Hans Christian Pape

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. pmc Kindling-induced changes in plasticity of the rat amygdala and hippocampus
    Manja Schubert
    Institute of Neurophysiology Charité University Medicine Berlin, 10117 Berlin, Germany
    Learn Mem 12:520-6. 2005
  2. ncbi request reprint Dissociated theta phase synchronization in amygdalo- hippocampal circuits during various stages of fear memory
    Rajeevan T Narayanan
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, Munster, Germany
    Eur J Neurosci 25:1823-31. 2007
  3. pmc Activation of neuropeptide S-expressing neurons in the locus coeruleus by corticotropin-releasing factor
    Kay Jüngling
    H C Pape Institute of Physiology I Robert Koch Str 27a, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Physiol 590:3701-17. 2012
  4. pmc Neuropeptide S: a transmitter system in the brain regulating fear and anxiety
    Hans Christian Pape
    Institute of Physiology I, Westfalische Wilhelms University, Munster, Robert Koch Str 27 A, D 48149, Germany
    Neuropharmacology 58:29-34. 2010
  5. pmc Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear
    Hans Christian Pape
    Institute of Physiology, Westfaelische Wilhelms University, Muenster, Germany and Rutgers State University, Newark, New Jersey, USA
    Physiol Rev 90:419-63. 2010
  6. ncbi request reprint Theta activity in neurons and networks of the amygdala related to long-term fear memory
    Hans Christian Pape
    Institut fuer Physiologie I Neurophysiologie, Westfaelische Wilhelms Universitaet, Germany
    Hippocampus 15:874-80. 2005
  7. ncbi request reprint Contribution of TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons
    Sven G Meuth
    Institute of Physiology, Otto von Guericke Universitat, D 39120 Magdeburg, Germany
    J Neurosci 23:6460-9. 2003
  8. ncbi request reprint T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy
    Tilman Broicher
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    Neuropharmacology 53:431-46. 2007
  9. doi request reprint Impaired extinction of fear and maintained amygdala-hippocampal theta synchrony in a mouse model of temporal lobe epilepsy
    Jörg Lesting
    Institute for Physiology I, Muenster, Germany
    Epilepsia 52:337-46. 2011
  10. ncbi request reprint Specific expression of low-voltage-activated calcium channel isoforms and splice variants in thalamic local circuit interneurons
    Tilman Broicher
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    Mol Cell Neurosci 36:132-45. 2007

Collaborators

Detail Information

Publications68

  1. pmc Kindling-induced changes in plasticity of the rat amygdala and hippocampus
    Manja Schubert
    Institute of Neurophysiology Charité University Medicine Berlin, 10117 Berlin, Germany
    Learn Mem 12:520-6. 2005
    ..In conclusion, kindling differentially affects the magnitude, saturation, and polarity of LTP in the CA1 and LA, respectively, most likely indicating an activity-dependent mechanism in the context of synaptic metaplasticity...
  2. ncbi request reprint Dissociated theta phase synchronization in amygdalo- hippocampal circuits during various stages of fear memory
    Rajeevan T Narayanan
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, Munster, Germany
    Eur J Neurosci 25:1823-31. 2007
    ....
  3. pmc Activation of neuropeptide S-expressing neurons in the locus coeruleus by corticotropin-releasing factor
    Kay Jüngling
    H C Pape Institute of Physiology I Robert Koch Str 27a, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Physiol 590:3701-17. 2012
    ..These data provide evidence for a direct interaction between the CRF and the NPS system and thereby extend previous observations of NPS-modulated stress responsiveness towards a mechanistic level...
  4. pmc Neuropeptide S: a transmitter system in the brain regulating fear and anxiety
    Hans Christian Pape
    Institute of Physiology I, Westfalische Wilhelms University, Munster, Robert Koch Str 27 A, D 48149, Germany
    Neuropharmacology 58:29-34. 2010
    ..These functions could provide interesting opportunities for both basic research and clinical applications...
  5. pmc Plastic synaptic networks of the amygdala for the acquisition, expression, and extinction of conditioned fear
    Hans Christian Pape
    Institute of Physiology, Westfaelische Wilhelms University, Muenster, Germany and Rutgers State University, Newark, New Jersey, USA
    Physiol Rev 90:419-63. 2010
    ..We will focus on Pavlovian fear conditioning as a model and the amygdala as a key component for the acquisition and extinction of fear responses...
