C Opherk

Summary

Affiliation: University of Munich
Country: Germany

Publications

  1. ncbi request reprint Subarachnoid hemorrhage and diplopia as initial presentation of polycythemia vera
    Christian Opherk
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Cerebrovasc Dis 19:279-80. 2005
  2. ncbi request reprint Successful bilateral pallidal stimulation for Meige syndrome and spasmodic torticollis
    C Opherk
    Department of Neurology, Klinikum Grosshadern Marchioninistr 15, D 81377 Munich, Germany
    Neurology 66:E14. 2006
  3. pmc Age determination of vessel wall hematoma in spontaneous cervical artery dissection: a multi-sequence 3T cardiovascular magnetic resonance study
    Maximilian Habs
    Dept, of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    J Cardiovasc Magn Reson 13:76. 2011
  4. ncbi request reprint The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementia
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Am J Psychiatry 162:2078-85. 2005
  5. doi request reprint Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL
    Nils Peters
    Dept of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 255:1203-8. 2008
  6. doi request reprint Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patients
    Thomas Pfefferkorn
    Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Stroke 39:1496-500. 2008
  7. ncbi request reprint Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASIL
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    J Neurol Sci 260:100-5. 2007
  8. doi request reprint CADASIL mutations enhance spontaneous multimerization of NOTCH3
    Christian Opherk
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Hum Mol Genet 18:2761-7. 2009
  9. ncbi request reprint Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients
    Christian Opherk
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Brain 127:2533-9. 2004
  10. ncbi request reprint Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study
    Markus Holtmannspotter
    Abteilung fur Neuroradiologie, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Stroke 36:2559-65. 2005

Collaborators

Detail Information

Publications12

  1. ncbi request reprint Subarachnoid hemorrhage and diplopia as initial presentation of polycythemia vera
    Christian Opherk
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Cerebrovasc Dis 19:279-80. 2005
  2. ncbi request reprint Successful bilateral pallidal stimulation for Meige syndrome and spasmodic torticollis
    C Opherk
    Department of Neurology, Klinikum Grosshadern Marchioninistr 15, D 81377 Munich, Germany
    Neurology 66:E14. 2006
  3. pmc Age determination of vessel wall hematoma in spontaneous cervical artery dissection: a multi-sequence 3T cardiovascular magnetic resonance study
    Maximilian Habs
    Dept, of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
    J Cardiovasc Magn Reson 13:76. 2011
    ..Using these classifications, we systematically investigated the value of cardiovascular magnetic resonance (CMR) in determining the age of vessel wall hematoma (VWH) in patients with spontaneous cervical artery dissection (sCAD)...
  4. ncbi request reprint The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementia
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    Am J Psychiatry 162:2078-85. 2005
    ..Mutation carriers almost invariably develop cognitive deficits and eventually dementia. The current study describes the profile of cognitive abnormalities in CADASIL subjects...
  5. doi request reprint Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASIL
    Nils Peters
    Dept of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
    J Neurol 255:1203-8. 2008
    ..Vasoreactivity induced by L-arginine, which is the substrate for endothelial nitric oxide synthase, is a parameter of endothelial function and has been shown to be altered in patients with cerebrovascular disease...
  6. doi request reprint Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patients
    Thomas Pfefferkorn
    Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
    Stroke 39:1496-500. 2008
    ..The combination of IVT with consecutive on-demand EMT may allow for early treatment initiation with high recanalization rates but has never been systematically tested in patients with BAO...
  7. ncbi request reprint Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASIL
    Nils Peters
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
    J Neurol Sci 260:100-5. 2007
    ..CADASIL is a monogenic form of SVD caused by mutations in the Notch3 gene. Treatment options are limited and little is known about the therapeutic role of statins in CADASIL...
  8. doi request reprint CADASIL mutations enhance spontaneous multimerization of NOTCH3
    Christian Opherk
    Department of Neurology, Ludwig Maximilians University, Munich, Germany
    Hum Mol Genet 18:2761-7. 2009
    ..Taken together, our results for the first time provide experimental evidence for N3 self-association and strongly argue for a neomorphic effect of CADASIL mutations in disease pathogenesis...
  9. ncbi request reprint Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patients
    Christian Opherk
    Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Brain 127:2533-9. 2004
    ..Our findings suggest possible genotype-phenotype correlations with regard to disease progression. The data presented may serve as source material for counselling CADASIL patients and for designing future interventional trials...
  10. ncbi request reprint Diffusion magnetic resonance histograms as a surrogate marker and predictor of disease progression in CADASIL: a two-year follow-up study
    Markus Holtmannspotter
    Abteilung fur Neuroradiologie, Klinikum Grosshadern, Ludwig Maximilians Universitat, Munich, Germany
    Stroke 36:2559-65. 2005
    ..In this study, we assessed the role of quantitative MRI (T2-lesion volume and diffusion tensor imaging [DTI]-derived metrics) in monitoring and predicting disease progression...
  11. ncbi request reprint Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategies
    Nils Peters
    Department of Neurology, Neurogenetics Laboratory, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
    Arch Neurol 62:1091-4. 2005
    ..Mutations are typically located within epidermal growth factor-like repeat domains in the extracellular part of the Notch3 receptor. Identification of the mutation is critical for genetic counseling and testing of relatives at risk...
  12. ncbi request reprint Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiers
    Christian Opherk
    Neurologische Klinik, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munchen, Germany
    Stroke 37:2684-9. 2006
    ..However, little is known about the factors that underlie this variability. We sought to quantify the contribution of modifying genetic effects to individual differences in the volume of cerebral ischemic lesions...