC recombination vector described here will enable the specific analysis of effector gene functions in hypertrophic cartilage during skeletal development, endochondral ossification, and fracture callus healing...
  4. ncbi Twisted gastrulation modulates bone morphogenetic protein-induced collagen II and X expression in chondrocytes in vitro and in vivo
    Martina Schmidl
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, 91054 Erlangen, Germany
    J Biol Chem 281:31790-800. 2006
    ..The data suggest that TSG is an important modulator of BMP-regulated cartilage development and chondrocyte differentiation...
  5. ncbi Distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms
    Helga von der Mark
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuernberg, 91054 Erlangen, Germany
    J Mol Biol 371:1188-203. 2007
    ..In conclusion, specific surface epitopes containing charged and hydrophobic residues are essential for ligand binding and define specific interactions with laminin isoforms...
  6. ncbi A highly conserved enhancer in mammalian type X collagen genes drives high levels of tissue-specific expression in hypertrophic cartilage in vitro and in vivo
    Sonja Gebhard
    Department of Experimental Medicine I, Nikolaus Fiebiger Center of Molecular Medicine, University of Erlangen Nuremberg, Glueckstr 6, D 91054, Germany
    Matrix Biol 23:309-22. 2004
    ..These established transgenic lines should facilitate the genetic analysis of regulatory pathways of chondrocyte maturation and Col10a1 gene expression in the future...
  7. ncbi Differential gene expression in pseudoexfoliation syndrome
    Matthias Zenkel
    Department of Ophthalmology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 46:3742-52. 2005
    ..To identify and characterize genes differentially expressed in anterior segment tissues of eyes with pseudoexfoliation (PEX) syndrome and glaucoma...
  8. ncbi The NC1 domain of human collagen IV is necessary to initiate triple helix formation
    Stephan Soder
    Osteoarticular and Arthritis Research, Department of Pathology, University of Erlangen Nurnberg, Germany
    Biochem Biophys Res Commun 325:276-80. 2004
    ..Additionally, we could show that the human alpha2(IV) chain can form chimeric alpha1.alpha1.alpha2(IV) heterotrimers with mouse subunits when expressed in PF-HR9 cells...
  9. ncbi Role of c-fos in the regulation of type X collagen gene expression by PTH and PTHrP: localization of a PTH/PTHrP-responsive region in the human COL10A1 enhancer
    Silvia Riemer
    Department of Experimental Medicine I, University of Erlangen Nuremberg, Germany
    J Cell Biochem 86:688-99. 2002
    ..These results indicate the presence of a PTH/PTHrP responsive element in the human COL10A1 enhancer, which may be represented by multiple putative AP-1 sites located in this region...
  10. ncbi SOX9 expression does not correlate with type II collagen expression in adult articular chondrocytes
    Thomas Aigner
    Cartilage Research, Department of Pathology, University of Erlangen Nurnberg, Krankenhausstrasse 8 10, Erlangen 91504, Germany
    Matrix Biol 22:363-72. 2003
    ..However, SOX9 might still be involved in maintaining the chondrocytic phenotype in normal and osteoarthritic cartilage...
  11. ncbi The role of annexin A5 in the modulation of the immune response against dying and dead cells
    Luis E Munoz
    Institute for Clinical Immunology and Exp Medicine I, Friedrich Alexander University of Erlangen Nuremberg, Glückstrasse 4a and 6, 91054 Erlangen, Germany
    Curr Med Chem 14:271-7. 2007
    ..Taken together, annexin A5 is an important modulator of the immune response against PS-exposing particles like apoptotic cells, necrotic cells, and certain viruses...
  12. ncbi Alternative splice variants of alpha 7 beta 1 integrin selectively recognize different laminin isoforms
    Helga von der Mark
    Friedrich Alexander Universitat Erlangen Nurnberg, Nikolaus Fiebiger Zentrum für Molekulare Medizin, Department of Experimental Medicine I, 91054 Erlangen, Germany
    J Biol Chem 277:6012-6. 2002
    ....
  13. ncbi The influence on the immunomodulatory effects of dying and dead cells of Annexin V
    Luis E Munoz
    Institute for Clinical Immunology, Department of Internal Medicne 3, Friedrich Alexander University of Erlangen Nuremberg, Glueckstrasse 4a, 91054 Erlangen, Germany
    J Leukoc Biol 81:6-14. 2007
    ..From the experiments presented above, we conclude that AxV influences the clearance of several PS-exposing particles such as viruses, dying, and dead cells...