  6. ncbi request reprint Theta activity in neurons and networks of the amygdala related to long-term fear memory
    Hans Christian Pape
    Institut fuer Physiologie I Neurophysiologie, Westfaelische Wilhelms Universitaet, Germany
    Hippocampus 15:874-80. 2005
    ..Synchronization at theta frequencies is suggested to represent activity in amygdalo-hippocampal pathways associated with system consolidation of fear memory, which is supported by the cholinergic system...
  7. ncbi request reprint Contribution of TWIK-related acid-sensitive K+ channel 1 (TASK1) and TASK3 channels to the control of activity modes in thalamocortical neurons
    Sven G Meuth
    Institute of Physiology, Otto von Guericke Universitat, D 39120 Magdeburg, Germany
    J Neurosci 23:6460-9. 2003
    ....
  8. ncbi request reprint T-current related effects of antiepileptic drugs and a Ca2+ channel antagonist on thalamic relay and local circuit interneurons in a rat model of absence epilepsy
    Tilman Broicher
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    Neuropharmacology 53:431-46. 2007
    ..In summary, these results support the hypothesis of IT reduction as part of the mechanism of action of anti-absence drugs and demonstrate the ability of a specific IT antagonist to attenuate rhythmic burst firing and SWDs...
  9. doi request reprint Impaired extinction of fear and maintained amygdala-hippocampal theta synchrony in a mouse model of temporal lobe epilepsy
    Jörg Lesting
    Institute for Physiology I, Muenster, Germany
    Epilepsia 52:337-46. 2011
    ..Therefore, this project was set up to characterize the neurophysiologic basis of seizure-related fear and the contribution of the amygdala-hippocampus system...
  10. ncbi request reprint Specific expression of low-voltage-activated calcium channel isoforms and splice variants in thalamic local circuit interneurons
    Tilman Broicher
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    Mol Cell Neurosci 36:132-45. 2007
    ....
  11. ncbi request reprint The contribution of TWIK-related acid-sensitive K+-containing channels to the function of dorsal lateral geniculate thalamocortical relay neurons
    Sven G Meuth
    Institut für Experimentelle Epilepsieforschung, Westfalische Wilhelms Universitat Munster, Hüfferstr 68, D 48149 Munster, Germany
    Mol Pharmacol 69:1468-76. 2006
    ..In conclusion, our findings demonstrate a significant contribution of TASK-1 channels to ISO in DLG TC neurons, although the genetic knockout of TASK-1 did not produce severe deficits in the thalamocortical system...
  12. ncbi request reprint Generalisation of conditioned fear and its behavioural expression in mice
    T Rao Laxmi
    Institute of Physiology, Otto von Guericke University Magdeburg, Leipziger Str 44, D 39120 Magdeburg, Germany
    Behav Brain Res 145:89-98. 2003
    ....
  13. doi request reprint Reciprocal modulation of I (h) and I (TASK) in thalamocortical relay neurons by halothane
    Thomas Budde
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, 48149, Munster, Germany
    Pflugers Arch 456:1061-73. 2008
    ..It is concluded that the reciprocal modulation of I (h) and I (TASK) is an important mechanism of halothane action in the thalamus...
  14. ncbi request reprint Plasticity of inhibitory synaptic network interactions in the lateral amygdala upon fear conditioning in mice
    Csaba Szinyei
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    Eur J Neurosci 25:1205-11. 2007
    ....
  15. doi request reprint Alteration of NMDA receptor-mediated synaptic interactions in the lateral amygdala associated with seizure activity in a mouse model of chronic temporal lobe epilepsy
    Stéphanie Graebenitz
    Institute for Physiology I, Westfalische Wilhelms Universitat, Munster, Germany
    Epilepsia 51:1754-62. 2010
    ....
  16. pmc Prevention of stress-impaired fear extinction through neuropeptide s action in the lateral amygdala
    Frederic Chauveau
    Institute of Physiology I Neurophysiology, Westfälische Wilhelms University Münster, Munster, Germany
    Neuropsychopharmacology 37:1588-99. 2012
    ..Together these results suggest that the neuropeptide S system is capable of interfering with mechanisms in the amygdala that transform stressful events into anxiety and impaired fear extinction...
