Gerhard Opelz

Summary

Affiliation: University of Heidelberg
Country: Germany

Publications

  1. doi request reprint Association between steroid dosage and death with a functioning graft after kidney transplantation
    G Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 13:2096-105. 2013
  2. pmc In-vitro inhibition of IFNγ+ iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function
    Volker Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
    BMC Immunol 13:47. 2012
  3. doi request reprint Association of HLA mismatch with death with a functioning graft after kidney transplantation: a collaborative transplant study report
    G Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 12:3031-8. 2012
  4. doi request reprint The collaborative transplant study registry
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, D 61920 Heidelberg, Germany
    Transplant Rev (Orlando) 27:43-5. 2013
  5. pmc Cytokine expression during early and late phase of acute Puumala hantavirus infection
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    BMC Immunol 12:65. 2011
  6. ncbi request reprint Cytomegalovirus prophylaxis and graft outcome in solid organ transplantation: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 4:928-36. 2004
  7. ncbi request reprint Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Lancet 365:1570-6. 2005
  8. ncbi request reprint Long-term prospective study of steroid withdrawal in kidney and heart transplant recipients
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 5:720-8. 2005
  9. doi request reprint Impact of HLA mismatching on incidence of posttransplant non-hodgkin lymphoma after kidney transplantation
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 61920 Heidelberg, Germany
    Transplantation 89:567-72. 2010
  10. ncbi request reprint Lymphomas after solid organ transplantation: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 4:222-30. 2004

Collaborators

Detail Information

Publications116 found, 100 shown here

  1. doi request reprint Association between steroid dosage and death with a functioning graft after kidney transplantation
    G Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 13:2096-105. 2013
    ....
  2. pmc In-vitro inhibition of IFNγ+ iTreg mediated by monoclonal antibodies against cell surface determinants essential for iTreg function
    Volker Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
    BMC Immunol 13:47. 2012
    ..To study the mechanism of immunosuppression, we attempted to block cell surface receptors and thereby inhibited the function of this iTreg subset in-vitro using monoclonal antibodies and recombinant proteins...
  3. doi request reprint Association of HLA mismatch with death with a functioning graft after kidney transplantation: a collaborative transplant study report
    G Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 12:3031-8. 2012
    ..001) or bacterial (p = 0.002) infection. Multivariable analysis showed that mismatches for HLA class II were more strongly associated with both hospitalization and DWFG than mismatches for HLA class I...
  4. doi request reprint The collaborative transplant study registry
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, D 61920 Heidelberg, Germany
    Transplant Rev (Orlando) 27:43-5. 2013
    ..Participation is voluntary and the study has strictly scientific objectives. Analyses of the CTS database serve as an international reference source in the field of solid organ transplantation...
  5. pmc Cytokine expression during early and late phase of acute Puumala hantavirus infection
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    BMC Immunol 12:65. 2011
    ..An immune-mediated pathogenesis is discussed for both syndromes. The aim of our study was to investigate cytokine expression during the course of acute Puumala hantavirus infection...
  6. ncbi request reprint Cytomegalovirus prophylaxis and graft outcome in solid organ transplantation: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 4:928-36. 2004
    ..These results may contribute to a better understanding of the influence of pretransplant CMV serology on the effect of CMV prophylaxis...
  7. ncbi request reprint Non-HLA transplantation immunity revealed by lymphocytotoxic antibodies
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Lancet 365:1570-6. 2005
    ..Transplants from HLA-identical sibling donors do not provide a target for antibodies to HLA antigens and should therefore not be affected by PRA...
  8. ncbi request reprint Long-term prospective study of steroid withdrawal in kidney and heart transplant recipients
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 5:720-8. 2005
    ..Rates of the development of osteoporosis and cataracts did not differ in the entire patient cohort, but were strikingly lower in patients taken off steroids during the first posttransplant year...
  9. doi request reprint Impact of HLA mismatching on incidence of posttransplant non-hodgkin lymphoma after kidney transplantation
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 61920 Heidelberg, Germany
    Transplantation 89:567-72. 2010
    ..Posttransplant non-Hodgkin lymphoma is a rare complication but associated with high mortality. The extent to which human leukocyte antigen (HLA) mismatching influences the rate of posttransplant lymphoma has not been clarified...
  10. ncbi request reprint Lymphomas after solid organ transplantation: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 4:222-30. 2004
    ..This study highlights the continuing risk for lymphoma with time post-transplantation, the contribution of immunosuppression to increased risk, and continuing poor outcomes in patients with post-transplant lymphoma...
