Aurel Popa-Wagner

Summary

Affiliation: University of Greifswald
Country: Germany

Publications

  1. ncbi Accelerated delimitation of the infarct zone by capillary-derived nestin-positive cells in aged rats
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Curr Neurovasc Res 3:3-13. 2006
  2. ncbi The response of the aged brain to stroke: too much, too soon?
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Curr Neurovasc Res 4:216-27. 2007
  3. ncbi Cognitive impairment with vascular impairment and degeneration
    Ryszard Pluta
    Laboratory of Ischemic and Neurodegenerative Brain Research, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Curr Neurovasc Res 8:342-50. 2011
  4. doi Perturbed cellular response to brain injury during aging
    Aurel Popa-Wagner
    Dept of Neurology, University of Greifswald, Ellernholzstr 1 2, 17487 Greifswald, Germany
    Ageing Res Rev 10:71-9. 2011
  5. ncbi Central nervous system aging and regeneration after injuries. A systematic approach
    A Popa-Wagner
    Department of Neurology, Clinic of Neurology, University of Greifswald, Germany
    Rom J Morphol Embryol 50:155-67. 2009
  6. ncbi Premature cellular proliferation following cortical infarct in aged rats
    A Popa-Wagner
    Department of Neurology, University of Greifswald, Germany
    Rom J Morphol Embryol 47:215-28. 2006
  7. ncbi Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Ellernholzstr 1 2, 17487, Greifswald, Germany
    Acta Neuropathol 113:277-93. 2007
  8. pmc Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia
    Christy Joseph
    Molecular Neurobiology Laboratory, Clinic of Neurology, University of Medicine, Greifswald, Germany
    J Cereb Blood Flow Metab 32:1632-42. 2012
  9. doi Long-term hypothermia reduces infarct volume in aged rats after focal ischemia
    Baltromejus Florian
    Department of Neurology, University of Greifswald, Ellernholzstr 1 2, 17487 Greifswald, Germany
    Neurosci Lett 438:180-5. 2008
  10. pmc Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period
    Harald Schmoll
    Department of Neurology, Ernst Moritz Arndt University, Greifswald, Germany
    Am J Pathol 162:1027-34. 2003

