Michael Orth

Summary

Affiliation: University of Ulm
Country: Germany

Publications

  1. ncbi request reprint Caffeine has no effect on measures of cortical excitability
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, London, UK
    Clin Neurophysiol 116:308-14. 2005
  2. doi request reprint Transcranial magnetic stimulation studies of sensorimotor networks in Tourette syndrome
    Michael Orth
    Department of Neurology, University of Ulm, Ulm, Germany
    Behav Neurol 27:57-64. 2013
  3. doi request reprint Motor cortex excitability and comorbidity in Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 80:29-34. 2009
  4. doi request reprint Transcranial magnetic stimulation in Gilles de la Tourette syndrome
    Michael Orth
    Department of Neurology, Universitatsklinikum Ulm, Ulm, Germany
    J Psychosom Res 67:591-8. 2009
  5. pmc Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 81:267-70. 2010
  6. ncbi request reprint Imitation in patients with Gilles de la Tourette syndrome--a behavioral study
    Melanie Jonas
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:991-9. 2010
  7. doi request reprint Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
    Tobias Bäumer
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:2828-37. 2010
  8. pmc Abnormal motor cortex excitability in preclinical and very early Huntington's disease
    Sven Schippling
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Biol Psychiatry 65:959-65. 2009
  9. doi request reprint Corticospinal system excitability at rest is associated with tic severity in tourette syndrome
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 64:248-51. 2008
  10. doi request reprint Fragile X syndrome associated with tic disorders
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:1108-12. 2008