  11. doi request reprint Influence of immunosuppressive regimens on graft survival and secondary outcomes after kidney transplantation
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 87:795-802. 2009
    ..There have been striking changes during the last 10 years concerning the choice of calcineurin inhibitor and antimetabolite agent prescribed after kidney transplantation...
  12. doi request reprint Epidemiology of pretransplant EBV and CMV serostatus in relation to posttransplant non-Hodgkin lymphoma
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 88:962-7. 2009
    ..CMV serostatus was not independently associated with risk of NHL after kidney transplantation. Surprisingly, in liver transplantation, the risk of NHL was virtually unaffected by EBV serostatus...
  13. doi request reprint Influence of time of rejection on long-term graft survival in renal transplantation
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
    Transplantation 85:661-6. 2008
    ....
  14. doi request reprint Pediatric kidney transplantation: analysis of donor age, HLA match, and posttransplant non-Hodgkin lymphoma: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 90:292-7. 2010
    ..The impact and relationship of donor age, human leukocyte antigen (HLA) matching, and posttransplant non-Hodgkin lymphoma in pediatric kidney recipients are not completely understood...
  15. doi request reprint Analysis of positive kidney, heart, and liver transplant crossmatches reported to the Collaborative Transplant Study
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 70:627-30. 2009
    ..It is concluded that a positive lymphocytotoxic crossmatch continues to indicate an increased risk of graft loss and that pretransplantation crossmatches should be performed regardless of type of organ transplanted...
  16. doi request reprint Impact of HLA compatibility on lung transplant survival and evidence for an HLA restriction phenomenon: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 90:912-7. 2010
    ..Data concerning the impact of human leukocyte antigen (HLA) compatibility on lung transplant survival rates are limited...
  17. ncbi request reprint Effect of cytomegalovirus prophylaxis with immunoglobulin or with antiviral drugs on post-transplant non-Hodgkin lymphoma: a multicentre retrospective analysis
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Lancet Oncol 8:212-8. 2007
    ..No reliable methods for the prevention of EBV infection and lymphoma are available. We aimed to elucidate the effect of prophylactic treatment for cytomegalovirus (CMV) infection on the incidence of post-transplant lymphomas...
  18. ncbi request reprint Multicenter analysis of kidney preservation
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
    Transplantation 83:247-53. 2007
    ..Changes in the use of preservation methods and storage solutions, ischemic preservation times, and the relationship between ischemia time and human leukocyte antigen (HLA) match have not been extensively studied in recent years...
  19. ncbi request reprint No improvement of patient or graft survival in transplant recipients treated with angiotensin-converting enzyme inhibitors or angiotensin II type 1 receptor blockers: a collaborative transplant study report
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 17:3257-62. 2006
    ..It is concluded that recommendations for a widespread use of ACEI/ARB treatment in transplant recipients are unwarranted...
  20. ncbi request reprint Disassociation between risk of graft loss and risk of non-Hodgkin lymphoma with induction agents in renal transplant recipients
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 81:1227-33. 2006
    ..It is widely assumed that the graft-enhancing properties of antilymphocyte induction agents and their lymphoma-inducing potential are intimately related...
  21. ncbi request reprint Effect of human leukocyte antigen compatibility on kidney graft survival: comparative analysis of two decades
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 84:137-43. 2007
    ....
  22. ncbi request reprint Improved long-term outcomes after renal transplantation associated with blood pressure control
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
    Am J Transplant 5:2725-31. 2005
    ..Lowering SBP, even after several years of posttransplantation hypertension, is associated with improved graft and patient survival in renal allograft recipients...
  23. doi request reprint Living donor kidney transplantation in patients with donor-specific HLA antibodies enabled by anti-CD20 therapy and peritransplant apheresis
    Katrin Klein
    Department of Nephrology, University of Heidelberg, INF 162, 69120 Heidelberg, Germany
    Atheroscler Suppl 14:199-202. 2013
    ..Due to increasing waiting times for deceased donor kidneys, living donor kidney transplantation is increasingly performed in the presence of donor-specific antibodies (DSA)...
  24. pmc Proteasome inhibition suppresses essential immune functions of human CD4+ T cells
    Carsten Berges
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Immunology 124:234-46. 2008
    ..Thus, the proteasome is required for essential immune functions of activated CD4(+) T cells and can be defined as a molecular target for the suppression of deregulated and unwanted T-cell-mediated immune responses...
