Mario Perl

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. doi Silencing of fas, fas-associated via death domain, or caspase 3 differentially affects lung inflammation, apoptosis, and development of trauma-induced septic acute lung injury
    Mirko Philipp Messer
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 39:19-27. 2013
  2. doi Role of activated neutrophils in chest trauma-induced septic acute lung injury
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 38:98-106. 2012
  3. doi Granzyme B: a new crossroad of complement and apoptosis
    Mario Perl
    Department of Traumatology, Hand, Plastic, and Reconstructive Surgery, University Hospital of Ulm, Steinhoevelstr 9, 89075 Ulm, Germany
    Adv Exp Med Biol 946:135-46. 2012
  4. doi Inflammatory and apoptotic alterations in serum and injured tissue after experimental polytrauma in mice: distinct early response compared with single trauma or "double-hit" injury
    Sebastian Weckbach
    Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Ulm, 89075 Ulm, Germany
    J Trauma Acute Care Surg 74:489-98. 2013
  5. ncbi Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge
    Mario Perl
    Department of Trauma, Hand, and Reconstructive Surgery, University of Ulm, Germany
    Crit Care Med 33:1351-8. 2005
  6. doi Blunt chest trauma induces mediator-dependent monocyte migration to the lung
    Daniel H Seitz
    Department of Trauma Surgery, Hand, Plastic and Reconstructive Surgery University of Ulm, Ulm, Germany
    Crit Care Med 38:1852-9. 2010
  7. doi Inflammatory alterations in a novel combination model of blunt chest trauma and hemorrhagic shock
    Daniel H Seitz
    Department of Trauma Surgery, Hand, Plastic and Reconstructive Surgery and Division of Surgical Research, University of Ulm, Ulm, Germany
    J Trauma 70:189-96. 2011
  8. ncbi The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Germany
    Crit Care Med 34:1152-9. 2006
  9. doi Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury
    Sebastian Weckbach
    Department of Trauma, University of Ulm, Ulm, Germany
    J Trauma Acute Care Surg 74:792-800. 2013
  10. ncbi Blunt chest trauma induces delayed splenic immunosuppression
    Markus W Knoferl
    Department of Trauma, Hand and Reconstructive Surgery, University of Ulm, 89075 Ulm, Germany
    Shock 22:51-6. 2004

