Research Topics
| M PinkawaSummaryAffiliation: University Hospital Country: Germany Publications
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Publications
Dose-escalation using intensity-modulated radiotherapy for prostate cancer--evaluation of the dose distribution with and without 18F-choline PET-CT detected simultaneous integrated boostMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 93:213-9. 2009..The aim of the study was to evaluate the impact of a dose escalation to an (18)F-choline PET-CT defined simultaneous integrated boost (IB) on the dose distribution and changes of the equivalent uniform dose (EUD)...- Spacer stability and prostate position variability during radiotherapy for prostate cancer applying a hydrogel to protect the rectal wallMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Germany Electronic address
Radiother Oncol 106:220-4. 2013..The aim was to evaluate the spacer dimensions and prostate position variability during the course of radiotherapy for prostate cancer... - Current standards and future directions for prostate cancer radiation therapyMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
Expert Rev Anticancer Ther 13:75-88. 2013..The application of a spacer is a promising concept for optimal protection of the rectal wall... 
Local prostate cancer radiotherapy after prostate-specific antigen progression during primary hormonal therapyMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
Radiat Oncol 7:209. 2012..The outcome of patients after radiotherapy (RT) for localized prostate cancer in case of prostate-specific antigen (PSA) progression during primary hormonal therapy (HT) is not well known...
Quality of life after intensity-modulated radiotherapy for prostate cancer with a hydrogel spacer. Matched-pair analysisM Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstr 30, 52072 Aachen, Germany
Strahlenther Onkol 188:917-25. 2012..Hydrogel spacer is an innovative method to protect the rectal wall during prostate cancer radiotherapy. Clinical effects are not well known...- Urinary morbidity after permanent prostate brachytherapy - impact of dose to the urethra vs. sources placed in close vicinity to the urethraMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 103:247-51. 2012..The impact of the dose to the urethra and sources placed close to the urethra on urinary morbidity after permanent prostate brachytherapy (PPB) is not well known... - Dose-escalation using intensity-modulated radiotherapy for prostate cancer - evaluation of quality of life with and without (18)F-choline PET-CT detected simultaneous integrated boostMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
Radiat Oncol 7:14. 2012..Quality of life after radiotherapy (RT) with vs. without (18)F-choline PET-CT detected simultaneous integrated boost (SIB) was prospectively evaluated in this study... - Integrated-boost IMRT or 3-D-CRT using FET-PET based auto-contoured target volume delineation for glioblastoma multiforme--a dosimetric comparisonMarc D Piroth
Department of Radiation Oncology, RWTH Aachen University Hospital, Pauwelsstrasse 30, 52074 Aachen Germany
Radiat Oncol 4:57. 2009.... - [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography in response evaluation after chemo-/radiotherapy of non-small-cell lung cancer: a feasibility studyBernd Gagel
Department of Radiotherapy, University of Aachen, Germany
BMC Cancer 6:51. 2006..The aim of the present study was to show the feasibility of determining radiotherapeutically relevant hypoxia and early tumour response by ([18F] Fluoromisonidazole (FMISO) and [18F]-2-fluoro-2'-deoxyglucose (FDG) PET... - Sequential (gemcitabine/vinorelbine) and concurrent (gemcitabine) radiochemotherapy with FDG-PET-based target volume definition in locally advanced non-small cell lung cancer: first results of a phase I/II studyBernd Gagel
Department of Radiotherapy, RWTH Aachen University, Germany
BMC Cancer 7:112. 2007.... - Sequencing chemotherapy and radiotherapy in locoregional advanced breast cancer patients after mastectomy - a retrospective analysisMarc D Piroth
Department of Radiation Oncology, RWTH Aachen University Hospital, Aachen, Germany