  25. ncbi request reprint Soluble CD30 and ELISA-detected human leukocyte antigen antibodies for the prediction of acute rejection in pediatric renal transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, D 69120 Heidelberg, Germany
    Transpl Int 26:331-8. 2013
    ..TWIST, Clinical Trial No: FG-506-02-43)...
  26. ncbi request reprint Association of circulating interleukin (IL)-12- and IL-10-producing dendritic cells with time posttransplant, dose of immunosuppression, and plasma cytokines in renal-transplant recipients
    Volker Daniel
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, S 69120 Heidelberg, Germany
    Transplantation 79:1498-506. 2005
    ..We investigated DC and plasma cytokine patterns early and late after transplantation...
  27. doi request reprint Plasmapheresis adjusts inflammatory responses in potential kidney transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 95:1021-9. 2013
    ..The effect of PP on lymphocyte subpopulations, plasma neopterin, and cytokines in renal transplant recipients was investigated in this study...
  28. doi request reprint An integrative approach for the transplantation of high-risk sensitized patients
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 90:645-53. 2010
    ..Sensitized patients have a lower chance of receiving a crossmatch-negative kidney and, if transplanted, are at risk of antibody-mediated allograft rejection...
  29. ncbi request reprint Normal or even increased dendritic cell and peripheral blood lymphocyte subsets with regulatory phenotype in clinically stable long-term HIV-infected patients with hemophilia on highly active antiretroviral therapy
    Volker Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    J Acquir Immune Defic Syndr 47:1-15. 2008
    ..Increased CD8 PBL counts imply immunocompetence. Increased CD8 PBL counts and normal or even upregulated immunoregulatory cells might stabilize our long-term HIV-infected patients with hemophilia clinically...
  30. doi request reprint Association of pretransplant soluble glycoprotein 130 (sgp130) plasma levels and posttransplant acute tubular necrosis in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Transplantation 88:266-71. 2009
    ..Previously, we reported that high pretransplant sIL-6R plasma levels are associated with posttransplant acute tubular necrosis (ATN). In this study, we examined associations of pretransplant plasma levels of sgp130 with ATN...
  31. doi request reprint Genetic polymorphisms of adhesion molecules and kidney transplant survival
    Andreas Heinold
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 89:1079-87. 2010
    ..Our results demonstrate the importance of testing large sample sizes and of performing confirmation studies to validate genetic associations...
  32. doi request reprint Proteasome inhibition activates the mitochondrial pathway of apoptosis in human CD4+ T cells
    Carsten Berges
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    J Cell Biochem 108:935-46. 2009
    ..These results provide novel insights into the mechanisms of apoptosis induced by proteasome inhibition in activated T cells and underscore the future use of proteasome inhibitors for immunosuppression...
  33. ncbi request reprint Inhibition of heart allograft rejection with mitomycin C-treated donor dendritic cells
    Lucian P Jiga
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 83:347-50. 2007
    ..We conclude that allogeneic MMC-DCs specifically inhibit the T-cell response in vivo and that downregulation of CD80, CD86, and ICAM-1 is a potential mechanism of this effect...
  34. doi request reprint No association of kidney graft loss with human leukocyte antigen antibodies detected exclusively by sensitive Luminex single-antigen testing: a Collaborative Transplant Study report
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 91:883-7. 2011
    ....
  35. doi request reprint Kidney graft survival in Europe and the United States: strikingly different long-term outcomes
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Transplantation 95:267-74. 2013
    ..Kidney graft survival has never been systematically compared between Europe and the United States...
  36. ncbi request reprint Short communication: decreasing soluble CD30 and increasing IFN-gamma plasma levels are indicators of effective highly active antiretroviral therapy
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    AIDS Res Hum Retroviruses 23:886-90. 2007
    ..Our data suggest that decreasing sCD30 and increasing IFN-gamma plasma levels are indicators of effective HAART treatment and CD4 Th1 cell recovery in HIV-infected patients...
  37. doi request reprint Decreasing plasma soluble IL-1 receptor antagonist and increasing monocyte activation early post-transplant may be involved in pathogenesis of delayed graft function in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Clin Transplant 24:415-23. 2010
    ..Blocking of monocyte activity after renal transplantation may be considered a potential approach for improving graft outcome...
