Research Topics
Species | Michael OrthSummaryAffiliation: University of Ulm Country: Germany Publications
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Publications
Caffeine has no effect on measures of cortical excitabilityM Orth
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, London, UK
Clin Neurophysiol 116:308-14. 2005..To assess the effect of caffeine on motor thresholds, short interval intra-cortical inhibition (SICI), intra-cortical facilitation (ICF) and cortical silent periods in a placebo controlled double-blinded trial...
Transcranial magnetic stimulation in Gilles de la Tourette syndromeMichael Orth
Department of Neurology, Universitatsklinikum Ulm, Ulm, Germany
J Psychosom Res 67:591-8. 2009..The extent to which various different neuronal circuits are affected may be relevant for the phenotype of Tourette spectrum disorders...
Abnormal motor cortex plasticity in premanifest and very early manifest Huntington diseaseMichael Orth
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 81:267-70. 2010....- Motor cortex excitability and comorbidity in Gilles de la Tourette syndromeM Orth
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
J Neurol Neurosurg Psychiatry 80:29-34. 2009..This study examines whether motor cortex excitability differs between uncomplicated GTS patients and those complicated by ADHD or OCD... - Imitation in patients with Gilles de la Tourette syndrome--a behavioral studyMelanie Jonas
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Mov Disord 25:991-9. 2010..Thus, movement stimuli may facilitate similar motor responses less but interfere more with different responses in these patients... - Interhemispheric motor networks are abnormal in patients with Gilles de la Tourette syndromeTobias Bäumer
Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Mov Disord 25:2828-37. 2010..Our combined TMS-DTI approach demonstrates abnormal functional interhemispheric connectivity in GTS accompanied by an altered structure-function relationship in the motor CC... - Abnormal motor cortex excitability in preclinical and very early Huntington's diseaseSven Schippling
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Biol Psychiatry 65:959-65. 2009..In Huntington's disease (HD), the cerebral cortex is involved early in the disease process. The study of cortical excitability can therefore contribute to understanding HD pathophysiology... - Corticospinal system excitability at rest is associated with tic severity in tourette syndromeMichael Orth
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
Biol Psychiatry 64:248-51. 2008..However, it is not clear whether these represent abnormalities of specific pathways or reflect a more widespread reduction of motor cortex excitability. Their significance for the clinical phenotype is also unknown... - Fragile X syndrome associated with tic disordersSusanne A Schneider
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, United Kingdom
Mov Disord 23:1108-12. 2008..We suggest considering fragile X syndrome in GTS complicated by co-morbidity with late onset of atypical tics, in particular when learning disability and dysmorphic features are present... - Structural changes in the somatosensory system correlate with tic severity in Gilles de la Tourette syndromeGotz Thomalla
Department of Neurology, University Medial Center Hamburg Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany
Brain 132:765-77. 2009..The negative correlation between higher regional FA values and fewer tics suggests that these alterations of white matter microstructure represent adaptive reorganization of somatosensory processing in GTS... - Effects of DBS, premotor rTMS, and levodopa on motor function and silent period in advanced Parkinson's diseaseTobias Bäumer
Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Mov Disord 24:672-6. 2009..e., only partially reversed abnormal motor network activity... - Excitability of motor cortex inhibitory circuits in Tourette syndrome before and after single dose nicotineM Orth
Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Queen Square, London WC1N 3BG, UK
Brain 128:1292-300. 2005..This indicates that cholinergic input can modulate the efficiency of SICI and SAI differently in GTS and healthy controls... - Rate of change in early Huntington's disease: a clinicometric analysisChristina Meyer
Department of Neurology, University of Ulm, Ulm, Germany
Mov Disord 27:118-24. 2012..It may be possible to select sensitive items to create a simplified version of the UHDRS, which would be more efficient and more sensitive for the assessment of disease progression in clinical trials and natural history studies... - Autosomal dominant myoclonus-dystonia and Tourette syndrome in a family without linkage to the SGCE geneMichael Orth
Department of Neurology, University Medical Centre Hamburg Eppendorf, Hamburg, Germany
Mov Disord 22:2090-6. 2007..No changes were found in the SLITRK1 gene. The presence of both M-D and GTS in one family, in which all known M-D loci and a recently discovered GTS locus were excluded, suggests a novel susceptibility gene for both M-D and GTS... - Intracortical inhibition is reduced in a patient with a lesion in the posterolateral thalamusAlexander Munchau
Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Queen Square, London, United Kingdom
Mov Disord 17:208-12. 2002.... - Antineuronal antibody status and phenotype analysis in Tourette's syndromeDavide Martino
Department of Neuroinflammation, Institute of Neurology, University College London, London, United Kingdom
Mov Disord 22:1424-9. 2007..14; P = 0.002; 95% confidence interval 0.04-0.49). ANeA status does not differentiate a specific phenotype of GTS... - Motor inhibition in patients with Gilles de la Tourette syndrome: functional activation patterns as revealed by EEG coherenceDeborah J Serrien
Sobell Department of Motor Neuroscience and Movement Disorders Box 146, Institute of Neurology, Queen Square, London WC1N 3BG, UK
Brain 128:116-25. 2005..It is concluded that the gain in inhibitory frontomesial cortical networks is adaptively heightened in TS, and that the same network can also be engaged in the voluntary suppression of tics... - Prevalence and phenomenology of eye tics in Gilles de la Tourette syndromeDavide Martino
