K Plaschke

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint In contrast to its anti-inflammatory and anti-apoptotic peripheral effect, levosimendan failed to induce a long-term neuroprotective effect in a rat model of mild septic encephalopathy: A pilot study
    Konstanze Plaschke
    Department of Anesthesiology, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany Electronic address
    Neurosci Lett 560:117-21. 2014
  2. doi request reprint The accuracy and responsiveness of continuous noninvasive arterial pressure during rapid ventricular pacing for transcatheter aortic valve replacement
    Christoph Schramm
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Anesth Analg 117:76-82. 2013
  3. doi request reprint The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery
    Konstanze Plaschke
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Thorac Cardiovasc Surg 145:805-11. 2013
  4. doi request reprint The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor
    Konstanze Plaschke
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    Coron Artery Dis 23:215-20. 2012
  5. pmc Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium
    Christine Thomas
    Centre for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Vossstr, Heidelberg, Germany
    BMC Neurosci 9:86. 2008
  6. doi request reprint Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer's disease?
    Konstanze Plaschke
    Department of Anesthesiology, Experimental Anesthesiology, Medical Faculty of the University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Neural Transm 117:1419-22. 2010
  7. doi request reprint VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion
    Konstanze Plaschke
    Department of Anesthesiology, Medical Faculty, University of Heidelberg, Germany
    Exp Neurol 214:285-92. 2008
  8. ncbi request reprint Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the Intensive Care Delirium Screening Checklist (ICDSC) for delirium in critical care patients gives high agreement rate(s)
    Konstanze Plaschke
    Department of Anaesthesiology, Clinical Experimental Anaesthesiology, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Intensive Care Med 34:431-6. 2008
  9. ncbi request reprint EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit
    K Plaschke
    Department of Anaesthesiology, Medical Faculty of the University of Heidelberg, Germany
    Anaesthesia 62:1217-23. 2007
  10. ncbi request reprint Significant correlation between plasma and CSF anticholinergic activity in presurgical patients
    Konstanze Plaschke
    Department of Anesthesia, Medical Faculty of the University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Neurosci Lett 417:16-20. 2007

Detail Information

Publications33

  1. doi request reprint In contrast to its anti-inflammatory and anti-apoptotic peripheral effect, levosimendan failed to induce a long-term neuroprotective effect in a rat model of mild septic encephalopathy: A pilot study
    Konstanze Plaschke
    Department of Anesthesiology, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 110, D 69120 Heidelberg, Germany Electronic address
    Neurosci Lett 560:117-21. 2014
    ..LPS induced a reduction in body weight, increased splenic apoptosis and blood cytokine level. Levosimendan showed anti-inflammatory and anti-apoptotic properties in spleen but failed to show a long-term neuroprotective effect. ..
  2. doi request reprint The accuracy and responsiveness of continuous noninvasive arterial pressure during rapid ventricular pacing for transcatheter aortic valve replacement
    Christoph Schramm
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Anesth Analg 117:76-82. 2013
    ..The accuracy of measurement of the continuous noninvasive arterial blood pressure (CNAP) technique is unknown during sudden cardiocirculatory arrest...
  3. doi request reprint The influence of preoperative serum anticholinergic activity and other risk factors for the development of postoperative cognitive dysfunction after cardiac surgery
    Konstanze Plaschke
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Thorac Cardiovasc Surg 145:805-11. 2013
    ..Serum anticholinergic activity (SAA) has already been described as a risk factor for developing delirium in an elderly study population. However, the role of SAA for long-lasting POCD is unknown...
  4. doi request reprint The inhibitory in-vitro effect of high-dose levosimendan on platelet function may be mediated through its action as a phosphodiesterase inhibitor
    Konstanze Plaschke
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    Coron Artery Dis 23:215-20. 2012
    ..The effect of levosimendan on the cyclic AMP concentration was determined according to its second mode of action as a selective phosphodiesterase III inhibitor...