  38. doi request reprint Living donor kidney transplantation in crossmatch-positive patients enabled by peritransplant immunoadsorption and anti-CD20 therapy
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 25:506-17. 2012
    ..We describe a treatment algorithm for desensitization of living donor kidney transplant recipients that allows the rapid elimination of DSA with a low rate of side effects and results in good graft outcome...
  39. pmc Proteasomal chymotrypsin-like peptidase activity is required for essential functions of human monocyte-derived dendritic cells
    Cord Naujokat
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Immunology 120:120-32. 2007
    ....
  40. doi request reprint Successful deceased-donor kidney transplantation in crossmatch-positive patients with peritransplant plasma exchange and Rituximab
    Jörg H M Beimler
    Department of Medicine, Division of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transplantation 87:668-71. 2009
    ..Both patients showed good graft outcome at 27 and 21 months after transplantation with serum creatinine values of 1.60 and 1.25 mg/dL, respectively...
  41. ncbi request reprint Evidence for IFN-gamma up- and IL-4 downregulation late post-transplant in patients with good kidney graft outcome
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 21:449-59. 2007
    ..These data suggest that increased plasma IFN-gamma and decreased plasma IL-4 late post-transplant might be involved in the induction of mechanisms that facilitate good long-term graft outcome...
  42. doi request reprint Increased pretransplantation plasma kynurenine levels do not protect from but predict acute kidney allograft rejection
    Imad Lahdou
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 71:1067-72. 2010
    ..Although informative in overall terms, at the present stage, Kyn levels do not allow the concise risk differentiation of individual patients...
  43. doi request reprint Helenalin suppresses essential immune functions of activated CD4+ T cells by multiple mechanisms
    Carsten Berges
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Mol Immunol 46:2892-901. 2009
    ..Thus, helenalin can be defined as a new immunosuppressive compound suited for the treatment of deregulated and unwanted T cell-mediated immune responses...
  44. ncbi request reprint Immunosuppressive effect of tryptophan metabolites in composite tissue allotransplantation
    Christian A Radu
    Department of Hand, Plastic, and Reconstructive Surgery, Burn Center, BG Trauma Center Ludwigshafen, Heidelberg, Germany
    Plast Reconstr Surg 119:2023-8. 2007
    ..In this study, the authors applied to composite tissue allotransplantation what nature has developed for pregnancy, and examined the immunosuppressive effect of tryptophan metabolites in a model of hind limb transplantation...
  45. doi request reprint Increased peripheral blood leukocyte subsets with regulatory phenotype in clinically stable long-term HIV-infected hemophilia patients on HAART may be beneficial and contribute to a decrease in autoimmunity
    Volker Daniel
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Viral Immunol 23:87-97. 2010
    ..Increased immunoregulatory T PBL might decrease autoimmunity, thereby contributing to immunological reconstitution and stabilization of long-term HIV-infected hemophilia patients on HAART...
  46. doi request reprint Urinary proinflammatory cytokine response in renal transplant recipients with polyomavirus BK viruria
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 88:1109-16. 2009
    ..BKV-associated nephropathy develops in approximately 5% to 8% of renal transplant recipients, and its prognosis is poor. The relationship between urine cytokines and BK viruria in kidney recipients has not been defined...
  47. ncbi request reprint Mitomycin C-treated antigen-presenting cells as a tool for control of allograft rejection and autoimmunity: from bench to bedside
    Peter Terness
    Institute of Immunology, University of Heidelberg, Department of Transplantation Immunology, Heidelberg, Germany
    Hum Immunol 70:506-12. 2009
    ..Although many questions remain, MMC-treated cells are a promising clinical tool for controlling allograft rejection and deleterious immune responses in autoimmune diseases...
  48. doi request reprint Association of high IFN-gamma plasma levels with low B-cell counts in renal transplant recipients with stable long-term graft function
    Volker Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 24:281-9. 2010
    ..High IFN-gamma plasma levels might prevent the development of an immunological alloresponse and thereby contribute to the maintenance of graft acceptance...
  49. ncbi request reprint Evaluation of hepatocyte growth factor as a sensitive marker for early detection of acute renal allograft rejection
    Khaled Mahmoud
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 83:1035-40. 2007
    ..In the present study we investigated whether HGF can serve as a marker for detection of acute rejection in the early posttransplantation period...