  17. doi request reprint Thalamic involvement in patients with neurologic impairment due to Shiga toxin 2
    Sven G Meuth
    Institute of Physiology I, Department of Neurology, University Hospital Munster, Westphalian Wilhelms University, Munster, Germany
    Ann Neurol 73:419-29. 2013
    ..Owing to these observations, we designed a series of experimental studies to evaluate the underlying mechanism of action of this clinical picture...
  18. doi request reprint Adenylyl cyclases: expression in the developing rat thalamus and their role in absence epilepsy
    Petra Ehling
    Neurology Clinic Inflammatory Disorders of the Nervous System and Neurooncology, and Institute of Physiology I Neuropathophysiology, Westfalische Wilhelms University, ICB, Mendelstr 7, 48149, Muenster, Germany
    J Mol Neurosci 48:45-52. 2012
    ..Despite previous hints pointing to a major contribution of ACs, the presented data show that there is no apparent causality between AC activity and the occurrence of the epileptic phenotype...
  19. doi request reprint Burst discharges in neurons of the thalamic reticular nucleus are shaped by calcium-induced calcium release
    Philippe Coulon
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, 48149 Munster, Germany
    Cell Calcium 46:333-46. 2009
    ..We conclude that the activation of LVACC specifically causes CICR via RyR in neurons of the NRT, thereby adding a Ca2+-dependent intracellular route to the mechanisms determining rhythmic oscillatory bursting in this nucleus...
  20. pmc Social defeat: impact on fear extinction and amygdala-prefrontal cortical theta synchrony in 5-HTT deficient mice
    Venu Narayanan
    Institute of Physiology I, Westfalische Wilhelms University, Munster, Germany
    PLoS ONE 6:e22600. 2011
    ....
  21. ncbi request reprint Contribution of NR2B subunits to synaptic transmission in amygdaloid interneurons
    Csaba Szinyei
    Institute of Physiology, Medical School, Otto von Guericke University, 39120 Magdeburg, Germany
    J Neurosci 23:2549-56. 2003
    ....
  22. ncbi request reprint Genes and mechanisms in the amygdala involved in the formation of fear memory
    Hans Christian Pape
    Institute of Physiology, Otto von Guericke University Medical School, D 39120 Magdeburg, Germany
    Ann N Y Acad Sci 985:92-105. 2003
    ....
  23. doi request reprint Ca(2+)-dependent large conductance K(+) currents in thalamocortical relay neurons of different rat strains
    Petra Ehling
    Institute of Physiology I, University of Munster, Robert Koch Str 27a, Munster, Germany
    Pflugers Arch 465:469-80. 2013
    ..In addition, we show that BKCa channel functioning differs in epileptic WAG/Rij and thereby likely contributes to highly synchronised, epileptic network activity...
  24. pmc Differential regulation of HCN channel isoform expression in thalamic neurons of epileptic and non-epileptic rat strains
    Tatyana Kanyshkova
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    Neurobiol Dis 45:450-61. 2012
    ..Because HCN3 is expressed higher in young versus older animals, HCN3 likely does not contribute to alterations in I(h) in older animals...
  25. doi request reprint Differential regulation of glutamic acid decarboxylase gene expression after extinction of a recent memory vs. intermediate memory
    Susan Sangha
    Institute for Physiology I, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    Learn Mem 19:194-200. 2012
    ..Extinguishing an intermediate memory increased Gad65 gene expression in the central amygdala. These results indicate a differential regulation of Gad gene expression after extinction of a recent memory vs. intermediate memory...
  26. ncbi request reprint The effect of estrogen and progesterone on spreading depression in rat neocortical tissues
    Martin Sachs
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Strasse 27a, 48149 Munster, Germany
    Neurobiol Dis 25:27-34. 2007
    ..These hormones may exert their effects on SD via facilitation of synaptic transmission...
