Affiliation: University of Rostock
- Clinico-pathologic function of cerebral ABC transporters - implications for the pathogenesis of Alzheimer's diseaseJens Pahnke
University of Rostock, Department of Neurology, Neurodegeneration Research Laboratory NRL, Gehlsheimer Str 20, 18147 Rostock, Germany
Curr Alzheimer Res 5:396-405. 2008..Here, we summarize findings from cell culture experiments, animal models and studies of patients with Alzheimer's disease. Furthermore, we discuss pharmacological interactions and computational methods for risk assessment...
- In vivo 1H-magnetic resonance spectroscopy can detect metabolic changes in APP/PS1 mice after donepezil treatmentEric Westman
Department of Neurobiology, Health Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden
BMC Neurosci 10:33. 2009..The aim of this study was to investigate if multivariate data analysis could detect changes in the pattern of the metabolic profile after donepezil treatment...
- [The role of blood-brain barrier in the pathogenesis of Alzheimer dementia--implications for immunological therapies for plaque dissolution]J Pahnke
Universitat Rostock, Klinik und Poliklinik fur Neurologie, Neurodegeneration Research Lab, Gehlsheimer Strasse 20, Rostock
Fortschr Neurol Psychiatr 77:S21-4. 2009..Changes of specific transport functions evoke important alterations for the known pathogenesis and future therapies of AD, especially approaches that target plaque dissolution and plaque reduction...
- Alzheimer's disease and blood-brain barrier function-Why have anti-beta-amyloid therapies failed to prevent dementia progression?Jens Pahnke
University of Rostock, Department of Neurology, Germany
Neurosci Biobehav Rev 33:1099-108. 2009..We further discuss a possible role of oligomers in limiting the efficacy of immunotherapy...
- Lesion pathology predicts response to plasma exchange in secondary progressive MSU K Zettl
Department of Neurology, University of Rostock, Gehlsheimer Strasse 20, D-18147 Rostock, Germany
Neurology 67:1515-6. 2006
- Collection of soluble variants of membrane proteins for transcriptomics and proteomicsSteffen Möller
University of Rostock, Institute of Immunology, Schillingallee 70, 18057 Rostock, Germany
In Silico Biol 5:295-311. 2005..The findings then are confirmed by a comparison with identified proteins of a recent global proteomics study of human blood plasma. Finally, a tool to determine novel soluble variants by proteomics is provided...
- Deep brain stimulation in a rat model modulates TH, CaMKIIa and Homer1 gene expressionJeannette Henning
Department of Neurology, University of Rostock, Gehlsheimer Str 20, 18147 Rostock, Germany
Eur J Neurosci 25:239-50. 2007..Furthermore, a downregulation of calcium/calmodulin-dependent protein kinase type IIA and Homer1 was observed. This downregulation could result in a reduced sensitivity towards glutamate in basal ganglia downstream of STN...
- 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor Atorvastatin mediated effects depend on the activation status of target cells in PLP-EAEEilhard Mix
Department of Neurology, University of Rostock, Gehlsheimer Str 20, D 18147 Rostock, Germany
J Autoimmun 27:251-65. 2006..Monitoring of expression of the newly identified candidate genes and patterns of lymphocyte subpopulations might predict the responsiveness of multiple sclerosis patients to statin treatment...
- An impaired neocortical Ih is associated with enhanced excitability and absence epilepsyUlf Strauss
Department of Neurology, University Rostock, Gehlsheimer Strasse 20, 18147 Rostock, Germany
Eur J Neurosci 19:3048-58. 2004..We suggest that the deficit in Ih-mediated functions may contribute to the development and onset of spontaneously occurring hyperexcitability in a rat model of absence seizures...
- Gene-expression profiling of the early stages of MOG-induced EAE proves EAE-resistance as an active processEilhard Mix
Department of Neurology, University of Rostock, Gehlsheimer Str 20, Rostock D 18055, Germany
J Neuroimmunol 151:158-70. 2004..Thus, monitoring of the expression of these new candidate genes may serve as a tool for the disease progression and the pharmaceutical treatment...
- Prevalence of Fabry disease in patients with cryptogenic stroke: a prospective studyArndt Rolfs
Department of Neurology, University of Rostock, Rostock, Germany
Lancet 366:1794-6. 2005..To determine the importance of Fabry disease in young people with stroke, we measured the frequency of unrecognised Fabry disease in a cohort of acute stroke patients...
- The proteasomal subunit S6 ATPase is a novel synphilin-1 interacting protein--implications for Parkinson's diseaseFrank P Marx
Center of Neurology and Hertie Institute for Clinical Brain Research, University of Tubingen, Tubingen, Germany
FASEB J 21:1759-67. 2007..Our data suggest a direct interaction of synphilin-1 with the regulatory complex of the proteasome modulating proteasomal function...
