Research Topics
Species | A PahlSummaryAffiliation: University of Erlangen-Nuremberg Country: Germany Publications
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Detail Information
Publications
Smoke induced changes in epithelial cell gene expression: development of an in vitro model for COPDRuzica Puljic
Department of Experimental and Clinical Pharmacology and Toxicology, , Germany
ALTEX 21:3-7. 2004..This approach may result in the replacement of animal experimentation in screening of new therapeutics for COPD...
Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophiliaLigia Chialda
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
Respir Res 6:36. 2005..Therefore, interference of signaling pathways precipitated by ICOS may present new therapeutic options for Th2 dominated diseases such as asthma. However, these signaling pathways are poorly characterized in vitro and in vivo...- Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factorsAndreas Nitsche
Charité CCM, CC14 Haematology Oncology, Chariteplatz 1, 10117 Berlin, Germany
BMC Immunol 8:18. 2007..We compared levels of secreted proteins and cytokine mRNA induced in cord blood leukocytes (CBL) and adult blood leukocytes (ABL) by various stimuli... - Controlled adjustment of PCR amplificationAndreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, University of Erlangen-Nuremberg, D-91054 Erlangen, Germany
Anal Biochem 369:262-4. 2007 
Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapyAndreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
Br J Pharmacol 135:1915-26. 2002..Characterizing highly potent inhibitors of IL-13 synthesis can be exploited to identify new drugs to treat immunological diseases such as asthma...- Gene expression profiling using RNA extracted from whole blood: technologies and clinical applicationsAndreas Pahl
University of Erlangen Nurnberg, Department of Experimental and Clinical Pharmacology and Toxicology, Fahrstr 17, D 91054 Erlangen, Germany
Expert Rev Mol Diagn 5:43-52. 2005..After providing a general overview of technologies for gene expression profiling and respective caveats, this review will focus on clinical applications of blood sample profiling... 
Preclinical modelling using nasal epithelial cells for the evaluation of herbal extracts for the treatment of upper airway diseasesAndreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
Planta Med 74:693-6. 2008....- Synergistic effects of the anti-cholinergic R,R-glycopyrrolate with anti-inflammatory drugsAndreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
Biochem Pharmacol 72:1690-6. 2006..In conclusion, R,R-glycopyrrolate acts synergistically with the PDE4 inhibitor rolipram and the steroid budesonide in inhibiting inflammatory mediators... - Stabilization of gene expression profiles in blood after phlebotomyAndreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, Emil-Fischer-Center, University of Erlangen-Nuremberg, Fahrstrasse 17, D-91054 Erlangen, Germany
Clin Chem 48:2251-3. 2002 - Pharmacogenomics of asthmaAndreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
Curr Pharm Des 12:3195-206. 2006..The utility of the mouse as an experimental system for pharmacogenomic discovery will also be discussed in the context of asthma therapy... - Asthma therapy in the new millenniumA Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen, Germany
Inflamm Res 51:273-82. 2002..Today's intensive search for new treatments should ensure a greater diversity of therapeutic possibilities for the management of asthma in the next millennium... - Hypoxia induced chemokine expression in nasal epithelial cells: development of an in vitro model for chronic rhinosinusitisAndreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuernberg, Erlangen, Germany
ALTEX 23:59-63. 2006..This approach may result in replacing and refining animal experimentation in the screening of new therapeutics for CRS... - Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugsB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, Erlangen, D 91054, Germany
Biochem Biophys Res Commun 278:790-6. 2000..PGE(2), a cAMP-elevating final product of the COX-2 pathway, may autoregulate COX-2 expression in human monocytes via a positive feedback mechanism... - Nitric oxide inhibits inducible nitric oxide synthase mRNA expression in RAW 264.7 macrophagesB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, Erlangen, D 91054, Germany
Biochem Biophys Res Commun 271:353-7. 2000..In conclusion, NO may control the extent of iNOS mRNA expression by a negative autoregulatory feedback... - Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophagesB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Biochem Biophys Res Commun 272:744-8. 2000..In conclusion, upregulation of COX-2 expression via an autocrine feed-forward loop may in part contribute to the well-known capacity of PGE(2)/cAMP to modulate inflammatory processes... - R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanismR Ramer
Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, Erlangen, D-91054, Germany
Biochem Biophys Res Commun 286:1144-52. 2001..In conclusion, induction of COX-2 expression may represent a novel mechanism by which cannabinoids mediate PG-dependent effects within the central nervous system... - Constitutive expression and localization of COX-1 and COX-2 in rabbit iris and ciliary bodyJ Damm
Institute for Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Erlangen, Germany
Exp Eye Res 72:611-21. 2001..This could account for differences in the regulation of intraocular pressure and/or blood-aqueous barrier between human and rabbit eyes... - Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injuryKatrin Schuh
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
Biochem Pharmacol 77:1827-34. 2009..These data suggest that ERK signaling plays an important role in acute lung injury and pharmacologic inhibition of ERK provides a promising new therapeutic strategy for lung inflammatory diseases and in particular COPD... - Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787Andreas Pahl
Department of Experimental and Clinical Pharmacology and Toxicology, , Erlangen, Germany
J Pharmacol Exp Ther 301:738-46. 2002..In conclusion, we characterized a novel Th2 selective immunosuppressive drug with possible anti-asthmatic/anti-inflammatory effects. Its mode of action is distinct from that of CsA... - Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesiaH Guhring
Institut für Experimentelle Pharmakologie and Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
Inflamm Res 50:83-8. 2001..To assess the involvement of spinal inducible nitric oxide synthase (iNOS) in inflammation and nociception... - Are there any realistic chances to develop new drugs for asthma?Annette Amon
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Erlangen, Germany
