K Pantel

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. pmc Bone marrow micrometastases and circulating tumor cells: current aspects and future perspectives
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 6:258-61. 2004
  2. pmc Recent translational research: circulating tumor cells in breast cancer patients
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Breast Cancer Res 8:110. 2006
  3. doi request reprint The potential of circulating tumor cells as a liquid biopsy to guide therapy in prostate cancer
    Klaus Pantel
    Department of Tumour Biology, Centre of Experimental Medicine, University Cancer Center Hamburg, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Cancer Discov 2:974-5. 2012
  4. pmc Clinical relevance and biology of circulating tumor cells
    Natalia Bednarz-Knoll
    Department of Tumour Biology, University Medical Centre Hamburg Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    Breast Cancer Res 13:228. 2011
  5. pmc Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20241 Hamburg, Germany
    Breast Cancer Res 13:R71. 2011
  6. pmc Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 12:R90. 2010
  7. pmc A critical evaluation of loss of heterozygosity detected in tumor tissues, blood serum and bone marrow plasma from patients with breast cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 9:R66. 2007
  8. pmc Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance
    Tanja Fehm
    Department of Gynecology and Obstetrics, University Tübingen, Tubingen, Germany
    Breast Cancer Res 10:S1. 2008
  9. pmc Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    Breast Cancer Res 11:R71. 2009
  10. pmc Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    BMC Cancer 11:4. 2011

Detail Information

Publications101 found, 100 shown here

  1. pmc Bone marrow micrometastases and circulating tumor cells: current aspects and future perspectives
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 6:258-61. 2004
    ..These findings provide the basis for the potential use of disseminated tumor cells in bone marrow or blood as markers for the early assessment of therapeutic response in prospective clinical trials...
  2. pmc Recent translational research: circulating tumor cells in breast cancer patients
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Breast Cancer Res 8:110. 2006
    ..In this article we briefly summarize recent studies examining the presence of circulating tumor cells in the blood and discuss further clinical applications...
  3. doi request reprint The potential of circulating tumor cells as a liquid biopsy to guide therapy in prostate cancer
    Klaus Pantel
    Department of Tumour Biology, Centre of Experimental Medicine, University Cancer Center Hamburg, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Cancer Discov 2:974-5. 2012
    ..This finding indicates that measuring AR signaling within CTCs may help to guide therapy in metastatic prostate cancer and highlights the use of CTCs as liquid biopsy...
  4. pmc Clinical relevance and biology of circulating tumor cells
    Natalia Bednarz-Knoll
    Department of Tumour Biology, University Medical Centre Hamburg Eppendorf, Martinistr, 52, 20246 Hamburg, Germany
    Breast Cancer Res 13:228. 2011
    ..This review focuses on investigations regarding the biology and clinical relevance of circulating tumor cells in breast cancer...
  5. pmc Prospective evaluation of serum tissue inhibitor of metalloproteinase 1 and carbonic anhydrase IX in correlation to circulating tumor cells in patients with metastatic breast cancer
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20241 Hamburg, Germany
    Breast Cancer Res 13:R71. 2011
    ..The aim of the study was to investigate whether serum concentrations of TIMP-1 and CAIX are associated with the detection of CTC in metastatic breast cancer...
  6. pmc Circulating microRNAs as blood-based markers for patients with primary and metastatic breast cancer
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 12:R90. 2010
    ..Here we evaluated, for the first time, the feasibility and clinical utility of circulating miRs as biomarkers for the detection and staging of breast cancer...
  7. pmc A critical evaluation of loss of heterozygosity detected in tumor tissues, blood serum and bone marrow plasma from patients with breast cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Breast Cancer Res 9:R66. 2007
    ..The aim of the study was to perform a comparative analysis of LOH (loss of heterozygosity) in primary tumors as well as peripheral blood and bone marrow (BM) of patients with breast cancer (BCa)...
  8. pmc Micrometastatic spread in breast cancer: detection, molecular characterization and clinical relevance
    Tanja Fehm
    Department of Gynecology and Obstetrics, University Tübingen, Tubingen, Germany
    Breast Cancer Res 10:S1. 2008
    ..In addition, understanding tumor 'dormancy' and identifying metastatic stem cells might result in the development of new therapeutic concepts...
  9. pmc Comparative evaluation of cell-free tumor DNA in blood and disseminated tumor cells in bone marrow of patients with primary breast cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    Breast Cancer Res 11:R71. 2009
    ..Here we investigated whether the detection of this DNA is related to bone marrow (BM) micrometastasis and tumor recurrence in breast cancer patients...
  10. pmc Apoptosis-related deregulation of proteolytic activities and high serum levels of circulating nucleosomes and DNA in blood correlate with breast cancer progression
    Carina Roth
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    BMC Cancer 11:4. 2011
    ....
  11. doi request reprint Cancer micrometastases
    Klaus Pantel
    Institute of Tumour Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Nat Rev Clin Oncol 6:339-51. 2009
    ..This Review focuses on the clinical relevance of the latest research results on blood-borne cancer micrometastases in patients with cancer...
