Research Topics
Genomes and GenesSpecies | F PadbergSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Switch to mania after slow rTMS of the right prefrontal cortexRobin Ella
J Clin Psychiatry 63:249. 2002
The combined dexamethasone-CRH test before and after repetitive transcranial magnetic stimulation (rTMS) in major depressionP Zwanzger
Department of Psychiatry, Ludwig-Maximilians-University of Munich, Nussbaumstrasse 7, Germany
Psychoneuroendocrinology 28:376-85. 2003..CONCLUSIONS: The persisting HPA system hyperactivity after rTMS suggests a high risk for relapse and therefore argues for an immediate maintenance therapy in patients responding to this treatment...
Regarding "Evaluating outcomes in chronic venous disorders of the leg: development of a scientifically rigorous, patient-reported measure of symptoms and quality of life"Frank Padberg
Division of Vascular Surgery, Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey and the Section of Vascular Surgery, Department of Veterans Affairs of New Jersey Health Care System, Newark, USA
J Vasc Surg 37:911-2. 2003
Effects of tiagabine on cholecystokinin-tetrapeptide (CCK-4)-induced anxiety in healthy volunteersPeter Zwanzger
Department of Psychiatry, University of Munich, Munich, Germany
Depress Anxiety 18:140-3. 2003..Our results suggest anxiolytic properties of tiagabine in humans, which provide sufficient rationale to assess its putative anxiolytic effects in patients with panic disorder under controlled conditions...
Neuropsychopharmacological properties of neuroactive steroids in depression and anxiety disordersDaniela Eser
Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr. 7, 80336, Munich, Germany
Psychopharmacology (Berl) 186:373-87. 2006..They are important endogenous modulators of depression and anxiety and may provide a basis for the development of novel therapeutic agents in the treatment of affective disorders...
No association between anti-myelin oligodendrocyte glycoprotein antibodies and serum/cerebrospinal fluid levels of the soluble interleukin-6 receptor complex in multiple sclerosisF Padberg
Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336, Munich, Germany
Neurosci Lett 305:13-6. 2001..There was no difference in IL-6 and sIL-6RC levels between anti-MOG abs positive and negative samples. Thus, no association between the presence of anti-MOG abs and serum/CSF levels of IL-6/sIL-6RC was found...
Prefrontal cortex modulation of mood and emotionally induced facial expressions: a transcranial magnetic stimulation studyF Padberg
Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
J Neuropsychiatry Clin Neurosci 13:206-12. 2001..On the basis of this study, the authors propose to combine rTMS and facial expression analysis for further studies of the cortical modulation of emotions in humans...
Prefrontal cortex stimulation as antidepressant treatment: mode of action and clinical effectiveness of rTMSFrank Padberg
Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstr. 7, D-80336 Munich, Germany
Suppl Clin Neurophysiol 56:406-32. 2003
Repetitive transcranial magnetic stimulation (rTMS) in pharmacotherapy-refractory major depression: comparative study of fast, slow and sham rTMSF Padberg
Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
Psychiatry Res 88:163-71. 1999..In conclusion, this study further supported the safety of rTMS but does not show any clinically meaningful antidepressant efficacy of rTMS at 250 daily stimuli over 5 days in pharmacotherapy-refractory major depression...
CSF and serum levels of soluble interleukin-6 receptors (sIL-6R and sgp130), but not of interleukin-6 are altered in multiple sclerosisF Padberg
Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
J Neuroimmunol 99:218-23. 1999..Furthermore, sgp130 CSF levels were decreased in MS, suggesting a possibly altered IL-6 regulation in the CSF...
Repetitive transcranial magnetic stimulation : does it have potential in the treatment of depression?Frank Padberg
Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
CNS Drugs 17:383-403. 2003..Research efforts should be intensified to further investigate the effectiveness of rTMS as an antidepressant intervention and to test specific applications of the technique in the treatment of depressive episodes...
Relation between responses to repetitive transcranial magnetic stimulation and partial sleep deprivation in major depressionFrank Padberg
Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
J Psychiatr Res 36:131-5. 2002..Apparently, different subgroups of depressed patients respond to both interventions. Further studies are needed to characterize the response to rTMS by means of clinical and biological parameters...
Polymorphisms in the apolipoprotein E (APOE) gene in gerontopsychiatric patientsP Zill
Psychiatric Hospital, Ludwig Maximilians University, Munich Nussbaumstrasse 7, 80336 Munich, Germany
Eur Arch Psychiatry Clin Neurosci 251:24-8. 2001..However, if we combine our results with three previous published positive reports there seems to be an association between the -491A/T polymorphism and AD, though its size is less than found in the original publication...
