J Pahnke

Summary

Affiliation: University of Rostock
Country: Germany

Publications

  1. pmc Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease
    Jens Pahnke
    University of Rostock, Department of Neurology, Neurodegeneration Research Laboratory NRL, Gehlsheimer Str 20, 18147 Rostock, Germany
    Curr Alzheimer Res 5:396-405. 2008
  2. pmc In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
    Eric Westman
    Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    BMC Neurosci 10:33. 2009
  3. doi request reprint [The role of blood-brain barrier in the pathogenesis of Alzheimer dementia--implications for immunological therapies for plaque dissolution]
    J Pahnke
    Universitat Rostock, Klinik und Poliklinik fur Neurologie, Neurodegeneration Research Lab, Gehlsheimer Strasse 20, Rostock
    Fortschr Neurol Psychiatr 77:S21-4. 2009
  4. pmc Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?
    Jens Pahnke
    University of Rostock, Department of Neurology, Germany
    Neurosci Biobehav Rev 33:1099-108. 2009
  5. ncbi request reprint Lesion pathology predicts response to plasma exchange in secondary progressive MS
    U K Zettl
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Neurology 67:1515-6. 2006
  6. ncbi request reprint Collection of soluble variants of membrane proteins for transcriptomics and proteomics
    Steffen Möller
    University of Rostock, Institute of Immunology, Schillingallee 70, 18057 Rostock, Germany
    In Silico Biol 5:295-311. 2005
  7. ncbi request reprint Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression
    Jeannette Henning
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
    Eur J Neurosci 25:239-50. 2007
  8. ncbi request reprint 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    J Autoimmun 27:251-65. 2006
  9. ncbi request reprint An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy
    Ulf Strauss
    Department of Neurology, University Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Eur J Neurosci 19:3048-58. 2004
  10. ncbi request reprint Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, Rostock D 18055, Germany
    J Neuroimmunol 151:158-70. 2004