  12. ncbi request reprint Detection and clinical implications of early systemic tumor cell dissemination in breast cancer
    Klaus Pantel
    Institut für Tumorbiologie, Universitatsklinikum Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 9:6326-34. 2003
    ..Here, we will review the existing tumor cell assays and discuss their current clinical relevance and perspectives for the clinical management of breast cancer patients...
  13. doi request reprint Detection, clinical relevance and specific biological properties of disseminating tumour cells
    Klaus Pantel
    Institute of Tumour Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, Germany
    Nat Rev Cancer 8:329-40. 2008
    ..Here we review the evidence that disseminating tumour cells have a variety of uses for understanding tumour biology and improving cancer treatment...
  14. ncbi request reprint [Minimal residual disease in breast cancer: detection and clinical relevance]
    K Pantel
    Institut für Tumorbiologie, Zentrum für Experimentelle Medizin Hamburg Eppendorf, Deutschland
    Verh Dtsch Ges Pathol 89:68-75. 2005
    ..In this review, we will therefore discuss the detection, characterisation and clinical relevance of DTC...
  15. ncbi request reprint The clinical significance of circulating tumor cells
    Klaus Pantel
    Institute of Tumor Biology, University Medical Center, Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Nat Clin Pract Oncol 4:62-3. 2007
  16. ncbi request reprint Detection and molecular characterisation of disseminated tumour cells: implications for anti-cancer therapy
    Klaus Pantel
    Institute of Tumour Biology, Centre of Experimental Medicine, University Medical Center Hamburg, Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    Biochim Biophys Acta 1756:53-64. 2005
    ..In this review, we will therefore discuss the detection and characterisation of DTC in the light of new therapeutic strategies targeting tumour-associated molecules and signalling pathways...
  17. ncbi request reprint Dissecting the metastatic cascade
    Klaus Pantel
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg 202461, Germany
    Nat Rev Cancer 4:448-56. 2004
  18. ncbi request reprint Micrometastasis in breast cancer and other solid tumors
    K Pantel
    Institute of Tumor Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    J Biol Regul Homeost Agents 18:120-5. 2004
    ..Thus, dissemination of tumor cells appears to be an early process associated with a specific molecular signature of the primary tumor...
  19. ncbi request reprint Occult micrometastasis: enrichment, identification and characterization of single disseminated tumour cells
    K Pantel
    Molekulare Onkologie, Frauenklinik, Universitäts Klinikum Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Semin Cancer Biol 11:327-37. 2001
    ..Taken together, the advancing characterization of disseminated tumour cells opens the avenue for the development of new therapeutic approaches aimed at preventing metastatic relapse...
  20. ncbi request reprint Identification and characterisation of minimal residual disease in solid tumors
    K Pantel
    Department of Molecular Diagnostics and Therapy, University Hospital Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Acta Med Austriaca Suppl 52:8-12. 2000
    ..For the first time these methods give access to this critical stage of tumor progression and also contribute to the development of new approaches to therapy aimed at preventing manifest metastasis...
  21. doi request reprint Circulating tumour cells in cancer patients: challenges and perspectives
    Klaus Pantel
    Institute of Tumour Biology, Centre of Experimental Medicine, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Trends Mol Med 16:398-406. 2010
    ..Moreover, molecular analyses of CTCs/DTCs have provided new insights into the biology of metastasis with important implications for the clinical management of cancer patients...
  22. ncbi request reprint Molecular profiling of micrometastatic cancer cells
    K Pantel
    Department of Molecular Oncology, University Women s Clinic, University Hospital Eppendorf, Hamburg, Germany
    Ann Surg Oncol 8:18S-21S. 2001
    ..These methods not only can identify this critical stage of tumor progression but also may facilitate the development of therapies to prevent manifest metastasis...
  23. ncbi request reprint Molecular determinants of occult metastatic tumor cells in bone marrow
    K Pantel
    Universitats Frauenklinik, Universitätsklinikum Eppendorf, Martinistrasse 52, D 20246 Hamburg, Germany
    Clin Breast Cancer 2:222-8. 2001
    ..This review summarizes the current knowledge of the biological characteristics of micrometastatic cancer cells in bone marrow of breast cancer patients...
  24. ncbi request reprint Clinical utility of determination of HER-2/neu and EGFR fragments in serum of patients with metastatic breast cancer
    I Witzel
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Germany
    Int J Biol Markers 21:131-40. 2006
    ..However, the optimal method of determination in order to obtain clinically relevant information remains a source of controversy...
  25. ncbi request reprint Detection of tumor-specific DNA in blood and bone marrow plasma from patients with prostate cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Int J Cancer 120:1465-71. 2007
    ..These data demonstrate, for the first time, the presence of free tumor-specific DNA in blood and BM of PCa patients and suggest a possible relationship to BM micrometastasis...
  26. ncbi request reprint Circulating tumor cells in breast cancer: correlation to bone marrow micrometastases, heterogeneous response to systemic therapy and low proliferative activity
    Volkmar Muller
    Institute of Tumor Biology, Clinic of Gynecology, Institute of Experimental Pharmacology and Toxicology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 11:3678-85. 2005
    ....