BMC Cancer 8:114. 2008..This retrospective analysis aimed to assess the role of sequencing in patients after mastectomy because of advanced locoregional disease... - pO polarography, contrast enhanced color duplex sonography (CDS), [18F] fluoromisonidazole and [18F] fluorodeoxyglucose positron emission tomography: validated methods for the evaluation of therapy-relevant tumor oxygenation or only bricks in the puzzle oBernd Gagel
Department of Radiotherapy, RWTH Aachen University, Germany
BMC Cancer 7:113. 2007..As a standard for measuring tissue oxygenation in human tumors, the invasive, computerized polarographic needle electrode system (pO2 histography) was used for comparing the different non invasive measurements... - Rectal morbidity after permanent interstitial brachytherapy for prostate cancer--impact of day 1 vs. day 30 computed tomography-based postimplant dosimetryMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, Aachen, Germany
Brachytherapy 9:1-7. 2010..The aim of the study was to evaluate bowel quality-of-life changes after prostate brachytherapy and the impact of Day 1 vs. Day 30 postimplant dosimetry... - Impact of age and comorbidities on health-related quality of life for patients with prostate cancer: evaluation before a curative treatmentMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
BMC Cancer 9:296. 2009..Furthermore, age-related changes can hardly be discriminated from therapy-related changes. The evaluation of age-and comorbidity-related changes was in focus of this study... - Neoadjuvant hormonal therapy and external-beam radiotherapy versus external-beam irradiation alone for prostate cancer. A quality-of-life analysisMichael Pinkawa
Klinik fur Strahlentherapie, Universitätsklinikum RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
Strahlenther Onkol 185:101-8. 2009..To evaluate the impact of neoadjuvant hormonal therapy (NHT) on quality of life after external-beam radiotherapy (EBRT) for prostate cancer... - Image-guided radiotherapy for prostate cancer. Implementation of ultrasound-based prostate localization for the analysis of inter- and intrafraction organ motionMichael Pinkawa
Department of Radiation Therapy, University Hospital RWTH Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
Strahlenther Onkol 184:679-85. 2008..To evaluate inter- and intrafraction organ motion with an ultrasound-based prostate localization system (BAT) for patients treated with intensity-modulated radiotherapy for prostate cancer... - Self-assessed bowel toxicity after external beam radiotherapy for prostate cancer--predictive factors on irritative symptoms, incontinence and rectal bleedingMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
Radiat Oncol 4:36. 2009..In contrast to rectal bleeding, information concerning irritative symptoms (rectal urgency, pain) and incontinence after RT has not been adequately documented and reported in the past... - Impact of the target volume (prostate alone vs. prostate with seminal vesicles) and fraction dose (1.8 Gy vs. 2.0 Gy) on quality of life changes after external-beam radiotherapy for prostate cancerMichael Pinkawa
Department of Radiotherapy, RWTH Aachen, Aachen, Germany
Strahlenther Onkol 185:724-30. 2009..To evaluate the impact of the clinical target volume (CTV) and fraction dose on quality of life (QoL) after external-beam radiotherapy (EBRT) for prostate cancer... - Low-grade toxicity after conformal radiation therapy for prostate cancer--impact of bladder volumeMichael Pinkawa
Department of Radiotherapy, RWTH Aachen University, Aachen, Germany
Int J Radiat Oncol Biol Phys 64:835-41. 2006..To assess the impact of dose-volume histogram parameters on low-grade toxicity after radiotherapy for prostate cancer... - Application of a spacer gel to optimize three-dimensional conformal and intensity modulated radiotherapy for prostate cancerMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Germany
Radiother Oncol 100:436-41. 2011..The aim was to evaluate the impact of a spacer gel on the dose distribution, applying three-dimensional conformal (3D CRT) and intensity modulated radiotherapy (IMRT) planning techniques... - Combination of dose escalation with technological advances (intensity-modulated and image-guided radiotherapy) is not associated with increased morbidity for patients with prostate cancerMichael Pinkawa