Detail Information

Publications36

  1. ncbi request reprint Caffeine has no effect on measures of cortical excitability
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, London, UK
    Clin Neurophysiol 116:308-14. 2005
    ..To assess the effect of caffeine on motor thresholds, short interval intra-cortical inhibition (SICI), intra-cortical facilitation (ICF) and cortical silent periods in a placebo controlled double-blinded trial...
  2. doi request reprint Transcranial magnetic stimulation studies of sensorimotor networks in Tourette syndrome
    Michael Orth
    Department of Neurology, University of Ulm, Ulm, Germany
    Behav Neurol 27:57-64. 2013
    ..In GTS the gain of many motor circuits may be reduced and hence less sensitive to small changes in input from other areas. These cortical changes may constitute an adaptive response to abnormal basal ganglia-motor cortex inputs...
  3. doi request reprint Motor cortex excitability and comorbidity in Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 80:29-34. 2009
    ..This study examines whether motor cortex excitability differs between uncomplicated GTS patients and those complicated by ADHD or OCD...
  4. doi request reprint Transcranial magnetic stimulation in Gilles de la Tourette syndrome
    Michael Orth
    Department of Neurology, Universitatsklinikum Ulm, Ulm, Germany
    J Psychosom Res 67:591-8. 2009
    ..The extent to which various different neuronal circuits are affected may be relevant for the phenotype of Tourette spectrum disorders...
  5. pmc Abnormal motor cortex plasticity in premanifest and very early manifest Huntington disease
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 81:267-70. 2010
    ....
  6. ncbi request reprint Imitation in patients with Gilles de la Tourette syndrome--a behavioral study
    Melanie Jonas
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:991-9. 2010
    ..Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients...
  7. doi request reprint Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndrome
    Tobias Bäumer
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 25:2828-37. 2010
    ..Our combined TMS-DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure-function relationship in the motor CC...
  8. pmc Abnormal motor cortex excitability in preclinical and very early Huntington's disease
    Sven Schippling
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Biol Psychiatry 65:959-65. 2009
    ..In Huntington's disease (HD), the cerebral cortex is involved early in the disease process. The study of cortical excitability can therefore contribute to understanding HD pathophysiology...
  9. doi request reprint Corticospinal system excitability at rest is associated with tic severity in tourette syndrome
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 64:248-51. 2008
    ..However, it is not clear whether these represent abnormalities of specific pathways or reflect a more widespread reduction of motor cortex excitability. Their significance for the clinical phenotype is also unknown...
  10. doi request reprint Fragile X syndrome associated with tic disorders
    Susanne A Schneider
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
    Mov Disord 23:1108-12. 2008
    ..We suggest considering fragile X syndrome in GTS complicated by co-morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present...
  11. ncbi request reprint Progressive hepatic mitochondrial dysfunction in premanifest Huntington's disease
    Rainer Hoffmann
    Department of Neurology, Huntington Center NRW, Ruhr University Bochum, St Josef Hospital, Bochum, Germany
    Mov Disord 29:831-4. 2014
    ..In this longitudinal pilot study, we investigated whether there is evidence for progressive hepatic mitochondrial dysfunction in premanifest HD...
  12. doi request reprint Effects of DBS, premotor rTMS, and levodopa on motor function and silent period in advanced Parkinson's disease
    Tobias Bäumer
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 24:672-6. 2009
    ..e., only partially reversed abnormal motor network activity...
  13. doi request reprint Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndrome
    Gotz Thomalla
    Department of Neurology, University Medial Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
    Brain 132:765-77. 2009
    ..The negative correlation between higher regional FA values and fewer tics suggests that these alterations of white matter microstructure represent adaptive reorganization of somatosensory processing in GTS...
  14. ncbi request reprint Excitability of motor cortex inhibitory circuits in Tourette syndrome before and after single dose nicotine
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Queen Square, London WC1N 3BG, UK
    Brain 128:1292-300. 2005
    ..This indicates that cholinergic input can modulate the efficiency of SICI and SAI differently in GTS and healthy controls...
  15. ncbi request reprint Intracortical inhibition is reduced in a patient with a lesion in the posterolateral thalamus
    Alexander Munchau
    Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
    Mov Disord 17:208-12. 2002
    ....
  16. doi request reprint Prevalence and phenomenology of eye tics in Gilles de la Tourette syndrome
    Davide Martino
    Neuroscience and Trauma Centre, Barts and The London School Medicine and Dentistry, Queen Mary University of London, London, UK
    J Neurol 259:2137-40. 2012
    ..Eye tic phenomenology was similar in patients with or without co-morbidity. Eye tics are therefore likely to be a core feature of GTS and should be routinely evaluated in order to strengthen the clinician's confidence in diagnosing GTS...
  17. doi request reprint Rate of change in early Huntington's disease: a clinicometric analysis
    Christina Meyer
    Department of Neurology, University of Ulm, Ulm, Germany
    Mov Disord 27:118-24. 2012
    ..It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies...
  18. pmc Observing Huntington's Disease: the European Huntington's Disease Network's REGISTRY
    Michael Orth
    Department of Neurology, University of Ulm, Ulm Germany
    PLoS Curr 2:RRN1184. 2010
    ....
  19. ncbi request reprint Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE gene
    Michael Orth
    Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
    Mov Disord 22:2090-6. 2007
    ..No changes were found in the SLITRK1 gene. The presence of both M-D and GTS in one family, in which all known M-D loci and a recently discovered GTS locus were excluded, suggests a novel susceptibility gene for both M-D and GTS...
