Otilia Obreja

Summary

Affiliation: University of Heidelberg
Location: , Germany

Publications

  1. ncbi request reprint PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia
    Parvinder Kaur Rathee
    Institute of Physiology, Department of Anaesthesiology, University of Erlangen, D 91054 Erlangen, Germany
    J Neurosci 22:4740-5. 2002
  2. doi request reprint Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo
    Roman Rukwied
    University Clinics of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurosci Res 88:2066-72. 2010
  3. doi request reprint NGF enhances electrically induced pain, but not axon reflex sweating
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Pain 152:1856-63. 2011
  4. doi request reprint NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin
    Roman Rukwied
    Department of Anaesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Germany
    Pain 148:407-13. 2010
  5. doi request reprint Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
    Otilia Obreja
    Department of Anesthesiology Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Pain 148:59-69. 2010
  6. doi request reprint Single-fiber recordings of unmyelinated afferents in pig
    Otilia Obreja
    Dept Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68137 Mannheim, Germany
    Neurosci Lett 470:175-9. 2010
  7. doi request reprint Comparison of electrically induced flare response patterns in human and pig skin
    M Dusch
    Department of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Inflamm Res 58:639-48. 2009
  8. doi request reprint A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels
    Otilia Obreja
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Eur J Pain 12:775-89. 2008
  9. ncbi request reprint Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2
    Roman Rukwied
    Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Pain 8:443-51. 2007
  10. ncbi request reprint Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006

Collaborators

Detail Information

Publications17

  1. ncbi request reprint PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia
    Parvinder Kaur Rathee
    Institute of Physiology, Department of Anaesthesiology, University of Erlangen, D 91054 Erlangen, Germany
    J Neurosci 22:4740-5. 2002
    ..Thus, the PKA/AKAP/VR-1 module presents as the molecular correlate of G(s)-mediated inflammatory hyperalgesia...
  2. doi request reprint Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo
    Roman Rukwied
    University Clinics of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurosci Res 88:2066-72. 2010
    ..Thus, long-lasting sensitization processes of nociceptor endings or axonal sodium channel desensitization mechanisms can be explored in the pig as a translational experimental animal model...
  3. doi request reprint NGF enhances electrically induced pain, but not axon reflex sweating
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Pain 152:1856-63. 2011
    ..4%). In summary, axonal sensitization of nociceptors by NGF could underlie the hyperalgesia to electrical stimulation. Enhanced responses were limited to nociceptors, as no sensitization was found in sympathetic efferent neurons...
  4. doi request reprint NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin
    Roman Rukwied
    Department of Anaesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Germany
    Pain 148:407-13. 2010
    ..Intradermal NGF administration provokes a pattern of sensitization that can be used as experimental model for neuropathic pain...
  5. doi request reprint Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
    Otilia Obreja
    Department of Anesthesiology Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Pain 148:59-69. 2010
    ..Notably, cold nociceptors with a distinct ADS pattern were first detected in pig. Our results therefore suggest that the pig is a suitable model to study nociceptor class-specific changes of ADS...
  6. doi request reprint Single-fiber recordings of unmyelinated afferents in pig
    Otilia Obreja
    Dept Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68137 Mannheim, Germany
    Neurosci Lett 470:175-9. 2010
    ..It is suggested that the pig is an attractive model for studying modulation of excitability in nociceptive and non-nociceptive C-fiber classes that correspond to those in man...
  7. doi request reprint Comparison of electrically induced flare response patterns in human and pig skin
    M Dusch
    Department of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Inflamm Res 58:639-48. 2009
    ..We compared the characteristics of neurogenic flare responses in human and pig skin to establish a translational research animal model...
  8. doi request reprint A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels
    Otilia Obreja
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Eur J Pain 12:775-89. 2008
    ..In conclusion, in porcine dorsal root ganglion neurons there is a subset of capsaicin-positive, IB4-negative neurons lacking HCN-1 and/or HCN-2 channel isoforms...
  9. ncbi request reprint Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2
    Roman Rukwied
    Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Pain 8:443-51. 2007
    ..Intriguingly, when compared with skin, muscle pain was significantly lower in the initial phase (0 to 15 seconds) but significantly higher in the second phase (20 to 100 seconds after injection)...
  10. ncbi request reprint Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
    ..Thrombin-induced PE and VD are mediated mainly by a non-neurogenic mechanism...
  11. ncbi request reprint Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons
    O Obreja
    Institut fur Physiologie und Experimentelle Pathophysiologie, Friedrich Alexander Universitat, Erlangen Nurnberg, Germany
    Brain 128:1634-41. 2005
    ..Together, the results suggest that IL-6-sIL-6R acts directly on sensory neurons. It increases their susceptibility to noxious heat via the gp130/Jak/PKCdelta signalling pathway...
  12. ncbi request reprint Fast Ca2+-induced potentiation of heat-activated ionic currents requires cAMP/PKA signaling and functional AKAP anchoring
    C Distler
    Institute of Physiology and Experimental Pathophysiology, D 91054 Erlangen, Germany
    J Neurophysiol 89:2499-505. 2003
    ..This calcium-dependent pathway can account for the sensitizing properties of many excitatory mediators that activate cationic membrane currents...
  13. ncbi request reprint The inflammatory mediators serotonin, prostaglandin E2 and bradykinin evoke calcium influx in rat sensory neurons
    O Linhart
    Institut fur Physiologie und Experimentelle Pathophysiologie, Universitaetsstrasse 17, D 91054, Erlangen, Germany
    Neuroscience 118:69-74. 2003
    ..However, they do not utilize a calcium-dependent cooperative mechanism to facilitate proton-induced currents...
  14. ncbi request reprint IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C
    Otilia Obreja
    Institut fuer Physiologie und Experimentelle Pathophysiologie, Friedrich Alexander Universitaet, 91054 Erlangen, Germany
    FASEB J 16:1497-503. 2002
    ..IL-1 beta acts on sensory neurons to increase their susceptibility for noxious heat via an IL-1RI/PTK/PKC-dependent mechanism...
  15. ncbi request reprint Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo
    Otilia Obreja
    Institut fur Physiologie und Experimentelle Pathophysiologie, Universitatsstrasse 17, Erlangen, Germany
    Pain 96:57-62. 2002
    ....
  16. doi request reprint The differential effects of two sodium channel modulators on the conductive properties of C-fibers in pig skin in vivo
    Otilia Obreja
    Department of Anesthesiology and Operative Intensive Care, Heidelberg University, Mannheim, Germany
    Anesth Analg 115:560-71. 2012
    ....