Research Topics
Genomes and Genes
Species | Gerhard OpelzSummaryAffiliation: University of Heidelberg Country: Germany Publications
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Detail Information
Publications
Cytokine expression during early and late phase of acute Puumala hantavirus infectionMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
BMC Immunol 12:65. 2011..An immune-mediated pathogenesis is discussed for both syndromes. The aim of our study was to investigate cytokine expression during the course of acute Puumala hantavirus infection...
Multicenter analysis of kidney preservationGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
Transplantation 83:247-53. 2007..Changes in the use of preservation methods and storage solutions, ischemic preservation times, and the relationship between ischemia time and human leukocyte antigen (HLA) match have not been extensively studied in recent years...- Lymphomas after solid organ transplantation: a collaborative transplant study reportGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Am J Transplant 4:222-30. 2004..This study highlights the continuing risk for lymphoma with time post-transplantation, the contribution of immunosuppression to increased risk, and continuing poor outcomes in patients with post-transplant lymphoma... - Cytomegalovirus prophylaxis and graft outcome in solid organ transplantation: a collaborative transplant study reportGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Am J Transplant 4:928-36. 2004..These results may contribute to a better understanding of the influence of pretransplant CMV serology on the effect of CMV prophylaxis... 
Influence of time of rejection on long-term graft survival in renal transplantationGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
Transplantation 85:661-6. 2008....- Analysis of positive kidney, heart, and liver transplant crossmatches reported to the Collaborative Transplant StudyGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 70:627-30. 2009..It is concluded that a positive lymphocytotoxic crossmatch continues to indicate an increased risk of graft loss and that pretransplantation crossmatches should be performed regardless of type of organ transplanted... - Influence of immunosuppressive regimens on graft survival and secondary outcomes after kidney transplantationGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 87:795-802. 2009..There have been striking changes during the last 10 years concerning the choice of calcineurin inhibitor and antimetabolite agent prescribed after kidney transplantation... - Long-term prospective study of steroid withdrawal in kidney and heart transplant recipientsGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Am J Transplant 5:720-8. 2005..Rates of the development of osteoporosis and cataracts did not differ in the entire patient cohort, but were strikingly lower in patients taken off steroids during the first posttransplant year... - Non-HLA transplantation immunity revealed by lymphocytotoxic antibodiesGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Lancet 365:1570-6. 2005..Transplants from HLA-identical sibling donors do not provide a target for antibodies to HLA antigens and should therefore not be affected by PRA... - Effect of cytomegalovirus prophylaxis with immunoglobulin or with antiviral drugs on post-transplant non-Hodgkin lymphoma: a multicentre retrospective analysisGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Lancet Oncol 8:212-8. 2007..No reliable methods for the prevention of EBV infection and lymphoma are available. We aimed to elucidate the effect of prophylactic treatment for cytomegalovirus (CMV) infection on the incidence of post-transplant lymphomas... - Improved long-term outcomes after renal transplantation associated with blood pressure controlGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
Am J Transplant 5:2725-31. 2005..Lowering SBP, even after several years of posttransplantation hypertension, is associated with improved graft and patient survival in renal allograft recipients... - Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decadesGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 84:137-43. 2007.... - Disassociation between risk of graft loss and risk of non-Hodgkin lymphoma with induction agents in renal transplant recipientsGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 81:1227-33. 2006..It is widely assumed that the graft-enhancing properties of antilymphocyte induction agents and their lymphoma-inducing potential are intimately related... - Epidemiology of pretransplant EBV and CMV serostatus in relation to posttransplant non-Hodgkin lymphomaGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 88:962-7. 2009..CMV serostatus was not independently associated with risk of NHL after kidney transplantation. Surprisingly, in liver transplantation, the risk of NHL was virtually unaffected by EBV serostatus... - Impact of HLA compatibility on lung transplant survival and evidence for an HLA restriction phenomenon: a collaborative transplant study reportGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 90:912-7. 2010..Data concerning the impact of human leukocyte antigen (HLA) compatibility on lung transplant survival rates are limited... - No improvement of patient or graft survival in transplant recipients treated with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers: a collaborative transplant study reportGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
