B Otto

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
    B Otto
    Medical Department, Innenstadt, University Hospital, Ziemssenstrasse 1, D 80336 Munich, Germany
    Eur J Endocrinol 145:669-73. 2001
  2. ncbi Peptide YY release in anorectic patients after liquid meal
    B Otto
    Medical Department, University Hospital Innenstadt, Ziemssenstr 1, D 80336 Munich, Germany
    Appetite 48:301-4. 2007
  3. ncbi Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans
    B Otto
    Medical Department, University Hospital Innenstadt, Ziemssenstrasse 1, 80336 Munich, Germany
    Eur J Endocrinol 151:113-7. 2004
  4. ncbi mu-Opiate receptor agonist loperamide blocks bethanechol-induced gallbladder contraction, despite higher cholecystokinin plasma levels in man
    B Otto
    Department of Internal Medicine Innenstadt, University Hospital, Munich, Germany
    Neurogastroenterol Motil 17:761-6. 2005
  5. ncbi Post-prandial decrease of human plasma ghrelin in the absence of insulin
    J Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, Bergholz Rehbrücke, Germany
    J Endocrinol Invest 26:RC19-22. 2003
  6. ncbi Euglycemic hyperinsulinemia differentially modulates circulating total and acylated-ghrelin in humans
    M O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Endocrinol Invest 31:119-24. 2008
  7. ncbi Short-term therapy with atorvastatin or fenofibrate does not affect plasma ghrelin, resistin or adiponectin levels in type 2 diabetic patients with mixed hyperlipoproteinaemia
    C Otto
    Medical Department 2 Grosshadern, University Hospital Munich, Marchioninistrasse 15, D 81377, Munich, Germany
    Acta Diabetol 44:65-8. 2007
  8. ncbi Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36
    P T Pfluger
    Department of Psychiatry, University of Cincinnati, Office E 217, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    J Clin Endocrinol Metab 92:583-8. 2007
  9. ncbi Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance
    A L Garcia
    Dietary Fibre and the Metabolic Syndrome Group, German Institute of Human Nutrition, Potsdam Rehbruecke, Nuthetal, Germany
    Eur J Clin Nutr 61:334-41. 2007
  10. ncbi Regulation of ghrelin is related to estimated insulin sensitivity in obese children
    K Krohn
    Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich, Germany
    Int J Obes (Lond) 30:1482-7. 2006

