Otilia Obreja

Summary

Affiliation: University of Heidelberg
Location: , Germany

Publications

  1. ncbi Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo
    Roman Rukwied
    University Clinics of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurosci Res 88:2066-72. 2010
  2. ncbi NGF enhances electrically induced pain, but not axon reflex sweating
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Pain 152:1856-63. 2011
  3. ncbi NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin
    Roman Rukwied
    Department of Anaesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Germany
    Pain 148:407-13. 2010
  4. ncbi Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
    Otilia Obreja
    Department of Anesthesiology Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Pain 148:59-69. 2010
  5. ncbi Single-fiber recordings of unmyelinated afferents in pig
    Otilia Obreja
    Dept Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68137 Mannheim, Germany
    Neurosci Lett 470:175-9. 2010
  6. ncbi Comparison of electrically induced flare response patterns in human and pig skin
    M Dusch
    Department of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Inflamm Res 58:639-48. 2009
  7. ncbi A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels
    Otilia Obreja
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Eur J Pain 12:775-89. 2008
  8. ncbi Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2
    Roman Rukwied
    Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Pain 8:443-51. 2007
  9. ncbi Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
  10. ncbi Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons
    O Obreja
    , , , Germany
    Brain 128:1634-41. 2005

Collaborators

Detail Information

Publications17

  1. ncbi Nerve growth factor-evoked nociceptor sensitization in pig skin in vivo
    Roman Rukwied
    University Clinics of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68167 Mannheim, Germany
    J Neurosci Res 88:2066-72. 2010
    ..Thus, long-lasting sensitization processes of nociceptor endings or axonal sodium channel desensitization mechanisms can be explored in the pig as a translational experimental animal model...
  2. ncbi NGF enhances electrically induced pain, but not axon reflex sweating
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, Heidelberg University, Theodor Kutzer Ufer 1 3, Mannheim 68167, Germany
    Pain 152:1856-63. 2011
    ..4%). In summary, axonal sensitization of nociceptors by NGF could underlie the hyperalgesia to electrical stimulation. Enhanced responses were limited to nociceptors, as no sensitization was found in sympathetic efferent neurons...
  3. ncbi NGF induces non-inflammatory localized and lasting mechanical and thermal hypersensitivity in human skin
    Roman Rukwied
    Department of Anaesthesiology and Intensive Care Medicine Mannheim, Heidelberg University, Germany
    Pain 148:407-13. 2010
    ..Intradermal NGF administration provokes a pattern of sensitization that can be used as experimental model for neuropathic pain...
  4. ncbi Patterns of activity-dependent conduction velocity changes differentiate classes of unmyelinated mechano-insensitive afferents including cold nociceptors, in pig and in human
    Otilia Obreja
    Department of Anesthesiology Mannheim, University of Heidelberg, 68167 Mannheim, Germany
    Pain 148:59-69. 2010
    ..Notably, cold nociceptors with a distinct ADS pattern were first detected in pig. Our results therefore suggest that the pig is a suitable model to study nociceptor class-specific changes of ADS...
  5. ncbi Single-fiber recordings of unmyelinated afferents in pig
    Otilia Obreja
    Dept Anesthesiology and Intensive Care Medicine, Medical Faculty Mannheim, University of Heidelberg, Theodor Kutzer Ufer 1 3, 68137 Mannheim, Germany
    Neurosci Lett 470:175-9. 2010
    ..It is suggested that the pig is an attractive model for studying modulation of excitability in nociceptive and non-nociceptive C-fiber classes that correspond to those in man...
  6. ncbi Comparison of electrically induced flare response patterns in human and pig skin
    M Dusch