  27. pmc Overexpression of TACE and TIMP3 mRNA in head and neck cancer: association with tumour development and progression
    J W Kornfeld
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Br J Cancer 104:138-45. 2011
    ..TACE-dependent proteolysis is regulated by its inhibitor, tissue inhibitor of metalloproteinases 3 (TIMP3). This study analyses the role of TACE and TIMP3 mRNA expression in squamous cell carcinomas of the head and neck (HNSCCs)...
  28. ncbi request reprint Strong prognostic value of nodal and bone marrow micro-involvement in patients with pancreatic ductal carcinoma receiving no adjuvant chemotherapy
    Emre F Yekebas
    Department of General, Visceral and Thoracic Surgery, University Medical Centre of Hamburg Eppendorf, Martinistrabe 52, 20246 Hamburg, Germany
    World J Gastroenterol 12:6515-21. 2006
    ..To study the prognostic value of adjuvant chemotherapy in patients with pancreatic, ductal adenocarcinoma...
  29. doi request reprint Insulin-like growth factor-1 receptor as a novel prognostic marker and its implication as a cotarget in the treatment of human adenocarcinoma of the esophagus
    Tatyana Kalinina
    Department of General, Visceral and Thoracic Surgery, University Medical Center, Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 127:1931-40. 2010
    ..IGF-1R expression can be used as a novel prognostic marker for adenocarcinomas of the esophagus. Cotreatment with IGF-1R and HER2 antibodies might become a valuable and effective treatment option in esophageal adenocarcinoma...
  30. ncbi request reprint Comparison of genetic alterations detected in circulating microsatellite DNA in blood plasma samples of patients with prostate cancer and benign prostatic hyperplasia
    Imke Müller
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Ann N Y Acad Sci 1075:222-9. 2006
    ..These results indicate that microsatellite analysis using plasma DNA may be an interesting tool for molecular screening of PCa patients...
  31. ncbi request reprint Lymphatic spread and microinvolvement in adenocarcinoma of the esophago-gastric junction
    Paulus G Schurr
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Surg Oncol 94:307-15. 2006
    ..Adenocarcinoma of the esophago-gastric junction (EGJ) potentially spreads to abdominal and mediastinal lymph nodes...
  32. doi request reprint Discovery of a novel unfolded protein response phenotype of cancer stem/progenitor cells from the bone marrow of breast cancer patients
    Kai Bartkowiak
    Institute for Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistr 52, Hamburg, Germany
    J Proteome Res 9:3158-68. 2010
    ..Our results suggest the presence of a previously not recognized stress resistant DTC population that combines stem/progenitor attributes with an UPR phenotype...
  33. doi request reprint Review: Biological relevance of disseminated tumor cells in cancer patients
    Sabine Riethdorf
    Institute of Tumor Biology, Center of Experimental Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 123:1991-2006. 2008
    ..Our review will focus on breast, colon, lung, and prostate cancer as the main tumor entities in Europe and the United States...
  34. doi request reprint Advancing personalized cancer therapy by detection and characterization of circulating carcinoma cells
    Sabine Riethdorf
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Ann N Y Acad Sci 1210:66-77. 2010
    ..This information might support assessing individual prognosis, stratifying patients at risk to systemic therapies, and monitoring therapeutic efficacy...
  35. ncbi request reprint Expression of extracellular matrix metalloproteases inducer on micrometastatic and primary mammary carcinoma cells
    Natalie Reimers
    Institute of Tumor Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 10:3422-8. 2004
    ..We here evaluated whether EMMPRIN expression is related to tumor progression in human breast cancer...
  36. ncbi request reprint Detection and clinical importance of micrometastatic disease
    K Pantel
    K Pantel, Universitatsfrauenklinik, Universitätsklinikum Eppendorf, Hamburg, Germany
    J Natl Cancer Inst 91:1113-24. 1999
    ....
  37. ncbi request reprint Characterization of disseminated tumor cells
    S B Hosch
    Chirurgische Klinik, , Hamburg, Germany
    Semin Surg Oncol 20:265-71. 2001
    ..This review summarizes the current knowledge on the biological characteristics of micrometastatic cancer cells in bone marrow and lymph nodes of cancer patients...
  38. ncbi request reprint Circulating tumour-associated plasma DNA represents an independent and informative predictor of prostate cancer
    Felix K H Chun
    Department of Urology, University Hospital Hamburg Epppendorf, Hamburg, Germany
    BJU Int 98:544-8. 2006
    ..To investigate whether preoperative plasma levels of free DNA can discriminate between men with localized prostate cancer and benign prostatic hyperplasia (BPH)...
  39. doi request reprint Detection and HER2 expression of circulating tumor cells: prospective monitoring in breast cancer patients treated in the neoadjuvant GeparQuattro trial
    Sabine Riethdorf
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 16:2634-45. 2010
    ..This study was aimed at detecting and characterizing circulating tumor cells (CTC) before and after neoadjuvant therapy (NT) in the peripheral blood of patients with breast cancer...
