A Pahl

Summary

Affiliation: University of Erlangen-Nuremberg
Country: Germany

Publications

  1. ncbi request reprint Smoke induced changes in epithelial cell gene expression: development of an in vitro model for COPD
    Ruzica Puljic
    Department of Experimental and Clinical Pharmacology and Toxicology, University of D Erlangen Nürnberg, Germany
    ALTEX 21:3-7. 2004
  2. pmc Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia
    Ligia Chialda
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Respir Res 6:36. 2005
  3. pmc Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors
    Andreas Nitsche
    Charité CCM, CC14 Haematology Oncology, Chariteplatz 1, 10117 Berlin, Germany
    BMC Immunol 8:18. 2007
  4. pmc Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Br J Pharmacol 135:1915-26. 2002
  5. ncbi request reprint Asthma therapy in the new millennium
    A Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen, Germany
    Inflamm Res 51:273-82. 2002
  6. ncbi request reprint Stabilization of gene expression profiles in blood after phlebotomy
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, University of Erlangen Nuremberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Clin Chem 48:2251-3. 2002
  7. ncbi request reprint Pharmacogenomics of asthma
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Curr Pharm Des 12:3195-206. 2006
  8. ncbi request reprint Synergistic effects of the anti-cholinergic R,R-glycopyrrolate with anti-inflammatory drugs
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Biochem Pharmacol 72:1690-6. 2006
  9. ncbi request reprint Controlled adjustment of PCR amplification
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Anal Biochem 369:262-4. 2007
  10. ncbi request reprint Hypoxia induced chemokine expression in nasal epithelial cells: development of an in vitro model for chronic rhinosinusitis
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuernberg, Erlangen, Germany
    ALTEX 23:59-63. 2006

