M Orth

Summary

Affiliation: University of Hamburg
Country: Germany

Publications

  1. ncbi request reprint Friedrich Nietzsche's mental illness--general paralysis of the insane vs. frontotemporal dementia
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    Acta Psychiatr Scand 114:439-44; discussion 445. 2006
  2. doi request reprint Corticospinal system excitability at rest is associated with tic severity in tourette syndrome
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 64:248-51. 2008
  3. ncbi request reprint Excitability of motor cortex inhibitory circuits in Tourette syndrome before and after single dose nicotine
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Queen Square, London WC1N 3BG, UK
    Brain 128:1292-300. 2005
  4. ncbi request reprint Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients
    M A S Y Wright
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK
    Neurology 67:1646-51. 2006
  5. doi request reprint Motor cortex excitability and comorbidity in Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 80:29-34. 2009
  6. ncbi request reprint Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Box 77, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 116:764-8. 2005
  7. ncbi request reprint Caffeine has no effect on measures of cortical excitability
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, London, UK
    Clin Neurophysiol 116:308-14. 2005
  8. pmc Mirtazapine increases cortical excitability in healthy controls and epilepsy patients with major depression
    A Munchau
    Sobell Department of Motor Neuroscience and Movement Disorders, Dept of Clinical and Experimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 76:527-33. 2005
  9. pmc Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome
    A H Snijders
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 77:787-9. 2006
  10. ncbi request reprint The cortical silent period: intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulse
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Institute of Neurology, London, UK
    Clin Neurophysiol 115:1076-82. 2004

