F P Paulsen

Summary

Affiliation: University of Kiel
Country: Germany

Publications

  1. ncbi [Tear outflow. Impact of mucins and TFF-peptides]
    F Paulsen
    Anatomisches Institut, Christian Albrechts Universitat, Kiel
    Ophthalmologe 101:19-24. 2004
  2. pmc Similarities and differences in lectin cytochemistry of laryngeal and tracheal epithelium and subepithelial seromucous glands in cases of sudden infant death and controls
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, D 24098 Kiel, Germany
    Thorax 56:223-7. 2001
  3. pmc Expression of natural peptide antibiotics in human articular cartilage and synovial membrane
    F Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Olshausenstr 40, 24098 Kiel, Germany
    Clin Diagn Lab Immunol 8:1021-3. 2001
  4. ncbi Detection of natural peptide antibiotics in human nasolacrimal ducts
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    Invest Ophthalmol Vis Sci 42:2157-63. 2001
  5. ncbi The human nasolacrimal ducts
    Friedrich Paulsen
    Institute of Anatomy, Christian Albrechts University of Kiel, Olshausenstr 40, 24098 Kiel, Germany
    Adv Anat Embryol Cell Biol 170:III-XI, 1-106. 2003
  6. ncbi Functional anatomy of the papilla Vateri: biomechanical aspects and impact of difficult endoscopic intubation
    F P Paulsen
    Department of Anatomy, Christian Albrecht University, Olshausenstrasse 40, D 24098 Kiel, Germany
    Surg Endosc 16:296-301. 2002
  7. ncbi [Mucins in otorhinolaryngology]
    F Paulsen
    Anatomisches Institut, Christian Albrechts Universitat, Olshausenstrasse 40, 24098 Kiel
    HNO 50:209-16. 2002
  8. ncbi Upper airway epithelial structural changes in obstructive sleep-disordered breathing
    Friedrich P Paulsen
    Institute of Anatomy, Christian Albrecht University of Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    Am J Respir Crit Care Med 166:501-9. 2002
  9. ncbi Animal model for the absorption of lipophilic substances from tear fluid by the epithelium of the nasolacrimal ducts
    Friedrich P Paulsen
    Institute of Anatomy, Christian Albrecht University of Kiel, Kiel, Germany
    Invest Ophthalmol Vis Sci 43:3137-43. 2002
  10. ncbi Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes
    Friedrich Paulsen
    Institute of Anatomy, Christian Albrecht University of Kiel, Germany
    J Pathol 198:369-77. 2002