  27. doi request reprint Deficiency of the 65 kDa isoform of glutamic acid decarboxylase impairs extinction of cued but not contextual fear memory
    Susan Sangha
    Institute of Physiology I, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Neurosci 29:15713-20. 2009
    ..In view of the more pronounced effect on cued versus contextual fear extinction, these influences may rely more on GABAergic mechanisms in the amygdala...
  28. pmc Patterns of coupled theta activity in amygdala-hippocampal-prefrontal cortical circuits during fear extinction
    Jörg Lesting
    Institute of Physiology 1, Westfalische Wilhelms Universitat, Munster, Germany
    PLoS ONE 6:e21714. 2011
    ..More specifically, theta oscillations seem to contribute to a population code indicating conditioned stimuli during recall of fear memory before and after extinction...
  29. ncbi request reprint A maternal blood-borne factor promotes survival of the developing thalamus
    Peter Landgraf
    Institute of Physiology, Otto von Guericke University, Magdeburg, Germany
    FASEB J 19:225-7. 2005
    ..e., optic nerve crush), which points to a potential role of the factor not only in neuronal development but also in neuroinflammation after white matter injury...
  30. ncbi request reprint Fear memory and the amygdala: insights from a molecular perspective
    Oliver Stork
    Institute of Physiology, Otto von Guericke University Magdeburg, Leipziger Str 44, 39120 Magdeburg, Germany
    Cell Tissue Res 310:271-7. 2002
    ....
  31. ncbi request reprint GABAergic neurons: gate masters of the amygdala, mastered by dopamine
    Hans Christian Pape
    Institute of Physiology I, Department of Medicine, Westfaelische Wilhelms University, D 48149 Muenster, Germany
    Neuron 48:877-9. 2005
    ....
  32. ncbi request reprint Theta resynchronization during reconsolidation of remote contextual fear memory
    Rajeevan T Narayanan
    Institute of Physiology I, Westfälische Wilhelms University Münster, Munster, Germany
    Neuroreport 18:1107-11. 2007
    ..These data indicate that the reconsolidation of remote contextual fear memory includes changes in ensemble activities between the lateral amygdala and CA1...
  33. doi request reprint GABAergic interneurons in the mouse lateral amygdala: a classification study
    Ludmila Sosulina
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Munster, Germany
    J Neurophysiol 104:617-26. 2010
    ..Overall, these data represent a detailed and reliable classification scheme of LA GABAergic interneurons and will provide a feasible basis for subsequent functional studies...
  34. doi request reprint Identification of the muscarinic pathway underlying cessation of sleep-related burst activity in rat thalamocortical relay neurons
    Pawan Bista
    Institut fur Physiologie I, Westfalische Wilhelms Universitat, Robert Koch Str 27a, 48149, Munster, Germany
    Pflugers Arch 463:89-102. 2012
    ..These findings point to a critical role of G proteins and PLC as well as TASK and TREK channels in the muscarinic modulation of thalamic activity modes...
  35. doi request reprint Muscarinic ACh receptor-mediated control of thalamic activity via G(q)/G (11)-family G-proteins
    Tilman Broicher
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, 48149, Munster, Germany
    Pflugers Arch 456:1049-60. 2008
    ....
  36. pmc Neuropeptide S-mediated control of fear expression and extinction: role of intercalated GABAergic neurons in the amygdala
    Kay Jüngling
    Institute of Physiology I Neurophysiology, Westfälische Wilhelms University Münster, Robert Koch Strasse 27a, D 48149 Munster, Germany
    Neuron 59:298-310. 2008
    ..These results identify mechanisms of NPS in the brain, a key role of intercalated neurons in the amygdala for fear extinction, and a potential pharmacological avenue for treating anxiety disorders...
  37. doi request reprint A-type K+ currents in intralaminar thalamocortical relay neurons
    Tatyana Kanyshkova
    Institute of Physiology I, Westfalische Wilhelms Universitat, Robert Koch Str 27a, 48149, Munster, Germany
    Pflugers Arch 461:545-56. 2011
    ..2 and K(V)4.3 channels, allows prominent burst firing at hyperpolarized potentials, prevents the generation of high-threshold potentials, generates a delayed onset of firing at more depolarized potentials, and allows fast tonic firing...