    Department of Anaesthesiology and Intensive Care Medicine, University Medicine Mannheim, Ruprecht Karls University Heidelberg, Theodor Kutzer Ufer 1 3, 68167, Mannheim, Germany
    Inflamm Res 58:639-48. 2009
    ..We compared the characteristics of neurogenic flare responses in human and pig skin to establish a translational research animal model...
  7. ncbi A subpopulation of capsaicin-sensitive porcine dorsal root ganglion neurons is lacking hyperpolarization-activated cyclic nucleotide-gated channels
    Otilia Obreja
    Department of Anesthesiology and Intensive Care Medicine, Faculty of Clinical Medicine, University of Heidelberg, Mannheim, Germany
    Eur J Pain 12:775-89. 2008
    ..In conclusion, in porcine dorsal root ganglion neurons there is a subset of capsaicin-positive, IB4-negative neurons lacking HCN-1 and/or HCN-2 channel isoforms...
  8. ncbi Potentiation of nociceptive responses to low pH injections in humans by prostaglandin E2
    Roman Rukwied
    Department of Anesthesiology and Intensive Care Medicine, Clinical Faculty Mannheim, University of Heidelberg, Mannheim, Germany
    J Pain 8:443-51. 2007
    ..This can be best explained by TRPV1 sensitization in the presence of PGE2, a mechanism potentially relevant for inflammatory and injury-induced pain...
  9. ncbi Neurogenic components of trypsin- and thrombin-induced inflammation in rat skin, in vivo
    Otilia Obreja
    Department of Anaesthesiology and Intensive Care, Faculty of Clinical Medicine Mannheim, University of Medicine Heidelberg, Mannheim, Germany
    Exp Dermatol 15:58-65. 2006
    ..Thrombin-induced PE and VD are mediated mainly by a non-neurogenic mechanism...
  10. ncbi Fast modulation of heat-activated ionic current by proinflammatory interleukin 6 in rat sensory neurons
    O Obreja
    , , , Germany
    Brain 128:1634-41. 2005
    ..Together, the results suggest that IL-6-sIL-6R acts directly on sensory neurons. It increases their susceptibility to noxious heat via the gp130/Jak/PKCdelta signalling pathway...
  11. ncbi Fast Ca2+-induced potentiation of heat-activated ionic currents requires cAMP/PKA signaling and functional AKAP anchoring
    C Distler
    Institute of Physiology and Experimental Pathophysiology, D-91054 Erlangen, Germany
    J Neurophysiol 89:2499-505. 2003
    ..This calcium-dependent pathway can account for the sensitizing properties of many excitatory mediators that activate cationic membrane currents...
  12. ncbi The inflammatory mediators serotonin, prostaglandin E2 and bradykinin evoke calcium influx in rat sensory neurons
    O Linhart
    Institut fur Physiologie und Experimentelle Pathophysiologie, Universitaetsstrasse 17, D-91054, Erlangen, Germany
    Neuroscience 118:69-74. 2003
    ..However, they do not utilize a calcium-dependent cooperative mechanism to facilitate proton-induced currents...
  13. ncbi IL-1 beta potentiates heat-activated currents in rat sensory neurons: involvement of IL-1RI, tyrosine kinase, and protein kinase C
    Otilia Obreja
    Institut fuer Physiologie und Experimentelle Pathophysiologie, Friedrich-Alexander Universitaet, 91054 Erlangen, Germany
    FASEB J 16:1497-503. 2002
    ..IL-1 beta acts on sensory neurons to increase their susceptibility for noxious heat via an IL-1RI/PTK/PKC-dependent mechanism...
  14. ncbi PKA/AKAP/VR-1 module: A common link of Gs-mediated signaling to thermal hyperalgesia
    Parvinder Kaur Rathee
    Institute of Physiology, Department of Anaesthesiology, University of Erlangen, D 91054 Erlangen, Germany
    J Neurosci 22:4740-5. 2002
    ..Thus, the PKA/AKAP/VR-1 module presents as the molecular correlate of G(s)-mediated inflammatory hyperalgesia...
  15. ncbi Interleukin-6 in combination with its soluble IL-6 receptor sensitises rat skin nociceptors to heat, in vivo
    Otilia Obreja
    , , Erlangen, Germany
    Pain 96:57-62. 2002
    ....
  16. ncbi The differential effects of two sodium channel modulators on the conductive properties of C-fibers in pig skin in vivo
    Otilia Obreja
    Department of Anesthesiology and Operative Intensive Care, Heidelberg University, Mannheim, Germany
    Anesth Analg 115:560-71. 2012
    ....