  40. doi request reprint Insights into minimal residual disease in cancer patients: implications for anti-cancer therapies
    Volkmar Muller
    Department of Gynecology, University Breast Center, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Eur J Cancer 46:1189-97. 2010
    ..In this article, we summarize the clinical background and the technical aspects of current methods used for the detection and characterization of DTC in BM and CTC in blood, with a special focus on breast cancer...
  41. pmc Mode of spread in the early phase of lymphatic metastasis in pancreatic ductal adenocarcinoma: prognostic significance of nodal microinvolvement
    Dean Bogoevski
    Department of General, Visceral and Thoracic Surgery, University Medical Centre of Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Ann Surg 240:993-1000; discussion 1000-1. 2004
    ..The aim of this study was to assess the prognostic significance of nodal microinvolvement as well as the mode of spread in the early phase of lymphatic metastasis in patients with node-negative pancreatic ductal adenocarcinoma...
  42. ncbi request reprint MAGE-A gene expression pattern in primary breast cancer
    M Otte
    Molekulare Onkologie, Frauenklinik, , Germany
    Cancer Res 61:6682-7. 2001
    ..Our findings suggests a potential involvement of MAGE-A in tumor progression, with potential implications for active immunotherapy...
  43. ncbi request reprint BM micrometastases and circulating tumor cells in breast cancer patients: where have we been, where are we now and where does the future lie?
    V Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Germany
    Cytotherapy 7:478-82. 2005
    ..The valuable information derived from these trials should help to improve future treatment of breast cancer patients...
  44. ncbi request reprint In vitro differentiation of endothelial cells from AC133-positive progenitor cells
    U M Gehling
    Department of Hematology Oncology, University Hospital Eppendorf, Hamburg, Germany
    Blood 95:3106-12. 2000
    ..Whether these hematopoietic and endothelial progenitors develop from a common precursor, the hemangioblast will be studied at the single-cell level...
  45. ncbi request reprint Comparison of multitarget fluorescence in situ hybridization in urine with other noninvasive tests for detecting bladder cancer
    M G Friedrich
    Department of Urology, University Hospital Hamburg Eppendorf, University of Hamburg, Germany
    BJU Int 92:911-4. 2003
    ..g. loss at 9p21) using a multitarget fluorescence in situ hybridization (FISH) system, as identifying genetic alterations in urine specimens is a promising approach for the noninvasive detection of bladder cancer...
  46. ncbi request reprint Short tandem repeat polymorphism in exon 4 of esophageal cancer-related gene 2 detected in genomic DNA is a prognostic marker for esophageal cancer
    Jussuf T Kaifi
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Am J Surg 194:380-4. 2007
    ..Short tandem repeat (STR) polymorphisms in exon 4 of the esophageal cancer-related gene 2 (ECRG2) are a risk marker for esophageal carcinoma. The aim of the present study was to correlate these STRs with clinical outcome...
  47. ncbi request reprint L1 is associated with micrometastatic spread and poor outcome in colorectal cancer
    Jussuf T Kaifi
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mod Pathol 20:1183-90. 2007
    ..It may have a role in early metastatic spread, as L1 is associated with micrometastases to both the lymph nodes and bone marrow. Thus, L1 should be explored further as a target for adjuvant therapy for micrometastatic disease...
  48. doi request reprint Detection and monitoring of cell-free DNA in blood of patients with colorectal cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Ann N Y Acad Sci 1137:190-6. 2008
    ..02). Quantitative analysis demonstrates that elevated DNA levels can be detected in blood of patients with colorectal cancer and may be a useful tool in combination with other tumor markers for detection of colorectal cancer...
  49. doi request reprint Microsatellite analysis of allelic imbalance in tumour and blood from patients with prostate cancer
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Centre, Hamburg Eppendorf, Germany
    BJU Int 102:253-8. 2008
    ..To investigate whether a high frequency of allelic imbalance (AI) is associated with clinicopathological variables of patients with prostate cancer...
  50. doi request reprint Identification of loss of heterozygosity on circulating free DNA in peripheral blood of prostate cancer patients: potential and technical improvements
    Imke Müller
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Germany
    Clin Chem 54:688-96. 2008
    ..However, plasma DNA may harbor tumor-specific genetic alterations and could therefore be an interesting target for noninvasive examinations of tumor DNA...
  51. doi request reprint Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment
    Jens Kollermann
    Institute of Pathology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    J Clin Oncol 26:4928-33. 2008
    ..To explore whether the presence of occult disseminated tumor cells (DTCs) in the bone marrow before neoadjuvant hormone therapy influences the prognosis of patients with organ confined prostate cancer treated by radical prostatectomy...
  52. doi request reprint Strong impact of micrometastatic tumor cell load in patients with esophageal carcinoma
    Alexandra M Koenig
    Department of General, Visceral and Thoracic Surgery, University Medical Centre of Hamburg Eppendorf, Germany
    Ann Surg Oncol 16:454-62. 2009
    ..To assess the role of immunohistochemically detectable nodal microinvolvement of patients with "curatively" resected esophageal carcinoma...