Klinik fur Strahlentherapie, RWTH Aachen, Aachen, Germany
Strahlenther Onkol 187:479-84. 2011..2-72 Gy for patients with prostate cancer... - External beam radiotherapy for prostate cancerM Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Panminerva Med 52:195-207. 2010..Total doses of at least 70 Gy should be administered in case of macroscopic recurrences, but the curative chances are considerably lower in comparison to a biochemical recurrence alone... - Intensity-modulated radiotherapy for prostate cancer implementing molecular imaging with 18F-choline PET-CT to define a simultaneous integrated boostMichael Pinkawa
Department of Radiotherapy, RWTH Aachen, Aachen, Germany
Strahlenther Onkol 186:600-6. 2010..To report the own experience with 66 patients who received 18F-choline PET-CT (positron emission tomography-computed tomography) for treatment planning... - Quality of life after whole pelvic versus prostate-only external beam radiotherapy for prostate cancer: a matched-pair comparisonMichael Pinkawa
Department of Radiotherapy, RWTH Aachen University, Aachen, Germany
Int J Radiat Oncol Biol Phys 81:23-8. 2011..Comparison of health-related quality of life after whole pelvic (WPRT) and prostate-only (PORT) external beam radiotherapy for prostate cancer... - Consequential late effects after radiotherapy for prostate cancer - a prospective longitudinal quality of life studyMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52072 Aachen, Germany
Radiat Oncol 5:27. 2010..To answer the question if and to which extent acute symptoms at the end and/or several weeks after radiotherapy can predict adverse urinary and gastrointestinal long-term quality of life (QoL)... - Prostate-specific antigen kinetics following external-beam radiotherapy and temporary (Ir-192) or permanent (I-125) brachytherapy for prostate cancerMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 96:25-9. 2010..The aim of the study was the evaluation of PSA kinetics after different radiotherapy methods... - Rectal dosimetry following prostate brachytherapy with stranded seeds--comparison of transrectal ultrasound intra-operative planning (day 0) and computed tomography-postplanning (day 1 vs. day 30) with special focus on sources placed close to the rectal wMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 91:207-12. 2009..The aim of the study was to compare intra-operative and postplanning at different intervals with special focus on sources placed close to the rectal wall... - Health-related quality of life after permanent I-125 brachytherapy and conformal external beam radiotherapy for prostate cancer--a matched-pair comparisonMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 91:225-31. 2009..The aim of the study was to compare quality of life after permanent I-125 brachytherapy (BT) and external beam radiotherapy (EBRT) for prostate cancer... - Seed displacements after permanent brachytherapy for prostate cancer in dependence on the prostate levelMichael Pinkawa
Department of Radiotherapy, RWTH Aachen, Aachen, Germany
Strahlenther Onkol 184:520-5. 2008..To evaluate seed displacements after permanent prostate brachytherapy considering different prostate levels... - Prostate position variability and dose-volume histograms in radiotherapy for prostate cancer with full and empty bladderMichael Pinkawa
Department of Radiotherapy, Rheinisch Westfälische Technische Hochschule Aachen, Aachen, Germany
Int J Radiat Oncol Biol Phys 64:856-61. 2006..To evaluate prostate position variability and dose-volume histograms in prostate radiotherapy with full bladder (FB) and empty bladder (EB)... - Dose-volume impact in high-dose-rate Iridium-192 brachytherapy as a boost to external beam radiotherapy for localized prostate cancer--a phase II studyMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 78:41-6. 2006..Evaluation of dose-volume-time-related factors in 64 patients treated with high-dose-rate brachytherapy (HDR-BT) as a boost to external beam radiotherapy (EBRT) for localized prostate cancer... - Association of neoadjuvant hormonal therapy with adverse health-related quality of life after permanent iodine-125 brachytherapy for localized prostate cancerMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Urology 68:104-9. 2006..To characterize the influence of neoadjuvant hormonal therapy (NHT) on health-related quality of life after permanent iodine-125 brachytherapy (BT) for prostate cancer... - Changes of dose delivery distribution within the first month after permanent interstitial brachytherapy for prostate cancerMichael Pinkawa