Drug News Perspect 19:189-200. 2006..With these imperatives in mind, we can hope to better manage this multifactor disease in the near future... - Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyesC Maihofner
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
Invest Ophthalmol Vis Sci 42:2616-24. 2001.... - Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient miceH Guhring
Department of Experimental and Clinical Pharmacology and Toxicology, D 91054 Erlangen, Germany
J Neurosci 20:6714-20. 2000..These results indicate that NO derived from spinal iNOS acts as a fast inductor of spinal thermal hyperalgesia... - Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSFRuzica Puljic
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
Eur J Pharmacol 557:230-5. 2007..These data suggest that neutralization of GM-CSF may represent a novel treatment modality for lung inflammation and in particular for COPD... - 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanismBurkhard Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Biochem Biophys Res Commun 302:415-20. 2003..Moreover, it is concluded that both inhibition of proinflammatory gene expression and restoration of LPS-induced decrease of PPAR-gamma expression may contribute to the biological action of 15d-PGJ(2)... - Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant allelesChristopher Schmitt
Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, University of Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
Clin Chem 48:1661-7. 2002..Genetic variations in these receptors may lead to an altered host immune response to pathogens... - Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometryUlrike Werner
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, D 91051 Erlangen, Germany
Biomed Chromatogr 16:56-60. 2002..8+/-2.7h. The area under the curve (AUC(infinity)) for the PM was 12561 microg h/L. However, we found no noticeable increase in half life in the PM (11.5 h) after a single dose of celecoxib... - Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophagesB Hinz
Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
Pharm Res 18:151-6. 2001..7 macrophages, the present study investigates the influence of optically pure enantiomers of the nonsteroidal anti-inflammatory drug flurbiprofen on lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression... - Is asthma research in dead end?Annette Amon
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Fahrstr 17, 91054 Erlangen, Germany
Exp Toxicol Pathol 57:45-7. 2006..The present drug screening strategy should be reconsidered and probably be replaced by new and more serendipity-based research... - CYP3A5 genotype is associated with elevated blood pressureMartin F Fromm
Institute of Clinical and Experimental Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
Pharmacogenet Genomics 15:737-41. 2005..We interpret the lower serum aldosterone concentration in the genotype group with the elevated systolic blood pressure as a counter-regulatory mechanism to attenuate the increased blood pressure associated with the CYP3A5*3/*3 genotype... - Can corticosteroids be beaten in future asthma therapy?A Amon
Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuernberg, Erlangen, Germany
Pharmazie 61:122-4. 2006..The so-called soft-steroids such as loteprednol and etiprednol belong to the future promising therapeutically effective and safe treatments of allergic disorders... - Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptorS Ahmadi
, , Erlangen, Germany
Mol Pharmacol 59:612-8. 2001.... - Protection against progressive leishmaniasis by IFN-betaJochen Mattner
Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
J Immunol 172:7574-82. 2004..These results identify IFN-beta as a novel cytokine with a strong, dose-dependent protective effect against progressive cutaneous leishmaniasis that results from IL-12- and STAT4-dependent as well as -independent events... - Cytochrome p450 polymorphisms in geriatric patients: impact on adverse drug reactions--a pilot studyTobias Egger
Department of Experimental and Clinical Pharmacology and Toxicology, University Erlangen Nuremberg, Erlangen, Germany
Drugs Aging 22:265-72. 2005..The aim of this survey was to determine the relationship between genetical polymorphisms in these CYP enzymes and adverse drug reactions (ADRs) in geriatric patients... - Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurinC Rascher
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
Biochem J 334:659-67. 1998..These observations indicate that resistance of L. major to CsA in vitro is mediated by the lack of complex formation with calcineurin despite CsA binding by parasitic Cyp... - Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtypeHeiko Reinold
Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
J Clin Invest 115:673-9. 2005..Our results thus demonstrate that inflammatory hyperalgesia can be treated by targeting of a single PG receptor subtype and provide a rational basis for new analgesic strategies going beyond COX inhibition... - Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th2-like cellsChristian Veldman
Department of Dermatology, University of Erlangen Nurnberg, Erlangen, Germany
J Immunol 176:3215-22. 2006..In conclusion, Foxp3 expression is inherent to Tr1 function, and modulation of Foxp3 expression in autoaggressive Th2 cells may provide a novel therapeutic approach aimed at restoring tolerance against Dsg3 in PV... - MDR1 genotype-dependent regulation of the aldosterone system in humansOliver Zolk
Institute of Clinical and Experimental Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
Pharmacogenet Genomics 17:137-44. 2007.... - RNA-based drug screening using automated RNA purification and real-time RT-PCR1Susanne Ullmann
QIAGEN, Hilden, Germany
J Biomol Screen 9:95-102. 2004..In conclusion, the authors established fully automated RNA isolation and precise gene expression profiling using real-time RT-PCR for drug screening... - The association of ABCB1 polymorphisms and elevated serum digitoxin concentrations in geriatric patientsCharalampos Dragonas
Institute for Biomedicine of Aging, Department of Internal Medicine V Geriatrics, University of Erlangen Nuremberg, Nuremberg, Germany
Eur J Clin Pharmacol 64:367-72. 2008..Our objective was to examine the association of ABCB1 C3435T genotype and elevated serum digitoxin concentrations (SDC) in a cohort of 77 geriatric patients consecutively admitted to a geriatric department over a 12-month period... - Gene expression changes in blood after phlebotomy: implications for gene expression profilingAndreas Pahl
Blood 100:1094-5. 2002 - Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stentsDietmar Trenk
Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
J Am Coll Cardiol 51:1925-34. 2008....