  5. pmc Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium
    Christine Thomas
    Centre for Psychosocial Medicine, Department of General Psychiatry, University of Heidelberg, Vossstr, Heidelberg, Germany
    BMC Neurosci 9:86. 2008
    ....
  6. doi request reprint Insulin-resistant brain state (IRBS) changes membrane composition of fatty acids in temporal and entorhinal brain cortices of rats: relevance to sporadic Alzheimer's disease?
    Konstanze Plaschke
    Department of Anesthesiology, Experimental Anesthesiology, Medical Faculty of the University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Neural Transm 117:1419-22. 2010
    ..The relevance of these changes is discussed in relation to sporadic Alzheimer's disease...
  7. doi request reprint VEGF overexpression improves mice cognitive abilities after unilateral common carotid artery occlusion
    Konstanze Plaschke
    Department of Anesthesiology, Medical Faculty, University of Heidelberg, Germany
    Exp Neurol 214:285-92. 2008
    ....
  8. ncbi request reprint Comparison of the confusion assessment method for the intensive care unit (CAM-ICU) with the Intensive Care Delirium Screening Checklist (ICDSC) for delirium in critical care patients gives high agreement rate(s)
    Konstanze Plaschke
    Department of Anaesthesiology, Clinical Experimental Anaesthesiology, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Intensive Care Med 34:431-6. 2008
    ....
  9. ncbi request reprint EEG changes and serum anticholinergic activity measured in patients with delirium in the intensive care unit
    K Plaschke
    Department of Anaesthesiology, Medical Faculty of the University of Heidelberg, Germany
    Anaesthesia 62:1217-23. 2007
    ..We conclude that, in contrast to the EEG, the SAA level cannot be proposed as a tool for diagnosing delirium in ICU patients...
  10. ncbi request reprint Significant correlation between plasma and CSF anticholinergic activity in presurgical patients
    Konstanze Plaschke
    Department of Anesthesia, Medical Faculty of the University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    Neurosci Lett 417:16-20. 2007
    ..When patients receiving or not receiving anticholinergic medication were compared, anticholinergic activity tended to increase in blood and CSF after receiving anticholinergic medication > or =4 weeks (p>0.05)...
  11. doi request reprint A single systemic transient hypotension induces long-term changes in rats' MRI parameters and behavior: relation to aging
    Konstanze Plaschke
    Clinic of Anesthesiology, University of Heidelberg Medical School, Heidelberg, Germany
    Neurol Res 31:304-12. 2009
    ..OBJECTIVES AND AIM: The aim of this work was to examine whether a single 20-minute systemic hypotension induces short- and long-term changes in 12- and 18-month-old rat brain...
  12. ncbi request reprint Adenosine-induced cardiac arrest and EEG changes in patients with thoracic aorta endovascular repair
    K Plaschke
    Clinic of Anaesthesiology, University of Heidelberg, Germany
    Br J Anaesth 96:310-6. 2006
    ..We studied haemodynamic and metabolic variables, and cerebral function after cardiac arrest induced by high dose of adenosine in patients undergoing thoracic aorta endovascular repair...
  13. doi request reprint Ginkgo extract EGb 761(®) shields from slowly accumulating neurodegenerative-like changes in a newly developed cell culture model induced by the combined action of low doses of antimycin A1 and 2-deoxy-D-glucose
    Konstanze Plaschke
    Clinic of Anaesthesiology, University Hospital of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    J Neural Transm 118:1247-54. 2011
    ..This cell culture system characterizing moderate cellular stress will be applied in future studies to further investigate the mode of action of single EGb 761(®) compounds...
  14. doi request reprint Early postoperative delirium after open-heart cardiac surgery is associated with decreased bispectral EEG and increased cortisol and interleukin-6
    Konstanze Plaschke
    Department of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Intensive Care Med 36:2081-9. 2010
    ....
  15. doi request reprint Increased cortisol levels and anticholinergic activity in cognitively unimpaired patients
    Konstanze Plaschke
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Neuropsychiatry Clin Neurosci 22:433-41. 2010
    ..A significant linear correlation was detected between anticholinergic activities and cortisol levels. Thus, endogenous factors such as patients' stress levels should be taken into account for interpretation of the role of SAA...