Collaborators

Detail Information

Publications22

  1. ncbi Weight gain decreases elevated plasma ghrelin concentrations of patients with anorexia nervosa
    B Otto
    Medical Department, Innenstadt, University Hospital, Ziemssenstrasse 1, D 80336 Munich, Germany
    Eur J Endocrinol 145:669-73. 2001
    ....
  2. ncbi Peptide YY release in anorectic patients after liquid meal
    B Otto
    Medical Department, University Hospital Innenstadt, Ziemssenstr 1, D 80336 Munich, Germany
    Appetite 48:301-4. 2007
    ..We could not confirm the recently published blunted postprandial PYY response in anorexia, a finding that merits further study...
  3. ncbi Endogenous and exogenous glucocorticoids decrease plasma ghrelin in humans
    B Otto
    Medical Department, University Hospital Innenstadt, Ziemssenstrasse 1, 80336 Munich, Germany
    Eur J Endocrinol 151:113-7. 2004
    ..However, little is known about the influence of glucocorticoids on ghrelin levels. We therefore studied human plasma ghrelin levels in the presence and absence of elevated glucocorticoid levels of either endogenous or exogenous origin...
  4. ncbi mu-Opiate receptor agonist loperamide blocks bethanechol-induced gallbladder contraction, despite higher cholecystokinin plasma levels in man
    B Otto
    Department of Internal Medicine Innenstadt, University Hospital, Munich, Germany
    Neurogastroenterol Motil 17:761-6. 2005
    ..The effects of loperamide on gallbladder contraction and peptide release were performed to resolve this discrepancy...
  5. ncbi Post-prandial decrease of human plasma ghrelin in the absence of insulin
    J Spranger
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, Bergholz Rehbrücke, Germany
    J Endocrinol Invest 26:RC19-22. 2003
    ..These data tentatively suggest that post-prandial secretion of ghrelin is not exclusively regulated by plasma insulin or plasma glucose but may depend on other metabolic factors yet to be identified...
  6. ncbi Euglycemic hyperinsulinemia differentially modulates circulating total and acylated-ghrelin in humans
    M O Weickert
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    J Endocrinol Invest 31:119-24. 2008
    ..Factors other than changes in insulin and lipid concentrations are likely to contribute to the previously reported post-prandial reduction of circulating acyl-ghrelin...
  7. ncbi Short-term therapy with atorvastatin or fenofibrate does not affect plasma ghrelin, resistin or adiponectin levels in type 2 diabetic patients with mixed hyperlipoproteinaemia
    C Otto
    Medical Department 2 Grosshadern, University Hospital Munich, Marchioninistrasse 15, D 81377, Munich, Germany
    Acta Diabetol 44:65-8. 2007
    ..In patients with type 2 diabetes and mixed hyperlipoproteinaemia, short-term atorvastatin as well as fenofibrate therapy had no significant effects on adiponectin, ghrelin or resistin levels...
  8. ncbi Effect of human body weight changes on circulating levels of peptide YY and peptide YY3-36
    P T Pfluger
    Department of Psychiatry, University of Cincinnati, Office E 217, Genome Research Institute, 2170 East Galbraith Road, Cincinnati, Ohio 45237, USA
    J Clin Endocrinol Metab 92:583-8. 2007
    ..Although the pharmacological value of PYY is controversial, further study of the secretion of the precursor PYY(1-36) and the pharmacologically active PYY(3-36) is indicated to determine the potential role in energy balance regulation...
  9. ncbi Arabinoxylan consumption decreases postprandial serum glucose, serum insulin and plasma total ghrelin response in subjects with impaired glucose tolerance
    A L Garcia
    Dietary Fibre and the Metabolic Syndrome Group, German Institute of Human Nutrition, Potsdam Rehbruecke, Nuthetal, Germany
    Eur J Clin Nutr 61:334-41. 2007
    ..Therefore, we investigated the postprandial responses to AX consumption of serum glucose, insulin and triglycerides and plasma total and acylated ghrelin in subjects with impaired glucose tolerance (IGT)...
  10. ncbi Regulation of ghrelin is related to estimated insulin sensitivity in obese children
    K Krohn
    Division of Metabolic Diseases and Nutritional Medicine, Dr von Hauner Children's Hospital, University of Munich, Germany
    Int J Obes (Lond) 30:1482-7. 2006
    ..CONCLUSIONS: Changes in ghrelin are independently associated with changes in glucose and insulin metabolism. The increase in plasma ghrelin above control levels was limited to obese children with high WBISI...
  11. ncbi Glucagon suppression of ghrelin secretion is exerted at hypothalamus-pituitary level
    A M Arafat
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Hindenburgdamm 30, 12200 Berlin, Germany
    J Clin Endocrinol Metab 91:3528-33. 2006