J Am Soc Nephrol 17:3257-62. 2006..It is concluded that recommendations for a widespread use of ACEI/ARB treatment in transplant recipients are unwarranted... - Impact of HLA mismatching on incidence of posttransplant non-hodgkin lymphoma after kidney transplantationGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 61920 Heidelberg, Germany
Transplantation 89:567-72. 2010..Posttransplant non-Hodgkin lymphoma is a rare complication but associated with high mortality. The extent to which human leukocyte antigen (HLA) mismatching influences the rate of posttransplant lymphoma has not been clarified... - Pediatric kidney transplantation: analysis of donor age, HLA match, and posttransplant non-Hodgkin lymphoma: a collaborative transplant study reportGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 90:292-7. 2010..The impact and relationship of donor age, human leukocyte antigen (HLA) matching, and posttransplant non-Hodgkin lymphoma in pediatric kidney recipients are not completely understood... - Proteasome inhibition suppresses essential immune functions of human CD4+ T cellsCarsten Berges
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Immunology 124:234-46. 2008..Thus, the proteasome is required for essential immune functions of activated CD4(+) T cells and can be defined as a molecular target for the suppression of deregulated and unwanted T-cell-mediated immune responses... - Normal or even increased dendritic cell and peripheral blood lymphocyte subsets with regulatory phenotype in clinically stable long-term HIV-infected patients with hemophilia on highly active antiretroviral therapyVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
J Acquir Immune Defic Syndr 47:1-15. 2008..Increased CD8 PBL counts imply immunocompetence. Increased CD8 PBL counts and normal or even upregulated immunoregulatory cells might stabilize our long-term HIV-infected patients with hemophilia clinically... - Association of circulating interleukin (IL)-12- and IL-10-producing dendritic cells with time posttransplant, dose of immunosuppression, and plasma cytokines in renal-transplant recipientsVolker Daniel
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, S 69120 Heidelberg, Germany
Transplantation 79:1498-506. 2005..We investigated DC and plasma cytokine patterns early and late after transplantation... - An integrative approach for the transplantation of high-risk sensitized patientsChristian Morath
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Transplantation 90:645-53. 2010..Sensitized patients have a lower chance of receiving a crossmatch-negative kidney and, if transplanted, are at risk of antibody-mediated allograft rejection... - Association of pretransplant soluble glycoprotein 130 (sgp130) plasma levels and posttransplant acute tubular necrosis in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
Transplantation 88:266-71. 2009..Previously, we reported that high pretransplant sIL-6R plasma levels are associated with posttransplant acute tubular necrosis (ATN). In this study, we examined associations of pretransplant plasma levels of sgp130 with ATN... - Inhibition of heart allograft rejection with mitomycin C-treated donor dendritic cellsLucian P Jiga
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 83:347-50. 2007..We conclude that allogeneic MMC-DCs specifically inhibit the T-cell response in vivo and that downregulation of CD80, CD86, and ICAM-1 is a potential mechanism of this effect... - No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing: a Collaborative Transplant Study reportCaner Süsal
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 91:883-7. 2011.... - Genetic polymorphisms of adhesion molecules and kidney transplant survivalAndreas Heinold
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 89:1079-87. 2010..Our results demonstrate the importance of testing large sample sizes and of performing confirmation studies to validate genetic associations... - Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cellsCarsten Berges
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
J Cell Biochem 108:935-46. 2009..These results provide novel insights into the mechanisms of apoptosis induced by proteasome inhibition in activated T cells and underscore the future use of proteasome inhibitors for immunosuppression... - Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapyMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