  50. doi request reprint HLA antibodies and the occurrence of early adverse events in the modern era of transplantation: a collaborative transplant study report
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 87:1367-71. 2009
    ..Adverse events occurring early after kidney transplantation were reported to influence graft outcome...
  51. ncbi request reprint Serial peripheral blood perforin and granzyme B gene expression measurements for prediction of acute rejection in kidney graft recipients
    Tania Simon
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Am J Transplant 3:1121-7. 2003
    ..Serial measurements could be implemented as a monitoring system to highlight patients at higher risk of rejection, making them candidates for biopsy or pre-emptive anti-rejection therapy...
  52. doi request reprint Dysregulated cytokine responses during cytomegalovirus infection in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 86:275-85. 2008
    ..The aim of this study was to examine whether there are differences in plasma cytokine levels pretransplant, before and during CMV replication in renal transplant recipients...
  53. doi request reprint Posttransplant sCD30 as a predictor of kidney graft outcome
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 91:1364-9. 2011
    ..Reliable markers for assessing the biological effect of immunosuppressive drugs and identification of transplant recipients at risk of developing rejection are not available...
  54. doi request reprint Deleterious impact of mismatching for human leukocyte antigen-C in presensitized recipients of kidney transplants
    Thuong Hien Tran
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 92:419-25. 2011
    ..We investigated the influence of HLA-C compatibility on renal allograft survival. In addition, we tested an approach of matching for HLA-C epitopes...
  55. ncbi request reprint Serial peripheral blood interleukin-18 and perforin gene expression measurements for prediction of acute kidney graft rejection
    Tania Simon
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Transplantation 77:1589-95. 2004
    ....
  56. ncbi request reprint The effect of donor gender on graft survival
    Martin Zeier
    Department of Internal Medicine Nephrology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 13:2570-6. 2002
    ..Therefore, in addition to potential "nephron underdosing," further pathomechanisms must play a role, possibly differences in immunogenicity according to donor gender...
  57. ncbi request reprint Association of IL-12+ DC with High CD3+CD4-DR+ lymphocyte counts in long-term HIV-infected hemophilia patients with clinically stable disease
    Volker Daniel
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    J Clin Immunol 28:58-72. 2008
    ..These data suggest that long-term HIV-infected hemophilia patients with clinically stable disease have normal levels of functional IL-10(+) DC and IL-12(+) DC that might be involved in halting the progression of disease...
  58. doi request reprint Deleterious impact of HLA-DRB1 allele mismatch in sensitized recipients of kidney retransplants
    Andreas Heinold
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 95:137-41. 2013
    ..Whether mismatches between donor and recipient of a kidney transplant at the HLA allele level can elicit an immune response strong enough to impact graft survival is not known...
  59. doi request reprint IVIG and rituximab for treatment of chronic antibody-mediated rejection: a prospective study in paediatric renal transplantation with a 2-year follow-up
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Transpl Int 25:1165-73. 2012
    ....
  60. doi request reprint Presensitized kidney graft recipients with HLA class I and II antibodies are at increased risk for graft failure: a Collaborative Transplant Study report
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 70:569-73. 2009
    ....
  61. doi request reprint Suppressive dendritic cells as a tool for controlling allograft rejection in organ transplantation: promises and difficulties
    Sandra Ehser
    Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 69:165-73. 2008
    ..Based on lessons learned from the use of DCs as tools in clinical vaccine trials in cancer, we discuss the unknown aspects and risks of DC therapy in transplantation...
  62. doi request reprint Does borderline kidney allograft rejection always require treatment?
    Dorottya Németh
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 90:427-32. 2010
    ..We analyzed Treg-associated forkhead box P3 (Foxp3) gene expression in Bord-R and more severe forms of acute rejection episodes (ARE)...
  63. doi request reprint Observational support for an immunoregulatory role of CD3+CD4+CD25+IFN-gamma+ blood lymphocytes in kidney transplant recipients with good long-term graft outcome
    Volker Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 21:646-60. 2008
    ..Our data support an immunoregulatory role of CD3+CD4+CD25+Foxp3+IFN-gamma+ cells in a subgroup of transplant recipients with good graft acceptance...
  64. ncbi request reprint Association of mismatches for HLA-DR with incidence of posttransplant hip fracture in kidney transplant recipients
    Gerhard Opelz
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 91:65-9. 2011
    ..Bone fractures are a frequent complication after kidney transplantation, for which various predisposing factors have been identified. It has been suggested that human leukocyte antigen (HLA) mismatch increases the risk...