    ..The mechanisms underlying the well-known glucagon-induced satiety effect are unclear. Recently, we showed that glucagon induces a remarkable decrease in the orexigenic hormone ghrelin that might be responsible for this effect...
  12. ncbi Increase in adiponectin levels during pioglitazone therapy in relation to glucose control, insulin resistance as well as ghrelin and resistin levels
    C Otto
    Medical Department 2, Grosshadern, University Hospital of Munich, Marchioninistrasse 15, D 81377 Munich, Germany
    J Endocrinol Invest 29:231-6. 2006
    ....
  13. ncbi Effects of euglycemic hyperinsulinemia and lipid infusion on circulating cholecystokinin
    M O Weickert
    Department of Endocrinology, Diabetes, and Nutrition, Charite University Medicine, Campus Benjamin Franklin, Free University of Berlin, Berlin, Germany
    J Clin Endocrinol Metab 93:2328-33. 2008
    ..Postprandial CCK responses are significantly blunted in type 2 diabetic patients by unknown mechanisms. We hypothesized that hyperinsulinemia and lipid infusion influence circulating levels of biologically active CCK...
  14. ncbi Gastric emptying of solid and liquid meals in healthy controls compared with long-term type-1 diabetes mellitus under optimal glucose control
    C Folwaczny
    City Department of Gastroenterology, Ludwig Maximilians University, Munich, Germany
    Exp Clin Endocrinol Diabetes 111:223-9. 2003
    ..Neuropathy of the enteric nervous system and hyperglycaemia are regarded as the main causes of diabetic gastroparesis...
  15. ncbi Postprandial ghrelin release in anorectic patients before and after weight gain
    B Otto
    Department of Medicine, University Hospital Innenstadt, Ziemssenstr 1, 80336 Munich, Germany
    Psychoneuroendocrinology 30:577-81. 2005
    ..These findings indicate that in anorexia nervosa the suppression of ghrelin release by acute changes of energy balance (feeding) is not disturbed and that it is independent from chronic changes in energy balance (weight gain)...
  16. ncbi A prospective study of serum ghrelin levels in patients treated with clozapine
    F M Theisen
    Clinical Research Group, Department of Child and Adolescent Psychiatry, Philipps University, Marburg, Germany
    J Neural Transm 112:1411-6. 2005
    ..Linear mixed model analysis could not detect effects of age, sex, BMI, SLL and serum clozapine levels on SGL. Our results do not support a causal involvement of ghrelin in clozapine-related weight gain...
  17. ncbi Arabinoxylan-enriched meal increases serum ghrelin levels in healthy humans
    M Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbruecke, Nuthetal, Germany
    Horm Metab Res 37:303-8. 2005
    ..This effect is therefore unlikely to be mediated by insulin, but the underlying mechanism remains to be elucidated...
  18. ncbi Glucagon inhibits ghrelin secretion in humans
    M A Arafat
    Department of Endocrinology, Diabetes and Nutrition, Benjamin Franklin Medical Center, Charite University Berlin, Germany
    Eur J Endocrinol 153:397-402. 2005
    ..The aim of the present study was to investigate the role of ghrelin in mediating the stimulatory effects of glucagon and to evaluate the effect of glucagon on ghrelin secretion...
  19. ncbi Euglycemic hyperinsulinemia, but not lipid infusion, decreases circulating ghrelin levels in humans
    M Mohlig
    Department of Clinical Nutrition, German Institute of Human Nutrition Potsdam Rehbrucke, Bergholz Rehbrücke, Germany
    J Endocrinol Invest 25:RC36-8. 2002
    ....
  20. ncbi Effects of duodenal fat, protein or mixed-nutrient infusions on epigastric sensations during sustained gastric distension in healthy humans
    C Feinle
    Gastroenterology Division, University Hospital Zurich, Switzerland
    Neurogastroenterol Motil 14:205-13. 2002
    ..Our results offer new insights into the role of dietary nutrient composition in gastrointestinal sensations, and may have implications for the dietary management of digestive symptoms...
  21. ncbi Ghrelin is not suppressed in hyperglycemic clamps by gastric inhibitory polypeptide and arginine
    Natalia N Rudovich
    Department of Clinical Nutrition, , Arthur-Scheunert-Street 114-116, 14558 Nuthetal, Germany
    Regul Pept 127:95-9. 2005
    ..Moreover, there is no dose-dependent suppression of ghrelin by insulin in the hyperglycemic condition. Neither GIP nor arginine affected ghrelin release...
  22. ncbi Adaptation of the hypothalamic-pituitary hormones during intensive endurance training
    T Bobbert
    Department of Endocrinology, Diabetes and Nutrition, Charite University Medicine Berlin, Campus Benjamin Franklin, Germany
    Clin Endocrinol (Oxf) 63:530-6. 2005
    ..In particular, we focused on adaptations of the hypothalamic-pituitary-adrenocortical (HPA) axis, regarding the activation or inactivation of cortisol to cortisone by the 11beta-hydroxysteroid-dehydrogenase system (11beta-HSD)...