Detail Information

Publications43

  1. ncbi [Tear outflow. Impact of mucins and TFF-peptides]
    F Paulsen
    Anatomisches Institut, Christian Albrechts Universitat, Kiel
    Ophthalmologe 101:19-24. 2004
    ..Disorders in the balance of single mucins could be of importance with regard to dacryostenosis, dacryocystitis and dacryolith formation...
  2. pmc Similarities and differences in lectin cytochemistry of laryngeal and tracheal epithelium and subepithelial seromucous glands in cases of sudden infant death and controls
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, D 24098 Kiel, Germany
    Thorax 56:223-7. 2001
    ..It has been speculated that non-specific defence mechanisms of the epithelium and subepithelial seromucous glands play a role in the larynx and lungs in cases of sudden infant death...
  3. pmc Expression of natural peptide antibiotics in human articular cartilage and synovial membrane
    F Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Olshausenstr 40, 24098 Kiel, Germany
    Clin Diagn Lab Immunol 8:1021-3. 2001
    ..Our results implicate defensins in the protection of human articular joints against pathogens...
  4. ncbi Detection of natural peptide antibiotics in human nasolacrimal ducts
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    Invest Ophthalmol Vis Sci 42:2157-63. 2001
    ..To determine the expression and production of antimicrobial peptides by mucosal cells of the lacrimal passage in healthy and pathologic states...
  5. ncbi The human nasolacrimal ducts
    Friedrich Paulsen
    Institute of Anatomy, Christian Albrechts University of Kiel, Olshausenstr 40, 24098 Kiel, Germany
    Adv Anat Embryol Cell Biol 170:III-XI, 1-106. 2003
    ..Defective stimulation of tear duct-associated lymphoid tissue (TALT) could result in abnormal immune deviation at the ocular surface leading to an autoimmunologic response that could cause dry eye pathology...
  6. ncbi Functional anatomy of the papilla Vateri: biomechanical aspects and impact of difficult endoscopic intubation
    F P Paulsen
    Department of Anatomy, Christian Albrecht University, Olshausenstrasse 40, D 24098 Kiel, Germany
    Surg Endosc 16:296-301. 2002
    ..The ampulla Vateri was analyzed three-dimensionally to determine whether these difficulties have a structural background...
  7. ncbi [Mucins in otorhinolaryngology]
    F Paulsen
    Anatomisches Institut, Christian Albrechts Universitat, Olshausenstrasse 40, 24098 Kiel
    HNO 50:209-16. 2002
    ..They are an important component of the mucous layer covering the epithelia of the upper aerodigestive tract. Until now there has been little interest with regard to mucins in otorhinolaryngology...
  8. ncbi Upper airway epithelial structural changes in obstructive sleep-disordered breathing
    Friedrich P Paulsen
    Institute of Anatomy, Christian Albrecht University of Kiel, Olshausenstrasse 40, D 24098 Kiel, Germany
    Am J Respir Crit Care Med 166:501-9. 2002
    ..In conclusion, these results support the hypothesis that progressive structural changes in the mucosa caused by the trauma of snoring are a possible contributory factor to upper airway collapsibility...
  9. ncbi Animal model for the absorption of lipophilic substances from tear fluid by the epithelium of the nasolacrimal ducts
    Friedrich P Paulsen
    Institute of Anatomy, Christian Albrecht University of Kiel, Kiel, Germany
    Invest Ophthalmol Vis Sci 43:3137-43. 2002
    ....
  10. ncbi Antimicrobial peptides are expressed and produced in healthy and inflamed human synovial membranes
    Friedrich Paulsen
    Institute of Anatomy, Christian Albrecht University of Kiel, Germany
    J Pathol 198:369-77. 2002
    ..However, caution is appropriate since defensins also promote fibrin formation and cell proliferation - key elements in joint infection. Clarification of the role of antimicrobial peptides in OA and RA will require further investigation...
  11. ncbi TFF peptides in the human efferent tear ducts
    Friedrich P Paulsen
    Institute of Anatomy, Christian Albrechts University, Kiel, Germany
    Invest Ophthalmol Vis Sci 43:3359-64. 2002
    ..To determine whether the lining epithelium of the human lacrimal sac and nasolacrimal duct synthesizes TFF peptides (formerly P-domain peptides, trefoil factors), a family of mucin-associated secretory peptides...
  12. pmc Curving and looping of the internal carotid artery in relation to the pharynx: frequency, embryology and clinical implications
    F Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    J Anat 197:373-81. 2000
    ....
  13. pmc Innervation of the cavernous body of the human efferent tear ducts and function in tear outflow mechanism
    F Paulsen
    Department of Anatomy, Head and Neck Surgery, Christian Albrecht University of Kiel, Germany
    J Anat 197:177-87. 2000
    ..Moreover, malfunction in the innervation of the cavernous body may lead to disturbances in the tear outflow cycle, ocular congestion or total occlusion of the lacrimal passages...
  14. ncbi Functional anatomy of human lacrimal duct epithelium
    F Paulsen
    Department of Anatomy, Christian Albrechts University of Kiel, Germany
    Anat Embryol (Berl) 198:1-12. 1998
    ..The facing of epithelial cells by microvilli gives hints of re-absorption of lacrimal fluid inside the lacrimal ducts...
  15. ncbi Degenerative changes in the human cricoarytenoid joint
