Holger Nuckel

Summary

Affiliation: University Hospital
Country: Germany

Publications

  1. ncbi request reprint HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University of Duisburg Essen, Germany
    Blood 105:1694-8. 2005
  2. doi request reprint FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University of Duisburg Essen, Germany
    Eur J Haematol 83:541-9. 2009
  3. ncbi request reprint Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Germany
    Blood 109:290-7. 2007
  4. doi request reprint p53 protein expression in chronic lymphocytic leukemia
    Ludger Sellmann
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Leuk Lymphoma 53:1282-8. 2012
  5. doi request reprint The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels
    Hagen S Bachmann
    Institute of Pharmacogenetics, Medical Faculty, University of Duisburg Essen, Duisburg, Germany
    Eur J Haematol 85:108-13. 2010
  6. ncbi request reprint The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients
    Hagen S Bachmann
    Institute of Pharmacogenetics, University of Duisburg Essen, Germany
    Clin Cancer Res 13:5790-7. 2007
  7. doi request reprint Telomeres and prognosis in patients with chronic lymphocytic leukaemia
    Ludger Sellmann
    Department of Haematology, University of Duisburg Essen, Essen, Germany
    Int J Hematol 93:74-82. 2011
  8. doi request reprint Association of the CC genotype of the regulatory BCL2 promoter polymorphism (-938C>A) with better 2-year survival in patients with glioblastoma multiforme
    Nicolai El Hindy
    Department of Neurosurgery, Medical Faculty, University of Duisburg Essen, Essen, Germany
    J Neurosurg 114:1631-9. 2011
  9. doi request reprint High CD49d protein and mRNA expression predicts poor outcome in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Haematology, University of Duisburg Essen, Germany
    Clin Immunol 131:472-80. 2009
  10. doi request reprint Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model
    Semra Aydin
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Eur J Haematol 87:10-9. 2011