Collaborators

Detail Information

Publications24

  1. pmc Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's disease
    Jens Pahnke
    University of Rostock, Department of Neurology, Neurodegeneration Research Laboratory NRL, Gehlsheimer Str 20, 18147 Rostock, Germany
    Curr Alzheimer Res 5:396-405. 2008
    ..Here, we summarize findings from cell culture experiments, animal models and studies of patients with Alzheimer's disease. Furthermore, we discuss pharmacological interactions and computational methods for risk assessment...
  2. pmc In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatment
    Eric Westman
    Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
    BMC Neurosci 10:33. 2009
    ..The aim of this study was to investigate if multivariate data analysis could detect changes in the pattern of the metabolic profile after donepezil treatment...
  3. doi request reprint [The role of blood-brain barrier in the pathogenesis of Alzheimer dementia--implications for immunological therapies for plaque dissolution]
    J Pahnke
    Universitat Rostock, Klinik und Poliklinik fur Neurologie, Neurodegeneration Research Lab, Gehlsheimer Strasse 20, Rostock
    Fortschr Neurol Psychiatr 77:S21-4. 2009
    ..Changes of specific transport functions evoke important alterations for the known pathogenesis and future therapies of AD, especially approaches that target plaque dissolution and plaque reduction...
  4. pmc Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?
    Jens Pahnke
    University of Rostock, Department of Neurology, Germany
    Neurosci Biobehav Rev 33:1099-108. 2009
    ..We further discuss a possible role of oligomers in limiting the efficacy of immunotherapy...
  5. ncbi request reprint Lesion pathology predicts response to plasma exchange in secondary progressive MS
    U K Zettl
    Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D 18147 Rostock, Germany
    Neurology 67:1515-6. 2006
  6. ncbi request reprint Collection of soluble variants of membrane proteins for transcriptomics and proteomics
    Steffen Möller
    University of Rostock, Institute of Immunology, Schillingallee 70, 18057 Rostock, Germany
    In Silico Biol 5:295-311. 2005
    ..The findings then are confirmed by a comparison with identified proteins of a recent global proteomics study of human blood plasma. Finally, a tool to determine novel soluble variants by proteomics is provided...
  7. ncbi request reprint Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expression
    Jeannette Henning
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
    Eur J Neurosci 25:239-50. 2007
    ..Furthermore, a downregulation of calcium/calmodulin-dependent protein kinase type IIA and Homer1 was observed. This downregulation could result in a reduced sensitivity towards glutamate in basal ganglia downstream of STN...
  8. ncbi request reprint 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAE
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
    J Autoimmun 27:251-65. 2006
    ..Monitoring of expression of the newly identified candidate genes and patterns of lymphocyte subpopulations might predict the responsiveness of multiple sclerosis patients to statin treatment...
  9. ncbi request reprint An impaired neocortical Ih is associated with enhanced excitability and absence epilepsy
    Ulf Strauss
    Department of Neurology, University Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
    Eur J Neurosci 19:3048-58. 2004
    ..We suggest that the deficit in Ih-mediated functions may contribute to the development and onset of spontaneously occurring hyperexcitability in a rat model of absence seizures...
  10. ncbi request reprint Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active process
    Eilhard Mix
    Department of Neurology, University of Rostock, Gehlsheimer Str 20, Rostock D 18055, Germany
    J Neuroimmunol 151:158-70. 2004
    ..Thus, monitoring of the expression of these new candidate genes may serve as a tool for the disease progression and the pharmaceutical treatment...
  11. ncbi request reprint Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective study
    Arndt Rolfs
    Department of Neurology, University of Rostock, Rostock, Germany
    Lancet 366:1794-6. 2005
    ..To determine the importance of Fabry disease in young people with stroke, we measured the frequency of unrecognised Fabry disease in a cohort of acute stroke patients...
  12. ncbi request reprint The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's disease
    Frank P Marx
    Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
    FASEB J 21:1759-67. 2007
    ..Our data suggest a direct interaction of synphilin-1 with the regulatory complex of the proteasome modulating proteasomal function...
  13. ncbi request reprint Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesis
    Matthias T Wyss
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
    J Nucl Med 48:608-14. 2007
    ....
  14. ncbi request reprint Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19)
    Nicolas Spaeth
    PET Center, Division of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland
    Nucl Med Biol 33:661-6. 2006
    ..In this study, we assessed the efficacy of a novel radioimmunotherapeutic approach targeting the extra domain B (EDB) of fibronectin, a marker of angiogenesis, in glioma-bearing rats...
  15. pmc Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitis
    Susanne Vogler
    Department of Immunology, University of Rostock, Germany
    Am J Pathol 168:1570-5. 2006
    ..Concomitantly, CD4 and CD8 cells of the UCP2-deficient mice showed increased production of reactive oxygen species. These results suggest a protective function of UCP2 in chronic inflammatory diseases such as multiple sclerosis...
  16. ncbi request reprint Gene-expression profiling of experimental autoimmune encephalomyelitis
    Eilhard Mix
    Neurochem Res 27:1157-63. 2002
    ..Here we review our preliminary work on the use of gene expression mapping to identify new putative genetic pathways contributing to the pathogenesis of EAE...
  17. ncbi request reprint Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiation
    Tobias Böttcher
    Department of Neurology, University of Rostock, Rostock, Germany
    J Neurosci Res 73:42-53. 2003
    ..g., of Huntington's disease...
  18. ncbi request reprint McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvement
    Hans H Jung
    Department of Neurology and the Institutes of Neuropathology, Nuclear Medicine, and Neuroradiology, University Hospital Zurich, Switzerland
    Transfusion 43:928-38. 2003
    ..All carriers of the McLeod blood group phenotype examined so far had at least subclinical signs of systemic involvement...
  19. ncbi request reprint Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cells
    Jens Pahnke
    Department of Pathology, University Hospital Zurich, Switzerland
    Exp Cell Res 297:484-94. 2004
    ..Many proteins are anchored by farnesyl-derivates at the cell membrane. The identification of these GDNF-regulated genes may open new opportunities for directly influencing differentiation and developmental processes of neurons...
  20. ncbi request reprint Wnt-5a expression in the rat neuronal progenitor cell line ST14A
    Sabine Peters
    Department of Neurology, University of Rostock, PO Box 100888, 18055 Rostock, Germany
    Exp Brain Res 158:189-95. 2004
    ..However, they raise the possibility that neuronal progenitor cells that might be used to treat neurodegenerative diseases express Wnt-5a, thus promoting their potential for dopaminergic differentiation...
  21. pmc The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's disease
    Silke Vogelgesang
    Department of Neuropathology, University of Greifswald, Germany
    Curr Alzheimer Res 1:121-5. 2004
    ..The impairment of Abeta clearance could lead to the accumulation and earlier deposition of Abeta, both in the walls of blood vessels and in the brain parenchyma, thus elevating the risk of CAA and AD...
  22. ncbi request reprint 2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM)
    Raimund Hoffrogge
    Neurobiological Laboratory, Department of Neurology, Medical Faculty, University of Rostock, Germany
    Proteomics 6:1833-47. 2006
    ....
  23. ncbi request reprint Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the rat
    Nicolas Spaeth
    PET Center, Division of Nuclear Medicine, University Hospital, Ramistrasse 100, 8091, Zurich, Switzerland
    Eur J Nucl Med Mol Imaging 33:673-82. 2006
    ....
  24. ncbi request reprint Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humans
    Silke Vogelgesang
    Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
    Pharmacogenetics 12:535-41. 2002
    ..Our results provide the first evidence in human brain tissue that the accumulation of Abeta may be influenced by the expression of P-gp in blood vessels, and suggest that P-gp may influence the elimination of Abeta from brain...