Collaborators

Detail Information

Publications25

  1. doi Silencing of fas, fas-associated via death domain, or caspase 3 differentially affects lung inflammation, apoptosis, and development of trauma-induced septic acute lung injury
    Mirko Philipp Messer
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 39:19-27. 2013
    ..This indicates a major pathophysiological role of lung apoptosis and suggests the importance of other than Fas-driven apoptotic pathways in trauma-induced septic ALI...
  2. doi Role of activated neutrophils in chest trauma-induced septic acute lung injury
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 38:98-106. 2012
    ..In particular, the depletion of neutrophils substantially mitigated the extent of lung injury, indicating a pathomechanistic role for neutrophils in chest trauma-induced septic ALI...
  3. doi Granzyme B: a new crossroad of complement and apoptosis
    Mario Perl
    Department of Traumatology, Hand, Plastic, and Reconstructive Surgery, University Hospital of Ulm, Steinhoevelstr 9, 89075 Ulm, Germany
    Adv Exp Med Biol 946:135-46. 2012
    ..The present data suggest a new form of interaction between the complement and the apoptosis system on the level of granzyme B that is capable to generate C3a and C5a independently of the established complement proteases...
  4. doi Inflammatory and apoptotic alterations in serum and injured tissue after experimental polytrauma in mice: distinct early response compared with single trauma or "double-hit" injury
    Sebastian Weckbach
    Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Ulm, 89075 Ulm, Germany
    J Trauma Acute Care Surg 74:489-98. 2013
    ..Thus, the early local and systemic inflammatory and apoptotic response was characterized in a new polytrauma model and compared with the alterations seen after single or combined injuries...
  5. ncbi Pulmonary contusion causes impairment of macrophage and lymphocyte immune functions and increases mortality associated with a subsequent septic challenge
    Mario Perl
    Department of Trauma, Hand, and Reconstructive Surgery, University of Ulm, Germany
    Crit Care Med 33:1351-8. 2005
    ..To address the significance of the immunosuppression associated with lung contusion, we investigated how the consecutive addition of moderate or severe sepsis affected survival after blunt chest trauma...
  6. doi Blunt chest trauma induces mediator-dependent monocyte migration to the lung
    Daniel H Seitz
    Department of Trauma Surgery, Hand, Plastic and Reconstructive Surgery University of Ulm, Ulm, Germany
    Crit Care Med 38:1852-9. 2010
    ..This study was designed to determine whether lung contusion induces an increased pulmonary recruitment of monocytes as a source of alveolar macrophages and which mediators are involved...
  7. doi Inflammatory alterations in a novel combination model of blunt chest trauma and hemorrhagic shock
    Daniel H Seitz
    Department of Trauma Surgery, Hand, Plastic and Reconstructive Surgery and Division of Surgical Research, University of Ulm, Ulm, Germany
    J Trauma 70:189-96. 2011
    ..Immune dysfunction contributes to the adverse outcome of multiple injuries. The aims of this study were to establish a combined model of lung contusion and hemorrhage and to evaluate the cardiopulmonary and immunologic response...
  8. ncbi The pulmonary and hepatic immune microenvironment and its contribution to the early systemic inflammation following blunt chest trauma
    Mario Perl
    Department of Trauma, Hand, Plastic, and Reconstructive Surgery, University of Ulm, Germany
    Crit Care Med 34:1152-9. 2006
    ..In addition, the correlation between intratracheally instilled interleukin-6 and its systemic release were studied...
  9. doi Apoptotic and inflammatory signaling via Fas and tumor necrosis factor receptor I contribute to the development of chest trauma-induced septic acute lung injury
    Sebastian Weckbach
    Department of Trauma, University of Ulm, Ulm, Germany
    J Trauma Acute Care Surg 74:792-800. 2013
    ..Based on this background here, we hypothesized that signaling through Fas and tumor necrosis factor receptor 1 (TNFR-1) is involved in mediating apoptosis and inflammation in chest trauma induced septic ALI...
  10. ncbi Blunt chest trauma induces delayed splenic immunosuppression
    Markus W Knoferl
    Department of Trauma, Hand and Reconstructive Surgery, University of Ulm, 89075 Ulm, Germany
    Shock 22:51-6. 2004
    ..Thus, lung contusion as a localized type of trauma causes dysfunction of immunocompetent cell populations, which are located distant from the site of injury...
  11. pmc A new experimental polytrauma model in rats: molecular characterization of the early inflammatory response
    Sebastian Weckbach
    Department of Orthopaedic Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital of Ulm, 89075 Ulm, Germany
    Mediators Inflamm 2012:890816. 2012
    ..In this paper, we characterize a new standardized polytrauma model in rats based on the early molecular inflammatory and apoptotic response...
  12. doi Is the function of alveolar macrophages altered following blunt chest trauma?
    Ulrich C Liener
    Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Ulm Surgical Center, Steinhövelstraße 9, 89075 Ulm, Germany
    Langenbecks Arch Surg 396:251-9. 2011