Collaborators

Detail Information

Publications19

  1. ncbi request reprint HLA-G expression is associated with an unfavorable outcome and immunodeficiency in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University of Duisburg Essen, Germany
    Blood 105:1694-8. 2005
    ..HLA-G may contribute to the impairment of immune responses against tumor cells and infections. Thus, these findings need to be confirmed in a prospective study...
  2. doi request reprint FCRL2 mRNA expression is inversely associated with clinical progression in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University of Duisburg Essen, Germany
    Eur J Haematol 83:541-9. 2009
    ..In multivariate analysis low FCRL2 expression was a significant independent prognostic factor (HR 2.4; P = 0.005). Here we demonstrate that the level of FCRL2 expression is correlated with prognosis in B-CLL...
  3. ncbi request reprint Association of a novel regulatory polymorphism (-938C>A) in the BCL2 gene promoter with disease progression and survival in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Germany
    Blood 109:290-7. 2007
    ..034) together with disease stage at diagnosis (HR 2.5; P = .004) and ZAP-70 status (HR 3.0; P = .001). The BCL2-938AA genotype is associated with increased Bcl-2 expression and a novel unfavorable genetic marker in patients with B-CLL...
  4. doi request reprint p53 protein expression in chronic lymphocytic leukemia
    Ludger Sellmann
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Leuk Lymphoma 53:1282-8. 2012
    ..Taken together, the differential expression of p53 isoforms could disrupt the p53 response and contribute to CLL pathogenesis...
  5. doi request reprint The G-Allele of the PSMA6-8C>G polymorphism is associated with poor outcome in multiple myeloma independently of circulating proteasome serum levels
    Hagen S Bachmann
    Institute of Pharmacogenetics, Medical Faculty, University of Duisburg Essen, Duisburg, Germany
    Eur J Haematol 85:108-13. 2010
    ..Moreover, PSMA6 mRNA expression in human B-cell lines depended on genotypes. We investigated a potential role of this novel SNP in patients with MM...
  6. ncbi request reprint The AA genotype of the regulatory BCL2 promoter polymorphism ( 938C>A) is associated with a favorable outcome in lymph node negative invasive breast cancer patients
    Hagen S Bachmann
    Institute of Pharmacogenetics, University of Duisburg Essen, Germany
    Clin Cancer Res 13:5790-7. 2007
    ..We recently showed a novel regulatory (-938C>A) single-nucleotide polymorphism (SNP) in the inhibitory P2 BCL2 gene promoter generating significantly different BCL2 promoter activities...
  7. doi request reprint Telomeres and prognosis in patients with chronic lymphocytic leukaemia
    Ludger Sellmann
    Department of Haematology, University of Duisburg Essen, Essen, Germany
    Int J Hematol 93:74-82. 2011
    ..Short telomeres and high telomerase activity as occurs in some patients with CLL with a worse prognosis might be an ideal target for treatment with telomerase inhibitors...
  8. doi request reprint Association of the CC genotype of the regulatory BCL2 promoter polymorphism (-938C>A) with better 2-year survival in patients with glioblastoma multiforme
    Nicolai El Hindy
    Department of Neurosurgery, Medical Faculty, University of Duisburg Essen, Essen, Germany
    J Neurosurg 114:1631-9. 2011
    ..The authors investigated the role of a common regulatory single-nucleotide polymorphism (-938C>A), which is located in the inhibitory P2 promoter of BCL2...
  9. doi request reprint High CD49d protein and mRNA expression predicts poor outcome in chronic lymphocytic leukemia
    Holger Nuckel
    Department of Haematology, University of Duisburg Essen, Germany
    Clin Immunol 131:472-80. 2009
    ..Collectively, our data confirm the prognostic significance supporting the idea to use CD49d as target molecules for therapeutic approaches in B-CLL...
  10. doi request reprint Investigating the role of CD38 and functionally related molecular risk factors in the CLL NOD/SCID xenograft model
    Semra Aydin
    Department of Hematology, University of Duisburg Essen Medical School, Essen, Germany
    Eur J Haematol 87:10-9. 2011
    ..This model could be useful for evaluating the biological basis of CLL growth in the context of the hematopoietic microenvironment as well as preclinical testing of novel compounds...
  11. ncbi request reprint Alemtuzumab induces enhanced apoptosis in vitro in B-cells from patients with chronic lymphocytic leukemia by antibody-dependent cellular cytotoxicity
    Holger Nuckel
    Department of Hematology, Medical School, University of Duisburg Essen, Germany
    Eur J Pharmacol 514:217-24. 2005
    ..Alemtuzumab significantly enhances apoptosis in chronic lymphocytic leukemia cells in vitro, especially in combination with a cross-linking anti-Fc-antibody, this effect being mediated by a caspase-dependent pathway...
  12. doi request reprint Combined PER2 and CRY1 expression predicts outcome in chronic lymphocytic leukemia
    Lewin Eisele
    Department of Hematology, University Hospital, Hufelandstrasse 55, Essen, Germany
    Eur J Haematol 83:320-7. 2009
    ..Because of their role in the expression of cell cycle-related and DNA-damage response genes, we suggest that the deregulated expression of circadian genes may be linked to the molecular pathogenesis of CLL...
  13. doi request reprint Prognostic significance of serum cystatin C in multiple myeloma
    Holger Nuckel
    Department of Hematology, University Hospital Essen, Hufelandstr 55, 45122, Essen, Germany
    Int J Hematol 95:545-50. 2012
    ..The level of serum cystatin C is not only a sensitive marker of renal function, but also reflects tumor burden and delivers prognostic information in MM...
  14. doi request reprint Gene dosage effects in chronic lymphocytic leukemia
    Ludger Sellmann
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Hufelandstrase 55, 45122 Essen, Germany
    Cancer Genet Cytogenet 203:149-60. 2010
    ..We did not confirm a consistent correlation between MIRN15A and MIRN16-1 expression levels and BCL2 protein levels, indicating a complex regulation of BCL2 expression...
  15. ncbi request reprint Rituximab plus ASHAP for the treatment of patients with relapsed or refractory aggressive non-Hodgkin's lymphoma: a single-centre study of 20 patients
    Semra Aydin
    Department of Hematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Ann Hematol 86:271-6. 2007
    ....
  16. ncbi request reprint Trisomy 19 is associated with trisomy 12 and mutated IGHV genes in B-chronic lymphocytic leukaemia
    Ludger Sellmann
    Department of Haematology, Medical Faculty, University of Duisburg Essen, Essen, Germany
    Br J Haematol 138:217-20. 2007
    ..Karyotypes of the present study and the literature identified a strong correlation to trisomy 18 in addition to trisomy 12. Trisomy 19 seems to be a secondary event in B-CLL with trisomy 12, mostly originating from mutated B cells...
  17. ncbi request reprint Lipoprotein lipase expression is a novel prognostic factor in B-cell chronic lymphocytic leukemia
    Holger Nuckel
    Department of Hematology, University Hospital Essen, Essen, Germany
    Leuk Lymphoma 47:1053-61. 2006
    ..The LPL/ADAM29 expression ratio was not found to be an independent prognostic factor and did not offer any advantages over the use of LPL alone. Collectively, our data confirm a role for LPL as a novel prognostic indicator in B-CLL...
  18. ncbi request reprint 1513A/C polymorphism in the P2X7 receptor gene in chronic lymphocytic leukemia: absence of correlation with clinical outcome
    Holger Nuckel
    Department of Hematology, Medical Faculty, University of Essen, Essen, Germany
    Eur J Haematol 72:259-63. 2004
    ..In conclusion, our data do not support a role of the P2X7 genotype as a prognostic marker in B-cell CLL...
  19. ncbi request reprint Anti-CD20 monoclonal antibody therapy in relapsed MALT lymphoma of the conjunctiva
    Holger Nuckel
    Department of Hematology, Medical Faculty, University of Essen, Germany
    Eur J Haematol 73:258-62. 2004
    ..Rituximab is a highly effective and well-tolerated treatment of conjunctival MALT lymphoma, which may not only be of value in relapse, but also in cases of contraindication to radiotherapy...