  38. ncbi request reprint Calcium-dependent inactivation of neuronal calcium channels
    Thomas Budde
    Otto von Guericke Universitat, Institute of Physiology, Leipziger Strabetae 44, D 39120 Magdeburg, Germany
    Nat Rev Neurosci 3:873-83. 2002
  39. ncbi request reprint Neuronal functions of the novel serine/threonine kinase Ndr2
    Oliver Stork
    Institute of Physiology, Otto von Guericke University Magdeburg, D 39120 Magdeburg, Germany
    J Biol Chem 279:45773-81. 2004
    ..Together, our data suggest that Ndr2 is an interesting candidate gene for the regulation of structural processes in differentiating and mature neuronal cells...
  40. pmc Short-term adaptation of conditioned fear responses through endocannabinoid signaling in the central amygdala
    Kornelia Kamprath
    Institute of Physiology I Neurophysiology, Westfaelische Wilhelms University, Muenster, Germany
    Neuropsychopharmacology 36:652-63. 2011
    ....
  41. doi request reprint Seizure-related activity of intralaminar thalamic neurons in a genetic model of absence epilepsy
    Ali Gorji
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Strasse 27a, 48149 Munster, Germany
    Neurobiol Dis 43:266-74. 2011
    ..These data show a unique pattern of rhythmic SWD-locked IPSPs in PC and CL associated with paroxysms apt to impose a transient dysfunctional state to thalamo-striato-prefrontocortical networks during absence seizures...
  42. doi request reprint The sleep relay--the role of the thalamus in central and decentral sleep regulation
    Philippe Coulon
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, 48149, Munster, Germany
    Pflugers Arch 463:53-71. 2012
    ..We propose that future studies should integrate ideas of central, decentral, and thalamic sleep generation...
  43. doi request reprint Interictal-like network activity and receptor expression in the epileptic human lateral amygdala
    Stéphanie Graebenitz
    Institute of Physiology I, Westfaelische Wilhelms Universität Münster, D 48149 Munster, Germany
    Brain 134:2929-47. 2011
    ....
  44. pmc Postnatal expression pattern of HCN channel isoforms in thalamic neurons: relationship to maturation of thalamocortical oscillations
    Tatyana Kanyshkova
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Neurosci 29:8847-57. 2009
    ....
  45. doi request reprint Neuropeptide Y activates a G-protein-coupled inwardly rectifying potassium current and dampens excitability in the lateral amygdala
    Ludmila Sosulina
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Mol Cell Neurosci 39:491-8. 2008
    ..Functionally, the dampening of excitability in projection neurons of the amygdala may contribute to the decrease in anxiogenic behavior during action of NPY...
  46. doi request reprint Abnormalities in GABAergic synaptic transmission of intralaminar thalamic neurons in a genetic rat model of absence epilepsy
    Johannes Brockhaus
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Mol Cell Neurosci 46:444-51. 2011
    ....
  47. doi request reprint Cortical spreading depression modulates synaptic transmission of the rat lateral amygdala
    Shahab Dehbandi
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Strasse 27a, D 48149 Munster, Germany
    Eur J Neurosci 27:2057-65. 2008
    ..The results indicate the disturbances of LA synaptic transmission triggered by propagation of CSD. This perturbation of LA synaptic transmission induced by CSD may relate to some symptoms occurring during migraine attacks...
  48. doi request reprint Cannabinoid CB1 receptor in dorsal telencephalic glutamatergic neurons: distinctive sufficiency for hippocampus-dependent and amygdala-dependent synaptic and behavioral functions
    Sabine Ruehle
    Institute of Physiological Chemistry, University Medical Center of the Johannes Gutenberg University Mainz, 55128 Mainz, Germany
    J Neurosci 33:10264-77. 2013
    ..Our data pave the way to a better understanding of neuronal networks in the context of behavior, by fine-tuned interference with synaptic transmission processes...
  49. doi request reprint Selective loss of noradrenaline exacerbates early cognitive dysfunction and synaptic deficits in APP/PS1 mice
    Thea Hammerschmidt
    Department of Neurology, Clinical Neurosciences, University of Bonn, Bonn, Germany
    Biol Psychiatry 73:454-63. 2013
    ..Because the LC contains multiple neuromodulators known to affect amyloid β toxicity and cognitive function, the specific role of noradrenaline (NA) in AD is not well understood...