    ..The purpose of this study was to characterize the local pulmonary inflammatory environment and to elucidate alterations of alveolar macrophage (AMØ) functions after blunt chest trauma...
  13. doi Pulmonary contusion induces alveolar type 2 epithelial cell apoptosis: role of alveolar macrophages and neutrophils
    Daniel H Seitz
    Department of Trauma, Hand, Plastic and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 30:537-44. 2008
    ..In summary, blunt chest trauma induced apoptosis in AT-2 cells, possibly involving the extrinsic death receptor pathway. Furthermore, mediators released by AMs appeared to be involved in the induction of AT-2 cell apoptosis...
  14. ncbi The role of C5a in the innate immune response after experimental blunt chest trauma
    Michael A Flierl
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm Medical School, Ulm, Germany
    Shock 29:25-31. 2008
    ..Thus, C5a might represent a potential target for therapeutic immunomodulation to prevent immune dysfunctions post-trauma and thereby, perhaps, the progression to acute respiratory distress syndrome...
  15. doi Cathepsin D is released after severe tissue trauma in vivo and is capable of generating C5a in vitro
    Markus Huber-Lang
    Department of Orthopedic Trauma, Hand, Plastic and Reconstructive Surgery, University Hospital Ulm, Germany
    Mol Immunol 50:60-5. 2012
    ..Furthermore, the results provide in vitro evidence of cleavage of C5 by an aspartic protease with subsequent generation of functional C5a, which represents a new path of complement activation...
  16. doi Divergent effects of activated neutrophils on inflammation, Kupffer cell/splenocyte activation, and lung injury following blunt chest trauma
    Mario Perl
    Department of Trauma, University of Ulm, Germany
    Shock 37:210-8. 2012
    ..Thus, keeping in mind potential inflammatory adverse effects, modulation of neutrophil activation or trafficking might be a reasonable therapeutic approach in chest trauma-induced lung injury...
  17. ncbi Cardiopulmonary, histological, and inflammatory alterations after lung contusion in a novel mouse model of blunt chest trauma
    Markus W Knoferl
    Department of Trauma, Hand, and Reconstructive Surgery, University of Ulm, 89075 Ulm, Germany
    Shock 19:519-25. 2003
    ..On the basis of these findings, this novel mouse model of blunt chest trauma appears suitable for detailed studies on immunological effects of lung contusion...
  18. doi Early expression changes of complement regulatory proteins and C5A receptor (CD88) on leukocytes after multiple injury in humans
    Umme Amara
    Department of Traumatology, Hand, Plastic and Reconstructive Surgery, University Hospital Ulm, Germany
    Shock 33:568-75. 2010
    ..In summary, expression profiles of CRegs and CD88 on leukocytes are specifically altered after polytrauma in humans, indicating a trauma-induced "complementopathy."..
  19. doi Changes and Regulation of the C5a Receptor on Neutrophils during Septic Shock in Humans
    Heike Unnewehr
    Department of Orthopedic Trauma, Hand, Plastic, and Reconstructive Surgery, University Hospital Ulm, 89081 Ulm, Germany
    J Immunol 190:4215-25. 2013
    ..Therefore, cC5aR may represent a new sepsis marker to be considered in tailoring individualized immune-modulating therapy...
  20. pmc Pathogenesis of indirect (secondary) acute lung injury
    Mario Perl
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm Medical School, Ulm, Germany
    Expert Rev Respir Med 5:115-26. 2011
    ....
  21. ncbi Biochemical characterization of individual injury pattern and injury severity
    Wolf Strecker
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm, Steinhoevelstrasse 9, D 89075 Ulm, Germany
    Injury 34:879-87. 2003
    ..Therefore, the aim of this prospective study was to detect laboratory markers that may reflect the pattern and extent of individual trauma in the very early phase after injury...
  22. pmc Early complementopathy after multiple injuries in humans
    Anne Maud Burk
    Department of Traumatology, Hand, Plastic, and Reconstructive Surgery, University Hospital Ulm, Ulm, Germany
    Shock 37:348-54. 2012
    ..These events may participate in the impairment of the innate immune response observed after severe trauma...
  23. pmc Epithelial cell apoptosis and neutrophil recruitment in acute lung injury-a unifying hypothesis? What we have learned from small interfering RNAs
    Mario Perl
    Department of Traumatology, Hand and Reconstructive Surgery, University of Ulm Medical School, Ulm, Germany
    Mol Med 14:465-75. 2008
    ....
  24. pmc Dysplasia epiphysealis hemimelica: a case report with novel pathophysiologic aspects
    Mario Perl
    Department of Orthopaedics, University of Ulm Medical School, Ulm, Germany
    Clin Orthop Relat Res 467:2472-8. 2009
    ..Immunohistochemical analysis of the lesion provided a more accurate diagnosis and may contribute to unraveling potential novel mechanisms involved in its pathogenesis...
  25. ncbi The pattern of preformed cytokines in tissues frequently affected by blunt trauma
    Mario Perl
    Department of Trauma, Hand, and Reconstructive Surgery, University of Ulm, Ulm, Germany
    Shock 19:299-304. 2003
    ..This indicates their relevance in post-traumatic monitoring. Furthermore, albumin is a suitable and necessary indicator to evaluate influences of possible blood contamination in tissue samples...