Effects of alprazolam on cholecystokinin-tetrapeptide-induced panic and hypothalamic-pituitary-adrenal-axis activity: a placebo-controlled studyP Zwanzger
Department of Psychiatry, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
Neuropsychopharmacology 28:979-84. 2003..In conclusion, our data show that alprazolam reduces CCK-4-induced panic, which supports the hypothesis of a possible interaction between the GABA and the CCK system...
Discriminant power of combined cerebrospinal fluid tau protein and of the soluble interleukin-6 receptor complex in the diagnosis of Alzheimer's diseaseH Hampel
Department of Psychiatry, Geriatric Psychiatry Branch, Dementia Research Section, Ludwig Maximilian University Munich, Nussbaumstr 7, 80336, Munich, Germany
Brain Res 823:104-12. 1999....
Sleep deprivation and hypothalamic-pituitary-adrenal (HPA) axis activity in depressed patientsC Schule
Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
J Psychiatr Res 35:239-47. 2001....
Interleukin-6 is not altered in cerebrospinal fluid of first-degree relatives and patients with Alzheimer's diseaseH Hampel
Department of Psychiatry, Ludwig Maximilian University, School of Medicine, Munich, Germany
Neurosci Lett 228:143-6. 1997..We suggest that combined measurement of all parameters of the IL-6-receptor complex could yield more insight in a probably altered IL-6 function...
Serotonin transporter (5-HTT) gene polymorphism in psychogeriatric patientsP Zill
Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
Neurosci Lett 284:113-5. 2000..This finding indicates that the serotonin transporter does not appear to be a major susceptibility factor in the pathophysiology of Alzheimer's disease and other psychogeriatric disorders...
Neuroactive steroids as modulators of depression and anxietyD Eser
Department of Psychiatry, Ludwig-Maximilian-University, Munich, Germany
Neuroscience 138:1041-8. 2006..The modulation of GABA type A-receptors by neuroactive steroids might contribute to the pathophysiology of depression and anxiety disorders and might offer new targets for the development of novel anxiolytic compounds...
Interleukin-6 and the soluble IL-6 receptor are decreased in cerebrospinal fluid of geriatric patients with major depression: no alteration of soluble gp130S Stubner
Department of Psychiatry, Ludwig Maximillian University, Munich, Germany
Neurosci Lett 259:145-8. 1999..We found statistically significant decreased CSF concentrations of IL-6 (P<0.001) and of the sIL-6R (P<0.001) of patients with MD. Levels of sgp130 showed no statistically significant difference between patients and controls...
Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's diseaseH Hampel
Department of Psychiatry, Ludwig Maximilian University Munich, School of Medicine, Germany
Brain Res 780:356-9. 1998..We found a statistically significant decrease in sIL-6R levels in the AD group compared to controls. Complete analysis of the IL-6R complex seems crucial to better understand the impact of IL-6 in AD pathophysiology...
Vigabatrin decreases cholecystokinin-tetrapeptide (CCK-4) induced panic in healthy volunteersP Zwanzger
Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
Neuropsychopharmacology 25:699-703. 2001....
Transcranial direct current stimulation in treatment resistant depression: a randomized double-blind, placebo-controlled studyU Palm
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Munich, Germany
Brain Stimul 5:242-51. 2012..According to clinical needs, this study addresses the question whether tDCS is effective in treatment resistant major depressive episodes...
Cerebrospinal fluid tau protein shows a better discrimination in young old (<70 years) than in old old patients with Alzheimer's disease compared with controlsK Bürger née Buch
Department of Psychiatry, Geriatric Psychiatry Branch, Dementia Research Section and Memory Clinic, Ludwig Maximilian University, Munich, Germany
Neurosci Lett 277:21-4. 1999..We suggest that the effect of age should be considered in studies investigating CSF tau as a diagnostic marker for neurodegenerative disorders...
Plasma gamma-amino-butyric acid (GABA) levels in cholecystokinine-tetrapeptide (CCK-4) induced anxietyP Zwanzger
Department of Psychiatry, University of Munich, Munich, Germany
J Neural Transm 110:313-6. 2003..To evaluate a possible relationship between plasma GABA and CCK-4 induced panic plasma GABA levels in healthy volunteers were investigated...
Prefrontal direct current stimulation modulates resting EEG and event-related potentials in healthy subjects: a standardized low resolution tomography (sLORETA) studyD Keeser
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University Munich, Munich, Germany
Neuroimage 55:644-57. 2011....