  16. doi request reprint Human adult mesenchymal stem cells improve rat spatial cognitive function after systemic hemorrhagic shock
    Konstanze Plaschke
    Clinic of Anesthesiology, University of Heidelberg Medical School, Heidelberg D 69120, Germany
    Behav Brain Res 201:332-7. 2009
    ..Identifying the underlying mechanism for this, however, should be the subject of further investigations...
  17. pmc Neuromodulatory effect of propentofylline on rat brain under acute and long-term hypoperfusion
    K Plaschke
    Clinic of Anesthesiology, University of Heidelberg, Germany
    Br J Pharmacol 133:107-16. 2001
    ..6. These results underscore the benefit of treatment with PPF in clinical practice, particularly during stroke, but also in cerebrovascular and neurodegenerative disorders...
  18. doi request reprint A subchronic application period of glucocorticoids leads to rat cognitive dysfunction whereas physostigmine induces a mild neuroprotection
    Katrin Wüppen
    Department of Anesthesiology, Experimental Anesthesiology, Medical Faculty, University of Heidelberg, Im Neuenheimer Feld 110, 69120 Heidelberg, Germany
    J Neural Transm 117:1055-65. 2010
    ..An apparently existing interaction between glucocorticoid excess and ACh metabolism is discussed...
  19. ncbi request reprint Aspects of ageing in chronic cerebral oligaemia. Mechanisms of degeneration and compensation in rat models
    K Plaschke
    Clinic of Anaesthesia, University of Heidelberg, Germany
    J Neural Transm 112:393-413. 2005
    ..In the future, these findings could lead to new neuroprotective strategies for counteracting degenerative changes in ageing and in age-associated chronic brain diseases...
  20. doi request reprint [Delirium in the intensive care unit]
    R von Haken
    Klinik fur Anaesthesiologie, Ruprecht Karls Universitat Heidelberg, Deutschland
    Anaesthesist 59:235-47. 2010
    ..Currently, the administration of neuroleptics, enforced physiotherapy, re-orientation measures and appropriate pain treatment are the basis of the therapeutic approach...
  21. ncbi request reprint Does permanent carotid artery occlusion produce a 'preconditioning-like' effect towards more severe hypotension in energy metabolites? Role of cerebral adenosine
    Konstanze Plaschke
    Clinic of Anaesthesia, University of Heidelberg, Heidelberg, Germany
    Clin Exp Pharmacol Physiol 32:54-9. 2005
    ..Obviously, adenosine A1 receptor-specific effects after delayed cerebral ischaemic preconditioning do not seem to play an essential role if BCCAO is followed by a prolonged additional severe ischaemic event...
  22. doi request reprint Injury of the blood brain barrier and up-regulation of icam-1 in polymicrobial sepsis
    Stefan Hofer
    Department of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Surg Res 146:276-81. 2008
    ....
  23. ncbi request reprint In vivo monitoring of age-related changes in rat brain using quantitative diffusion magnetic resonance imaging and magnetic resonance relaxometry
    Sabine Heiland
    Department of Neuroradiology, University of Heidelberg Medical School, Im Neuenheimer Feld 400, D 69120 Heidelberg, Germany
    Neurosci Lett 334:157-60. 2002
    ..Our study also shows that age-related changes in diffusion should be considered when performing longitudinal studies in rats...
  24. ncbi request reprint Evolution of apparent diffusion coefficient and transverse relaxation time (T2) in the subchronic stage of global cerebral oligemia in different rat models
    Konstanze Plaschke
    Department of Anaesthesia, University of Heidelberg Medical Center, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Exp Brain Res 169:361-8. 2006
    ....
