Stefan Pohlmann

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo
    Stefan Pohlmann
    University of Pennsylvania, Department of Microbiology, Philadelphia, PA 19104, USA
    Virology 360:275-85. 2007
  2. pmc Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors
    Stefan Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 78:3223-32. 2004
  3. pmc Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR
    Stefan Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:4070-80. 2003
  4. pmc Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells
    Frederic Baribaud
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:9135-42. 2002
  5. pmc Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR
    George Lin
    Hematology Oncology Division, Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Virol 77:1337-46. 2003
  6. pmc CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity
    Bridget A Puffer
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:2595-605. 2002
  7. ncbi request reprint Prospects of HIV-1 entry inhibitors as novel therapeutics
    Theodore C Pierson
    Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Rev Med Virol 14:255-70. 2004
  8. ncbi request reprint Cellular entry of HIV: Evaluation of therapeutic targets
    Stefan Pohlmann
    Institute for Clinical and molecular Virology and Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Curr Pharm Des 12:1963-73. 2006
  9. pmc Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:16249-54. 2002
  10. ncbi request reprint The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?
    Frederic Baribaud
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Expert Opin Ther Targets 6:423-31. 2002

Collaborators

Detail Information

Publications10

  1. ncbi request reprint A simian immunodeficiency virus V3 loop mutant that does not efficiently use CCR5 or common alternative coreceptors is moderately attenuated in vivo
    Stefan Pohlmann
    University of Pennsylvania, Department of Microbiology, Philadelphia, PA 19104, USA
    Virology 360:275-85. 2007
    ..Thus, changes in the V3 loop that diminished CCR5 usage and altered Env interactions with CCR5 reduced the pathogenic potential of SIVmac in rhesus macaques but did not abolish it entirely...
  2. pmc Amino acid 324 in the simian immunodeficiency virus SIVmac V3 loop can confer CD4 independence and modulate the interaction with CCR5 and alternative coreceptors
    Stefan Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 78:3223-32. 2004
    ..In summary, we found that a single amino acid at position 324 in the SIV Env V3 loop can modulate both the efficiency and the types of coreceptors engaged by Env and allow for CD4-independent fusion in some cases...
  3. pmc Hepatitis C virus glycoproteins interact with DC-SIGN and DC-SIGNR
    Stefan Pohlmann
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 77:4070-80. 2003
    ..HCV interactions with DC-SIGN and DC-SIGNR may contribute to the establishment or persistence of infection both by the capture and delivery of virus to the liver and by modulating dendritic cell function...
  4. pmc Quantitative expression and virus transmission analysis of DC-SIGN on monocyte-derived dendritic cells
    Frederic Baribaud
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:9135-42. 2002
    ..These results indicate that factors other than DC-SIGN may play important roles in the ability of DCs to capture and transmit HIV...
  5. pmc Differential N-linked glycosylation of human immunodeficiency virus and Ebola virus envelope glycoproteins modulates interactions with DC-SIGN and DC-SIGNR
    George Lin
    Hematology Oncology Division, Department of Medicine, University of Pennsylvania, Philadelphia 19104, USA
    J Virol 77:1337-46. 2003
    ..Thus, the virus-producing cell type is an important factor in dictating both N-glycan status and virus interactions with DC-SIGN(R), which may impact virus tropism and transmissibility in vivo...
  6. pmc CD4 independence of simian immunodeficiency virus Envs is associated with macrophage tropism, neutralization sensitivity, and attenuated pathogenicity
    Bridget A Puffer
    Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    J Virol 76:2595-605. 2002
    ..Finally, genetic modification of viral Envs to enhance CD4 independence may also result in improved humoral immune responses...
  7. ncbi request reprint Prospects of HIV-1 entry inhibitors as novel therapeutics
    Theodore C Pierson
    Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Rev Med Virol 14:255-70. 2004
    ..The mechanism by which Env mediates HIV-1 entry and the therapeutic potential of small molecule inhibitors of this dynamic process will be discussed in detail...
  8. ncbi request reprint Cellular entry of HIV: Evaluation of therapeutic targets
    Stefan Pohlmann
    Institute for Clinical and molecular Virology and Nikolaus Fiebiger Center for Molecular Medicine, University Erlangen Nurnberg, Erlangen, Germany
    Curr Pharm Des 12:1963-73. 2006
    ..Both, cellular receptors and structures in Env associated with membrane fusion are targets for therapeutic intervention. Here, we will discuss how HIV-1 enters cells and introduce strategies how this process can be inhibited...
  9. pmc Sensitivity of HIV-1 to entry inhibitors correlates with envelope/coreceptor affinity, receptor density, and fusion kinetics
    Jacqueline D Reeves
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 99:16249-54. 2002
    ....
  10. ncbi request reprint The role of DC-SIGN and DC-SIGNR in HIV and Ebola virus infection: can potential therapeutics block virus transmission and dissemination?
    Frederic Baribaud
    Department of Microbiology, University of Pennsylvania, 225 Johnson Pavilion, 3610 Hamilton Walk, Philadelphia, PA 19104, USA
    Expert Opin Ther Targets 6:423-31. 2002
    ..This article reviews the interaction of DC-SIGN and DC-SIGNR with HIV and Ebola, discusses the mechanism of DC-SIGN-mediated viral transmission and examines how this process could be inhibited by potential therapeutics...