Severe hirsutism associated with psychopharmacological treatment in major depressionH Hampel
Department of Psychiatry, Ludwig Maximilians University, Nussbaumstrasse 7, 80336 Munich, Germany
World J Biol Psychiatry 2:48-9. 2001..The higher prevalence of hirsutism in women who suffer from chronic psychiatric diseases highlights the importance of further investigating the aetiology of hirsutism in major depression...
[Treatment of vitally endangered anorexia nervosa patients based on guardianship laws]G Laakmann
Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat Munchen
Nervenarzt 77:35-6, 38-40, 43-9. 2006..The chosen treatment is shown with the therapy courses of 25 patients treated according to this concept...
[Modern therapy for dementia]F Padberg
Oberarzt der Klinik fur Psychiatrie und Psychotherapie, LMU Munchen
MMW Fortschr Med 147:71-4, 76-7. 2005..During the last decade, the classic neuroleptics and benzodiazepine have been largely replaced by modern antidepressants, atypical antipsychotics and benzodiazepine analogues...
[Repetitive transcranial magnetic stimulation of the prefrontal cortex--the last resort in the treatment of depression?]F Padberg
Klinik fur Psychiatrie und Psychotherapie, LMU Munchen
MMW Fortschr Med 146:16-7. 2004
[Late onset Huntington's disease - a differential diagnosis of Alzheimer's disease]K Burger
Klinik und Poliklinik fur Psychiatrie und Psychotherapie, Demenzforschungsstation und Gedächtnissprechstunde, Alzheimer Gedächtnis Zentrum, Ludwig Maximilians Universitat Munchen, Germany
Nervenarzt 73:870-3. 2002..This case shows the relevance of an accurate differential diagnosis of cognitive disturbances in order to detect rare causes of dementia...
Polymorphisms in the alpha-2 macroglobulin gene in psychogeriatric patientsP Zill
Psychiatric Hospital of the Ludwig Maximilians University, Munich, Nussbaumstrasse 7, D 80336, Munich, Germany
Neurosci Lett 294:69-72. 2000....
Transcranial magnetic stimulation in therapy studies: examination of the reliability of "standard" coil positioning by neuronavigationU Herwig
Department of Psychiatry, University of Ulm, Germany
Biol Psychiatry 50:58-61. 2001..g., above the premotor cortex). The current method for locating the DLPFC is not precise anatomically and may be improved by navigating procedures taking individual anatomy into account...
Anxiolytic effects of transcranial magnetic stimulation--an alternative treatment option in anxiety disorders?Peter Zwanzger
Department of Psychiatry, University of Munster, Albert Schweitzer Strasse 11, 49149 Munster, Germany
J Neural Transm 116:767-75. 2009..However, to further elucidate the putative anxiolytic action of rTMS in patients with anxiety disorders future studies have to be conducted addressing in particular the limitations of the studies mentioned above...
[Psychiatric disorders in intensive care--part three: psychic reactions, affective and anxiety disorders]Till Krauseneck
Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat Munchen, Munich, Germany
Anasthesiol Intensivmed Notfallmed Schmerzther 42:180-7. 2007....
Neuroactive steroids in responders and nonresponders to sleep deprivationCornelius Schule
Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336 Munich, Germany
Ann N Y Acad Sci 1032:216-23. 2004..In contrast to antidepressant drugs which correct the dysequilibrium of neuroactive steroids in major depression within several weeks, PSD does not affect the concentrations of neuroactive steroids in either responders or nonresponders...
Saccadic eye velocity after selective GABAergic treatment with tiagabine in healthy volunteersPeter Zwanzger
Department of Psychiatry, University of Munich, Nussbaumstrasse 7, DE 80336 Munich, Germany
Neuropsychobiology 52:147-50. 2005..Tiagabine is a new antiepileptic drug which acts via selective blockade of GABA reuptake. Therefore, we examined the effects of tiagabine on saccade parameters...
Striatal dopamine release after prefrontal repetitive transcranial magnetic stimulation in major depression: preliminary results of a dynamic [123I] IBZM SPECT studyOliver Pogarell
Department of Psychiatry, Ludwig-Maximilians-University, Nussbaumstr. 7, D-80336 Munich, Germany
J Psychiatr Res 40:307-14. 2006..In future, this approach can be used to differentiate specific and non-specific reward-related effects of rTMS on dopaminergic neurotransmission...