    F P Paulsen
    Department of Anatomy, Christian Albrechts University of Kiel, Germany
    Arch Otolaryngol Head Neck Surg 124:903-6. 1998
    ..Occurrence of compromising alterations in the cricoarytenoid joint has been hypothesized as a possible reason for voice changes seen in advanced age and has been discussed controversially until today...
  16. pmc Epithelial-connective tissue boundary in the oral part of the human soft palate
    F Paulsen
    Department of Anatomy, Christian Albrechts University of Kiel, Germany
    J Anat 193:457-67. 1998
    ..The function of the epithelial-connective tissue interface and the extracellular matrix arrangement in the lamina propria are discussed in order to promote the comparability of normal with pathologically altered human soft palates...
  17. ncbi Composition of the extracellular matrix in human cricoarytenoid joint articular cartilage
    F Paulsen
    Department of Anatomy, Christian Albrechts University of Kiel, Germany
    Arch Histol Cytol 62:149-63. 1999
    ..Evidence of type III collagen in the outermost layer of the articular cartilage of the cricoarytenoid joint presents a peculiarity, which has yet not be demonstrated in the articular cartilage of limb joints...
  18. ncbi New insights into the pathomechanism of postintubation arytenoid subluxation
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    Anesthesiology 91:659-66. 1999
    ..The biomechanics and pathomechanism of cricoarytenoid subluxation have not been demonstrated to date...
  19. ncbi The cricoarytenoid joint capsule and its relevance to endotracheal intubation
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    Anesth Analg 90:180-5. 2000
    ..We conclude that laxity of the joint capsule and the large synovial folds are predisposing factors for intubation trauma of the cricoarytenoid joint, potentially leading to hemarthros and finally to cricoarytenoid joint dysfunction...
  20. pmc Effects of ageing on the insertion zones of the human vocal fold
    F Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    J Anat 196:41-54. 2000
    ....
  21. ncbi The cavernous body of the human efferent tear ducts: function in tear outflow mechanism
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    Invest Ophthalmol Vis Sci 41:965-70. 2000
    ..To determine the structure and function of a system of large blood vessels integrated in the bony canal between the orbit and the inferior nasal duct...
  22. ncbi What happens to tears inside the efferent lacrimal passage? An animal experimental study
    F Paulsen
    Department of Anatomy, Christian Albrechts University of Kiel, Germany
    Graefes Arch Clin Exp Ophthalmol 238:496-9. 2000
    ..To determine whether absorption of protein components of the tear fluid occurs in normal efferent tear ducts, an animal experiment was carried out...
  23. ncbi Mucosa-associated lymphoid tissue in human efferent tear ducts
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Germany
    Virchows Arch 437:185-9. 2000
    ..These findings suggest that MALT is a feature that, although it need not be present in normal efferent tear ducts, is acquired during life in a proportion of apparently asymptomatic individuals...
  24. ncbi [The joint capsule of the cricoarytenoid joint: biomechanical and clinical aspects]
    F Paulsen
    Anatomisches Institut, Christian Albrechts Universitat Kiel
    Laryngorhinootologie 79:412-5. 2000
    ..Little is known to date about the cricoarytenoid joint capsule and its role in joint pathology...
  25. ncbi New insights into the pathophysiology of primary acquired dacryostenosis
    F P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Olshausenstrasse 40, D-24098 Kiel, Germany
    Ophthalmology 108:2329-36. 2001
    ....
  26. pmc Antimicrobial defence mechanisms of the human parotid duct
    H Kutta
    Institute of Anatomy, Christian Albrecht University of Kiel, Germany
    J Anat 208:609-19. 2006
    ..Our study demonstrates that the steady secretion of the parotid gland, together with the ductal cellular and biochemical immune protection system, is likely to thwart ascending infections in the parotid duct and gland...
  27. ncbi Trefoil factor family peptide 3 at the ocular surface. A promising therapeutic candidate for patients with dry eye syndrome?
    U Schulze
    Department of Anatomy, Martin Luther University Halle Wittenberg, Halle Saale, Germany
    Dev Ophthalmol 45:1-11. 2010
    ..It also discusses the potential of TFF3 as a candidate therapeutic agent for the treatment of, for example, ocular surface disorders...
  28. ncbi Detection of surfactant proteins A and D in human tear fluid and the human lacrimal system
    Lars Bräuer
    Department of Anatomy and Cell Biology, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Invest Ophthalmol Vis Sci 48:3945-53. 2007
    ..To evaluate the expression and presence of surfactant protein (SP) A and SP-D in the lacrimal apparatus, at the ocular surface, and in tears in healthy and pathologic states...
  29. ncbi Detection and localization of the hydrophobic surfactant proteins B and C in human tear fluid and the human lacrimal system
    Lars Bräuer
    Department of Anatomy and Cell Biology, Martin Luther University of Halle Wittenberg, Halle Saale, Germany
    Curr Eye Res 32:931-8. 2007
    ..To evaluate the expression and presence of the surfactant proteins (SP) B and C in the lacrimal apparatus at the ocular surface and in tear fluid...