  65. ncbi request reprint Association of high pretransplant sIL-6R plasma levels with acute tubular necrosis in kidney graft recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 81:1716-24. 2006
    ....
  66. ncbi request reprint Ex vivo perfusion with mitomycin C containing solution prolongs heart graft survival in rats
    Daohu Wang
    Institute for Immunology, Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 82:1537-40. 2006
    ..Our findings indicate that the targeted perfusion of donor hearts with MMC-containing solution protects the graft from rejection...
  67. ncbi request reprint Antithymocyte globulins suppress dendritic cell function by multiple mechanisms
    Cord Naujokat
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 83:485-97. 2007
    ..Although immunosuppressive mechanisms of ATGs on T cells are well studied, less is known about their impact on dendritic cells (DCs)...
  68. ncbi request reprint Studying the immunosuppressive role of indoleamine 2,3-dioxygenase: tryptophan metabolites suppress rat allogeneic T-cell responses in vitro and in vivo
    Thomas M Bauer
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, 69120 Heidelberg, Germany
    Transpl Int 18:95-100. 2005
    ..The metabolites induced a significant prolongation (P = 0.0018) of graft survival. We conclude that IDO-induced tryptophan metabolites suppress the T-cell response and prolong allograft survival in rats...
  69. doi request reprint Prevention of antibody-mediated kidney transplant rejection
    Christian Morath
    Department of Nephrology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 25:633-45. 2012
    ..In the current overview, we discuss the currently available measures for the prevention of antibody-mediated kidney graft rejection...
  70. doi request reprint Strong association of phenylalanine and tryptophan metabolites with activated cytomegalovirus infection in kidney transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, D 69117 Heidelberg, Germany
    Hum Immunol 73:186-92. 2012
    ..Moreover, tryptophan metabolite levels correlate with disease severity. Measurement of these amino acids is an inexpensive and fast method expected to complete conventional diagnostic assays...
  71. ncbi request reprint Risks of allogeneic hand transplantation
    Steffen Baumeister
    Department for Hand, Plastic and Reconstructive Surgery, Burn Center, BG Trauma Center, Plastic and Hand Surgery, University of Heidelberg, Heidelberg, Germany
    Microsurgery 24:98-103. 2004
    ..Although the incidence of side effects (particularly malignant disease) is likely to be lower than previously thought, the risk-benefit question must be answered by each hand surgeon for each individual patient...
  72. ncbi request reprint Pathway of apoptosis induced in Jurkat T lymphoblasts by anti-HLA class I antibodies
    Dinara Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 65:189-99. 2004
    ..This study clarifies the precise mechanism of anti-HLA antibody-induced apoptosis which might have clinical implications...
  73. ncbi request reprint High urine sIL-6R as a predictor of late graft failure in renal transplant recipients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany mahmoud sadeghi med uni heidelberg de
    Transplantation 76:1190-4. 2003
    ..Chronic allograft nephropathy is an important cause of late renal transplant failure. Although numerous studies on cytokines have been carried out, the pathogenetic role of cytokines in chronic renal allograft nephropathy remains unclear...
  74. doi request reprint HMG-CoA reductase inhibitor simvastatin overcomes bortezomib-induced apoptosis resistance by disrupting a geranylgeranyl pyrophosphate-dependent survival pathway
    Dominik Fuchs
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 374:309-14. 2008
    ..Thus, simvastatin overcomes bortezomib-induced apoptosis resistance by inhibiting synthesis of GGPP and disrupting a GGPP-dependent survival pathway...
  75. ncbi request reprint Strong inflammatory cytokine response in male and strong anti-inflammatory response in female kidney transplant recipients with urinary tract infection
    Mahmoud Sadeghi
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transpl Int 18:177-85. 2005
    ....
  76. ncbi request reprint Kidney graft failure and presensitization against HLA class I and class II antigens
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Transplantation 73:1269-73. 2002
    ..We investigated the clinical relevance of preformed anti-HLA class I and class II antibodies on graft outcome in more than 4000 kidney recipients...
  77. doi request reprint Successful treatment of chronic antibody-mediated rejection with IVIG and rituximab in pediatric renal transplant recipients
    Heiko Billing
    Department of Pediatrics I, University Children s Hospital, Heidelberg, Germany
    Transplantation 86:1214-21. 2008
    ..We therefore initiated a pilot study on treatment of CAMR with an antihumoral regimen consisting of high-dose intravenous immunoglobulin (IVIG) and the chimeric anti-CD20 antibody rituximab...