A case of persistent retrograde amnesia following a dissociative fugue: neuropsychological and neurofunctional underpinnings of loss of autobiographical memory and self-awarenessKristina Hennig-Fast
Department of Psychiatry and Psychotherapy, Ludwig Maximilians University, Nussbaumstr 7, Munich, Germany
Neuropsychologia 46:2993-3005. 2008..It is posited that our data provide evidence for the important role of visual processing in autobiographical memory as well as for the efficiency of protective control mechanisms that constitute functional retrograde amnesia...
Electroencephalographic abnormalities associated with antidepressant treatment: a comparison of mirtazapine, venlafaxine, citalopram, reboxetine, and amitriptylineAndrea Sterr
J Clin Psychiatry 67:325-6. 2006
Patterns of response to repetitive transcranial magnetic stimulation (rTMS) in major depression: replication study in drug-free patientsEva Lotta Brakemeier
Department of Psychiatry and Psychotherapy, Charite Universitatsmedizin Berlin, Campus Benjamin Franklin, Berlin, Germany
J Affect Disord 108:59-70. 2008..Thus, this study aims to replicate previous findings and explore patterns of response in drug-free patients...
[Psychiatric disorders in the ICU I: delirium]Till Krauseneck
Klinik fur Psychiatrie und Psychotherapie, Ludwig Maximilians Universitat Munchen, Germany
Anasthesiol Intensivmed Notfallmed Schmerzther 41:720-6. 2006..This article reviews the different forms of delirium, its causes and therapy strategies. Also changes of the ICU environment to prevent patients from delirium are mentioned...
[Psychiatric emergencies on ICU]Till Krauseneck
Klinik für Psychiatrie und Psychotherapie der Ludwig Maximilians Universität München, Germany
Anasthesiol Intensivmed Notfallmed Schmerzther 42:10-3. 2007..Psychiatric emergencies are catatonia, stupor, central serotonine syndrome, malignant neuroleptic syndrome, suicide risk and agitation. In this article some clinical features of the aforementioned and its therapy are summarized...
Effects of repetitive transcranial magnetic stimulation (rTMS) on panic attacks induced by cholecystokinin-tetrapeptide (CCK-4)Peter Zwanzger
Department of Psychiatry, Ludwig Maximilian University of Munich, Munich, Germany
Int J Neuropsychopharmacol 10:285-9. 2007..In contrast to the effects of pretreatment with alprazolam on CCK-4-induced panic in healthy subjects LF rTMS does not affect CCK-4-induced panic and cortisol or ACTH release...
Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brainHarald Hampel
Alzheimer Memorial Centre, Geriatric Psychiatric Branch, Dementia Research Section, Dept of Psychiatry Ludwig Maximilian University, 80336 Munich, Germany
Eur Arch Psychiatry Clin Neurosci 255:269-78. 2005..Our findings indicate an altered cortical immunoreactivity pattern of the functional IL-6RC in AD supporting the hypothesis of a disease-related role of IL-6 in AD pathophysiology...
Differentiation of geriatric major depression from Alzheimer's disease with CSF tau protein phosphorylated at threonine 231Katharina Buerger
Dementia Research Section and Memory Clinic, Alzheimer Memorial Center and Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
Am J Psychiatry 160:376-9. 2003..The authors asked whether p-tau(231) levels improve the differential diagnosis between geriatric major depression and Alzheimer's disease...
Attenuation of hypothalamic-pituitary-adrenocortical hyperactivity in depressed patients by mirtazapineCornelius Schule
Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336, Munich, Germany
Psychopharmacology (Berl) 166:271-5. 2003..Mirtazapine acts as an antagonist at presynaptic alpha(2)-receptors and at postsynaptic 5-hydroxytryptamine (5-HT)(2), 5-HT(3) and histamine H(1) receptors. It has been shown acutely to inhibit cortisol secretion in healthy subjects...
Repetitive transcranial magnetic stimulation (rTMS) in major depression: relation between efficacy and stimulation intensityFrank Padberg
Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
Neuropsychopharmacology 27:638-45. 2002..These findings support the hypothesis of a relationship between stimulation intensity of rTMS and its antidepressant efficacy...
Occurrence of delusions during repetitive transcranial magnetic stimulation (rTMS) in major depressionPeter Zwanzger
Department of Psychiatry, University of Munich, Nussbaumstrasse 7, 80336 Munich, Germany
Biol Psychiatry 51:602-3. 2002..CONCLUSIONS: In light of preclinical findings showing increased dopaminergic activity after rTMS treatment, occurrence of psychotic symptoms should be considered a potential side effect of rTMS treatment...