AIDS Res Hum Retroviruses 23:886-90. 2007..Our data suggest that decreasing sCD30 and increasing IFN-gamma plasma levels are indicators of effective HAART treatment and CD4 Th1 cell recovery in HIV-infected patients... - Decreasing plasma soluble IL-1 receptor antagonist and increasing monocyte activation early post-transplant may be involved in pathogenesis of delayed graft function in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
Clin Transplant 24:415-23. 2010..Blocking of monocyte activity after renal transplantation may be considered a potential approach for improving graft outcome... - Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapyChristian Morath
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Transpl Int 25:506-17. 2012..We describe a treatment algorithm for desensitization of living donor kidney transplant recipients that allows the rapid elimination of DSA with a low rate of side effects and results in good graft outcome... - Evidence for IFN-gamma up- and IL-4 downregulation late post-transplant in patients with good kidney graft outcomeMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Clin Transplant 21:449-59. 2007..These data suggest that increased plasma IFN-gamma and decreased plasma IL-4 late post-transplant might be involved in the induction of mechanisms that facilitate good long-term graft outcome... - Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejectionImad Lahdou
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 71:1067-72. 2010..Although informative in overall terms, at the present stage, Kyn levels do not allow the concise risk differentiation of individual patients... - Successful deceased-donor kidney transplantation in crossmatch-positive patients with peritransplant plasma exchange and RituximabJörg H M Beimler
Department of Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
Transplantation 87:668-71. 2009..Both patients showed good graft outcome at 27 and 21 months after transplantation with serum creatinine values of 1.60 and 1.25 mg/dL, respectively... - Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruriaMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 88:1109-16. 2009..BKV-associated nephropathy develops in approximately 5% to 8% of renal transplant recipients, and its prognosis is poor. The relationship between urine cytokines and BK viruria in kidney recipients has not been defined... - Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cellsCord Naujokat
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Immunology 120:120-32. 2007.... - Immunosuppressive effect of tryptophan metabolites in composite tissue allotransplantationChristian A Radu
Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany
Plast Reconstr Surg 119:2023-8. 2007..In this study, the authors applied to composite tissue allotransplantation what nature has developed for pregnancy, and examined the immunosuppressive effect of tryptophan metabolites in a model of hind limb transplantation... - Association of high IFN-gamma plasma levels with low B-cell counts in renal transplant recipients with stable long-term graft functionVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Clin Transplant 24:281-9. 2010..High IFN-gamma plasma levels might prevent the development of an immunological alloresponse and thereby contribute to the maintenance of graft acceptance... - Increased peripheral blood leukocyte subsets with regulatory phenotype in clinically stable long-term HIV-infected hemophilia patients on HAART may be beneficial and contribute to a decrease in autoimmunityVolker Daniel
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Viral Immunol 23:87-97. 2010..Increased immunoregulatory T PBL might decrease autoimmunity, thereby contributing to immunological reconstitution and stabilization of long-term HIV-infected hemophilia patients on HAART... - Mitomycin C-treated antigen-presenting cells as a tool for control of allograft rejection and autoimmunity: from bench to bedsidePeter Terness
Institute of Immunology, University of Heidelberg, Department of Transplantation Immunology, Heidelberg, Germany
Hum Immunol 70:506-12. 2009..Although many questions remain, MMC-treated cells are a promising clinical tool for controlling allograft rejection and deleterious immune responses in autoimmune diseases... - Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanismsCarsten Berges
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Mol Immunol 46:2892-901. 2009..Thus, helenalin can be defined as a new immunosuppressive compound suited for the treatment of deregulated and unwanted T cell-mediated immune responses... - Deleterious impact of mismatching for human leukocyte antigen-C in presensitized recipients of kidney transplantsThuong Hien Tran
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 92:419-25. 2011..We investigated the influence of HLA-C compatibility on renal allograft survival. In addition, we tested an approach of matching for HLA-C epitopes... - Posttransplant sCD30 as a predictor of kidney graft outcomeCaner Süsal