  25. doi request reprint Insulin-resistant brain state after intracerebroventricular streptozotocin injection exacerbates Alzheimer-like changes in Tg2576 AbetaPP-overexpressing mice
    Konstanze Plaschke
    Clinic of Anesthesiology, University of Heidelberg Medical School, Heidelberg, Germany
    J Alzheimers Dis 19:691-704. 2010
    ..In conclusion, IRBS may aggravate AD-like changes such as behavioral and increase the formation of pathomorphological AD hallmarks via GSK-3alpha/beta pathway in AbetaPP-overexpressing mice...
  26. ncbi request reprint A mouse model of cerebral oligemia: relation to brain histopathology, cerebral blood flow, and energy state
    Konstanze Plaschke
    Clinic of Anesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, 69120, Heidelberg, Germany
    Exp Brain Res 162:324-31. 2005
    ..In conclusion, this sCCAO mouse model may be useful for long-lasting investigations of stepwise deterioration contributing to chronic cerebrovascular disorders...
  27. doi request reprint Reduction in rat phosphatidylethanolamine binding protein-1 (PEBP1) after chronic corticosterone treatment may be paralleled by cognitive impairment: a first study
    Robert E Feldmann
    Division of Systems Physiology, Department of Physiology and Pathophysiology, University of Heidelberg, Heidelberg, Germany
    Stress 11:134-47. 2008
    ..From this, we derive the preliminary hypothesis that PEBP1 may be a novel molecular mediator influencing cognitive integrity during chronic corticosterone exposure in rat hippocampus...
  28. ncbi request reprint Amyloid precursor protein (APP) and its derivatives change after cellular energy depletion. An in vitro-study
    A Hoyer
    Clinic of Anaesthesia, University of Heidelberg, Heidelberg, Germany
    J Neural Transm 112:239-53. 2005
    ..The data of the present study indicate that abnormalities in APP metabolism were generated in an energy-dependent manner. The obvious similarities to sporadic Alzheimer s disease are discussed...
  29. ncbi request reprint Pronounced arterial collateralization was induced after permanent rat cerebral four-vessel occlusion. Relation to neuropathology and capillary ultrastructure
    K Plaschke
    Department of Anesthesiology, University of Heidelberg, Germany
    J Neural Transm 110:719-32. 2003
    ..Thus, this rat model may be useful in investigations of long-lasting compensatory mechanisms contributing to cerebrovascular or neurodegenerative disorders...
  30. pmc Double-blinded, randomized controlled trial comparing real versus placebo acupuncture to improve tolerance of diagnostic esophagogastroduodenoscopy without sedation: a study protocol
    P Knebel
    Department of General, Visceral and Transplantation Surgery, University of Heidelberg, Germany
    Trials 12:52. 2011
    ..Therefore, we would like to examine if an acupuncture during elective, diagnostic EGDEs could increase the comfort of patients refusing systemic sedation...
  31. ncbi request reprint Apparent diffusion coefficient in the aging mouse brain: a magnetic resonance imaging study
    Philipp R Rau
    University of Heidelberg, Department of Neurology, INF 400 Kopfklinik, D 69120 Heidelberg, Germany
    Life Sci 78:1175-80. 2006
    ..According to our data ADCs remain nearly constant during the aging process of the brain with a small but statistically non-significant trend towards a decreased diffusion in older animals...
  32. ncbi request reprint Chronic corticosterone-induced deterioration in rat behaviour is not paralleled by changes in hippocampal NF-kappaB-activation
    Konstanze Plaschke
    Clinic of Anaesthesiology, University of Heidelberg, Im Neuenheimer Feld 110, D 69120, Heidelberg, Germany
    Stress 9:97-106. 2006
    ..Thus, cognitive alterations in rats seen after chronic corticosterone exposure are not paralleled by hippocampal NF-kappaB modulation...
  33. doi request reprint Effects of verum acupuncture compared to placebo acupuncture on quantitative EEG and heart rate variability in healthy volunteers
    Konrad Streitberger
    Clinic of Anesthesiology, University of Heidelberg, Heidelberg, Germany
    J Altern Complement Med 14:505-13. 2008
    ....