Influence of sleep deprivation on neuroactive steroids in major depressionCornelius Schule
Department of Psychiatry, Ludwig Maximilian University, Munich, Germany
Neuropsychopharmacology 28:577-81. 2003....
Transcranial magnetic stimulation for panicPeter Zwanzger
Am J Psychiatry 159:315-6. 2002
Value of event-related P300 subcomponents in the clinical diagnosis of mild cognitive impairment and Alzheimer's DiseaseThomas Frodl
Department of Psychiatry, Ludwig Maximilians University Munich, Germany
Psychophysiology 39:175-81. 2002..Similar results were found using Pz amplitudes as well as Fz latencies. Our data suggest that TB-P300 amplitudes and TS-P300 latencies may be an accurate clinically available, nonexpensive, noninvasive, and reliable marker for AD...
Differential diagnosis of Alzheimer disease with cerebrospinal fluid levels of tau protein phosphorylated at threonine 231Katharina Buerger
Dementia Research Section and Memory Clinic, Alzheimer Memorial Center, Geriatric Psychiatry Branch, Department of Psychiatry, Ludwig Maximilian University, Nussbaumstrasse 7, 80336 Munich, Germany
Arch Neurol 59:1267-72. 2002....
Evaluation of a salivary based combined dexamethasone/CRH test in patients with major depressionThomas C Baghai
Department of Psychiatry and Psychotherapy, Ludwig Maximilian University of Munich, Nussbaumstrasse 7, D 80336 Munich, Germany
Psychoneuroendocrinology 27:385-99. 2002....
Effects of antidepressant pharmacotherapy after repetitive transcranial magnetic stimulation in major depression: an open follow-up studyCornelius Schule
Department of Psychiatry, Ludwig Maximilian University, Nussbaumstr 7, 80336, Munich, Germany
J Psychiatr Res 37:145-53. 2003....
Antidepressant medications and other treatments of depressive disorders: a CINP Task Force report based on a review of evidenceNorman Sartorius
Chairperson of CINP Task Force, 14 Chemin Colladon, Geneva, Switzerland
Int J Neuropsychopharmacol 10:S1-207. 2007
Acute prefrontal rTMS increases striatal dopamine to a similar degree as D-amphetamineOliver Pogarell
Department of Psychiatry, Ludwig Maximilians University of Munich, Munich, Germany
Psychiatry Res 156:251-5. 2007..95% (difference not statistically significant). Acute rTMS challenge showed similar striatal dopaminergic effects to those associated with the administration of d-amphetamine, a substance known to increase synaptic dopamine...
Does severe venous insufficiency have a different etiology in the morbidly obese? Is it venous?Frank Padberg
Division of Vascular Surgery, Department of Surgery, New Jersey Medical School, University of Medicine and Dentistry of New Jersey and the Section of Vascular Surgery, VA NJ Health Care System, Orange, NJ, USA
J Vasc Surg 37:79-85. 2003..Patients with morbid obesity are remarkable for particularly recalcitrant ulcers. Because obesity is not specifically incorporated in CEAP or other venous scoring systems, we sought to characterize this group of patients more completely...
Plasma concentrations of neuroactive steroids before and after repetitive transcranial magnetic stimulation (rTMS) in major depressionFrank Padberg
Department of Psychiatry, Ludwig-Maximilian University, Nussbaumstr. 7, D-80336, Munich, Germany
Neuropsychopharmacology 27:874-8. 2002..Changes in neuroactive steroid levels after antidepressant pharmacotherapy more likely reflect specific pharmacological effects of antidepressant drugs and are not necessary for the amelioration of depressive symptoms...
Transcranial and deep brain stimulation approaches as treatment for depressionAnne Rau
Dept of Psychiatry and Psychotherapy, Ludwig Maximilians University Munich, Munich, Germany
Clin EEG Neurosci 38:105-15. 2007..Also, the methods vary regarding their degree of invasiveness. One or the other method may finally achieve antidepressant effectiveness with minimized side effects and constitute a new effective treatment for major depression...
Targets of antidementive therapy: drugs with a specific pharmacological mechanism of actionLutz Frolich
Klinik für Psychiatrie und Psychotherapie I Johann Wolfgang Goethe Universität, Heinrich Hoffmann Str 10, 60528 Frankfurt am Main, Germany
Curr Pharm Des 10:223-9. 2004..Selection and adaptation of medication becomes easier if such targets are considered and if therapeutic effects are monitored target-specifically...
Quetiapine as treatment for delirium during weaning from ventilation: a case reportFlorian Seemüller
J Clin Psychopharmacol 27:526-8. 2007