  53. doi request reprint Cell-free tumor DNA in blood plasma as a marker for circulating tumor cells in prostate cancer
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1032-8. 2009
    ..Circulating cell-free DNA in the blood of cancer patients harbors tumor-specific aberrations. Here, we investigated whether this DNA might also reflect the presence of circulating tumor cells (CTC)...
  54. ncbi request reprint Effects of whole body hyperthermia (41.8 degrees C) on the frequency of tumor cells in the peripheral blood of patients with advanced malignancies
    Susanna Hegewisch-Becker
    Department of Oncology Hematology, University Hospital Hamburg Eppendorf, Hamburg D 20246, Germany
    Clin Cancer Res 9:2079-84. 2003
    ..Here we investigated whether the hyperdynamic state of the circulation as a consequence of WBH may stimulate dissemination of malignant cells...
  55. doi request reprint Molecular analysis of the polymorphisms of thymidylate synthase on cell-free circulating DNA in blood of patients with advanced colorectal carcinoma
    Heidi Schwarzenbach
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 127:881-8. 2010
    ..Our data provide insight into the molecular diversity of the regulation of the TS gene expression. This is the first study that compares multi-variant TS genotypes in different clinical specimens...
  56. doi request reprint Genomic profiling of cell-free DNA in blood and bone marrow of prostate cancer patients
    Heidi Schwarzenbach
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, Hamburg, 20246, Germany
    J Cancer Res Clin Oncol 137:811-9. 2011
    ..MS-MLPA detects genetic and epigenetic aberrations of 37 tumor suppressor genes (TSG) in a single reaction and might, therefore, avoid the cumbersome single gene analyses...
  57. ncbi request reprint Central mesenteric lymph node BER-Ep4+ cells in colorectal cancer: challenge to sentinel node concept?
    Paulus G Schurr
    Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Dig Surg 24:19-27. 2007
    ..The role of sentinel lymph nodes in colorectal cancer remains unclear...
  58. ncbi request reprint Tumor-cell homing to lymph nodes and bone marrow and CXCR4 expression in esophageal cancer
    Jussuf T Kaifi
    Klinik fuer Allgemein, Viszeral und Thoraxchirurgie, Universitaetsklinikum Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    J Natl Cancer Inst 97:1840-7. 2005
    ..We investigated CXCR4 expression in esophageal cancer specimens and its association with survival, lymph node microinvolvement, and bone marrow micrometastasis...
  59. ncbi request reprint Bi-specific immunomagnetic enrichment of micrometastatic tumour cell clusters from bone marrow of cancer patients
    Ute Woelfle
    Institute of Tumour Biology, Center of Experimental Medicine, University Hospital Hamburg Eppendorf, Martinistr 52, 20246 Hamburg, Germany
    J Immunol Methods 300:136-45. 2005
    ..The method described offers an excellent tool for the enrichment of micrometastatic tumour cell clusters; these clusters may represent the initial stage of development from a single disseminated tumour cell towards an overt metastasis...
  60. ncbi request reprint Changes in cytoskeletal protein composition indicative of an epithelial-mesenchymal transition in human micrometastatic and primary breast carcinoma cells
    Birthe Willipinski-Stapelfeldt
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 11:8006-14. 2005
    ..Here, we aimed to profile the protein expression of these cells using unique cell line models and to evaluate the prognostic relevance of candidate gene expression for breast cancer patients...
  61. ncbi request reprint Down-regulated expression of cytokeratin 18 promotes progression of human breast cancer
    Ute Woelfle
    Institute of Tumor Biology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 10:2670-4. 2004
    ..Cytokeratins (CKs) have been recognized for >20 years as structural marker proteins specific for epithelial cells. Recent expression profiling analyses indicate, however, that CK down-regulation may occur in breast cancer...
  62. ncbi request reprint Detection and characterization of circulating microsatellite-DNA in blood of patients with breast cancer
    Heidi Schwarzenbach
    Institut of Tumor Biology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Ann N Y Acad Sci 1022:25-32. 2004
    ..Thus, screening for circulating tumor DNA may provide additional diagnostic information...
  63. ncbi request reprint Prognostic and predictive impact of soluble epidermal growth factor receptor (sEGFR) protein in the serum of patients treated with chemotherapy for metastatic breast cancer
    Volkmar Muller
    Department of Gynecology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Anticancer Res 26:1479-87. 2006
    ..A soluble fragment of the epidermal growth factor receptor (EGFR) extracellular domain (sEGFR) can be detected in the serum of cancer patients, but the role of sEGFR is still unclear...
  64. ncbi request reprint Determination of microvessel density by quantitative real-time PCR in esophageal cancer: correlation with histologic methods, angiogenic growth factor expression, and lymph node metastasis
    Sonja Loges
    Department of Internal Medicine II, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 13:76-80. 2007
    ..We compared MVD determination by immunohistology and quantitative real-time PCR and correlated the results with clinical variables...
  65. pmc BRCA1 loss preexisting in small subpopulations of prostate cancer is associated with advanced disease and metastatic spread to lymph nodes and peripheral blood
    Natalia Bednarz
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 16:3340-8. 2010
    ..The present analysis was aimed to elucidate the biological and clinical roles of BRCA1 losses in metastatic spread and tumor progression in PCa patients...