Collaborators

Detail Information

Publications43

  1. ncbi request reprint Smoke induced changes in epithelial cell gene expression: development of an in vitro model for COPD
    Ruzica Puljic
    Department of Experimental and Clinical Pharmacology and Toxicology, University of D Erlangen Nürnberg, Germany
    ALTEX 21:3-7. 2004
    ..This approach may result in the replacement of animal experimentation in screening of new therapeutics for COPD...
  2. pmc Inhibitors of mitogen-activated protein kinases differentially regulate costimulated T cell cytokine production and mouse airway eosinophilia
    Ligia Chialda
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Respir Res 6:36. 2005
    ..Therefore, interference of signaling pathways precipitated by ICOS may present new therapeutic options for Th2 dominated diseases such as asthma. However, these signaling pathways are poorly characterized in vitro and in vivo...
  3. pmc Cytokine profiles of cord and adult blood leukocytes: differences in expression are due to differences in expression and activation of transcription factors
    Andreas Nitsche
    Charité CCM, CC14 Haematology Oncology, Chariteplatz 1, 10117 Berlin, Germany
    BMC Immunol 8:18. 2007
    ..We compared levels of secreted proteins and cytokine mRNA induced in cord blood leukocytes (CBL) and adult blood leukocytes (ABL) by various stimuli...
  4. pmc Regulation of IL-13 synthesis in human lymphocytes: implications for asthma therapy
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Br J Pharmacol 135:1915-26. 2002
    ..Characterizing highly potent inhibitors of IL-13 synthesis can be exploited to identify new drugs to treat immunological diseases such as asthma...
  5. ncbi request reprint Asthma therapy in the new millennium
    A Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen, Germany
    Inflamm Res 51:273-82. 2002
    ..Today's intensive search for new treatments should ensure a greater diversity of therapeutic possibilities for the management of asthma in the next millennium...
  6. ncbi request reprint Stabilization of gene expression profiles in blood after phlebotomy
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, University of Erlangen Nuremberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Clin Chem 48:2251-3. 2002
  7. ncbi request reprint Pharmacogenomics of asthma
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Curr Pharm Des 12:3195-206. 2006
    ..The utility of the mouse as an experimental system for pharmacogenomic discovery will also be discussed in the context of asthma therapy...
  8. ncbi request reprint Synergistic effects of the anti-cholinergic R,R-glycopyrrolate with anti-inflammatory drugs
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Biochem Pharmacol 72:1690-6. 2006
    ..In conclusion, R,R-glycopyrrolate acts synergistically with the PDE4 inhibitor rolipram and the steroid budesonide in inhibiting inflammatory mediators...
  9. ncbi request reprint Controlled adjustment of PCR amplification
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, University of Erlangen Nuremberg, D 91054 Erlangen, Germany
    Anal Biochem 369:262-4. 2007
  10. ncbi request reprint Hypoxia induced chemokine expression in nasal epithelial cells: development of an in vitro model for chronic rhinosinusitis
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuernberg, Erlangen, Germany
    ALTEX 23:59-63. 2006
    ..This approach may result in replacing and refining animal experimentation in the screening of new therapeutics for CRS...
  11. ncbi request reprint Gene expression profiling using RNA extracted from whole blood: technologies and clinical applications
    Andreas Pahl
    University of Erlangen Nurnberg, Department of Experimental and Clinical Pharmacology and Toxicology, Fahrstr 17, D 91054 Erlangen, Germany
    Expert Rev Mol Diagn 5:43-52. 2005
    ..After providing a general overview of technologies for gene expression profiling and respective caveats, this review will focus on clinical applications of blood sample profiling...
  12. doi request reprint Preclinical modelling using nasal epithelial cells for the evaluation of herbal extracts for the treatment of upper airway diseases
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    Planta Med 74:693-6. 2008
    ....
  13. ncbi request reprint Nitric oxide inhibits inducible nitric oxide synthase mRNA expression in RAW 264.7 macrophages
    B Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, Erlangen, D 91054, Germany
    Biochem Biophys Res Commun 271:353-7. 2000
    ..In conclusion, NO may control the extent of iNOS mRNA expression by a negative autoregulatory feedback...
  14. ncbi request reprint Prostaglandin E(2) upregulates cyclooxygenase-2 expression in lipopolysaccharide-stimulated RAW 264.7 macrophages
    B Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Biochem Biophys Res Commun 272:744-8. 2000
    ..In conclusion, upregulation of COX-2 expression via an autocrine feed-forward loop may in part contribute to the well-known capacity of PGE(2)/cAMP to modulate inflammatory processes...
  15. ncbi request reprint Cyclooxygenase-2 expression in lipopolysaccharide-stimulated human monocytes is modulated by cyclic AMP, prostaglandin E(2), and nonsteroidal anti-inflammatory drugs
    B Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Fahrstrasse 17, Erlangen, D 91054, Germany
    Biochem Biophys Res Commun 278:790-6. 2000
    ..PGE(2), a cAMP-elevating final product of the COX-2 pathway, may autoregulate COX-2 expression in human monocytes via a positive feedback mechanism...