Department of Radiotherapy, RWTH Aachen, Aachen, Germany
Strahlenther Onkol 182:525-30. 2006..To evaluate changes of dose distribution for both the prostate and the surrounding tissues after permanent brachytherapy as monotherapy for prostate cancer... - Influence of the initial rectal distension on posterior margins in primary and postoperative radiotherapy for prostate cancerMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 81:284-90. 2006..The aim of the study was to define the effect of different rectum fillings in the planning CT study on the posterior clinical target volume (CTV) displacements (PD) in primary and postoperative radiotherapy (RT) for prostate cancer... - Postoperative radiotherapy for prostate cancer : evaluation of target motion and treatment techniques (intensity-modulated versus conformal radiotherapy)Michael Pinkawa
Klinik fur Strahlentherapie, Universitatsklinikum Aachen, Pauwelsstrasse 30, 52057, Aachen, Germany
Strahlenther Onkol 183:23-9. 2007..To determine the extent of target motion in postprostatectomy radiotherapy (RT) and the value of intensity-modulated radiotherapy (IMRT) compared to three-dimensional conformal radiotherapy (3D-CRT)... - Prostate-specific antigen kinetics after brachytherapy or external beam radiotherapy and neoadjuvant hormonal therapyMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Urology 69:129-33. 2007..To characterize the kinetics of prostate-specific antigen (PSA) after radiotherapy (RT) and neoadjuvant hormonal therapy (NHT) for localized prostate cancer... - Health-related quality of life after permanent interstitial brachytherapy for prostate cancer: correlation with postimplant CT scan parametersMichael Pinkawa
Department of Radiotherapy, RWTH Aachen, Pauwelsstrasse 30, 52057 Aachen, Germany
Strahlenther Onkol 182:660-5. 2006..To determine dosimetric risk factors for increased toxicity after permanent interstitial brachytherapy for prostate cancer... - Bladder extension variability during pelvic external beam radiotherapy with a full or empty bladderMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 83:163-7. 2007..The aim of the study was to compare the extent of bladder wall movements during parallel series with full bladder (FB) and empty bladder (EB)... - Evaluation of source displacement and dose--volume changes after permanent prostate brachytherapy with stranded seedsMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 84:190-6. 2007..The aim of the study was to analyze source displacements and dose-volume changes in the first month after a permanent implant... - Toxicity profile with a large prostate volume after external beam radiotherapy for localized prostate cancerMichael Pinkawa
Department of Radiotherapy, RWTH Aachen University, Aachen, Germany
Int J Radiat Oncol Biol Phys 70:83-9. 2008..To assess the impact of prostate volume on health-related quality of life (HRQOL) before and at different intervals after radiotherapy for prostate cancer... - Health-related quality of life after adjuvant and salvage postoperative radiotherapy for prostate cancer - a prospective analysisMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Aachen, Germany
Radiother Oncol 88:135-9. 2008..The aim of the study was to analyze health-related quality of life changes after postoperative radiotherapy (RT) for prostate cancer... - Erectile dysfunction after external beam radiotherapy for prostate cancerMichael Pinkawa
Department of Radiation Oncology, RWTH Aachen University, Pauwelsstrasse 30, 52057 Aachen, Germany
Eur Urol 55:227-34. 2009..There is a lack of prospective studies focusing on the sexual quality of life of prostate cancer patients after conformal radiotherapy (RT)... - pO(2) Polarography versus positron emission tomography ([(18)F] fluoromisonidazole, [(18)F]-2-fluoro-2'-deoxyglucose). An appraisal of radiotherapeutically relevant hypoxiaBernd Gagel