Collaborators

Detail Information

Publications29

  1. ncbi Accelerated delimitation of the infarct zone by capillary-derived nestin-positive cells in aged rats
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Curr Neurovasc Res 3:3-13. 2006
    ..Because capillary-derived cells help to form the glial scar, elucidating the molecular basis of this phenomenon and its acceleration in the aging brain could yield novel approaches to enhancing neurorestoration in the elderly...
  2. ncbi The response of the aged brain to stroke: too much, too soon?
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Curr Neurovasc Res 4:216-27. 2007
    ..Elucidating the molecular basis of this phenomenon in the aging brain could yield novel approaches to neurorestoration following stroke or head injury in the elderly...
  3. ncbi Cognitive impairment with vascular impairment and degeneration
    Ryszard Pluta
    Laboratory of Ischemic and Neurodegenerative Brain Research, Department of Neurodegenerative Disorders, Mossakowski Medical Research Centre, Polish Academy of Sciences, Warsaw, Poland
    Curr Neurovasc Res 8:342-50. 2011
    ....
  4. doi Perturbed cellular response to brain injury during aging
    Aurel Popa-Wagner
    Dept of Neurology, University of Greifswald, Ellernholzstr 1 2, 17487 Greifswald, Germany
    Ageing Res Rev 10:71-9. 2011
    ....
  5. ncbi Central nervous system aging and regeneration after injuries. A systematic approach
    A Popa-Wagner
    Department of Neurology, Clinic of Neurology, University of Greifswald, Germany
    Rom J Morphol Embryol 50:155-67. 2009
    ..Most importantly, data from animal models has shown that senescent systems do retain some capacity for regeneration and functional recovery after injuries...
  6. ncbi Premature cellular proliferation following cortical infarct in aged rats
    A Popa-Wagner
    Department of Neurology, University of Greifswald, Germany
    Rom J Morphol Embryol 47:215-28. 2006
    ..1996; Popa-Wagner A et al., 1998, 1999a). Hence, the aged post-acute animal model is clinically most relevant to stroke rehabilitation and cellular studies (Lindner MD et al., 2003; Brown AW et al., 2003; Badan I et al., 2003)...
  7. ncbi Accelerated infarct development, cytogenesis and apoptosis following transient cerebral ischemia in aged rats
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Ellernholzstr 1 2, 17487, Greifswald, Germany
    Acta Neuropathol 113:277-93. 2007
    ....
  8. pmc Prolonged gaseous hypothermia prevents the upregulation of phagocytosis-specific protein annexin 1 and causes low-amplitude EEG activity in the aged rat brain after cerebral ischemia
    Christy Joseph
    Molecular Neurobiology Laboratory, Clinic of Neurology, University of Medicine, Greifswald, Germany
    J Cereb Blood Flow Metab 32:1632-42. 2012
    ....
  9. doi Long-term hypothermia reduces infarct volume in aged rats after focal ischemia
    Baltromejus Florian
    Department of Neurology, University of Greifswald, Ellernholzstr 1 2, 17487 Greifswald, Germany
    Neurosci Lett 438:180-5. 2008
    ..Conclusions: Prolonged, H(2)S-induced hypothermia is a simple and efficacious method to limit the damage inflicted by stroke in aged rats...
  10. pmc Kindling status in sprague-dawley rats induced by pentylenetetrazole: involvement of a critical development period
    Harald Schmoll
    Department of Neurology, Ernst Moritz Arndt University, Greifswald, Germany
    Am J Pathol 162:1027-34. 2003
    ..The demonstration of a long, defined developmental interval for inducing the kindling criterion should enable a dissection of the cellular and genetic events underlying this phenomenon in the rat...
  11. ncbi Proteomic identification of the involvement of the mitochondrial rieske protein in epilepsy
    Heike Junker
    Institutes of Biochemistry, Ernst Moritz Arndt University, Greifswald, Germany
    Epilepsia 46:339-43. 2005
    ....
  12. ncbi Cellular and molecular events underlying the dysregulated response of the aged brain to stroke: a mini-review
    Eugen Bogdan Petcu
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Gerontology 54:6-17. 2008
    ..Age-related brain injuries, including stroke, are a major cause of physical and mental disabilities...
  13. ncbi Safety of vascular endothelial and hepatocyte growth factor gene therapy in patients with critical limb ischemia
    Andrei Anghel
    Biochemistry Department, University of Medicine and Pharmacy Victor Babes Timisoara
    Curr Neurovasc Res 8:183-9. 2011
    ..42% in the placebo group (p = 0.029). Pain at rest was improved in 65% of patients in the gene therapy group and in 7% in the placebo group (p = 0.0006). There were no significant adverse effects in the treatment group...
  14. ncbi Anomalous expression of microtubule-associated protein 1B in the hippocampus and cortex of aged rats treated with pentylenetetrazole
    A Popa-Wagner
    Department of Neurology, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Neuroscience 94:395-403. 1999
    ....
  15. ncbi Delayed and blunted induction of mRNA for tissue plasminogen activator in the brain of old rats following pentylenetetrazole-induced seizure activity
    A Popa-Wagner
    Department of Neurology, Ernst Moritz Arndt Universitat, Greifswald, Germany
    J Gerontol A Biol Sci Med Sci 55:B242-8. 2000