  16. ncbi request reprint R(+)-methanandamide induces cyclooxygenase-2 expression in human neuroglioma cells via a non-cannabinoid receptor-mediated mechanism
    R Ramer
    Department of Experimental and Clinical Pharmacology and Toxicology, , Fahrstrasse 17, Erlangen, D-91054, Germany
    Biochem Biophys Res Commun 286:1144-52. 2001
    ..In conclusion, induction of COX-2 expression may represent a novel mechanism by which cannabinoids mediate PG-dependent effects within the central nervous system...
  17. ncbi request reprint Constitutive expression and localization of COX-1 and COX-2 in rabbit iris and ciliary body
    J Damm
    Institute for Experimental and Clinical Pharmacology and Toxicology, University of Erlangen-Nuremberg, Erlangen, Germany
    Exp Eye Res 72:611-21. 2001
    ..This could account for differences in the regulation of intraocular pressure and/or blood-aqueous barrier between human and rabbit eyes...
  18. doi request reprint Inhibition of the MAP kinase ERK protects from lipopolysaccharide-induced lung injury
    Katrin Schuh
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Biochem Pharmacol 77:1827-34. 2009
    ..These data suggest that ERK signaling plays an important role in acute lung injury and pharmacologic inhibition of ERK provides a promising new therapeutic strategy for lung inflammatory diseases and in particular COPD...
  19. ncbi request reprint Anti-inflammatory effects of a cyclosporine receptor-binding compound, D-43787
    Andreas Pahl
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Erlangen, Germany
    J Pharmacol Exp Ther 301:738-46. 2002
    ..In conclusion, we characterized a novel Th2 selective immunosuppressive drug with possible anti-asthmatic/anti-inflammatory effects. Its mode of action is distinct from that of CsA...
  20. ncbi request reprint Role of nitric oxide in zymosan induced paw inflammation and thermal hyperalgesia
    H Guhring
    Institut für Experimentelle Pharmakologie and Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
    Inflamm Res 50:83-8. 2001
    ..To assess the involvement of spinal inducible nitric oxide synthase (iNOS) in inflammation and nociception...
  21. ncbi request reprint Are there any realistic chances to develop new drugs for asthma?
    Annette Amon
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Erlangen, Germany
    Drug News Perspect 19:189-200. 2006
    ..With these imperatives in mind, we can hope to better manage this multifactor disease in the near future...
  22. ncbi request reprint Expression of cyclooxygenase-1 and -2 in normal and glaucomatous human eyes
    C Maihofner
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    Invest Ophthalmol Vis Sci 42:2616-24. 2001
    ....
  23. ncbi request reprint Suppressed injury-induced rise in spinal prostaglandin E2 production and reduced early thermal hyperalgesia in iNOS-deficient mice
    H Guhring
    Department of Experimental and Clinical Pharmacology and Toxicology, D 91054 Erlangen, Germany
    J Neurosci 20:6714-20. 2000
    ..These results indicate that NO derived from spinal iNOS acts as a fast inductor of spinal thermal hyperalgesia...
  24. ncbi request reprint Lipopolysaccharide-induced lung inflammation is inhibited by neutralization of GM-CSF
    Ruzica Puljic
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Fahrstr 17, D 91054 Erlangen, Germany
    Eur J Pharmacol 557:230-5. 2007
    ..These data suggest that neutralization of GM-CSF may represent a novel treatment modality for lung inflammation and in particular for COPD...
  25. ncbi request reprint Investigation of the pharmacokinetics of celecoxib by liquid chromatography-mass spectrometry
    Ulrike Werner
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nuremberg, D 91051 Erlangen, Germany
    Biomed Chromatogr 16:56-60. 2002
    ..8+/-2.7h. The area under the curve (AUC(infinity)) for the PM was 12561 microg h/L. However, we found no noticeable increase in half life in the PM (11.5 h) after a single dose of celecoxib...
  26. ncbi request reprint 15-Deoxy-Delta(12,14)-prostaglandin J2 inhibits the expression of proinflammatory genes in human blood monocytes via a PPAR-gamma-independent mechanism
    Burkhard Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Biochem Biophys Res Commun 302:415-20. 2003
    ..Moreover, it is concluded that both inhibition of proinflammatory gene expression and restoration of LPS-induced decrease of PPAR-gamma expression may contribute to the biological action of 15d-PGJ(2)...
  27. ncbi request reprint Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles
    Christopher Schmitt
    Department of Experimental and Clinical Pharmacology and Toxicology, Emil Fischer Center, University of Erlangen Nurnberg, Fahrstrasse 17, D 91054 Erlangen, Germany
    Clin Chem 48:1661-7. 2002
    ..Genetic variations in these receptors may lead to an altered host immune response to pathogens...
  28. ncbi request reprint Possibilities in improvement of glucocorticoid treatments in asthma with special reference to loteprednol etabonate
    I Szelenyi
    Institute for Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University of Erlangen, Germany
    Pharmazie 59:409-11. 2004
    ..It may represent a promising new therapy in the treatment of allergic rhinitis and asthma...
  29. ncbi request reprint Can corticosteroids be beaten in future asthma therapy?
    A Amon
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nuernberg, Erlangen, Germany
    Pharmazie 61:122-4. 2006
    ..The so-called soft-steroids such as loteprednol and etiprednol belong to the future promising therapeutically effective and safe treatments of allergic disorders...