  50. doi request reprint Correlation of T-channel coding gene expression, IT, and the low threshold Ca2+ spike in the thalamus of a rat model of absence epilepsy
    Tilman Broicher
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Munster, Germany
    Mol Cell Neurosci 39:384-99. 2008
    ..Current density was larger in all nuclei of WAG/Rij rats when compared to ACI and correlated with LTS size and the minimum LTS generating slope, while T-type Ca(2+) current voltage dependency correlated with the LTS onset potential...
  51. pmc FGF signalling inhibits neural induction in human embryonic stem cells
    Boris Greber
    Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, Munster, Germany
    EMBO J 30:4874-84. 2011
    ..Our study assigns a novel, biphasic role to FGF/ERK signalling in the neural induction of hESCs, which may also have utility for applications requiring the rapid and efficient generation of peripheral neurons...
  52. ncbi request reprint Postsynaptic mechanisms underlying responsiveness of amygdaloid neurons to cholecystokinin are mediated by a transient receptor potential-like current
    Susanne Meis
    Institut fur Physiologie, Medizinische Fakultat, Otto von Guericke Universitat, Leipziger Str 44, D 39120 Magdeburg, Germany
    Mol Cell Neurosci 35:356-67. 2007
    ..Single cell PCR confirmed the expression of TRPC1,4,5 and coexpression of TRPC1 with TRPC4 or TRPC5 in some cells. CCK responses were associated with depolarization leading to an increase in cell excitability...
  53. pmc Role of the somatostatin system in contextual fear memory and hippocampal synaptic plasticity
    Christian Kluge
    Institute of Physiology I Neurophysiology, Westfälische Wilhelms University Münster, 48149 Munster, Germany
    Learn Mem 15:252-60. 2008
    ....
  54. ncbi request reprint Synaptic and non-synaptic mechanisms of amygdala recruitment into temporolimbic epileptiform activities
    Julia Klueva
    Institut fur Physiologie, Medizinische Fakultat, Otto von Guericke Universitat Magdeburg, D 39120 Magdeburg, Germany
    Eur J Neurosci 18:2779-91. 2003
    ..Antidromically conducted ectopic action potentials may provide a spreading mechanism of seizure activity mediated by diffuse axonal projections of LA neurons...
  55. ncbi request reprint Amygdalar and hippocampal theta rhythm synchronization during fear memory retrieval
    Thomas Seidenbecher
    Institut fur Physiologie, Otto von Guericke Universitat, Leipziger Strasse 44, Magdeburg D 39120, Germany
    Science 301:846-50. 2003
    ..Synchronization of theta activities in the amygdalohippocampal network represents a neuronal correlate of conditioned fear, apt to improve neuronal communication during memory retrieval...
  56. ncbi request reprint Antioscillatory effects of nociceptin/orphanin FQ in synaptic networks of the rat thalamus
    Susanne Meis
    Institut fur Physiologie, Otto von Guericke Universitat, D 39120 Magdeburg, Germany
    J Neurosci 22:718-27. 2002
    ..We conclude that N/OFQ reduces the excitability of NRT and VB neurons predominantly through an increase of a G-protein-coupled inwardly rectifying K(+) conductance...
  57. pmc Critical role of the 65-kDa isoform of glutamic acid decarboxylase in consolidation and generalization of Pavlovian fear memory
    Jorge R Bergado-Acosta
    Institute for Physiology, Otto von Guericke University Magdeburg, D 39120 Magdeburg, Germany
    Learn Mem 15:163-71. 2008
    ....
  58. ncbi request reprint Molecular and functional properties of neurons in the human lateral amygdala
    Kerstin Hüttmann
    Experimental Neurobiology, Neurosurgery, University of Bonn, Sigmund Freud Str 25, D 53105 Bonn, Germany
    Mol Cell Neurosci 31:210-7. 2006
    ..The most striking difference relates to the expression of postsynaptic GABA(B) receptors coupled to Kir3 channels in projection neurons and the lack of functional GABA(B) receptors in interneurons...