    ..Because TPA has been implicated in neuronal plasticity, this finding suggests that immediate early genes are important factors in the limited plasticity of the aging brain...
  16. ncbi Observations on experimental marginal periodontitis in rats
    A Kuhr
    Division of Periodontology, Department of Restorative Dentistry, Periodontology and Pediatric Dentistry, School of Dentistry, Greifswald, Germany
    J Periodontal Res 39:101-6. 2004
    ..The extent to which the physiological movement of teeth influenced the effect of the ligatures was also examined. In addition, two methods for measuring bone loss in the defleshed jaw were compared...
  17. ncbi Proteomic identification of an upregulated isoform of annexin A3 in the rat brain following reversible cerebral ischemia
    Heike Junker
    Molecular Neurobiology Laboratory, Clinic of Neurology, Ernst Moritz Arndt University, Greifswald, Germany
    Glia 55:1630-7. 2007
    ..Our study identifies ANXA3 as a novel marker of brain microglia, which should be of substantial value in future studies of microglial cells and its role in the postischemic brain...
  18. ncbi Mild systemic inflammation has a neuroprotective effect after stroke in rats
    Eugen Bogdan Petcu
    Neurological Clinic, Greifswald, Germany
    Curr Neurovasc Res 5:214-23. 2008
    ..In conclusion we found that mild systemic inflammation elicited prior to stroke onset may have a neuroprotective effect in rats by reducing the infarct volume and tissue destruction by brain macrophages...
  19. doi Effects of granulocyte-colony stimulating factor after stroke in aged rats
    Aurel Popa-Wagner
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Stroke 41:1027-31. 2010
    ..We tested the hypothesis that G-CSF provides a restorative therapeutic benefit in aged animals...
  20. doi The genomic response of the ipsilateral and contralateral cortex to stroke in aged rats
    A M Buga
    Molecular Neurobiology Laboratory, Clinic of Neurology, University of Greifswald, Germany
    J Cell Mol Med 12:2731-53. 2008
    ....
  21. ncbi Strategies to improve post-stroke behavioral recovery in aged subjects
    Ana Maria Buga
    Department of Neurology, University of Greifswald, Germany
    Rom J Morphol Embryol 50:559-82. 2009
    ..Future studies should focus on an optimization of treatment schedule to achieve a maximum of post-stroke recovery enhancement in aged subjects...
  22. ncbi Differential regulation of transport proteins in the periinfarct region following reversible middle cerebral artery occlusion in rats
    P Dazert
    Department of Pharmacology, Research Center of Pharmacology and Experimental Therapeutics, Ernst Moritz Arndt University, Greifswald, Germany
    Neuroscience 142:1071-9. 2006
    ..The study further suggests Bcrp as a pronounced marker for the regenerative process and a possible functional role of Mrp5 in surviving neurons...
  23. ncbi Modified variant of the Rieske iron-sulfur protein in the hippocampus of kindled rats and human epileptic patients
    E B Petcu
    Department of Neurology, Ernst Moritz Arndt Universitat, Greifswald, Germany
    Rom J Morphol Embryol 48:17-24. 2007
    ..These results suggest that the Rieske protein may play a role in the response of neurons to seizure activity and could give important new insights into the molecular pathogenesis of epilepsy...
  24. ncbi Cellular and molecular mechanisms underlying neurorehabilitation after stroke in aged subjects
    Ana Maria Buga
    Department of Neurology, University of Greifswald, Germany
    Rom J Morphol Embryol 49:279-302. 2008
    ....
  25. ncbi Environmental enrichment improves functional and neuropathological indices following stroke in young and aged rats
    B Buchhold
    Department of Neurology, University of Greifswald, Greifswald, Germany
    Restor Neurol Neurosci 25:467-84. 2007
    ..While environmental enrichment has been shown to improve the behavioral outcome of stroke in young animals, the effect of an enriched environment on behavioral and neuropathological recovery in aged animals is not known...
  26. ncbi Annexin A3 expression after stroke in the aged rat brain
    Ch Kessler
    Department of Neurology, Ernst Moritz Arndt University, Greifswald, Germany
    Rom J Morphol Embryol 49:27-35. 2008
    ..Occasionally, ANXA3-immunopositive cells wraped around neurons, suggesting that annexin A3 may be involved in the removal of dying neurons after stroke...
  27. ncbi Pathophysiology of the vascular wall and its relevance for cerebrovascular disorders in aged rodents
    A Popa-Wagner
    Aging and Neural Repair Laboratory, Clinic of Neurology, Ernst Moritz Arndt University Greifswald, Ellernholz strasse 1 2, Greifswald, Germany
    Curr Neurovasc Res 7:251-67. 2010
    ..Understanding the basic mechanisms underlying functional recovery after cerebral stroke in aging subjects is likely to yield new insights into the treatment of brain injury in the clinic...
  28. ncbi Accelerated accumulation of N- and C-terminal beta APP fragments and delayed recovery of microtubule-associated protein 1B expression following stroke in aged rats
    I Badan
    Klinik fur Neurologie, Ernst Moritz Arndt Universitat Greifswald, Ellernholzstrasse 1 2, 17487, Greifswald, Germany
    Eur J Neurosci 19:2270-80. 2004
    ....