Department of Radiotherapy, University of Aachen, Aachen, Germany
Strahlenther Onkol 180:616-22. 2004.... - Integrated boost IMRT with FET-PET-adapted local dose escalation in glioblastomas. Results of a prospective phase II studyM D Piroth
Department of Radiation Oncology, RWTH Aachen University Hospital, Pauwelsstr 30, 52074, Aachen, Germany
Strahlenther Onkol 188:334-9. 2012..With positron emission tomography (PET) using [(18)F]fluorethyl-L-tyrosine (FET), tumor coverage can be optimized with the option of regional dose escalation in the area of viable tumor tissue... - Inverse automated treatment planning with and without individual optimization in interstitial permanent prostate brachytherapy with high- and low-activity 125IMichael Pinkawa
Department of Radiotherapy, University Hospital, RWTH Aachen, Germany
Strahlenther Onkol 179:417-22. 2003..To determine whether dose distribution achieved with treatment plans using high- and low-activity (125)I implants differs... - Rectourethral fistula following LDR brachytherapyHolger Borchers
Urological Clinic, University Clinic Aachen, RWTH Aachen, Aachen, Germany
Urol Int 82:365-6. 2009..These fistulas cause severe patient morbidity and require interdisciplinary treatment. We report on the occurrence and management of a rectourethral fistula which occurred 4 years after (125)I seed implantation... - Gemcitabine concurrent with thoracic radiotherapy after induction chemotherapy with gemcitabine/vinorelbine in locally advanced non-small cell lung cancer: a phase I studyBernd Gagel
Department of Radiotherapy, RWTH Aachen University, Germany
Strahlenther Onkol 182:263-9. 2006.... - Postoperative radiotherapy of glioblastoma multiforme: analysis and critical assessment of different treatment strategies and predictive factorsMarc D Piroth
Department of Radiation Oncology, RWTH Aachen University Hospital, Aachen, Germany
Strahlenther Onkol 183:695-702. 2007..Different factors influence glioblastoma patients' prognosis. The aim of this retrospective, explorative analysis was to define the role of recent treatment strategies and to examine the value of different prognostic factors... - Active breathing control (ABC): determination and reduction of breathing-induced organ motion in the chestBernd Gagel
Department of Radiotherapy, RWTH Aachen University, Aachen, Germany
Int J Radiat Oncol Biol Phys 67:742-9. 2007..We evaluated the feasibility of respiratory observation tools using the active breathing control (ABC) system and the effect on breathing cycle regularity and reproducibility... - Permanent 125I-seed brachytherapy or radical prostatectomy: a prospective comparison considering oncological and quality of life resultsHolger Borchers
Urological Clinic, Rheinisch-Westfalisch Technical University, Aachen, Germany
BJU Int 94:805-11. 2004..As approximately 18% of patients considered to be appropriate candidates for BT had tumours extending beyond the prostate capsule or invading the seminal vesicles, nomograms are needed for more accurate information before therapy... - Dose-volume histogram evaluation of prone and supine patient position in external beam radiotherapy for cervical and endometrial cancerMichael Pinkawa
, , Pauwelsstr. 30, Aachen 52057, Germany
Radiother Oncol 69:99-105. 2003..An adequate bladder filling is important to reduce the irradiated bladder and bowel volumes... - Immediate reconstruction with an expander/implant following ablatio mammae because of breast cancer : side effects and cosmetic results after adjuvant chest wall radiotherapyMarc D Piroth
Department of Radiotherapy, University Hospital, RWTH Aachen, Aachen, Germany
Strahlenther Onkol 185:669-74. 2009..The aim of the present study was to assess the influence of adjuvant radiotherapy on morbidity and patient satisfaction after allogenous breast reconstruction... - Contrast-enhanced color duplex sonography (CDS): an alternative for the evaluation of therapy-relevant tumor oxygenation?Bernd Gagel
Department of Radiotherapy, University of Aachen, Aachen, Germany
Strahlenther Onkol 182:604-9. 2006..To evaluate the predictive value of radiotherapeutically relevant tumor hypoxia by contrast-enhanced color duplex sonography (CDS). The objectification was based on pO(2) histography...