  78. ncbi request reprint The effect of ATG on cytokine and cytotoxic T-lymphocyte gene expression in renal allograft recipients during the early post-transplant period
    Tania Simon
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Clin Transplant 17:217-24. 2003
    ..In the present study, we analyzed the effect of ATG-induction therapy on expression of 10 immunologically relevant genes in the early post-transplant period...
  79. ncbi request reprint Apoptosis-mediated selective killing of malignant cells by cardiac steroids: maintenance of cytotoxicity and loss of cardiac activity of chemically modified derivatives
    Dinara Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, 69120 Heidelberg, Germany
    Int Immunopharmacol 3:1791-801. 2003
    ..The description of compounds without cardiac activity but with tumor-specific cytotoxicity suggests the potential of using them in cancer therapy...
  80. ncbi request reprint Evaluation of posttransplantation soluble CD30 for diagnosis of acute renal allograft rejection
    Steffen Pelzl
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 75:421-3. 2003
    ..Posttransplantation measurement of soluble CD30 (sCD30) may be useful for identifying kidney graft recipients at risk of impending graft rejection in the early posttransplantation period...
  81. ncbi request reprint No association of factor V Leiden, prothrombin G20210A, and MTHFR C677T gene polymorphisms with kidney allograft survival: a multicenter study
    Marko Meyer
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 83:1055-8. 2007
    ..On the basis of this hypothesis, we performed a multicenter study, involving recipients of primary and repeat kidney transplants, to investigate the potential effect of these three single nucleotide polymorphisms (SNP) on graft survival...
  82. ncbi request reprint Soluble CD30 as a predictor of kidney graft outcome
    Steffen Pelzl
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Transplantation 73:3-6. 2002
    ..We also investigated whether the pretransplantation serum sCD30 content is related to kidney graft survival...
  83. ncbi request reprint Generation of tolerogenic dendritic cells by treatment with mitomycin C: inhibition of allogeneic T-cell response is mediated by downregulation of ICAM-1, CD80, and CD86
    Lucian P Jiga
    Department of Transplantation Immunology, Heidelberg, Germany
    Transplantation 77:1761-4. 2004
    ..In this article, the authors study the effect of mitomycin C (MMC)-treated DC on rat T cells and delineate the mechanism of their conversion into tolerogenic cells...
  84. doi request reprint Pharmacokinetics and immunodynamics of basiliximab in pediatric renal transplant recipients on mycophenolate mofetil comedication
    Britta Höcker
    Department of Pediatrics I, University Children s Hospital Heidelberg, Heidelberg, Germany
    Transplantation 86:1234-40. 2008
    ....
  85. ncbi request reprint Dissociation of CD4(+) cell counts from viral load and association with immune complexes in HIV(+) hemophilia patients
    Mahmoud Sadeghi
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120, Heidelberg, Germany
    Immunol Lett 91:23-32. 2004
    ..In this retrospective study, we investigated whether HIV causes CD4 depletion by direct cytotoxicity or indirectly by induction of a host autoimmune response...
  86. ncbi request reprint Polymorphisms of the tumor necrosis factor-alpha gene promoter predict for outcome after thalidomide therapy in relapsed and refractory multiple myeloma
    Kai Neben
    Department of Internal Medicine V, University of Heidelberg, Hospitalstrasse 3, 69115 Heidelberg, Germany
    Blood 100:2263-5. 2002
    ....
  87. doi request reprint Salinomycin in cancer: A new mission for an old agent
    Cord Naujokat
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, D 69120 Heidelberg, Germany
    Mol Med Report 3:555-9. 2010
    ..The ability of salinomycin to effectively kill both cancer stem cells and apoptosis-resistant cancer cells may define the compound as a novel and effective anticancer agent...
  88. ncbi request reprint Associations of dichlorodiphenyltrichloroethane (DDT) 4.4 and dichlorodiphenyldichloroethylene (DDE) 4.4 blood levels with plasma IL-4
    Volker Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Arch Environ Health 57:541-7. 2002
    ..The authors hypothesized that clinical symptoms, such as the frequent infections reported by many patients, could be a consequence of these immunological abnormalities...
  89. ncbi request reprint Good kidney transplant outcome in recipients with presensitization against HLA class II but not HLA class I
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Hum Immunol 65:810-6. 2004
    ..We conclude that the risk associated with sensitization against HLA class II in the absence of sensitization against HLA class I is negligible...