Detail Information

Publications25

  1. ncbi request reprint Friedrich Nietzsche's mental illness--general paralysis of the insane vs. frontotemporal dementia
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    Acta Psychiatr Scand 114:439-44; discussion 445. 2006
    ..For a long time it was thought that Nietzsche suffered from general paralysis of the insane (GPI). However, this diagnosis has been questioned recently, and alternative diagnoses have been proposed...
  2. doi request reprint Corticospinal system excitability at rest is associated with tic severity in tourette syndrome
    Michael Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, United Kingdom
    Biol Psychiatry 64:248-51. 2008
    ..However, it is not clear whether these represent abnormalities of specific pathways or reflect a more widespread reduction of motor cortex excitability. Their significance for the clinical phenotype is also unknown...
  3. ncbi request reprint Excitability of motor cortex inhibitory circuits in Tourette syndrome before and after single dose nicotine
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Queen Square, London WC1N 3BG, UK
    Brain 128:1292-300. 2005
    ..This indicates that cholinergic input can modulate the efficiency of SICI and SAI differently in GTS and healthy controls...
  4. ncbi request reprint Cortical excitability predicts seizures in acutely drug-reduced temporal lobe epilepsy patients
    M A S Y Wright
    Department of Clinical and Experimental Epilepsy, Institute of Neurology, University College London, UK
    Neurology 67:1646-51. 2006
    ..To test the hypothesis that cortical excitability changes prior to seizures, using transcranial magnetic brain stimulation (TMS)...
  5. doi request reprint Motor cortex excitability and comorbidity in Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, London, UK
    J Neurol Neurosurg Psychiatry 80:29-34. 2009
    ..This study examines whether motor cortex excitability differs between uncomplicated GTS patients and those complicated by ADHD or OCD...
  6. ncbi request reprint Subthreshold rTMS over pre-motor cortex has no effect on tics in patients with Gilles de la Tourette syndrome
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Box 77, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 116:764-8. 2005
    ..We modified the rTMS protocol in order to investigate some of the possible methodological reasons for the negative outcome in that study...
  7. ncbi request reprint Caffeine has no effect on measures of cortical excitability
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology and The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, London, UK
    Clin Neurophysiol 116:308-14. 2005
    ..To assess the effect of caffeine on motor thresholds, short interval intra-cortical inhibition (SICI), intra-cortical facilitation (ICF) and cortical silent periods in a placebo controlled double-blinded trial...
  8. pmc Mirtazapine increases cortical excitability in healthy controls and epilepsy patients with major depression
    A Munchau
    Sobell Department of Motor Neuroscience and Movement Disorders, Dept of Clinical and Experimental Epilepsy, Institute of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 76:527-33. 2005
    ..Epilepsy is often complicated by depression requiring antidepressant treatment. Such treatment might be proconvulsive...
  9. pmc Beck Depression Inventory is a useful screening tool for major depressive disorder in Gilles de la Tourette syndrome
    A H Snijders
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London, UK
    J Neurol Neurosurg Psychiatry 77:787-9. 2006
    ..The BDI score had a high negative predictive value for diagnosis of MDD, but a low positive predictive value. Using the BDI as a screening tool for comorbid MDD in patients with GTS is suggested...
  10. ncbi request reprint The cortical silent period: intrinsic variability and relation to the waveform of the transcranial magnetic stimulation pulse
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Royal Free and University College Medical School, Institute of Neurology, London, UK
    Clin Neurophysiol 115:1076-82. 2004
    ..To assess the variability of the duration of the contralateral cortical silent period (CSP) between individuals and to assess the effect of different transcranial magnetic stimulation (TMS) pulse waveforms...
  11. doi request reprint Inhibitory and facilitatory connectivity from ventral premotor to primary motor cortex in healthy humans at rest--a bifocal TMS study
    T Baumer
    Department of Neurology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Clin Neurophysiol 120:1724-31. 2009
    ..In macaques, intracortical electrical stimulation of ventral premotor cortex (PMv) can modulate ipsilateral primary motor cortex (M1) excitability at short interstimulus intervals (ISIs)...
  12. ncbi request reprint Soluble adhesion molecules in Gilles de la Tourette's syndrome
    D Martino
    Neuroimmunology Unit, Department of Neuroinflammation, Institute of Neurology, University College London, Queen Square, London WC1N 3BG, UK
    J Neurol Sci 234:79-85. 2005
    ..These results provide initial evidence for a role of adhesion molecules and systemic inflammation in TS, and support the hypothesis of an ongoing immune-mediated process in this condition...
  13. doi request reprint The Gilles de la Tourette syndrome-quality of life scale (GTS-QOL): development and validation
    A E Cavanna
    Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, Queen Square, London WC1N3BG, UK
    Neurology 71:1410-6. 2008