Neuroscience and Trauma Centre, Barts and The London School Medicine and Dentistry, Queen Mary University of London, London, UK
J Neurol 259:2137-40. 2012..Eye tic phenomenology was similar in patients with or without co-morbidity. Eye tics are therefore likely to be a core feature of GTS and should be routinely evaluated in order to strengthen the clinician's confidence in diagnosing GTS... - Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndromeA H Snijders
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 77:787-9. 2006..The BDI score had a high negative predictive value for diagnosis of MDD, but a low positive predictive value. Using the BDI as a screening tool for comorbid MDD in patients with GTS is suggested... - The variability of intracortical inhibition and facilitationM Orth
Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Institute of Neurology, Box 77, Royal Free and University College Medical School, Queen Square, London WC1N 3BG, UK
Clin Neurophysiol 114:2362-9. 2003..To assess the variability of transcranial magnetic stimulation paired pulse measurements of cortical excitability between subjects, between sessions and within subjects within sessions... - Mirtazapine increases cortical excitability in healthy controls and epilepsy patients with major depressionA Munchau
Sobell Department of Motor Neuroscience and Movement Disorders, Dept of Clinical and Experimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
J Neurol Neurosurg Psychiatry 76:527-33. 2005..Epilepsy is often complicated by depression requiring antidepressant treatment. Such treatment might be proconvulsive... - Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS studyT Baumer
Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
Clin Neurophysiol 120:1724-31. 2009..In macaques, intracortical electrical stimulation of ventral premotor cortex (PMv) can modulate ipsilateral primary motor cortex (M1) excitability at short interstimulus intervals (ISIs)... - Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patientsM-A S Y Wright
Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK
Neurology 67:1646-51. 2006..001). CONCLUSIONS: Change in cortical excitability, measured with transcranial magnetic brain stimulation, may reflect a long-lasting and widespread pre-ictal state... - Transcranial magnetic stimulation studies of sensorimotor networks in Tourette syndromeMichael Orth
Department of Neurology, University of Ulm, Ulm, Germany
Behav Neurol 27:57-64. 2013..In GTS the gain of many motor circuits may be reduced and hence less sensitive to small changes in input from other areas. These cortical changes may constitute an adaptive response to abnormal basal ganglia-motor cortex inputs... - Predictors during childhood of future health-related quality of life in adults with Gilles de la Tourette syndromeAndrea E Cavanna
Department of Neuropsychiatry, University of Birmingham and BSMHFT, Birmingham, United Kingdom
Eur J Paediatr Neurol 16:605-12. 2012..The diagnosis of GTS is usually established in childhood but little is known about factors that predict the long-term well-being of patients, especially in the presence of co-morbid behavioural problems... - Age-at-onset in Huntington diseaseMichael Orth
Department of Neurology, University of Ulm, Ulm, Germany and Independent Statistical Consultant, SCOSSiS, Germany
PLoS Curr 3:RRN1258. 2011.... - Abnormal peripheral chemokine profile in Huntington's diseaseEdward Wild
UCL Institute of Neurology, London, UK Bristol University, UK Department of Experimental Medical Science, Wallenberg Neuroscience Center, Lund University, Lund, Sweden Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK Lund University Diabetes Center Malmö Sweden and Department of Neurology, University of Ulm, Ulm, Germany
PLoS Curr 3:RRN1231. 2011..We conclude that, like cytokines, chemokines may be linked to the pathogenesis of HD, and that immune molecules may be valuable in tracking and exploring the pathogenesis of HD... - Models of Parkinson's diseaseMichael Orth
Department of Clinical and Experimental Epilepsy, Institute of Neurology, London, United Kingdom
Mov Disord 18:729-37. 2003..This study briefly reviews toxin-induced models and the genetics of PD. It focuses on recently developed animal models of PD, as well as in vitro approaches to model the disease... - Grip force behavior in Gilles de la Tourette syndromeDennis A Nowak
Sobell Department of Motor Neuroscience and Movements Disorders, Institute of Neurology, University of London, London, United Kingdom
Mov Disord 20:217-23. 2005..We found no significant effect of medication on the performance of GTS patients, regardless of the task performed. These results are consistent with deficient sensory-motor processing in Gilles de la Tourette syndrome... - Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndromeM Orth
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Box 77, Queen Square, London WC1N 3BG, UK
Clin Neurophysiol 116:764-8. 2005..We modified the rTMS protocol in order to investigate some of the possible methodological reasons for the negative outcome in that study... - The cortical silent period: intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulseM Orth
Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Institute of Neurology, London, UK
Clin Neurophysiol 115:1076-82. 2004..To assess the variability of the duration of the contralateral cortical silent period (CSP) between individuals and to assess the effect of different transcranial magnetic stimulation (TMS) pulse waveforms... - The Gilles de la Tourette syndrome-quality of life scale (GTS-QOL): development and validationA E Cavanna
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N3BG, UK
Neurology 71:1410-6. 2008..However, no patient-reported HR-QOL measures have been developed for this population... - Soluble adhesion molecules in Gilles de la Tourette's syndromeD Martino
Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
J Neurol Sci 234:79-85. 2005..These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and support the hypothesis of an ongoing immune-mediated process in this condition...