  66. doi request reprint Genomic profiles associated with early micrometastasis in lung cancer: relevance of 4q deletion
    Michaela Wrage
    Institute of Tumor Biology and Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 15:1566-74. 2009
    ..It is still unclear whether the shedding of DTC from the primary tumor is a random process or a selective release driven by a specific genomic pattern...
  67. ncbi request reprint Microsatellite analysis in serum DNA as a diagnostic tool for distinction of patients with unknown pancreatic masses
    Robin Wachowiak
    University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Diagn Mol Pathol 16:174-8. 2007
    ..These data suggest that LOH analysis may be a substantial help for diagnosing pancreatic masses. An extension of the panel, perhaps in combination with a better selection of markers may further improve this assay...
  68. doi request reprint Cancer micrometastasis and tumour dormancy
    Harriet Wikman
    Institute of Tumour Biology, University Medical Center Hamburg Eppendorf, Germany
    APMIS 116:754-70. 2008
    ..e., cancer patient). In this review, we will summarize the key findings of research on micrometastatic cancer cells and discuss these findings in the context of the concept of tumour dormancy...
  69. pmc Heterogeneous proliferative potential of occult metastatic cells in bone marrow of patients with solid epithelial tumors
    Oender Solakoglu
    Molekulare Onkologie, Klinik und Poliklinik fur Frauenheilkunde und Geburtshilfe, Hamburg, Germany
    Proc Natl Acad Sci U S A 99:2246-51. 2002
    ..006). In conclusion, the majority of cancer patients have viable tumor cells in their bone marrow at primary tumor diagnosis, and the proliferative potential of these cells determines the clinical outcome...
  70. ncbi request reprint Promoter demethylation and histone acetylation mediate gene expression of MAGE-A1, -A2, -A3, and -A12 in human cancer cells
    Frank Wischnewski
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Mol Cancer Res 4:339-49. 2006
    ..In conclusion, our data show for the first time that not only hypermethylation but also histone deacetylation is responsible for the mechanism underlying MAGE gene silencing...
  71. ncbi request reprint Molecular signature associated with bone marrow micrometastasis in human breast cancer
    Ute Woelfle
    Institute of Tumor Biology, University Hospital Hamburg Eppendorf, Germany
    Cancer Res 63:5679-84. 2003
    ..Thus, BM micrometastasis is a selective process with a specific molecular signature of the primary tumor...
  72. ncbi request reprint Comparative evaluation of urokinase-type plasminogen activator receptor expression in primary breast carcinomas and on metastatic tumor cells
    Alice Hemsen
    Institute for Tumor Biology, University Hospital Hamburg Eppendorf, Martinistrasse 52, D 20251 Hamburg, Germany
    Int J Cancer 107:903-9. 2003
    ..Our results indicate that uPAR plays an active role in breast cancer metastasis and may therefore be a promising target for new biologic therapies...
  73. ncbi request reprint Disseminated tumor cells in breast cancer: detection, characterization and clinical relevance
    Ute Wölfle
    University Medical Centre Hamburg Eppendorf, Institute of Tumor Biology, Martinistr 52, D 20246 Hamburg, Germany
    Future Oncol 2:553-61. 2006
    ....
  74. doi request reprint Disseminated tumor cells in bone marrow and circulating tumor cells in blood of breast cancer patients: current state of detection and characterization
    Sabine Riethdorf
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Pathobiology 75:140-8. 2008
    ..Furthermore, molecular characterization of CTCs might contribute to improving targeted and more individualized cancer therapies...
  75. ncbi request reprint Detection of circulating tumor cells in peripheral blood of patients with metastatic breast cancer: a validation study of the CellSearch system
    Sabine Riethdorf
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Cancer Res 13:920-8. 2007
    ..Here, we validated the analytic performance of this system for clinical use in patients with metastatic breast cancer...
  76. ncbi request reprint Quantitative assessment of HER-2/neu protein concentration in breast cancer by enzyme-linked immunosorbent assay
    V Muller
    Department of Obstetrics and Gynecology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Int J Biol Markers 18:13-20. 2003
    ..We tested the feasibility of a quantitative approach for HER-2/neu testing based on the analysis of tumor tissue extracts by an enzyme-linked immunosorbent assay (ELISA)...
  77. ncbi request reprint Lymph node micrometastases in lung cancer
    Katharina E Effenberger
    Institute of Tumor Biology, University Medical Center, Hamburg, Eppendorf, Germany
    Cancer Treat Res 135:167-75. 2007
  78. ncbi request reprint Micrometastasis in solid epithelial tumors: impact on surgical oncology
    Jakob R Izbicki
    Department of Surgery, University Hospital Eppendorf, Hamburg, Germany
    Surgery 131:1-5. 2002
  79. pmc Regulation of estrogen-dependent transcription by the LIM cofactors CLIM and RLIM in breast cancer
    Steven A Johnsen
    Department of Molecular Oncology, Göttingen Center for Molecular Biosciences, University of Gottingen, Justus von Liebig Weg 11, 37077 Gottingen, Germany
    Cancer Res 69:128-36. 2009
    ..Combined, these results indicate that LIM cofactors CLIM and RLIM regulate the biological activity of ERalpha during the development of human breast cancer...
