Research Topics
| C U PietrzikSummaryAffiliation: University of Mainz Country: Germany Publications
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Detail Information
Publications
LRP1 modulates APP trafficking along early compartments of the secretory pathwayElaine Waldron
Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
Neurobiol Dis 31:188-97. 2008..In addition, we provide evidence that APP metabolism occurs in close conjunction with LRP1 trafficking, highlighting a new role of lipoprotein receptors in neurodegenerative diseases...
APP dimer formation is initiated in the endoplasmic reticulum and differs between APP isoformsSimone Isbert
Department of Pathobiochemistry, Molecular Neurodegeneration, University Medical Center of the Johannes Gutenberg University Mainz, Germany
Cell Mol Life Sci 69:1353-75. 2012..Thus, suggesting that steric properties of KPI-APP might be the cause for weaker cis-interaction in the ER, compared to APP695. Finally, we provide evidence that APP/APLP1 heterointeractions are likewise initiated in the ER...
FE65 constitutes the functional link between the low-density lipoprotein receptor-related protein and the amyloid precursor proteinClaus U Pietrzik
Department of Neurosciences, University of California, San Diego, La Jolla, California 92093, USA
J Neurosci 24:4259-65. 2004..These results clearly demonstrate that FE65 acts as a functional linker between APP and LRP...- The amyloidogenic pathway of amyloid precursor protein (APP) is independent of its cleavage by caspasesS Soriano
Department of Neurosciences, University of California San Diego, La Jolla, California 92093 0691, USA
J Biol Chem 276:29045-50. 2001..Thus, caspase cleavage of APP is unlikely to play a direct role in amyloidogenesis... - The cytoplasmic domain of the LDL receptor-related protein regulates multiple steps in APP processingClaus U Pietrzik
Department of Neurosciences, University of California, San Diego, La Jolla 92093, USA
EMBO J 21:5691-700. 2002..Therefore, we propose a model by which LRP functionally modulates APP processing, including those steps critical for Abeta production, through interactions of the cytosolic domains... - Mechanisms of C-reactive protein-induced blood-brain barrier disruptionChristoph R W Kuhlmann
Institute of Physiology and Pathophysiology, Johannes Gutenberg University of Mainz, Mainz, Germany
Stroke 40:1458-66. 2009..The aim of this study was to examine whether CRP directly affects blood-brain barrier stability and to analyze the underlying signaling pathways... - Sequences from the low density lipoprotein receptor-related protein (LRP) cytoplasmic domain enhance amyloid beta protein production via the beta-secretase pathway without altering amyloid precursor protein/LRP nuclear signalingIl Sang Yoon
Department of Neurosciences, University of California, San Diego, La Jolla, 92093, USA
J Biol Chem 280:20140-7. 2005..These observations indicate that there are cellular pathways that may suppress Abeta generation but that can be altered to facilitate Abeta production... - Blood-brain-barrier models for the investigation of transporter- and receptor-mediated amyloid-β clearance in Alzheimer's diseaseT Pflanzner
Institute of Pathobiochemistry, Molecular Neurodegeneration, University Medical Center of the Johannes Gutenberg University Mainz, 55099 Mainz, Germany
Curr Alzheimer Res 7:578-90. 2010.... - A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activityS Weggen
Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
Nature 414:212-6. 2001.... - Abeta42-lowering nonsteroidal anti-inflammatory drugs preserve intramembrane cleavage of the amyloid precursor protein (APP) and ErbB-4 receptor and signaling through the APP intracellular domainSascha Weggen
Department of Neurosciences, University of California San Diego, La Jolla, California 92093, USA
J Biol Chem 278:30748-54. 2003.... - Amyloid precursor-like protein 1 influences endocytosis and proteolytic processing of the amyloid precursor proteinStephanie Neumann
Adolf Butenandt Institut, Ludwig Maximilians University, Schillerstrasse 44, 80336 Munich, Germany
J Biol Chem 281:7583-94. 2006..In summary, our study provides a novel mechanism for APP shedding, in which APLP1 affects the endocytosis of APP and makes more APP available for alpha-secretase cleavage... - Increased AICD generation does not result in increased nuclear translocation or activation of target gene transcriptionElaine Waldron
Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration, Johannes Gutenberg University Mainz, 55099 Mainz, Germany
Exp Cell Res 314:2419-33. 2008..Therefore we provide strong evidence that an increase in AICD generation does not directly promote gene activation of previously proposed target genes... - Cerebral small vessel disease-induced apolipoprotein E leakage is associated with Alzheimer disease and the accumulation of amyloid beta-protein in perivascular astrocytesSabrina Utter
Department of Neuropathology, University of Bonn, Bonn, Germany
J Neuropathol Exp Neurol 67:842-56. 2008..It is therefore tempting to speculate that apoE represents a pathogenetic link between SVD and AD... - The functional role of the second NPXY motif of the LRP1 beta-chain in tissue-type plasminogen activator-mediated activation of N-methyl-D-aspartate receptorsAnne M Martin
Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration and Institute of Physiology, Johannes Gutenberg University Mainz, D 55099 Mainz, Germany
J Biol Chem 283:12004-13. 2008..These results provide new insights into the mechanism of a tPA-induced, LRP1-mediated gating mechanism for NMDA receptors... - Functional role of lipoprotein receptors in Alzheimer's diseaseSebastian Jaeger
Institute of Physiological Chemistry and Pathobiochemistry, Molecular Neurodegeneration, Johannes Gutenberg University Mainz, Mainz, Germany
Curr Alzheimer Res 5:15-25. 2008..Although the involvement of LDLR family members in AD is not yet fully understood it becomes clear that they can directly affect APP production, Abeta-clearance and Abeta-transport over the blood brain barrier... - The secreted beta-amyloid precursor protein ectodomain APPs alpha is sufficient to rescue the anatomical, behavioral, and electrophysiological abnormalities of APP-deficient miceSabine Ring
Department of Bioinformatics and Functional Genomics, Institute for Pharmacy and Molecular Biotechnology, University of Heidelberg, D 69120 Heidelberg, Germany
J Neurosci 27:7817-26. 2007..Together, our data suggest that the APP C terminus is dispensable and that APPs alpha is sufficient to mediate the physiological functions of APP assessed by these tests... - Inhibitors of Rho-kinase modulate amyloid-beta (Abeta) secretion but lack selectivity for Abeta42Stefanie Leuchtenberger
Emmy Noether Research Group, Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
J Neurochem 96:355-65. 2006..Taken together, these results seem to exclude a mechanistic involvement of ROCK in the Abeta42-lowering activity of NSAIDs... - Low density lipoprotein receptor-related protein (LRP) interacts with presenilin 1 and is a competitive substrate of the amyloid precursor protein (APP) for gamma-secretaseAlberto Lleo
Alzheimer Research Unit, Massachusetts Institute for Neurodegenerative Disorders, Massachusetts General Hospital, Charlestown, Massachusetts 02129, USA
J Biol Chem 280:27303-9. 2005..In conclusion, LRP is a PS1 interactor and can compete with APP for gamma-secretase enzymatic activity... - Functional role of the low-density lipoprotein receptor-related protein in Alzheimer's diseaseElaine Waldron
Institute of Physiological Chemistry and Pathobiochemistry, Johannes Gutenberg University Mainz, Mainz, Germany
Neurodegener Dis 3:233-8. 2006..A more in-depth knowledge of the mechanisms regulating APP cleavage may offer additional targets for therapeutic intervention...