  90. pmc Inhibition of allogeneic T cell proliferation by indoleamine 2,3-dioxygenase-expressing dendritic cells: mediation of suppression by tryptophan metabolites
    Peter Terness
    Institute of Immunology, Department of Transplantation Immunology, University of Heidelberg, 69120 Heidelberg, Germany
    J Exp Med 196:447-57. 2002
    ....
  91. ncbi request reprint Immunosuppressive anti-immunoglobulin autoantibodies: specificity, gene structure and function in health and disease
    Peter I Terness
    Institute of Immunology, University of Heidelberg, Germany
    Cell Mol Biol (Noisy-le-grand) 48:271-8. 2002
    ..There is substantial evidence indicating that anti-Ig auto-Abs are important immunoregulatory molecules...
  92. ncbi request reprint Very short ischaemia is not the answer
    Gerhard Opelz
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Germany
    Nephrol Dial Transplant 17:715-6. 2002
  93. doi request reprint From cancer to transplantation: an evaluation of period analysis for calculating up-to-date long-term survival estimates
    Adam Gondos
    Division of Clinical Epidemiology and Aging Research, German Cancer Research Center, Heidelberg, Germany
    Am J Epidemiol 172:613-20. 2010
    ..The method appears useful for providing more up-to-date long-term survival estimates than traditional methods, and its use in pertinent studies is encouraged...
  94. ncbi request reprint Malignancy in renal transplantation
    Christian Morath
    Department of Nephrology, University of Heidelberg, Bergheimerstrasse 56a, 69115 Heidelberg, Germany
    J Am Soc Nephrol 15:1582-8. 2004
  95. ncbi request reprint Relevance of IL10, TGFbeta1, TNFalpha, and IL4Ralpha gene polymorphisms in kidney transplantation: a collaborative transplant study report
    Joannis Mytilineos
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Am J Transplant 4:1684-90. 2004
    ..The outcome of retransplants appears to be affected by TNFalpha genotypes only...
  96. ncbi request reprint Longitudinal analysis of T-helper cell phenotypes in renal-transplant recipients undergoing growth hormone therapy
    Anette Melk
    Department of Transplantation Immunology, University of Heidelberg, Heidelberg, Germany
    Transplantation 78:1792-801. 2004
    ..We therefore evaluated the immune phenotypes of pediatric renal-transplant recipients and controls in response to rhGH with regard to a possible shift toward a T-helper (TH)1-type response...
  97. ncbi request reprint Cell cycle- and activation-dependent regulation of cyclosporin A-induced T cell apoptosis
    Cord Naujokat
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Im Neuenheimer Feld 305, D 69120 Heidelberg, Germany
    Biochem Biophys Res Commun 310:347-54. 2003
    ....
  98. ncbi request reprint Clinical relevance of immune monitoring in solid organ transplantation
    Volker Daniel
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    Int Rev Immunol 28:155-84. 2009
    ..A multiparametric immune monitoring program, performed frequently and lifelong, might be the appropriate approach to predict dysfunction of the graft before clinical symptoms occur...
  99. ncbi request reprint The immunoregulatory role of IDO-producing human dendritic cells revisited
    Peter Terness
    Institute of Immunology, Department of Transplantation Immunology, INF 305, University of Heidelberg, 69120 Heidelberg, Germany
    Trends Immunol 27:68-73. 2006
    ..Here, we critically examine the arguments for and against a function of IDO-expressing human dendritic cells (DCs) and conclude that proof for an immunoregulatory role in vivo is still lacking...
  100. ncbi request reprint Identification of highly responsive kidney transplant recipients using pretransplant soluble CD30
    Caner Süsal
    Department of Transplantation Immunology, Institute of Immunology, University of Heidelberg, Heidelberg, Germany
    J Am Soc Nephrol 13:1650-6. 2002
    ....
  101. pmc Metabolic control improves long-term renal allograft and patient survival in type 1 diabetes
    Christian Morath
    Department of Nephrology, University of Heidelberg, Im Neuenheimer Feld 162, 69120 Heidelberg, Germany
    J Am Soc Nephrol 19:1557-63. 2008
    ..55; P = 0.005). In summary, the early survival advantage of LDK over SPK is lost during long-term follow-up, probably as a result of improved glycemic control in SPK recipients...