  30. ncbi request reprint Flurbiprofen enantiomers inhibit inducible nitric oxide synthase expression in RAW 264.7 macrophages
    B Hinz
    Department of Experimental and Clinical Pharmacology and Toxicology, Friedrich Alexander University Erlangen Nurnberg, Germany
    Pharm Res 18:151-6. 2001
    ..7 macrophages, the present study investigates the influence of optically pure enantiomers of the nonsteroidal anti-inflammatory drug flurbiprofen on lipopolysaccharide (LPS)-induced inducible nitric oxide synthase (iNOS) expression...
  31. ncbi request reprint Is asthma research in dead end?
    Annette Amon
    Department of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen, Fahrstr 17, 91054 Erlangen, Germany
    Exp Toxicol Pathol 57:45-7. 2006
    ..The present drug screening strategy should be reconsidered and probably be replaced by new and more serendipity-based research...
  32. ncbi request reprint CYP3A5 genotype is associated with elevated blood pressure
    Martin F Fromm
    Institute of Clinical and Experimental Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenet Genomics 15:737-41. 2005
    ..We interpret the lower serum aldosterone concentration in the genotype group with the elevated systolic blood pressure as a counter-regulatory mechanism to attenuate the increased blood pressure associated with the CYP3A5*3/*3 genotype...
  33. ncbi request reprint Modulation of synaptic transmission by nociceptin/orphanin FQ and nocistatin in the spinal cord dorsal horn of mutant mice lacking the nociceptin/orphanin FQ receptor
    S Ahmadi
    , , Erlangen, Germany
    Mol Pharmacol 59:612-8. 2001
    ....
  34. ncbi request reprint Protection against progressive leishmaniasis by IFN-beta
    Jochen Mattner
    Institute of Clinical Microbiology, Immunology and Hygiene, University of Erlangen Nuremberg, Erlangen, Germany
    J Immunol 172:7574-82. 2004
    ..These results identify IFN-beta as a novel cytokine with a strong, dose-dependent protective effect against progressive cutaneous leishmaniasis that results from IL-12- and STAT4-dependent as well as -independent events...
  35. ncbi request reprint Cytochrome p450 polymorphisms in geriatric patients: impact on adverse drug reactions--a pilot study
    Tobias Egger
    Department of Experimental and Clinical Pharmacology and Toxicology, University Erlangen Nuremberg, Erlangen, Germany
    Drugs Aging 22:265-72. 2005
    ..The aim of this survey was to determine the relationship between genetical polymorphisms in these CYP enzymes and adverse drug reactions (ADRs) in geriatric patients...
  36. pmc Leishmania major parasites express cyclophilin isoforms with an unusual interaction with calcineurin
    C Rascher
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, D 91054 Erlangen, Germany
    Biochem J 334:659-67. 1998
    ..These observations indicate that resistance of L. major to CsA in vitro is mediated by the lack of complex formation with calcineurin despite CsA binding by parasitic Cyp...
  37. ncbi request reprint Inhibition of the transcription factor Foxp3 converts desmoglein 3-specific type 1 regulatory T cells into Th2-like cells
    Christian Veldman
    Department of Dermatology, University of Erlangen Nurnberg, Erlangen, Germany
    J Immunol 176:3215-22. 2006
    ..In conclusion, Foxp3 expression is inherent to Tr1 function, and modulation of Foxp3 expression in autoaggressive Th2 cells may provide a novel therapeutic approach aimed at restoring tolerance against Dsg3 in PV...
  38. ncbi request reprint MDR1 genotype-dependent regulation of the aldosterone system in humans
    Oliver Zolk
    Institute of Clinical and Experimental Pharmacology and Toxicology, University of Erlangen Nuremberg, Erlangen, Germany
    Pharmacogenet Genomics 17:137-44. 2007
    ....
  39. pmc Spinal inflammatory hyperalgesia is mediated by prostaglandin E receptors of the EP2 subtype
    Heiko Reinold
    Institut fur Experimentelle und Klinische Pharmakologie und Toxikologie, Universitat Erlangen Nurnberg, Erlangen, Germany
    J Clin Invest 115:673-9. 2005
    ..Our results thus demonstrate that inflammatory hyperalgesia can be treated by targeting of a single PG receptor subtype and provide a rational basis for new analgesic strategies going beyond COX inhibition...
  40. ncbi request reprint Gene expression changes in blood after phlebotomy: implications for gene expression profiling
    Andreas Pahl
    Blood 100:1094-5. 2002
  41. ncbi request reprint The association of ABCB1 polymorphisms and elevated serum digitoxin concentrations in geriatric patients
    Charalampos Dragonas
    Institute for Biomedicine of Aging, Department of Internal Medicine V Geriatrics, University of Erlangen Nuremberg, Nuremberg, Germany
    Eur J Clin Pharmacol 64:367-72. 2008
    ..Our objective was to examine the association of ABCB1 C3435T genotype and elevated serum digitoxin concentrations (SDC) in a cohort of 77 geriatric patients consecutively admitted to a geriatric department over a 12-month period...
  42. ncbi request reprint RNA-based drug screening using automated RNA purification and real-time RT-PCR1
    Susanne Ullmann
    QIAGEN, Hilden, Germany
    J Biomol Screen 9:95-102. 2004
    ..In conclusion, the authors established fully automated RNA isolation and precise gene expression profiling using real-time RT-PCR for drug screening...
  43. doi request reprint Cytochrome P450 2C19 681G>A polymorphism and high on-clopidogrel platelet reactivity associated with adverse 1-year clinical outcome of elective percutaneous coronary intervention with drug-eluting or bare-metal stents
    Dietmar Trenk
    Herz Zentrum Bad Krozingen, Bad Krozingen, Germany
    J Am Coll Cardiol 51:1925-34. 2008
    ....