  30. ncbi MUC16 in the lacrimal apparatus
    Kristin Jäger
    Department of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstr 52, 06097, Halle, Saale, Germany
    Histochem Cell Biol 127:433-8. 2007
    ..Moreover, the results demonstrate the existence of so far not recognized qualitative differences in the secretion product of main lacrimal gland and accessory lacrimal glands (glands of Krause)...
  31. ncbi Mucins and TFF peptides of the tear film and lacrimal apparatus
    Friedrich P Paulsen
    Department of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstr 52 06097 Halle Saale, Germany
    Prog Histochem Cytochem 41:1-53. 2006
    ....
  32. pmc Intestinal trefoil factor/TFF3 promotes re-epithelialization of corneal wounds
    Friedrich P Paulsen
    Department of Anatomy, Martin Luther University Halle Wittenberg, D 06097 Halle, Germany
    J Biol Chem 283:13418-27. 2008
    ..These findings reveal a pivotal role for Tff3 in corneal wound healing mechanism and have broad implications for developing novel therapeutic strategies for treating nonhealing wounds...
  33. ncbi TFF peptides and mucins are major components of dacryoliths
    Friedrich P Paulsen
    Department of Anatomy and Cell Biology, Martin Luther University Halle Wittenberg, Grosse Steinstr 52, 06097, Halle Saale, Germany
    Graefes Arch Clin Exp Ophthalmol 244:1160-70. 2006
    ..The study was performed to determine whether trefoil factor peptides (TFF) and/or mucins are components of dacryoliths and to gain further insight into dacryolith composition and formation...
  34. ncbi Differential expression of vascular endothelial growth factor implies the limbal origin of pterygia
    Matthias Gebhardt
    Department of Anatomy, Christian Albrecht University of Kiel, Kiel, Germany
    Ophthalmology 112:1023-30. 2005
    ..To study the distribution of isoforms of vascular endothelial growth factor (VEGF) and its receptors VEGFR1 and VEGFR2 in pterygia and to compare it with that in healthy conjunctivas...
  35. ncbi TFF peptides in the human false vocal folds of the larynx
    Hannes Kutta
    Institute of Anatomy, Christian Albrecht University of Kiel, Germany
    Peptides 25:811-8. 2004
    ..These peptides may play a role in the rheological function of mucus secreted onto the true vocal folds and are thus important constituents of vocal production...
  36. ncbi Characterization of mucins in human lacrimal sac and nasolacrimal duct
    Friedrich P Paulsen
    Institute of Anatomy, Christian Albrechts University, Kiel, Germany
    Invest Ophthalmol Vis Sci 44:1807-13. 2003
    ..Mucin expression and distribution in human efferent tear ducts were tested in the physiological state, and potential differences in the expression pattern were investigated in the presence of primary acquired dacryostenosis (PANDO)...
  37. ncbi Protection of human efferent tear ducts by antimicrobial peptides
    Friedrich P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Kiel, Germany
    Adv Exp Med Biol 506:547-53. 2002
  38. ncbi Loss of tear duct-associated lymphoid tissue in association with the scarring of symptomatic dacryostenosis
    Friedrich P Paulsen
    Institute of Anatomy, Christian Albrecht University of Kiel, Kiel, Germany
    Ophthalmology 110:85-92. 2003
    ..To determine whether organized mucosa-associated lymphoid tissue (MALT) is a normal component of the human efferent tear ducts or is acquired in reaction to chronic inflammation...
  39. ncbi Prognostic value of mucins in the classification of ampullary carcinomas
    Friedrich P Paulsen
    Department of Anatomy and Cell Biology, Martin Luther University of Halle Wittenberg, Saale, Germany
    Hum Pathol 37:160-7. 2006
    ..The observed differences in the mucin distribution between the duodenum and the ampulla of Vater support the use of MUC2, MUC7, and MUC8 as useful tool in the classification of ampullary carcinomas...
  40. ncbi VEGF expression in adult permanent thyroid cartilage: implications for lack of cartilage ossification
    Thomas Pufe
    Institute of Anatomy, Christian Albrechts University, Kiel, Germany
    Bone 35:543-52. 2004
    ..VEGF concentration is high and changes in an age-related and sex-specific manner. Therefore, we postulate that VEGF is at least one of the key factors that is important for the lifelong ossification in thyroid cartilage...
  41. ncbi The cavernous body of the human efferent tear ducts contributes to regulation of tear outflow
    Muhammad Ayub
    Institute of Anatomy, Christian Albrecht University, Kiel, Germany
    Invest Ophthalmol Vis Sci 44:4900-7. 2003
    ..To test the hypothesis that the surrounding vascular plexus of the lacrimal sac and the nasolacrimal duct contributes to the regulation of tear outflow...
  42. ncbi Organized mucosa-associated lymphoid tissue in human nasolacrimal ducts
    Friedrich P Paulsen
    Department of Anatomy, Christian Albrecht University of Kiel, Kiel, Germany
    Adv Exp Med Biol 506:873-6. 2002
  43. ncbi Production of endogenous antibiotics in articular cartilage
    Deike Varoga
    Schleswig Holstein University and University Hospital, 24098 Kiel, Germany
    Arthritis Rheum 50:3526-34. 2004
    ..The present study was undertaken to investigate whether this may be explained by intraarticular production of gram-negative-specialized antimicrobial peptides...