  59. ncbi request reprint Impaired regulation of thalamic pacemaker channels through an imbalance of subunit expression in absence epilepsy
    Thomas Budde
    Institut für Experimentelle Epilepsieforschung, Westfalische Wilhelms Universitat Munster, D 48149 Munster, Germany
    J Neurosci 25:9871-82. 2005
    ....
  60. ncbi request reprint Effect of cortical spreading depression on synaptic transmission of rat hippocampal tissues
    Brigitta Wernsmann
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Germany
    Eur J Neurosci 23:1103-10. 2006
    ..This perturbation of hippocampal synaptic transmission induced by CSD may relate to some symptoms occurring during migraine attacks, such as amnesia and hyperactivity...
  61. ncbi request reprint Mechanisms of somatostatin-evoked responses in neurons of the rat lateral amygdala
    Susanne Meis
    Institut fur Physiologie, Medizinische Fakultat, Otto von Guericke Universitat, Leipziger Str 44, D 39120 Magdeburg, Germany
    Eur J Neurosci 21:755-62. 2005
    ..It is suggested that these cellular mechanisms contribute to the role of somatostatin in decreasing anxiety behaviour as well as to anticonvulsant and antiepileptogenic actions of somatostatin or somatostatin agonists in the amygdala...
  62. ncbi request reprint Influence of Ca2+-binding proteins and the cytoskeleton on Ca2+-dependent inactivation of high-voltage activated Ca2+ currents in thalamocortical relay neurons
    Sven G Meuth
    Otto von Guericke Universitat, Medizinische Fakultat, Institut fur Physiologie, Leipziger Strasse 44, 39120, Magdeburg, Germany
    Pflugers Arch 450:111-22. 2005
    ....
  63. pmc Effects of divalent cations and spermine on the K+ channel TASK-3 and on the outward current in thalamic neurons
    Boris Musset
    Institut fur Physiologie, Universitat Marburg, Deutschhausstrasse 2, 35037 Marburg, Germany
    J Physiol 572:639-57. 2006
    ..We conclude from our results that inhibition of TASK-3 channels may contribute to the neuromodulatory effect of spermine released from neurons during repetitive activity or during hypoxia...
  64. pmc Loss of K-Cl co-transporter KCC3 causes deafness, neurodegeneration and reduced seizure threshold
    Thomas Boettger
    Zentrum für Molekulare Neurobiologie, ZMNH, Universitat Hamburg, Falkenried 94, D 20251 Hamburg, Germany
    EMBO J 22:5422-34. 2003
    ..These cells slowly degenerated, as did sensory hair cells. The present mouse model has revealed important cellular and systemic functions of KCC3 and is highly relevant for Anderman syndrome...
  65. ncbi request reprint Classification of projection neurons and interneurons in the rat lateral amygdala based upon cluster analysis
    Ludmila Sosulina
    Institut fur Physiologie I, Westfalische Wilhelms Universitat Munster, Robert Koch Str 27a, D 48149 Munster, Germany
    Mol Cell Neurosci 33:57-67. 2006
    ..Morphologically, projection neurons were large, spiny cells, whereas the other neuronal classes displayed smaller somata and spine-sparse dendrites...
  66. pmc Absence epilepsy and sinus dysrhythmia in mice lacking the pacemaker channel HCN2
    Andreas Ludwig
    Institut fur Pharmakologie und Toxikologie, Technische Universitat Munchen, D 80802 München, Germany
    EMBO J 22:216-24. 2003
    ..Our results define the physiological role of the HCN2 subunit as a major determinant of membrane resting potential that is required for regular cardiac and neuronal rhythmicity...
  67. ncbi request reprint Modulation of Ca2+ currents in rat thalamocortical relay neurons by activity and phosphorylation
    Sven Meuth
    Institut fur Physiologie, Otto von Guericke Universitat, Leipziger Str 44, D 39120 Magdeburg, Germany
    Eur J Neurosci 15:1603-14. 2002
    ....
  68. ncbi request reprint Membrane resting potential of thalamocortical relay neurons is shaped by the interaction among TASK3 and HCN2 channels
    Sven G Meuth
    Neurologische Klinik, Bayerische Julius Maximilians Universität, Wurzburg, Germany
    J Neurophysiol 96:1517-29. 2006
    ....