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 91:1364-9. 2011..Reliable markers for assessing the biological effect of immunosuppressive drugs and identification of transplant recipients at risk of developing rejection are not available... - Dysregulated cytokine responses during cytomegalovirus infection in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 86:275-85. 2008..The aim of this study was to examine whether there are differences in plasma cytokine levels pretransplant, before and during CMV replication in renal transplant recipients... - The effect of donor gender on graft survivalMartin Zeier
Department of Internal Medicine Nephrology, University of Heidelberg, Heidelberg, Germany
J Am Soc Nephrol 13:2570-6. 2002..Therefore, in addition to potential "nephron underdosing," further pathomechanisms must play a role, possibly differences in immunogenicity according to donor gender... - Association of IL-12+ DC with High CD3+CD4-DR+ lymphocyte counts in long-term HIV-infected hemophilia patients with clinically stable diseaseVolker Daniel
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
J Clin Immunol 28:58-72. 2008..These data suggest that long-term HIV-infected hemophilia patients with clinically stable disease have normal levels of functional IL-10(+) DC and IL-12(+) DC that might be involved in halting the progression of disease... - Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipientsTania Simon
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
Am J Transplant 3:1121-7. 2003..Serial measurements could be implemented as a monitoring system to highlight patients at higher risk of rejection, making them candidates for biopsy or pre-emptive anti-rejection therapy... - HLA antibodies and the occurrence of early adverse events in the modern era of transplantation: a collaborative transplant study reportCaner Süsal
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 87:1367-71. 2009..Adverse events occurring early after kidney transplantation were reported to influence graft outcome... - Serial peripheral blood interleukin-18 and perforin gene expression measurements for prediction of acute kidney graft rejectionTania Simon
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany
Transplantation 77:1589-95. 2004..Serial measurements could be implemented as a monitoring system to identify patients at higher risk of rejection, making them candidates for biopsy or prophylactic increases in immunosuppression... - Suppressive dendritic cells as a tool for controlling allograft rejection in organ transplantation: promises and difficultiesSandra Ehser
Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 69:165-73. 2008..Based on lessons learned from the use of DCs as tools in clinical vaccine trials in cancer, we discuss the unknown aspects and risks of DC therapy in transplantation... - Association of mismatches for HLA-DR with incidence of posttransplant hip fracture in kidney transplant recipientsGerhard Opelz
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 91:65-9. 2011..Bone fractures are a frequent complication after kidney transplantation, for which various predisposing factors have been identified. It has been suggested that human leukocyte antigen (HLA) mismatch increases the risk... - Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: a Collaborative Transplant Study reportCaner Süsal
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 70:569-73. 2009.... - Observational support for an immunoregulatory role of CD3+CD4+CD25+IFN-gamma+ blood lymphocytes in kidney transplant recipients with good long-term graft outcomeVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transpl Int 21:646-60. 2008..Our data support an immunoregulatory role of CD3+CD4+CD25+Foxp3+IFN-gamma+ cells in a subgroup of transplant recipients with good graft acceptance... - Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivoThomas M Bauer
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany
Transpl Int 18:95-100. 2005..The metabolites induced a significant prolongation (P = 0.0018) of graft survival. We conclude that IDO-induced tryptophan metabolites suppress the T-cell response and prolong allograft survival in rats... - Antithymocyte globulins suppress dendritic cell function by multiple mechanismsCord Naujokat
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 83:485-97. 2007..Although immunosuppressive mechanisms of ATGs on T cells are well studied, less is known about their impact on dendritic cells (DCs)... - Ex vivo perfusion with mitomycin C containing solution prolongs heart graft survival in ratsDaohu Wang
Institute for Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 82:1537-40. 2006..Our findings indicate that the targeted perfusion of donor hearts with MMC-containing solution protects the graft from rejection... - Association of high pretransplant sIL-6R plasma levels with acute tubular necrosis in kidney graft recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 81:1716-24. 2006.... - Does borderline kidney allograft rejection always require treatment?Dorottya Németh
