Renate Paddenberg

Summary

Affiliation: University of Giessen
Country: Germany

Publications

  1. doi request reprint Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Excellence Cluster Cardio Pulmonary System, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Cardiovasc Res 93:702-10. 2012
  2. ncbi request reprint Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Justus Liebig University, 35385 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 284:L710-9. 2003
  3. doi request reprint Organ preservation solutions attenuate accumulation and nuclear translocation of hypoxia-inducible factor-1alpha in the hepatoma cell line HepG2
    Renate Paddenberg
    Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Cell Biochem Funct 27:516-25. 2009
  4. pmc Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Giessen University, Giessen, Germany
    Respir Res 8:15. 2007
  5. pmc Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices
    Renate Paddenberg
    University of Giessen Lung Center, Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Respir Res 7:93. 2006
  6. ncbi request reprint Hypoxia-induced increase of endostatin in murine aorta and lung
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Justus Liebig University, 35385, Giessen, Germany
    Histochem Cell Biol 125:497-508. 2006
  7. ncbi request reprint Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature
    Renate Paddenberg
    Institute for Anatomy and Cell Biology, Justus Liebig University, 35385 Giessen, Germany
    Adv Exp Med Biol 536:163-9. 2003
  8. pmc Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability
    Uwe Pfeil
    Institute for Anatomy and Cell Biology, Department of Internal Medicine, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 297:L837-45. 2009
  9. ncbi request reprint Mitochondrial regulation of hypoxia-induced increase of adrenomedullin mRNA in HL-1 cells
    Uwe Pfeil
    Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Biochem Biophys Res Commun 343:885-92. 2006
  10. doi request reprint Fumarate in the preservation solution aggravates chronic allograft nephropathy
    Christian Ploetz
    Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig University Giessen, Giessen, Germany
    J Surg Res 166:306-13. 2011

Detail Information

Publications13

  1. doi request reprint Mitochondrial complex II is essential for hypoxia-induced pulmonary vasoconstriction of intra- but not of pre-acinar arteries
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Excellence Cluster Cardio Pulmonary System, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Cardiovasc Res 93:702-10. 2012
    ....
  2. ncbi request reprint Essential role of complex II of the respiratory chain in hypoxia-induced ROS generation in the pulmonary vasculature
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Justus Liebig University, 35385 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 284:L710-9. 2003
    ..Presumably, its catalytic activity switches from succinate dehydrogenase to fumarate reductase at reduced oxygen tension, thereby modulating the directionality of the electron flow...
  3. doi request reprint Organ preservation solutions attenuate accumulation and nuclear translocation of hypoxia-inducible factor-1alpha in the hepatoma cell line HepG2
    Renate Paddenberg
    Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Cell Biochem Funct 27:516-25. 2009
    ..Thus, it appears feasible to design preservation solution specifically to modify HIF-1alpha accumulation and nuclear translocation...
  4. pmc Rapamycin attenuates hypoxia-induced pulmonary vascular remodeling and right ventricular hypertrophy in mice
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Giessen University, Giessen, Germany
    Respir Res 8:15. 2007
    ..We hypothesized that rapamycin (RAPA), a potent cell cycle inhibitor, prevents pulmonary hypertension in chronic hypoxic mice...
  5. pmc Hypoxic vasoconstriction of partial muscular intra-acinar pulmonary arteries in murine precision cut lung slices
    Renate Paddenberg
    University of Giessen Lung Center, Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Respir Res 7:93. 2006
    ..The aim of the present study was to establish a model which allows the investigation of HPV and its underlying mechanisms in small intra-acinar arteries...
  6. ncbi request reprint Hypoxia-induced increase of endostatin in murine aorta and lung
    Renate Paddenberg
    Institute of Anatomy and Cell Biology, Justus Liebig University, 35385, Giessen, Germany
    Histochem Cell Biol 125:497-508. 2006
    ..The surprising finding of increased endostatin in the lung presumably contributes to the development of pulmonary hypertension by reduction of angiogenesis...
  7. ncbi request reprint Mitochondrial complex II is essential for hypoxia-induced ROS generation and vasoconstriction in the pulmonary vasculature
    Renate Paddenberg
    Institute for Anatomy and Cell Biology, Justus Liebig University, 35385 Giessen, Germany
    Adv Exp Med Biol 536:163-9. 2003
    ..Functional complex II is also necessary for hypoxic pulmonary vasoconstriction...
  8. pmc Intermedin/adrenomedullin-2 is a hypoxia-induced endothelial peptide that stabilizes pulmonary microvascular permeability
    Uwe Pfeil
    Institute for Anatomy and Cell Biology, Department of Internal Medicine, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    Am J Physiol Lung Cell Mol Physiol 297:L837-45. 2009
    ..In conclusion, IMD is a novel hypoxia-induced gene and a potential interventional agent for the improvement of endothelial barrier function in systemic inflammatory responses and hypoxia-induced vascular leakage...
  9. ncbi request reprint Mitochondrial regulation of hypoxia-induced increase of adrenomedullin mRNA in HL-1 cells
    Uwe Pfeil
    Institute for Anatomy and Cell Biology, Justus Liebig University, Giessen, Germany
    Biochem Biophys Res Commun 343:885-92. 2006
    ..These ROS originate both from the mitochondrial complex III and from additional, presumably extramitochondrial, sources. Mitochondrial oxygen consumption appears to have impact on oxygen availability at these extramitochondrial sensors...
  10. doi request reprint Fumarate in the preservation solution aggravates chronic allograft nephropathy
    Christian Ploetz
    Laboratory of Experimental Surgery, Department of General and Thoracic Surgery, Justus Liebig University Giessen, Giessen, Germany
    J Surg Res 166:306-13. 2011
    ..To date, we do not know the mechanism resulting in fumarate-induced chronic graft damage. We suggest, however, that addition of fumarate to the conservation fluid does not improve graft outcome...
  11. pmc Intrinsic vascular dopamine - a key modulator of hypoxia-induced vasodilatation in splanchnic vessels
    Uwe Pfeil
    Institute for Anatomy and Cell Biology, Justus Liebig University, Aulweg 123, 35385 Giessen, Germany
    J Physiol 592:1745-56. 2014
    ..In the splanchnic vasculature, this intrinsic non-neuronal dopamine is the dominating vasodilator released upon lowering of oxygen tension. ..
  12. ncbi request reprint Hypobaric hypoxia affects endogenous levels of alpha-keto acids in murine heart ventricles
    Jörg Mühling
    Clinic of Anaesthesiology, Intensive Care Medicine, Pain Therapy and Palliative Medicine, Justus Liebig University, Giessen, Germany
    Biochem Biophys Res Commun 342:935-9. 2006
    ....
  13. ncbi request reprint Phosphodiesterase 1 upregulation in pulmonary arterial hypertension: target for reverse-remodeling therapy
    Ralph Theo Schermuly
    University of Giessen Lung Centre, Justus Liebig Universitat Giessen, Klinikstrasse 36, 35392 Giessen, Germany
    Circulation 115:2331-9. 2007
    ..The calcium/calmodulin-dependent phosphodiesterase 1 (PDE1) may play a major role in vascular smooth muscle cell proliferation...