- Uptake of 18F-Fluorocholine, 18F-FET, and 18F-FDG in C6 gliomas and correlation with 131I-SIP(L19), a marker of angiogenesisMatthias T Wyss
PET Center, Division of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland
J Nucl Med 48:608-14. 2007....
- Radioimmunotherapy targeting the extra domain B of fibronectin in C6 rat gliomas: a preliminary study about the therapeutic efficacy of iodine-131-labeled SIP(L19)Nicolas Spaeth
PET Center, Division of Nuclear Medicine, University Hospital Zurich, 8091 Zurich, Switzerland
Nucl Med Biol 33:661-6. 2006..However, larger trials with preferentially higher doses are needed to confirm this finding and, potentially, to further increase the efficacy of this treatment...
- Uncoupling protein 2 has protective function during experimental autoimmune encephalomyelitisSusanne Vogler
Department of Immunology, University of Rostock, Germany
Am J Pathol 168:1570-5. 2006..Concomitantly, CD4 and CD8 cells of the UCP2-deficient mice showed increased production of reactive oxygen species. These results suggest a protective function of UCP2 in chronic inflammatory diseases such as multiple sclerosis...
- Gene-expression profiling of experimental autoimmune encephalomyelitisEilhard Mix
Neurochem Res 27:1157-63. 2002..Here we review our preliminary work on the use of gene expression mapping to identify new putative genetic pathways contributing to the pathogenesis of EAE...
- Gene expression profiling of ciliary neurotrophic factor-overexpressing rat striatal progenitor cells (ST14A) indicates improved stress response during the early stage of differentiationTobias Böttcher
Department of Neurology, University of Rostock, Rostock, Germany
J Neurosci Res 73:42-53. 2003..g., of Huntington's disease...
- McLeod phenotype associated with a XK missense mutation without hematologic, neuromuscular, or cerebral involvementHans H Jung
Department of Neurology and the Institutes of Neuropathology, Nuclear Medicine, and Neuroradiology, University Hospital Zurich, Switzerland
Transfusion 43:928-38. 2003..All carriers of the McLeod blood group phenotype examined so far had at least subclinical signs of systemic involvement...
- Overexpression of glial cell line-derived neurotrophic factor induces genes regulating migration and differentiation of neuronal progenitor cellsJens Pahnke
Department of Pathology, University Hospital Zurich, Switzerland
Exp Cell Res 297:484-94. 2004..Many proteins are anchored by farnesyl-derivates at the cell membrane. The identification of these GDNF-regulated genes may open new opportunities for directly influencing differentiation and developmental processes of neurons...
- Wnt-5a expression in the rat neuronal progenitor cell line ST14ASabine Peters
Department of Neurology, University of Rostock, PO Box 100888, 18055 Rostock, Germany
Exp Brain Res 158:189-95. 2004..However, they raise the possibility that neuronal progenitor cells that might be used to treat neurodegenerative diseases express Wnt-5a, thus promoting their potential for dopaminergic differentiation...
- The role of P-glycoprotein in cerebral amyloid angiopathy; implications for the early pathogenesis of Alzheimer's diseaseSilke Vogelgesang
Department of Neuropathology, University of Greifswald, Germany
Curr Alzheimer Res 1:121-5. 2004..The impairment of Abeta clearance could lead to the accumulation and earlier deposition of Abeta, both in the walls of blood vessels and in the brain parenchyma, thus elevating the risk of CAA and AD...
- 2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM)Raimund Hoffrogge
Neurobiological Laboratory, Department of Neurology, Medical Faculty, University of Rostock, Germany
Proteomics 6:1833-47. 2006....
- Uptake of 18F-fluorocholine, 18F-fluoro-ethyl-L: -tyrosine and 18F-fluoro-2-deoxyglucose in F98 gliomas in the ratNicolas Spaeth
PET Center, Division of Nuclear Medicine, University Hospital, , 8091, , Switzerland
Eur J Nucl Med Mol Imaging 33:673-82. 2006..The degree of BBB disruption seems to affect the accumulation of FET and FCH, but not FDG. Mean tumour uptake for all tracers was significantly higher than the accumulation in radiation injuries...
- Deposition of Alzheimer's beta-amyloid is inversely correlated with P-glycoprotein expression in the brains of elderly non-demented humansSilke Vogelgesang
Departments of Neuropathology and Pharmacology, Peter Holtz Research Center of Pharmacology and Experimental Therapeutics, University of Greifswald, Greifswald, Germany
Pharmacogenetics 12:535-41. 2002..Our results provide the first evidence in human brain tissue that the accumulation of Abeta may be influenced by the expression of P-gp in blood vessels, and suggest that P-gp may influence the elimination of Abeta from brain...