H L Pahl

Summary

Affiliation: University of Freiburg
Country: Germany

Publications

  1. ncbi request reprint The ER-overload response: activation of NF-kappa B
    H L Pahl
    Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany
    Trends Biochem Sci 22:63-7. 1997
  2. ncbi request reprint Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F
    C Steimle
    Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Clinical Research, Freiburg, Germany
    Ann Hematol 86:239-44. 2007
  3. ncbi request reprint [Basic research within clinical departments: opportunities and limits]
    H L Pahl
    Sektion Experimentelle Anaesthesie, Universitatsklinikum Freiburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:137-9. 2006
  4. ncbi request reprint Towards a molecular understanding of polycythemia rubra vera
    H L Pahl
    Division of Experimental Anaesthesiology, University Hospital Freiburg, Center for Tumor Biology, Germany
    Eur J Biochem 267:3395-401. 2000
  5. ncbi request reprint Reduced activation of immunomodulatory transcription factors during positive end-expiratory pressure adjustment based on volume-dependent compliance in isolated perfused rabbit lungs
    E A Kirchner
    Department of Anaesthesiology and Critical Care Medicine, University Hospital, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Br J Anaesth 94:530-5. 2005
  6. ncbi request reprint STAT3 is constitutively active in some patients with Polycythemia rubra vera
    S Roder
    Department of Experimental Anesthesiology, University Hospital Freiburg, Freiburg, Germany
    Exp Hematol 29:694-702. 2001
  7. ncbi request reprint Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera
    S Temerinac
    Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Tumor Biology, Freiburg, Germany
    Blood 95:2569-76. 2000
  8. ncbi request reprint Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    A J García-Piñeres
    Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    J Biol Chem 276:39713-20. 2001
  9. ncbi request reprint Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat
    A Hoetzel
    Department of Anesthesiology and Critical Care Medicine, University of Freiburg, Germany
    Hepatology 33:925-37. 2001
  10. ncbi request reprint Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha
    V Imbert
    Inserm Unité 364 Faculté de Médecine Pasteur, Nice, France
    Cell 86:787-98. 1996

Collaborators

  • Gerold Meinhardt
  • G Mols
  • J Guttmann
  • E A Kirchner
  • Ulrich Lehmann
  • I Merfort
  • R A Rupec
  • C Steimle
  • S Temerinac
  • S Roder
  • A J García-Piñeres
  • A Hoetzel
  • E Strunck
  • H Kreipe
  • Ph S Goerttler
  • H Heimpel
  • V Imbert
  • T J Schmidt
  • G Mora
  • T Loop
  • D A Vagts
  • B H Pannen
  • V Castro
  • K K Geiger
  • M Humar
  • M Bauer
  • S Klippel
  • W Lange
  • M Azemar
  • M Lubbert
  • H E Schaefer
  • D Farahifar
  • B Rossi
  • P Auberger
  • J F Peyron
  • A Livolsi
  • E B Traenckner
  • C Mueller-Dieckmann
  • P A Baeuerle

Detail Information

Publications10

  1. ncbi request reprint The ER-overload response: activation of NF-kappa B
    H L Pahl
    Institute for Experimental Cancer Research, Tumor Biology Center, Freiburg, Germany
    Trends Biochem Sci 22:63-7. 1997
    ..This novel intracellular signal transduction pathway might be important in antiviral defense and play a role in various diseases as well as in B-cell development...
  2. ncbi request reprint Biomarker analysis in polycythemia vera under interferon-alpha treatment: clonality, EEC, PRV-1, and JAK2 V617F
    C Steimle
    Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Clinical Research, Freiburg, Germany
    Ann Hematol 86:239-44. 2007
    ..Long-term follow-up of large patient cohorts is required to determine whether rIFNalpha treatment can cause complete molecular remissions in PV...
  3. ncbi request reprint [Basic research within clinical departments: opportunities and limits]
    H L Pahl
    Sektion Experimentelle Anaesthesie, Universitatsklinikum Freiburg
    Anasthesiol Intensivmed Notfallmed Schmerzther 41:137-9. 2006
  4. ncbi request reprint Towards a molecular understanding of polycythemia rubra vera
    H L Pahl
    Division of Experimental Anaesthesiology, University Hospital Freiburg, Center for Tumor Biology, Germany
    Eur J Biochem 267:3395-401. 2000
    ..However, the molecular mechanisms leading to the development of these diseases are poorly understood. This review will summarize and evaluate recent advances in our understanding of one particular MPD, PV...
  5. ncbi request reprint Reduced activation of immunomodulatory transcription factors during positive end-expiratory pressure adjustment based on volume-dependent compliance in isolated perfused rabbit lungs
    E A Kirchner
    Department of Anaesthesiology and Critical Care Medicine, University Hospital, Hugstetterstrasse 55, 79106 Freiburg, Germany
    Br J Anaesth 94:530-5. 2005
    ....
  6. ncbi request reprint STAT3 is constitutively active in some patients with Polycythemia rubra vera
    S Roder
    Department of Experimental Anesthesiology, University Hospital Freiburg, Freiburg, Germany
    Exp Hematol 29:694-702. 2001
    ..A constitutive activation of STAT factors could explain the increased proliferation of P. vera cells even in the absence of growth factor stimulation...
  7. ncbi request reprint Cloning of PRV-1, a novel member of the uPAR receptor superfamily, which is overexpressed in polycythemia rubra vera
    S Temerinac
    Department of Experimental Anaesthesiology, University Hospital Freiburg, Center for Tumor Biology, Freiburg, Germany
    Blood 95:2569-76. 2000
    ..In addition, PRV-1 contains 2 cysteine-rich domains homologous to those found in the uPAR/Ly6/CD59/snake toxin-receptor superfamily. We therefore propose that PRV-1 represents a novel hematopoietic receptor. (Blood. 2000;95:2569-2576)..
  8. ncbi request reprint Cysteine 38 in p65/NF-kappaB plays a crucial role in DNA binding inhibition by sesquiterpene lactones
    A J García-Piñeres
    Institute of Pharmaceutical Biology, Albert Ludwigs Universitat Freiburg, Stefan Meier Strasse 19, 79104 Freiburg, Germany
    J Biol Chem 276:39713-20. 2001
    ..Although a slight inhibition of IkappaB degradation was detected for all SLs, the amount of remaining IkappaB was too low to explain the observed NF-kappaB inhibition...
  9. ncbi request reprint Effect of nitric oxide on shock-induced hepatic heme oxygenase-1 expression in the rat
    A Hoetzel
    Department of Anesthesiology and Critical Care Medicine, University of Freiburg, Germany
    Hepatology 33:925-37. 2001
    ....
  10. ncbi request reprint Tyrosine phosphorylation of I kappa B-alpha activates NF-kappa B without proteolytic degradation of I kappa B-alpha
    V Imbert
    Inserm Unité 364 Faculté de Médecine Pasteur, Nice, France
    Cell 86:787-98. 1996
    ..Tyrosine phosphorylation of I kappa B-alpha represents a proteolysis-independent mechanism of NF-kappa B activation that directly couples NF-kappa B to cellular tyrosine kinase...