  80. ncbi request reprint Methyl-CpG binding domain proteins and their involvement in the regulation of the MAGE-A1, MAGE-A2, MAGE-A3, and MAGE-A12 gene promoters
    Frank Wischnewski
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Martinstrasse 52, 20246 Hamburg, Germany
    Mol Cancer Res 5:749-59. 2007
    ..In conclusion, these data show, for the first time, the involvement of methyl-CpG binding domain proteins in the regulation of the MAGE-A genes...
  81. ncbi request reprint Two-dimensional differential gel electrophoresis of a cell line derived from a breast cancer micrometastasis revealed a stem/ progenitor cell protein profile
    Kai Bartkowiak
    Institute for Tumor Biology, University Medical Center Hamburg Eppendorf Martinistr 52, 20246 Hamburg, Germany
    J Proteome Res 8:2004-14. 2009
    ..Hence, DTC from breast cancer patients' bone marrow expressed cytokeratin 5, which further supports our hypothesis...
  82. ncbi request reprint High incidence of EMMPRIN expression in human tumors
    Sabine Riethdorf
    Institute of Tumor Biology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Int J Cancer 119:1800-10. 2006
    ..Our results may assist in defining the suitability of EMMPRIN as therapeutic target and predicting negative side effects...
  83. ncbi request reprint Genomic profiling of viable and proliferative micrometastatic cells from early-stage breast cancer patients
    Rainer Gangnus
    Institut fur Humangenetik, Technische Universitat Munchen, Munchen, Germany
    Clin Cancer Res 10:3457-64. 2004
    ..However, it remains still unclear which of these cells evolve into overt metastases. We therefore established a new approach based on the analysis of viable and proliferating cancer cells by single-cell comparative genomic hybridization...
  84. ncbi request reprint Patterns of disease recurrence influenced by hematogenous tumor cell dissemination in patients with cervical carcinoma of the uterus
    Wolfgang Janni
    Department of Gynecology and Obstetrics, I Frauenklinik, Klinikum der Ludwig Maximilians Universtitaet, Muenchen, Germany
    Cancer 97:405-11. 2003
    ..This study evaluates the prevalence and prognostic significance of ITC in patients with primary carcinoma of the cervix uteri...
  85. ncbi request reprint Detection of MAGE-A transcripts in bone marrow is an independent prognostic factor in operable non-small-cell lung cancer
    Wulf Sienel
    Department of Thoracic Surgery, Albert Ludwigs University Freiburg, Freiburg, Germany
    Clin Cancer Res 13:3840-7. 2007
    ..Thus far, the clinical relevance of MAGE-A transcripts as marker for disseminated tumor cells in bone marrow of patients with operable lung cancer without overt metastases is still unclear...
  86. ncbi request reprint Prognostic impact of matrix metalloproteinase-9 in operable non-small cell lung cancer
    Wulf Sienel
    Department of Surgery, Chirurgische Klinik Innenstadt, University of Munich, Munich, Germany
    Int J Cancer 103:647-51. 2003
    ..045). Thus, immunohistochemical evaluation of MMP-9 expression may provide a basis for the preselection of patients to be included in trials investigating specific protease inhibitor therapy after surgical resection of NSCLC...
  87. ncbi request reprint A pooled analysis of bone marrow micrometastasis in breast cancer
    Stephan Braun
    Department of Obstetrics and Gynecology, Innsbruck Medical University, Innsbruck, Austria
    N Engl J Med 353:793-802. 2005
    ..We assessed the prognostic significance of the presence of micrometastasis in the bone marrow at the time of diagnosis of breast cancer by means of a pooled analysis...
  88. ncbi request reprint Heterogeneous expression of MAGE-A genes in occult disseminated tumor cells: a novel multimarker reverse transcription-polymerase chain reaction for diagnosis of micrometastatic disease
    Peter Kufer
    Institute of Immunology, University of Munich, 80336 Munich, Germany
    Cancer Res 62:251-61. 2002
    ..Because MAGE antigens can induce autologous cytolytic T lymphocytes in vivo, the determination of individual MAGE expression patterns in cancer patients may furthermore identify candidate vaccine targets for adjuvant immunotherapy...
  89. ncbi request reprint Epigenetic analysis of body fluids and tumor tissues: application of a comprehensive molecular assessment for early-stage breast cancer patients
    Bret Taback
    Division of Surgical Oncology, Columbia University Medical Center, New York, New York 10032, USA
    Ann N Y Acad Sci 1075:211-21. 2006
    ..This study demonstrates the novel finding of tumor-associated epigenetic markers in BM aspirates/blood and their potential role as targets for molecular detection...
  90. ncbi request reprint Tumor cell dormancy: an NCI workshop report
    Robert L Vessella
    Department of Urology, University of Washington Medical Center and VA Puget Sound Health Care System, Seattle, Washington 98195, USA
    Cancer Biol Ther 6:1496-504. 2007
    ..The workshop concluded with an overall summary of the challenges and research opportunities associated with this field with recommendations for consideration by the NIH...