    ..However, no patient-reported HR-QOL measures have been developed for this population...
  14. ncbi request reprint The variability of intracortical inhibition and facilitation
    M Orth
    Sobell Department of Motor Neuroscience and Movement Disorders, The National Hospital for Neurology and Neurosurgery, Institute of Neurology, Box 77, Royal Free and University College Medical School, Queen Square, London WC1N 3BG, UK
    Clin Neurophysiol 114:2362-9. 2003
    ..To assess the variability of transcranial magnetic stimulation paired pulse measurements of cortical excitability between subjects, between sessions and within subjects within sessions...
  15. ncbi request reprint Characterization of matrix metalloproteinases in denervated muscle
    M Demestre
    Department of Clinical Neurosciences, Guy s, King s and St Thomas School of Medicine, London, SEI 1UL, UK
    Neuropathol Appl Neurobiol 31:545-55. 2005
    ..Further experiments are required to test the hypothesis that MMP inhibition may be beneficial in protecting muscle from excessive remodelling following denervation and therefore improve reinnervation...
  16. pmc Video assessment of rTMS for Tourette syndrome
    A H Snijders
    J Neurol Neurosurg Psychiatry 76:1743-4. 2005
  17. ncbi request reprint [Estimation of accident risk in obstructive sleep apnea syndrome (OSAS) by driving simulation]
    M Orth
    Berufsgenossenschaftliche Kliniken Bergmannsheil, Klinikum der Ruhr Universitat Bochum, Germany
    Pneumologie 56:13-8. 2002
    ..The driving simulator C.A.R. is an adequate tool for the evaluation of an increased accident risk in OSAS-patients and demonstrates the efficiency of CPAP-therapy...
  18. ncbi request reprint Investigations of the dynamic behaviour of the composition of combined sewage using on-line analyzers
    H Grüning
    Institute of Environmental Engineering, Ruhr University of Bochum, Germany
    Water Sci Technol 45:77-83. 2002
    ..However, due to the adverse conditions in a sewer system operational disturbances and stringent maintenance requirements are still an impediment to long-term operation...
  19. ncbi request reprint [Accidents caused by sleepiness--prediction by neurophysiologic/psychologic testing and simulated driving studies]
    M Orth
    Berufsgenossenschaftliche Kliniken Bergmannsheil Klinikum, Ruhr Universitat Bochum, Medizinische Klinik und Poliklinik, Abteilung fur Pneumologie, Allergologie und Schlafmedizin, Burkle de la Camp Platz 1, 44789 Bochum
    Biomed Tech (Berl) 48:55-61. 2003
    ..Our results suggest that the nearness of driving simulation to reality makes it a suitable additional test method, in particular for the monitoring of results under treatment...
  20. ncbi request reprint [Influence of nocturnal oxygen therapy on quality of life in patients with COPD and isolated sleep-related hypoxemia: a prospective, placebo-controlled cross-over trial]
    M Orth
    Berufsgenossenschaftliches Universitätsklinikum Bergmannsheil GmbH, Medizinische Klinik III, Pneumologie, Allergologie, Schlaf und Beatmungsmedizin, Bochum
    Pneumologie 62:11-6. 2008
    ..The aim of the present pilot study was to investigate the influence of nocturnal oxygen therapy on the quality of life in daytime normoxemic COPD patients with nocturnal oxygen desaturations...
  21. ncbi request reprint [Are there alternative therapeutical options other than CPAP in the treatment of the obstructive sleep apnea syndrome]
    W Randerath
    Institut für Pneumologie, Universitat Witten Herdecke, Krankenhaus Bethanien, Klinik für Pneumologie und Allergologie, Zentrum für Schlaf und Beatmungsmedizin, Solingen, Germany
    Pneumologie 61:458-66. 2007
    ..There is no evidence for any other treatment options...
  22. ncbi request reprint [Expert opinions regarding daytime sleepiness in neurological diseases and obstructive sleep apnea syndrome]
    S Kotterba
    Neurologische Klinik und Poliklinik, BG Kliniken Bergmannsheil, Universitatsklinik, Ruhr Universitat Bochum, Burkle de la Camp Platz 1, 44789, Bochum, Germany
    Nervenarzt 78:861-70. 2007
    ..In the present paper the legal guidelines in Germany and available test methods are presented...
  23. ncbi request reprint Halothane and propofol differentially affect electroencephalographic responses to noxious stimulation
    M Orth
    Department of Anesthesiology and Pain Medicine, University of California, Davis, 95616, USA
    Br J Anaesth 95:477-84. 2005
    ..We investigated the actions of propofol and halothane on EEG responses to noxious stimuli, including repetitive electrical C-fibre stimulation, which normally evokes neuronal wind-up...
  24. ncbi request reprint Driving simulator and neuropsychological [corrected] testing in OSAS before and under CPAP therapy
    M Orth
    University Hospital Bergmannsheil, Dept of Internal Medicine, Division of Pneumology, Allergology and Sleep Medicine, Burkle de la Camp Platz 1, 44789 Bochum, Germany
    Eur Respir J 26:898-903. 2005
    ..In conclusion, the present results suggest that driving simulation is a possible benchmark parameter of driving performance in obstructive sleep apnoea syndrome patients...
  25. ncbi request reprint [Incidence of chronic obstructive respiratory tract disease in patients with obstructive sleep apnea]
    M Orth
    Berufsgenossenschaftliche Kliniken Bergmannsheil, Medizinische Klinik und Poliklinik, , Allergologie und Schlafmedizin, Bochum
    Pneumologie 50:286-9. 1996
    ..As there is a high risk of developing hypercapnia, pulmonary arterial hypertension and cor pulmonale in patients with OSAS and COPD there is need for early diagnosis of the combination of both diseases...