Research Topics
| C OpherkSummaryAffiliation: University of Munich Country: Germany Publications
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Detail Information
Publications
Age determination of vessel wall hematoma in spontaneous cervical artery dissection: A multi-sequence 3T Cardiovascular Magnetic resonance studyMaximilian Habs
Dept, of Clinical Radiology, University of Munich, Grosshadern Campus, Munich, Germany
J Cardiovasc Magn Reson 13:76. 2011..abstract:..
Subarachnoid hemorrhage and diplopia as initial presentation of polycythemia veraChristian Opherk
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Cerebrovasc Dis 19:279-80. 2005
The pattern of cognitive performance in CADASIL: a monogenic condition leading to subcortical ischemic vascular dementiaNils Peters
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
Am J Psychiatry 162:2078-85. 2005..Mutation carriers almost invariably develop cognitive deficits and eventually dementia. The current study describes the profile of cognitive abnormalities in CADASIL subjects...
Enhanced L-arginine-induced vasoreactivity suggests endothelial dysfunction in CADASILNils Peters
Dept of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, 81377, Munich, Germany
J Neurol 255:1203-8. 2008..Vasoreactivity induced by L-arginine, which is the substrate for endothelial nitric oxide synthase, is a parameter of endothelial function and has been shown to be altered in patients with cerebrovascular disease...
Staged escalation therapy in acute basilar artery occlusion: intravenous thrombolysis and on-demand consecutive endovascular mechanical thrombectomy: preliminary experience in 16 patientsThomas Pfefferkorn
Klinikum Grosshadern, Department of Neurology, University of Munich, Marchioninistrasse 15, 81377 Munich, Germany
Stroke 39:1496-500. 2008..The combination of IVT with consecutive on-demand EMT may allow for early treatment initiation with high recanalization rates but has never been systematically tested in patients with BAO...
Effects of short term atorvastatin treatment on cerebral hemodynamics in CADASILNils Peters
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Marchioninistrasse 15, D 81377 Munich, Germany
J Neurol Sci 260:100-5. 2007..CADASIL is a monogenic form of SVD caused by mutations in the Notch3 gene. Treatment options are limited and little is known about the therapeutic role of statins in CADASIL...
CADASIL mutations enhance spontaneous multimerization of NOTCH3Christian Opherk
Department of Neurology, Ludwig Maximilians University, Munich, Germany
Hum Mol Genet 18:2761-7. 2009..Taken together, our results for the first time provide experimental evidence for N3 self-association and strongly argue for a neomorphic effect of CADASIL mutations in disease pathogenesis...
Long-term prognosis and causes of death in CADASIL: a retrospective study in 411 patientsChristian Opherk
Department of Neurology, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Brain 127:2533-9. 2004..Our findings suggest possible genotype-phenotype correlations with regard to disease progression. The data presented may serve as source material for counselling CADASIL patients and for designing future interventional trials...
Successful bilateral pallidal stimulation for Meige syndrome and spasmodic torticollisC Opherk
Department of Neurology, Klinikum Grosshadern Marchioninistr. 15, D-81377 Munich, Germany
Neurology 66:E14. 2006
Spectrum of mutations in biopsy-proven CADASIL: implications for diagnostic strategiesNils Peters
Department of Neurology, Neurogenetics Laboratory, Klinikum Grosshadern, Ludwig Maximilians University, Munich, Germany
Arch Neurol 62:1091-4. 2005..Mutations are typically located within epidermal growth factor-like repeat domains in the extracellular part of the Notch3 receptor. Identification of the mutation is critical for genetic counseling and testing of relatives at risk...
Heritability of MRI lesion volume in CADASIL: evidence for genetic modifiersChristian Opherk
Neurologische Klinik, Klinikum Grosshadern, Ludwig-Maximilians-University, Marchioninistrasse 15, , Germany
Stroke 37:2684-9. 2006..These findings justify a systematic search for genetic variants that modify disease progression...