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 90:427-32. 2010..We analyzed Treg-associated forkhead box P3 (Foxp3) gene expression in Bord-R and more severe forms of acute rejection episodes (ARE)... - Prevention of antibody-mediated kidney transplant rejectionChristian Morath
Department of Nephrology, University of Heidelberg, Heidelberg, Germany
Transpl Int 25:633-45. 2012..In the current overview, we discuss the currently available measures for the prevention of antibody-mediated kidney graft rejection... - Strong association of phenylalanine and tryptophan metabolites with activated cytomegalovirus infection in kidney transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, D 69117 Heidelberg, Germany
Hum Immunol 73:186-92. 2012..Moreover, tryptophan metabolite levels correlate with disease severity. Measurement of these amino acids is an inexpensive and fast method expected to complete conventional diagnostic assays... - HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathwayDominik Fuchs
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Biochem Biophys Res Commun 374:309-14. 2008..Thus, simvastatin overcomes bortezomib-induced apoptosis resistance by inhibiting synthesis of GGPP and disrupting a GGPP-dependent survival pathway... - High urine sIL-6R as a predictor of late graft failure in renal transplant recipientsMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany. mahmoud.sadeghi@ med.uni-heidelberg.de
Transplantation 76:1190-4. 2003..003 and P=0.01, respectively). Serum creatinine levels were not associated with increased urine sIL-6R. CONCLUSION: High urine sIL-6R appears to be predictive of late graft failure in renal transplant recipients... - Pathway of apoptosis induced in Jurkat T lymphoblasts by anti-HLA class I antibodiesDinara Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 65:189-99. 2004..This study clarifies the precise mechanism of anti-HLA antibody-induced apoptosis which might have clinical implications... - Risks of allogeneic hand transplantationSteffen Baumeister
Department for Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center, Plastic and Hand Surgery, University of Heidelberg, Heidelberg, Germany
Microsurgery 24:98-103. 2004..Although the incidence of side effects (particularly malignant disease) is likely to be lower than previously thought, the risk-benefit question must be answered by each hand surgeon for each individual patient... - Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infectionMahmoud Sadeghi
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transpl Int 18:177-85. 2005.... - Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejectionKhaled Mahmoud
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 83:1035-40. 2007..In the present study we investigated whether HGF can serve as a marker for detection of acute rejection in the early posttransplantation period... - Kidney graft failure and presensitization against HLA class I and class II antigensCaner Süsal
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
Transplantation 73:1269-73. 2002..We investigated the clinical relevance of preformed anti-HLA class I and class II antibodies on graft outcome in more than 4000 kidney recipients... - Successful treatment of chronic antibody-mediated rejection with IVIG and rituximab in pediatric renal transplant recipientsHeiko Billing
Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
Transplantation 86:1214-21. 2008..We therefore initiated a pilot study on treatment of CAMR with an antihumoral regimen consisting of high-dose intravenous immunoglobulin (IVIG) and the chimeric anti-CD20 antibody rituximab... - Evaluation of posttransplantation soluble CD30 for diagnosis of acute renal allograft rejectionSteffen Pelzl
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 75:421-3. 2003..CONCLUSIONS: sCD30 measured on posttransplantation days 3 to 5 offers a noninvasive means for differentiating patients with impending acute allograft rejection from patients with an uncomplicated course or with acute tubular necrosis... - No association of factor V Leiden, prothrombin G20210A, and MTHFR C677T gene polymorphisms with kidney allograft survival: a multicenter studyMarko Meyer
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 83:1055-8. 2007..On the basis of this hypothesis, we performed a multicenter study, involving recipients of primary and repeat kidney transplants, to investigate the potential effect of these three single nucleotide polymorphisms (SNP) on graft survival... - Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivativesDinara Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
Int Immunopharmacol 3:1791-801. 2003..The description of compounds without cardiac activity but with tumor-specific cytotoxicity suggests the potential of using them in cancer therapy... - The effect of ATG on cytokine and cytotoxic T-lymphocyte gene expression in renal allograft recipients during the early post-transplant periodTania Simon