  20. ncbi request reprint Motor inhibition in patients with Gilles de la Tourette syndrome: functional activation patterns as revealed by EEG coherence
    Deborah J Serrien
    Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square, London WC1N 3BG, UK
    Brain 128:116-25. 2005
    ..It is concluded that the gain in inhibitory frontomesial cortical networks is adaptively heightened in TS, and that the same network can also be engaged in the voluntary suppression of tics...
  21. ncbi request reprint Antineuronal antibody status and phenotype analysis in Tourette's syndrome
    Davide Martino
    Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
    Mov Disord 22:1424-9. 2007
    ..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS...
  22. ncbi request reprint The variability of intracortical inhibition and facilitation
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Institute of Neurology, Box 77, Royal Free and University College Medical School, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 114:2362-9. 2003
    ..To assess the variability of transcranial magnetic stimulation paired pulse measurements of cortical excitability between subjects, between sessions and within subjects within sessions...
  23. pmc Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome
    A H Snijders
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 77:787-9. 2006
    ..The BDI score had a high negative predictive value for diagnosis of MDD, but a low positive predictive value. Using the BDI as a screening tool for comorbid MDD in patients with GTS is suggested...
  24. ncbi request reprint Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients
    M A S Y Wright
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK
    Neurology 67:1646-51. 2006
    ..To test the hypothesis that cortical excitability changes prior to seizures, using transcranial magnetic brain stimulation (TMS)...
  25. pmc Mirtazapine increases cortical excitability in healthy controls and epilepsy patients with major depression
    A Munchau
    Sobell Department of Motor Neuroscience and Movement Disorders, Dept of Clinical and Experimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 76:527-33. 2005
    ..Epilepsy is often complicated by depression requiring antidepressant treatment. Such treatment might be proconvulsive...
  26. doi request reprint Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS study
    T Baumer
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Neurophysiol 120:1724-31. 2009
    ..In macaques, intracortical electrical stimulation of ventral premotor cortex (PMv) can modulate ipsilateral primary motor cortex (M1) excitability at short interstimulus intervals (ISIs)...
  27. ncbi request reprint Hepatic mitochondrial dysfunction in manifest and premanifest Huntington disease
    Sven H Stüwe
    Department of Neurology, Huntington Centre NRW, Ruhr University Bochum, Bochum, Germany
    Neurology 80:743-6. 2013
    ..In this cross-sectional study, we investigated whether there is evidence for hepatic mitochondrial dysfunction in manifest and/or premanifest Huntington disease (HD) by using the ¹³C-methionine breath test...
  28. doi request reprint Predictors during childhood of future health-related quality of life in adults with Gilles de la Tourette syndrome
    Andrea E Cavanna
    Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, United Kingdom
    Eur J Paediatr Neurol 16:605-12. 2012
    ..The diagnosis of GTS is usually established in childhood but little is known about factors that predict the long-term well-being of patients, especially in the presence of co-morbid behavioural problems...
  29. pmc Age-at-onset in Huntington disease
    Michael Orth
    Department of Neurology, University of Ulm, Ulm, Germany and Independent Statistical Consultant, SCOSSiS, Germany
    PLoS Curr 3:RRN1258. 2011
    ....
  30. ncbi request reprint Models of Parkinson's disease
    Michael Orth
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, United Kingdom
    Mov Disord 18:729-37. 2003
    ..This study briefly reviews toxin-induced models and the genetics of PD. It focuses on recently developed animal models of PD, as well as in vitro approaches to model the disease...
  31. pmc Abnormal peripheral chemokine profile in Huntington's disease
    Edward Wild
    UCL Institute of Neurology, London, UK Bristol University, UK Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK Lund University Diabetes Center Malmö Sweden and Department of Neurology, University of Ulm, Ulm, Germany
    PLoS Curr 3:RRN1231. 2011
    ..We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD...
  32. ncbi request reprint Grip force behavior in Gilles de la Tourette syndrome
    Dennis A Nowak
    Sobell Department of Motor Neuroscience and Movements Disorders, Institute of Neurology, University of London, London, United Kingdom
    Mov Disord 20:217-23. 2005
    ..We found no significant effect of medication on the performance of GTS patients, regardless of the task performed. These results are consistent with deficient sensory-motor processing in Gilles de la Tourette syndrome...
  33. ncbi request reprint The cortical silent period: intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulse
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Institute of Neurology, London, UK
    Clin Neurophysiol 115:1076-82. 2004
    ..To assess the variability of the duration of the contralateral cortical silent period (CSP) between individuals and to assess the effect of different transcranial magnetic stimulation (TMS) pulse waveforms...
  34. ncbi request reprint Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Box 77, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 116:764-8. 2005
    ..We modified the rTMS protocol in order to investigate some of the possible methodological reasons for the negative outcome in that study...
  35. doi request reprint The Gilles de la Tourette syndrome-quality of life scale (GTS-QOL): development and validation
    A E Cavanna
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N3BG, UK
    Neurology 71:1410-6. 2008
    ..However, no patient-reported HR-QOL measures have been developed for this population...
  36. ncbi request reprint Soluble adhesion molecules in Gilles de la Tourette's syndrome
    D Martino
    Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 234:79-85. 2005
    ..These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and support the hypothesis of an ongoing immune-mediated process in this condition...