  91. ncbi request reprint The persistence of isolated tumor cells in bone marrow from patients with breast carcinoma predicts an increased risk for recurrence
    Wolfgang Janni
    I Frauenklinik, Klinikum der Ludwig Maximilians Universtitaet, Muenchen, Germany
    Cancer 103:884-91. 2005
    ..If the persistence of ITCs after adjuvant therapy confers a similar risk for recurrence, then it would be an indication to consider secondary adjuvant therapy...
  92. ncbi request reprint Methylation-specific PCR for DNA-based detection of occult tumor cells in lymph nodes of prostate cancer patients
    Jens Kollermann
    Department of Urology, Universitatsklinikum Benjamin Franklin, Freie Universitat Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Eur Urol 44:533-8. 2003
    ..To assess the feasibility of methylation-specific PCR (MSP) for the detection of promoter hypermethylation of the detoxifying glutathione-S-transferase P1 gene (GSTP1) to detect occult prostate cancer cells in lymph nodes (LNs)...
  93. ncbi request reprint Genome-wide microarray gene expression, array-CGH analysis, and telomerase activity in advanced ovarian endometriosis: a high degree of differentiation rather than malignant potential
    Menelaos Zafrakas
    Heinrich Pette Institute for Experimental Virology and Immunology, University of Hamburg, 20251 Hamburg, Germany
    Int J Mol Med 21:335-44. 2008
    ..In conclusion, these data suggest that advanced ovarian endometriosis represents a highly differentiated tissue with minimal or no malignant potential...
  94. ncbi request reprint Prognostic and predictive impact of the HER-2/ neu extracellular domain (ECD) in the serum of patients treated with chemotherapy for metastatic breast cancer
    Volkmar Muller
    Department of Gynecology, University Hospital Hamburg Eppendorf, Germany
    Breast Cancer Res Treat 86:9-18. 2004
    ..The extracellular domain of the HER-2/neu -receptor (ECD) is shed from the receptor protein and can be detected in serum. However, the clinical implication of HER-2/neu ECD measurement must be further evaluated...
  95. ncbi request reprint Evaluation of bone marrow in breast cancer patients: prediction of clinical outcome and response to therapy
    Stephan Braun
    Department of Ob Gyn, University Hospital, Innsbruck, Austria
    Breast 12:397-404. 2003
    ..Except for promising pilot studies, no data are available to support the immediate use of bone marrow evaluation for treatment monitoring in order to enable the prediction of response to adjuvant therapy...
  96. ncbi request reprint Detection and characterization of putative metastatic precursor cells in cancer patients
    Catherine Alix-Panabieres
    Clin Chem 53:537-9. 2007
  97. ncbi request reprint High-resolution genomic profiling of occult micrometastatic tumor cells
    Jurgen Kraus
    Institut fur Humangenetik, Technische Universitat Munchen, Munich, Germany
    Genes Chromosomes Cancer 36:159-66. 2003
    ..Thus, occult micrometastatic cells are now amenable to detailed analyses of their genome. Markers for prognosis and treatment decisions can now be established...
  98. ncbi request reprint Rare expression of epithelial cell adhesion molecule on residual micrometastatic breast cancer cells after adjuvant chemotherapy
    Holger Thurm
    Institute for Tumor Biology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Clin Cancer Res 9:2598-604. 2003
    ..The subsequent 27 BM aspirates were specifically enriched for Ep-CAM(+) cells using magnetic beads coupled to Mab 3B10, and tumor cells were identified by Fab fragments of Mab A45-B/B3 directly conjugated with alkaline phosphatase...
  99. ncbi request reprint Current status in human breast cancer micrometastasis
    Catherine Alix-Panabieres
    University Medical Center, Lapeyronie Hospital, Montpellier, France
    Curr Opin Oncol 19:558-63. 2007
    ..Current research and clinical developments on hematogeneous micrometastasis in breast cancer patients are summarized...
  100. ncbi request reprint Tumour cells in the tumour draining vein of patients with non-small cell lung cancer: detection rate and clinical significance
    Wulf Sienel
    Department of Surgery, Chirurgische Klinik und Poliklinik Innenstadt, University of Munich, 80336 Munich, Germany
    Eur J Cardiothorac Surg 23:451-6. 2003
    ..This prospective study was performed to examine whether tumour cells are detectable in the tumour draining vein of patients with non-small cell lung cancer. Furthermore, the impact of these cells on the clinical course was analysed...
  101. ncbi request reprint Limitations of the immunocytochemical detection of isolated tumor cells in frozen samples of bone marrow obtained from melanoma patients
    Dirk Schadendorf
    Klinische Kooperationseinheit für Dermatoonkologie, Fakultät für Klinische Medizin Mannheim der Universität Heidelberg, Mannheim, Germany
    Exp Dermatol 12:165-71. 2003
    ..Massive invasion of bone marrow with melanoma cells is a rare event even in far-advanced metastatic stages and no clear correlation between tumor load and bone marrow infiltration could be established...