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Clin Transplant 17:217-24. 2003.... - Soluble CD30 as a predictor of kidney graft outcomeSteffen Pelzl
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120 Heidelberg, Germany
Transplantation 73:3-6. 2002..CONCLUSION: These data show that an elevated pretransplantation serum sCD30 reflects an immune state that is detrimental for kidney graft survival... - Generation of tolerogenic dendritic cells by treatment with mitomycin C: inhibition of allogeneic T-cell response is mediated by downregulation of ICAM-1, CD80, and CD86Lucian P Jiga
Department of Transplantation Immunology, Heidelberg, Germany
Transplantation 77:1761-4. 2004..CONCLUSIONS: MMC treatment converts rat DC into tolerogenic cells. This mechanism is mediated by decrease of ICAM-1, CD80, and CD86... - Dissociation of CD4(+) cell counts from viral load and association with immune complexes in HIV(+) hemophilia patientsMahmoud Sadeghi
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D-69120, Heidelberg, Germany
Immunol Lett 91:23-32. 2004..CONCLUSION: These data suggest that HIV regulates and mediates CD4 depletion in part by the induction of autoreactive ICs against CD4(+) lymphocytes, especially complement-fixing autoreactive IgG and gp120/IgG complexes... - Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedicationBritta Höcker
Department of Pediatrics I, University Children s Hospital Heidelberg, Heidelberg, Germany
Transplantation 86:1234-40. 2008.... - Associations of dichlorodiphenyltrichloroethane (DDT) 4.4 and dichlorodiphenyldichloroethylene (DDE) 4.4 blood levels with plasma IL-4Volker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Arch Environ Health 57:541-7. 2002..The authors hypothesized that clinical symptoms, such as the frequent infections reported by many patients, could be a consequence of these immunological abnormalities... - Malignancy in renal transplantationChristian Morath
Department of Nephrology, University of Heidelberg, Bergheimerstrasse 56a, 69115 Heidelberg, Germany
J Am Soc Nephrol 15:1582-8. 2004 - Very short ischaemia is not the answerGerhard Opelz
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
Nephrol Dial Transplant 17:715-6. 2002 - Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myelomaKai Neben
Department of Internal Medicine V, University of Heidelberg, Hospitalstrasse 3, 69115 Heidelberg, Germany
Blood 100:2263-5. 2002.... 
Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolitesPeter Terness
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, 69120 Heidelberg, Germany
J Exp Med 196:447-57. 2002....- From cancer to transplantation: an evaluation of period analysis for calculating up-to-date long-term survival estimatesAdam Gondos
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
Am J Epidemiol 172:613-20. 2010..The method appears useful for providing more up-to-date long-term survival estimates than traditional methods, and its use in pertinent studies is encouraged... - Immunosuppressive anti-immunoglobulin autoantibodies: specificity, gene structure and function in health and diseasePeter I Terness
Institute of Immunology, University of Heidelberg, Germany
Cell Mol Biol (Noisy-le-grand) 48:271-8. 2002..There is substantial evidence indicating that anti-Ig auto-Abs are important immunoregulatory molecules... - Salinomycin in cancer: A new mission for an old agentCord Naujokat
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
Mol Med Report 3:555-9. 2010..The ability of salinomycin to effectively kill both cancer stem cells and apoptosis-resistant cancer cells may define the compound as a novel and effective anticancer agent... - Good kidney transplant outcome in recipients with presensitization against HLA class II but not HLA class ICaner Süsal
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Hum Immunol 65:810-6. 2004..We conclude that the risk associated with sensitization against HLA class II in the absence of sensitization against HLA class I is negligible... - Relevance of IL10, TGFbeta1, TNFalpha, and IL4Ralpha gene polymorphisms in kidney transplantation: a collaborative transplant study reportJoannis Mytilineos
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Am J Transplant 4:1684-90. 2004..The outcome of retransplants appears to be affected by TNFalpha genotypes only... - Longitudinal analysis of T-helper cell phenotypes in renal-transplant recipients undergoing growth hormone therapyAnette Melk
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 78:1792-801. 2004..We therefore evaluated the immune phenotypes of pediatric renal-transplant recipients and controls in response to rhGH with regard to a possible shift toward a T-helper (TH)1-type response... - Cell cycle- and activation-dependent regulation of cyclosporin A-induced T cell apoptosisCord Naujokat
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Biochem Biophys Res Commun 310:347-54. 2003.... - Critical evaluation of the amino acid triplet-epitope matching concept in cadaver kidney transplantationGunter Laux
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 77:902-7. 2004..This approach was proposed as being especially suitable for the allocation of donor kidneys to highly sensitized patients... - Identification of highly responsive kidney transplant recipients using pretransplant soluble CD30Caner Süsal
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
J Am Soc Nephrol 13:1650-6. 2002.... - Regulation of human auto- and alloreactive T cells by indoleamine 2,3-dioxygenase (IDO)-producing dendritic cells: too much ado about IDO?Peter Terness
Institute of Immunology, University of Heidelberg, INF 305, 69120 Heidelberg, Germany
Blood 105:2480-6. 2005..Our findings show that nonadherent CD123+/CCR6+ human DCs do not constitutively express IDO, and, even if they express the enzyme after IFN-gamma treatment, they possess only limited T-cell regulatory function... - Metabolic control improves long-term renal allograft and patient survival in type 1 diabetesChristian Morath
Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
J Am Soc Nephrol 19:1557-63. 2008..55; P = 0.005). In summary, the early survival advantage of LDK over SPK is lost during long-term follow-up, probably as a result of improved glycemic control in SPK recipients... - The immunoregulatory role of IDO-producing human dendritic cells revisitedPeter Terness
Institute of Immunology, Department of Transplantation Immunology, INF 305, University of Heidelberg, 69120 Heidelberg, Germany
Trends Immunol 27:68-73. 2006..Here, we critically examine the arguments for and against a function of IDO-expressing human dendritic cells (DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking... - Strong human leukocyte antigen matching effect in nonsensitized kidney recipients with high pretransplant soluble CD30Caner Süsal
Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 76:1231-2. 2003..Patients should be tested for sCD30 while on the waiting list for a kidney transplant, and HLA well-matched kidneys should be allocated to patients with high sCD30... - Mitomycin C-treated dendritic cells inactivate autoreactive T cells: toward the development of a tolerogenic vaccine in autoimmune diseasesPeter Terness
Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
Proc Natl Acad Sci U S A 105:18442-7. 2008.... - A new epitope-based HLA-DPB matching approach for cadaver kidney retransplantsGunter Laux
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
Transplantation 75:1527-32. 2003..Several years ago a significant impact of matching for HLA-DPB1 alleles on the survival of cadaver kidney retransplants was shown. Here we report the results of a new approach, based on matching for HLA-DPB1 epitopes... - Immunological relevance of CREG matching in cadaver kidney transplantationGunter Laux
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Transplantation 78:442-6. 2004..Because CREG matching also improves the equity of kidney distribution to ethnic minorities, a CREG-based cadaver kidney allocation policy was introduced in the United States a few years ago... - Clinical relevance of immune monitoring in solid organ transplantationVolker Daniel
Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
Int Rev Immunol 28:155-84. 2009..A multiparametric immune monitoring program, performed frequently and lifelong, might be the appropriate approach to predict dysfunction of the graft before clinical symptoms occur... - Defective DNA mismatch repair in acute myeloid leukemia/myelodysplastic syndrome after organ transplantationJudith Offman
Cancer Research UK London Research Institute, Clare Hall Laboratories, South Mimms, United Kingdom
Blood 104:822-8. 2004..Identifying azathioprine as a risk factor for AML/MDS suggests that discontinuing the use of azathioprine as an immunosuppressant might reduce the incidence of posttransplantation AML/MDS... - ATG induction therapy: long-term effects on Th1 but not on Th2 responsesRolf Weimer
Department of Internal Medicine, University of Giessen, Giessen, Germany
Transpl Int 18:226-36. 2005.... - Antibodies against MICA antigens and kidney-transplant rejectionYizhou Zou
Transplantation Immunology Division, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, TX 75390 8886, USA
N Engl J Med 357:1293-300. 2007..We sought to determine whether an immune response to MICA antigens might play a role in the failure of kidney allografts... - Levo- but not dextro-1-methyl tryptophan abrogates the IDO activity of human dendritic cellsStefan Lob
Department of General, Visceral and Transplant Surgery, University Hospital of Tubingen, Tubingen, Germany
Blood 111:2152-4. 2008..Consequently, in humans any possible antitumor effects of D-1MT cannot be attributed to abrogation of IDO activity in DCs as described in this study...